netbook
desktop
mobile
tablet-landscape
tablet
phone-landscape
phone
Research to Prevent Blindness

Researchers ID Key Compounds Related to Blood Vessel Growth in Wet AMD

A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by RPB-supported researchers at Massachusetts Eye and Ear. The report, published online in the Proceedings of the National Academy of Sciences, suggests that it may be possible to prevent the vision loss observed in wet AMD by increasing the expression of specific bioactive lipid metabolites in the retina.

Choroidal neovascular lesion with associated blood vessels (red) and immune cells (Green). Photo courtesy: Dr. Kip Connor.

Disease-causing angiogenesis is a feature of advanced AMD in which blood vessels in the retina (the structure in the back of the eye that senses and perceives light) begin to grow new, abnormal blood vessels on the surface of the retina. These new vessels are immature, and can leak, rupture, or cause retinal detachment. Such cases, termed neovascular or “wet” AMD, account for 10 to 15 percent of AMD cases, develop abruptly, and rapidly lead to substantial vision loss.

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease. Given this, these molecules show promising therapeutic potential not only for AMD, but also for other major conditions that involve angiogenesis and inflammation, such as cardiovascular disease and cancer.

“Given the high prevalence and progressive nature of neovascular eye disease, the ability to stabilize bioactive lipids that mitigate or halt disease is of great and increasingly therapeutic significance,” said corresponding author and RPB grantee Kip Connor, PhD, a vision scientist at Mass. Eye and Ear and Assistant Professor of Ophthalmology at Harvard Medical School. “It is our hope that emerging technologies and future studies will expand on our work, and ultimately lead to safe, targeted, and cost-effective therapies that markedly improve visual outcomes and quality of life for patients suffering from these debilitating eye diseases.”

Read the full press release from Mass. Eye and Ear

Related News: Feature Story, Macular Degeneration, Retina Disorders , Top Story

RPB Logo

Research to Prevent Blindness Opens Applications for Vision Research Grants

The awards offered cover a wide variety of topics in vision science, including glaucoma, age-related macular degeneration, retinal diseases, and many more.

Read More

 
RPB logo

Vision Research Funding Partnership Event Takes Place Today

Leaders of organizations that fund vision research convene in Washington, D.C. to increase collaboration and maximize the impact of research funding for sight-threatening diseases.

Read More

 
Dr. Alex Huang

Research to Prevent Blindness and Alcon Award Glaucoma Grant

Dr. Alex Huang of the University of California San Diego School of Medicine will study glaucoma filtration surgeries with the aim of improving surgical success for lowering eye pressure and providing neuroprotection.

Read More

 
clock icon

Researchers Build An “Aging Clock” To Help Treat Eye Disease

The new way to measure ocular aging opens treatment avenues for numerous eye diseases.

Read More

 
RPB Logo

Research to Prevent Blindness and the American Academy of Ophthalmology Award Big Data Research Grants for Improved Patient Care

The American Academy of Ophthalmology (AAO) and Research to Prevent Blindness (RPB) today announced the 2023 recipients of the RPB/AAO Award for IRIS Registry Research.

Read More

 
RPB logo

In Memoriam: Herbert J. Siegel

RPB acknowledges the passing of a dedicated former Board member.

Read More

 

Subscribe

Get our email updates filled with the latest news from our researchers about preventing vision loss, treating eye disease and even restoring sight. Unsubscribe at any time. Under our privacy policy, we'll never share your contact information with a third party.