netbook
desktop
mobile
tablet-landscape
tablet
phone-landscape
phone
Research to Prevent Blindness

Researchers ID Key Compounds Related to Blood Vessel Growth in Wet AMD

A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by RPB-supported researchers at Massachusetts Eye and Ear. The report, published online in the Proceedings of the National Academy of Sciences, suggests that it may be possible to prevent the vision loss observed in wet AMD by increasing the expression of specific bioactive lipid metabolites in the retina.

Choroidal neovascular lesion with associated blood vessels (red) and immune cells (Green). Photo courtesy: Dr. Kip Connor.

Disease-causing angiogenesis is a feature of advanced AMD in which blood vessels in the retina (the structure in the back of the eye that senses and perceives light) begin to grow new, abnormal blood vessels on the surface of the retina. These new vessels are immature, and can leak, rupture, or cause retinal detachment. Such cases, termed neovascular or “wet” AMD, account for 10 to 15 percent of AMD cases, develop abruptly, and rapidly lead to substantial vision loss.

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease. Given this, these molecules show promising therapeutic potential not only for AMD, but also for other major conditions that involve angiogenesis and inflammation, such as cardiovascular disease and cancer.

“Given the high prevalence and progressive nature of neovascular eye disease, the ability to stabilize bioactive lipids that mitigate or halt disease is of great and increasingly therapeutic significance,” said corresponding author and RPB grantee Kip Connor, PhD, a vision scientist at Mass. Eye and Ear and Assistant Professor of Ophthalmology at Harvard Medical School. “It is our hope that emerging technologies and future studies will expand on our work, and ultimately lead to safe, targeted, and cost-effective therapies that markedly improve visual outcomes and quality of life for patients suffering from these debilitating eye diseases.”

Read the full press release from Mass. Eye and Ear

Related News: Feature Story, Macular Degeneration, Retina Disorders , Top Story

RPB-SUPPORTED RESEARCHERS WILL BE INTEGRAL PART OF LATEST EFFORT WITHIN NEI’S AUDACIOUS GOALS INITIATIVE

Vision scientists who have received RPB funding will help lead all five research teams, which will seek to accelerate development of regenerative treatments for blindness.

Read More

 

EMERGING VISION SCIENTISTS EDUCATE, THANK CONGRESS FOR RESEARCH APPROPRIATIONS

(NAEVR) held its Fourth Annual Emerging Vision Scientists (EVS) Day on Capitol Hill and twenty early-stage investigators participated.

Read More

 

RESEARCH TO PREVENT BLINDNESS AND LIONS CLUBS INTERNATIONAL FOUNDATION TO CONTINUE LOW VISION RESEARCH AWARD PARTNERSHIP

Research to Prevent Blindness (RPB) and Lions Clubs International Foundation (LCIF) announced today that they will continue their partnership in the RPB/LCIF Low Vision Research Award.

Read More

 

Four RPB-supported researchers and a Scientific Advisory Panel member have been honored with the prestigious 2018 António Champalimaud Vision Award for their groundbreaking research

Four RPB-supported researchers and a Scientific Advisory Panel member have been honored with the prestigious 2018 António Champalimaud Vision Award for their groundbreaking research

Read More

 

IN THE FUTURE, ALZHEIMER’S MAY BE PREDICTED DURING EYE EXAMS

RPB-funded researchers at Washington University School of Medicine in St. Louis (WUSTL) have found a correlation in 30 older patients between retina thinning and elevated levels of tau and amyloid proteins that are the hallmark of Alzheimer’s disease.

Read More

 

Research to Prevent Blindness and Association of University Professors of Ophthalmology Announce 2018 Recipient of RPB David F. Weeks Award for Outstanding AMD Research

RPB and AUPO announce 2018 recipient of David F. Weeks Award for outstanding AMD research.

Read More

 

Subscribe

Get our email updates filled with the latest news from our researchers about preventing vision loss, treating eye disease and even restoring sight. Unsubscribe at any time. Under our privacy policy, we'll never share your contact information with a third party.