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Research to Prevent Blindness

Research Database

University of Tennessee Research, funded by RPB from 2010-2014 matching Departmental Grant

104 Citations, Sorted by Month and Year

August, 2014
Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice.

Jiang Y, Zhang Q, Ye E-A, Steinle JJ

J Neuroinflamm. 2014 Aug;11(137):1-6

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation.

Sullivan EM, Wilson MW, Billups CA, Wu J, Merchant TE, Brennan RC, Haik BG, Shulkin B, Free TM, Given V, Rodriquez-Galindo C, Qaddoumi I

J Pediatr Hematol Oncol. 2014 Aug;36(6):e335-40

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology/Pterygium

July, 2014
IGFBP-3 inhibits TNFα production and TNFR-2 signaling to protect against retinal endothelial cell apoptosis.

Zhang Q, Steinle JJ

Microvas Res. 2014 Jul;95:76-81

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina.

Jiang Y, Pagadala J, Miller DD, Steinle JJ

Cytokine. 2014 Jul;70:115-9

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2014
Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK.

Toutounchian JJ, Steinle JJ, Makena PS, Waters CM, Wilson MW, Haik BG, Miller DD, Yates CR

PLOS One. 2014 Jun;9(6):1-12

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Β1-adrenergic receptor stimulation by agonist compound 49b restores insulin receptor signal transduction in vivo.

Jiang Y, Zhang Q, Ye E-A, Steinle JJ

Mol Vis. 2014 Jun;20:872-80

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

April, 2014
Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina.

Jiang Y, Zhang Q, Steinle JJ

PLOS One. 2014 Apr;9(4):1-8

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

March, 2014
Novel endogenous glycan therapy for retinal diseases: Safety, in vitro stability, ocular pharmaco-kinetic modeling, and biodistribution.

Swaminathan S, Li H, Palamoor M, Luchsinger de Obarrio WT, Madhura D, Meibohm B, Jablonski MM

J AAPOS. 2014 Mar;16(2):311-23

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene.

Mary-Sinclair MN, Wang XF, Swanson DJ, Sung CY, Mendonca EA, Wroblewski K, Baumer SH, Goldowitz D, Jablonski MM, Skapek SX

Mol Vis. 2014 Mar;20:215-30

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

February, 2014
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Alami NH, Smith RB, Carrasco, MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP

Neuron. 2014 Feb;81:536-43

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Other: Dystrophy-Related Genes

Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration.

Jackson GR, Scott IU, Kim IK, Quillen DA, Iannaccone A, Edwards JG

Invest Ophthalmol Vis Sci. 2014 Feb;55:1427-31

University of Tennessee - Departmental Grant

Keyword: AMD

Toward feedback controlled anesthesia: Automated flow analytical system for electrochemical monitoring of propofol in serum solutions.

Rainey F, Kivlehan F, Chaum E, Lindner E

Electroanalysis. 2014 Feb;26:1295-1303

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

January, 2014
A sensitive and fast LC-MS/MS method for determination of β-receptor agonist JP-49b: Application to a pharmaco-kinetic study in rats.

He H, Williams-Guy K, Pagadala J, Presley CS, Miller DD, Steinle JJ, Yates CR

J Chrom B. 2014 Jan;B953-954:86-91

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Automated detection of micro-aneurysms using scale-adapted blob analysis and semi-supervised learning.

Adal KM, Sidibé D, Ali S, Chaum E, Karnowski TP, Mériaudeau F

Computer Meth Prog Biomed. 2014; 114:1-10

University of Tennessee - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Retinal Vein and Artery Occlusion, Other: Microaneurysms

Comparative study on diffusion and evaporation emulsion methods used to load hydrophilic drugs in poly(ortho ester) nanoparticle emulsions.

Palamoor M, Jablonski MM

Powder Tech. 2014;253:53-62

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Current management of coats disease.

Sigler EJ, Randolph JC, Calzada JI, Wilson MW, Haik BG

Survey Ophthal. 2014;59:30-46

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

Macular pigment optical density is related to cognitive function in older people.

