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Research to Prevent Blindness

Possible Solution to Corneal Transplant Rejection

Lymphatic vessels, shown in green, can overgrow in response to a corneal transplant. Credit: Wei-Sheng Chen, Tufts University School of Medicine

A team that included RPB-supported researchers at Tufts University School of Medicine has successfully prevented corneal inflammation, a condition that contributes to corneal tissue transplantation rejection, by inhibiting the overgrowth of lymphatic vessels.

The findings, published in Nature Communications, may have wider impact because the same overgrowth of lymphatic vessels, called Lymphangiogenesis, occurs in organ transplant rejection, cancer metastasis, lymphatic obstruction, complications of diabetes and hypertension. 

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