Vishwanathan R, Iannaccone A, Scott TM, Kritchevsky SB, Jennings BJ, Carbon G, Forma G, Satterfield S, Harris T, Johnson KC, Schalch W, Renzi LM, Rosano C, Johnson EJ

Age Ageing. 2014 Jan;0:1-4

University of Tennessee - Departmental Grant

Keyword: AMD

Modulation of wolframin expression in human placenta during pregnancy: Comparison among physiological and pathological states.

Lucariello A, Perna A, Sellitto C, Baldi A, Iannaccone A, Cobellis L, De Luca A, De Falco M

BioMed Res Int. 2014; Article ID 985478:1-7

University of Tennessee - Departmental Grant

Keywords: Epidemiology, Other: Inflammation

Persistent binocular diplopia in childhood following successful treatment for esotropia: A case series.

Tae T, Devould C, Skilbeck L, Hoehn ME, Kerr N

Am Orthoptic J. 2014;64:117-22

University of Tennessee - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

RB1 gene inactivation by chromothripsis in human retinoblastoma.

McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen, X, Wilson M, Brennan R, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson, RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA, Washington University Pediatric Cancer Genome Project

Oncotarget. 2014 Jan;5(2):438-50

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology/Pterygium

December, 2013
Synthesis, characterization and in vitro studies of celecoxib-loaded poly(ortho ester) nanoparticles targeted for intraocular drug delivery.

Palamoor M, Jablonski MM

Colloids Surf B Biointerfaces. 2013 Dec 1;112:474-82

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

November, 2013
Novel topical ophthalmic formulations for management of glaucoma.

Ibrahim MM, Abd-Elgawad AE, Soliman OA, Jablonski MM

Pharm Res. 2013 Nov;30(11):2818-31

University of Tennessee - Departmental Grant

Keywords: Glaucoma, Nanotechnology/Drug Delivery

October, 2013
Comprehensive molecular diagnosis of 179 leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing.

Wang X, Wang H, Sun V, Tuan HF, Keser V, Wang K, Ren H, Lopez I, Zaneveld JE, Siddiqui S, Bowles S, Khan A, Salvo J, Jacobson SG, Iannaccone A, Wang F, Birch D, Heckenlively JR, Fishman GA, Traboulsi EI, Li Y, Wheaton D, Koenekoop RK, Chen R

J Med Genet. 2013 Oct;50(10):674-88

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Pediatric

September, 2013
Novel quinic acid derivative KZ-41 prevents retinal endothelial cell apoptosis without inhibiting retinoblastoma cell death through p38 signaling.

Zhang Q, Jiang Y, Toutounchian J, Wilson MW, Morales-Tirado V, Miller DD, Yates CR, Steinle JJ

Invest Ophthalmol Vis Sci. 2013 Sep 3;54(9):5937-43

University of Tennessee - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Ocular Oncology/Pterygium

Supratrochlear and supraorbital nerves: An anatomical study and applications in the head and neck area.

Konofaos P, Soto-Miranda MA, Ver Halen J, Fleming JC

Ophthal Plast Reconstr Surg. 2013 Sep;29(5):403-8

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

August, 2013
IGFBP-3 and TNF-alpha regulate retinal endothelial cell apoptosis.

Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ

Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5376-84

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Retina/Retinal Diseases

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Consortium for Refractive Error and Myopia, Burdon KP, Craig JE, Iyengar SK, Igo RP,Jr, Lass JH,Jr, Fuchs' Genetics Multi-Center Study Group, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Hohn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Wellcome Trust Case Control Consortium 2, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions, and Complications Research Group, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Parssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN

Am J Hum Genet. 2013 Aug 8;93(2):264-77

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Imaging

Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa.

Birch DG, Weleber RG, Duncan JL, Jaffe GJ, Tao W, Ciliary Neurotrophic Factor Retinitis Pigmentosa Study Groups

Am J Ophthalmol. 2013 Aug;156(2):283-92.e1

University of Tennessee - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Retinitis Pigmentosa

July, 2013
beta2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype.

Jiang Y, Zhang Q, Liu L, Tang J, Kern TS, Steinle JJ

PLoS One. 2013 Jul 24;8(7):e70555

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children.

Hoehn ME, Kelly SR, Wilson MW, Walton RC

Pediatr Blood Cancer. 2013 Jul;60(7):E35-7

University of Tennessee - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Ocular Oncology/Pterygium, Pediatric

Diamagnetic susceptibility artifact associated with graphite foreign body of the orbit.

Choudhri AF, Patel BJ, Phillips ME, Mills KA, Whitehead MT, Fleming JC

Ophthal Plast Reconstr Surg. 2013 Jul-Aug;29(4):e105-7

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

Genetic modulation of the iris transillumination defect: A systems genetics analysis using the expanded family of BXD glaucoma strains.

Swaminathan S, Lu H, Williams RW, Lu L, Jablonski MM

Pigment Cell Melanoma Res. 2013 Jul;26(4):487-98

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

Methods and reproducibility of grading optimized digital color fundus photographs in the age-related eye disease study 2 (AREDS2 report number 2).

Danis RP, Domalpally A, Chew EY, Clemons TE, Armstrong J, SanGiovanni JP, Ferris FL,3rd, AREDS2 Study Group

Invest Ophthalmol Vis Sci. 2013 Jul 8;54(7):4548-54

University of Tennessee - Departmental Grant

Keyword: AMD

Statistical atlas based exudate segmentation.

Ali S, Sidibe D, Adal KM, Giancardo L, Chaum E, Karnowski TP, Meriaudeau F

Comput Med Imaging Graph. 2013 Jul-Sep;37(5-6):358-68

University of Tennessee - Departmental Grant

Keyword: Imaging

Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: Histopathologic findings.

Tse BC, Steinle JJ, Johnson D, Haik BG, Wilson MW

JAMA Ophthalmol. 2013 Jul;131(7):903-11

University of Tennessee - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Ocular Oncology/Pterygium

June, 2013
Cross-species genomic and epigenomic landscape of retinoblastoma.

Benavente CA, McEvoy JD, Finkelstein D, Wei L, Kang G, Wang YD, Neale G, Ragsdale S, Valentine V, Bahrami A, Temirov J, Pounds S, Zhang J, Dyer MA

Oncotarget. 2013 Jun;4(6):844-59

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Ocular Oncology/Pterygium, Pediatric

Neuroblastoma: Developmental biology, cancer genomics and immunotherapy.

Cheung NK, Dyer MA

Nat Rev Cancer. 2013 Jun;13(6):397-411

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Ocular Oncology/Pterygium, Pediatric

Pediatric anophthalmic sockets and orbital implants: Outcomes with polymer-coated implants.

Kirzhner M, Shildkrot Y, Haik BG, Qaddoumi I, Rodriguez-Galindo C, Wilson MW

Ophthalmology. 2013 Jun;120(6):1300-4

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

May, 2013
Isolated pyocele of anterior clinoid process presenting as a cavernous sinus syndrome.

O'Donnell TJ, Michael LM,2nd, Laster R, Fleming JC

Tenn Med. 2013 May;106(5):37,8, 43

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children.

Estepp JH, Smeltzer MP, Wang WC, Hoehn ME, Hankins JS, Aygun B

Br J Haematol. 2013 May;161(3):402-5

University of Tennessee - Departmental Grant

Keywords: Epidemiology, Pediatric, Retina/Retinal Diseases

Validating retinal fundus image analysis algorithms: Issues and a proposal.

Trucco E, Ruggeri A, Karnowski T, Giancardo L, Chaum E, Hubschman JP, Al-Diri B, Cheung CY, Wong D, Abramoff M, Lim G, Kumar D, Burlina P, Bressler NM, Jelinek HF, Meriaudeau F, Quellec G, Macgillivray T, Dhillon B

Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3546-59

University of Tennessee - Departmental Grant

Keyword: Imaging

April, 2013
DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose.

Zhang Q, Steinle JJ

Invest Ophthalmol Vis Sci. 2013 Apr 30;54(4):3052-7

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Retina/Retinal Diseases

Innate immune network in the retina activated by optic nerve crush.

Templeton JP, Freeman NE, Nickerson JM, Jablonski MM, Rex TS, Williams RW, Geisert EE

Invest Ophthalmol Vis Sci. 2013 Apr 9;54(4):2599-606

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions.

Zhang Q, Jiang Y, Toutounchian JJ, Soderland C, Yates CR, Steinle JJ

Mol Vis. 2013 Apr 5;19:796-803

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Reduced insulin receptor signaling in retinal muller cells cultured in high glucose.

Jiang Y, Pagadala J, Miller D, Steinle JJ

Mol Vis. 2013 Apr 5;19:804-11

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

March, 2013
Nanoparticle-based topical ophthalmic formulations for sustained celecoxib release.

Ibrahim MM, Abd-Elgawad AE, Soliman OA, Jablonski MM

J Pharm Sci. 2013 Mar;102(3):1036-53

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor.

Zhang Q, Soderland C, Steinle JJ

Apoptosis. 2013 Mar;18(3):361-8

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

February, 2013
Poly(ortho ester) nanoparticle-based targeted intraocular therapy for controlled release of hydrophilic molecules.

Palamoor M, Jablonski MM

Mol Pharm. 2013 Feb 4;10(2):701-8

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

January, 2013
Natural bioadhesive biodegradable nanoparticles-based topical ophthalmic formulations for sustained celecoxib release: In vitro study.

Ibrahim MM, Abd-Elgawad A, Soliman OA, Jablonski MM

J Pharm Tech Drug Res. 2013;2(1)

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Retina image analysis and ocular telehealth: The oak ridge national laboratory-hamilton eye institute case study.

Karnowski TP, Giancardo L, Li Y, Tobin KW, Chaum E

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:7140-3

University of Tennessee - Departmental Grant

Keyword: Imaging

September, 2012
Chondromyxoid fibroma of the orbit.

Ditta LC, Qayyum S, O'Brien TF, Choudhri AF, Wilson MW

Ophthal Plast Reconstr Surg. 2012 Sep-Oct;28(5):e105-6

University of Tennessee - Departmental Grant

Keywords: Neuro-Ophthalmology, Ocular Oncology/Pterygium

Toward feedback-controlled anesthesia: Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions.

Kivlehan F, Garay F, Guo J, Chaum E, Lindner E

Anal Chem. 2012 Sep 18;84(18):7670-6

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

August, 2012
July, 2012
NON-biological membranes as drug delivery systems.

Swaminathan S, Jablonski M

J Memb Sci Technol. 2012 Jul;2(3):1-2

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene.

Burke TR, Fishman GA, Zernant J, Schubert C, Tsang SH, Smith RT, Ayyagari R, Koenekoop RK, Umfress A, Ciccarelli ML, Baldi A, Iannaccone A, Cremers FP, Klaver CC, Allikmets R

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4458-67

University of Tennessee - Physician-Scientist Award - Iannaccone, Alessandro / MD, MS Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

June, 2012
A mouse model of ocular blast injury that induces closed globe anterior and posterior pole damage.

Hines-Beard J, Marchetta J, Gordon S, Chaum E, Geisert EE, Rex TS

Exp Eye Res. 2012 Jun;99:63-70

University of Tennessee - Career Development Award - Rex, Tonia S / PhD Departmental Grant

Keyword: Other: Retinal Trauma

EDL-291, a novel isoquinoline, presents antiglioblastoma effects in vitro and in vivo.

Wang XD, Freeman NE, Patil R, Patil SA, Mitra S, Orr WE, Abner CW, Yates CR, Miller DD, Geisert EE

Anticancer Drugs. 2012 Jun;23(5):494-504

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology/Pterygium

US and MRI of pediatric ocular masses with histopathological correlation.

Brennan RC, Wilson MW, Kaste S, Helton KJ, McCarville MB

Pediatr Radiol. 2012 Jun;42(6):738-49

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology/Pterygium

May, 2012
Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels.

Zhang Q, Guy K, Pagadala J, Jiang Y, Walker RJ, Liu L, Soderland C, Kern TS, Ferry R,Jr, He H, Yates CR, Miller DD, Steinle JJ

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3004-13

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Nanotechnology/Drug Delivery

TNFalpha and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis.

Jiang Y, Zhang Q, Soderland C, Steinle JJ

Cell Signal. 2012 May;24(5):1086-92

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

April, 2012
Carboplatin-associated ototoxicity in children with retinoblastoma.

Qaddoumi I, Bass JK, Wu J, Billups CA, Wozniak AW, Merchant TE, Haik BG, Wilson MW, Rodriguez-Galindo C

J Clin Oncol. 2012 Apr 1;30(10):1034-41

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology/Pterygium

Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis.

Steinle JJ, Zhang Q, Thompson KE, Toutounchian J, Yates CR, Soderland C, Wang F, Stewart CF, Haik BG, Williams JS, Jackson JS, Mandrell TD, Johnson D, Wilson MW

Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2439-45

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Vein and Artery Occlusion

Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses.

Jadhao CS, Bhatwadekar AD, Jiang Y, Boulton ME, Steinle JJ, Grant MB

Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):2030-7

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Vein and Artery Occlusion

March, 2012
Dose-dependent treatment of optic nerve crush by exogenous systemic mutant erythropoietin.

Sullivan TA, Geisert EE, Templeton JP, Rex TS

Exp Eye Res. 2012 Mar;96(1):36-41

University of Tennessee - Career Development Award - Rex, Tonia S / PhD Departmental Grant

Keyword: Gene Research/Therapy

February, 2012
Silencing of insulin receptor substrate-1 increases cell death in retinal muller cells.

Walker RJ, Anderson NM, Bahouth S, Steinle JJ

Mol Vis. 2012 Feb;18:271-9

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Gene Research/Therapy

January, 2012
A novel retinoblastoma therapy from genomic and epigenetic analyses.

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA

Nature. 2012 Jan 11;481(7381):329-34

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Ocular Oncology/Pterygium

A practical approach to optic nerve crush in the mouse.

Templeton JP, Geisert EE

Mol Vis. 2012;18:2147-52

University of Tennessee - Departmental Grant

Keyword: Other: Ocular Trauma

Exudate-based diabetic macular edema detection in fundus images using publicly available datasets.

Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Garg S, Tobin KW,Jr, Chaum E

Med Image Anal. 2012 Jan;16(1):216-26

University of Tennessee - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: Safety and efficacy in 15 children and adults followed up to 3 years.

Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW

Arch Ophthalmol. 2012 Jan;130(1):9-24

University of Tennessee - Physician-Scientist Award - Iannaccone, Alessandro / MD, MS Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Inferior orbital septum release compared with lateral canthotomy and cantholysis in the management of orbital compartment syndrome.

Oester AE,Jr, Fowler BT, Fleming JC

Ophthal Plast Reconstr Surg. 2012 Jan;28(1):40-3

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

Ion-selective optodes in a sampling capillary for tear fluid analysis.

Lindner  E, Bordelon D, Kim M, Dergunov S, Pinkhassik  E, Chaum E

Electroanalysis. 2012 Jan;24(1):42-52

University of Tennessee - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Radiographic predictors of visual outcome in orbital compartment syndrome.

Oester AE,Jr, Sahu P, Fowler B, Fleming JC

Ophthal Plast Reconstr Surg. 2012 Jan;28(1):7-10

University of Tennessee - Departmental Grant

Keywords: Plastic Surgery, Imaging

December, 2011
Retinoblastoma (rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons.

Martins RA, Davis D, Kerekes R, Zhang J, Bayazitov IT, Hiler D, Karakaya M, Frase S, Gleason S, Zakharenko SS, Johnson DA, Dyer MA

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21111-6

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

The effect of cancer therapies on pediatric anophthalmic sockets.

Shildkrot Y, Kirzhner M, Haik BG, Qaddoumi I, Rodriguez-Galindo C, Wilson MW

Ophthalmology. 2011 Dec;118(12):2480-6

University of Tennessee - Departmental Grant

Keyword: Pediatric

November, 2011
Real-time ophthalmoscopic findings of superselective intraophthalmic artery chemotherapy in a nonhuman primate model.

Wilson MW, Jackson JS, Phillips BX, Buchanan J, Frase S, Wang F, Steinle JJ, Stewart CF, Mandrell TD, Haik BG, Williams JS

Arch Ophthalmol. 2011 Nov;129(11):1458-65

University of Tennessee - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Retinoblastoma

October, 2011
Electrochemical quantification of 2,6-diisopropylphenol (propofol).

Langmaier J, Garay F, Kivlehan F, Chaum E, Lindner E

Anal Chim Acta. 2011 Oct 17;704(1-2):63-7

University of Tennessee - Departmental Grant

Keyword: Other: Electrochemical Quantification

Pituitary adenoma causing visual disturbances in a 6-year-old girl.

Oliver TA, Hoehn ME, Boop F, Ellison DW

J AAPOS. 2011 Oct;15(5):495-8

University of Tennessee - Departmental Grant

Keyword: Pediatric

Systemic adeno-associated virus-mediated gene therapy preserves retinal ganglion cells and visual function in DBA/2J glaucomatous mice.

Sullivan TA, Geisert EE, Hines-Beard J, Rex TS

Hum Gene Ther. 2011 Oct;22(10):1191-200

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

September, 2011
Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy.

Adamus G, Brown L, Schiffman J, Iannaccone A

J Ophthalmic Inflamm Infect. 2011 Sep;1(3):111-21

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

Outcomes in 15 patients with conjunctival melanoma treated with adjuvant topical mitomycin C: Complications and recurrences.

Ditta LC, Shildkrot Y, Wilson MW

Ophthalmology. 2011 Sep;118(9):1754-9

University of Tennessee - Departmental Grant

Keyword: Ocular Oncology Melanoma

August, 2011
Acute systemic histoplasmosis associated with chorioretinitis in an immunocompetent adolescent.

Fowler BT, Shen C, Masterllonw J, Chaum E

J Ophthalmol. 2011 Aug;17(4):1-4

University of Tennessee - Departmental Grant

Keywords: Pediatric, Uveitis/Infectious Diseases

Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.

McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA

Cancer Cell. 2011 Aug 16;20(2):260-75

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Modulation of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C.

Yin J, Thomas F, Lang JC, Chaum E

J Cell Physiol. 2011 Aug;226(8):2025-32

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2011
Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease.

Gandhi PD, Fleming JC, Haik BG, Wilson MW

Ophthal Plast Reconstr Surg. 2011 Jul-Aug;27(4):241-6

University of Tennessee - Departmental Grant

Keyword: Plastic Surgery

June, 2011
Genetic dissection of the gpnmb network in the eye.

Lu H, Wang X, Pullen M, Guan H, Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM

Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4132-42

University of Tennessee - Departmental Grant

Keywords: Gene Research/Therapy, Genetics

The association of cataract with leukocyte telomere length in older adults: Defining a new marker of aging.

Sanders JL, Iannaccone A, Boudreau RM, Conley YP, Opresko PL, Hsueh WC, Cummings SR, Cawthon RM, Harris TB, Nalls MA, Kritchevsky SB, Newman AB, Health ABC Study

J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):639-45

University of Tennessee - Departmental Grant

Keyword: AMD

May, 2011
Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis.

Bhattacharya S, Ray RM, Chaum E, Johnson DA, Johnson LR

Invest Ophthalmol Vis Sci. 2011 May 1;52(6):3368-80

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2011
Genetic pathways regulating glutamate levels in retinal muller cells.

Jablonski MM, Freeman NE, Orr WE, Templeton JP, Lu L, Williams RW, Geisert EE

Neurochem Res. 2011 Apr;36(4):594-603

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Insulin and beta-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways.

Panjala SR, Steinle JJ

Neurochem Res. 2011 Apr;36(4):604-12

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

Molecular responses transduced by serial oxidative stress in the retinal pigment epithelium: Feedback control modeling of gene expression.

Chaum E, Yin J, Lang JC

Neurochem Res. 2011 Apr;36(4):574-82

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Systemic gene delivery protects the photoreceptors in the retinal degeneration slow mouse.

Sullivan T, Kodali K, Rex TS

Neurochem Res. 2011 Apr;36(4):613-8

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

The effects of a CD81 null mutation on retinal pigment epithelium in mice.

Pan Y, Geisert DF, Orr WE, Geisert EE

Neurochem Res. 2011 Apr;36(4):569-73

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

March, 2011
Textureless macula swelling detection with multiple retinal fundus images.

Giancardo L, Meriaudeau F, Karnowski TP, Tobin KW,Jr, Grisan E, Favaro P, Ruggeri A, Chaum E

IEEE Trans Biomed Eng. 2011 Mar;58(3):795-9

University of Tennessee - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration.

Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Agarwal A, Iannaccone A, Kritchevsky SB, Garcia M, Nalls MA, Newman AB, Scott WK, Pericak-Vance MA, Haines JL

PLoS One. 2011 Mar 24;6(3):e17784

University of Tennessee - Departmental Grant

Keywords: AMD, Genetics

February, 2011
Autosomal recessive best vitelliform macular dystrophy: Report of a family and management of early-onset neovascular complications.

Iannaccone A, Kerr NC, Kinnick TR, Calzada JI, Stone EM

Arch Ophthalmol. 2011 Feb;129(2):211-7

University of Tennessee - Departmental Grant

Keyword: Macular Dystrophy

January, 2011
Complex interactions of Tyrp1 in the eye.

Lu H, Li L, Watson ER, Williams RW, Geisert EE, Jablonski MM, Lu L

Mol Vis. 2011;17:2455-68

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Genetic networks in the mouse retina: Growth associated protein 43 and phosphatase tensin homolog network.

Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE

Mol Vis. 2011;17:1355-72

University of Tennessee - Departmental Grant

Keyword: Gene Research/Therapy

Increased tumor necrosis factor-alpha, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the beta-adrenergic receptor knockout mouse.

Panjala SR, Jiang Y, Kern TS, Thomas SA, Steinle JJ

Mol Vis. 2011;17:1822-8

University of Tennessee - Departmental Grant

Keyword: Diabetic Retinopathy

January, 2010
Cellular retinol binding protein 1 modulates photoreceptor outer segment folding in the isolated eye.

Wang XF, Tong Y, Giorgianni F, Beranova-Giorgianni S, Penn JS, Jablonski MM

Dev Neurobiol 2010;70(9):623-635

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

In search of the identity of the XAP-1 antigen: A protein localized to cone outer segments.

Nookla S, Gandrakota R, Wohabrebbi A, Wang XF, Howell D, Giorgianni F, Beranova-Giorgianni S, Desiderio DM, Jablonski MM

Invest Ophthalmol Vis Sci 2010;51(5):2736-2743

University of Tennessee - Departmental Grant

Keyword: Retina/Retinal Diseases

ModulationQ1 of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C.

Yin J, Thomas F, Lang JC, Chaum E

J Cell Physiol 2010;9999:1-9

University of Tennessee - Departmental Grant

Keywords: Retina/Retinal Diseases, Neuro-Ophthalmology

Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma.

Hoehn ME, Irshad F, Kerr NC, Wilson MW

JAAPOS 2010;14(3)232-234

University of Tennessee - Departmental Grant

Keywords: Cataract, Neuro-Ophthalmology, Ocular Oncology Melanoma

Treating retinoblastoma in tissue culture and in a rat model with novel isoquinoline derivative.

Nassr M, Wang XD, Mitra S, Freeman-Anderson NE, Patil R, Yates CR, Miller DD, Geisert EE

Invest Ophthalmol Vis Sci 2010;51(7):3813-3819

University of Tennessee - Departmental Grant

Keywords: Ocular Oncology Melanoma, Retina/Retinal Diseases

Uterine papillary serous carcinoma metastatic to the choroid.

Lawrence SC, Netland PA, Morris WR, Smiley L, Wilson MW

Retinal Cases Brief Reports 2010;4(1):62-64

University of Tennessee - Departmental Grant

Keywords: Neuro-Ophthalmology, Ocular Oncology Melanoma, Retina/Retinal Diseases

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