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Research to Prevent Blindness

Research Database

University of Missouri Research, funded by RPB from 2010-2014 matching Departmental Grant

49 Citations, Sorted by Month and Year

October, 2013
Pupillary light reflex deficits in a canine model of late infantile neuronal ceroid lipofuscinosis.

Whiting RE, Narfstrom K, Yao G, Pearce JW, Coates JR, Castaner LJ, Katz ML

Exp Eye Res. 2013 Oct 14;116C:402-10

University of Missouri - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2013
Quantitative assessment of the canine pupillary light reflex.

Whiting RE, Yao G, Narfstrom K, Pearce JW, Coates JR, Dodam JR, Castaner LJ, Katz ML

Invest Ophthalmol Vis Sci. 2013 Aug 13;54(8):5432-40

University of Missouri - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2013
Corneal gene therapy: Basic science and translational perspective.

Mohan RR, Rodier JT, Sharma A

Ocul Surf. 2013 Jul;11(3):150-64

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Surgical management of rhegmatogenous retinal detachment: A meta-analysis of randomized controlled trials.

Soni C, Hainsworth DP, Almony A

Ophthalmology. 2013 Jul;120(7):1440-7

University of Missouri - Departmental Grant

Keyword: Retinal Detachment

June, 2013
BMP7 gene transfer via gold nanoparticles into stroma inhibits corneal fibrosis in vivo.

Tandon A, Sharma A, Rodier JT, Klibanov AM, Rieger FG, Mohan RR

PLoS One. 2013 Jun 14;8(6):e66434

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Identification of subunit-subunit interaction sites in alphaA-WT crystallin and mutant alphaA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry.

Kannan R, Santhoshkumar P, Mooney BP, Sharma KK

PLoS One. 2013 Jun 5;8(6):e65610

University of Missouri - Departmental Grant

Keyword: Cataract

May, 2013
Chaperone peptides of alpha-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts.

Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH

J Biol Chem. 2013 May 3;288(18):13022-35

University of Missouri - Departmental Grant

Keyword: Cataract

The alphaA66-80 peptide interacts with soluble alpha-crystallin and induces its aggregation and precipitation: A contribution to age-related cataract formation.

Kannan R, Santhoshkumar P, Mooney BP, Sharma KK

Biochemistry. 2013 May 28;52(21):3638-50

University of Missouri - Departmental Grant

Keyword: Cataract

April, 2013
MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development.

Upadhya D, Ogata M, Reneker LW

Development. 2013 Apr;140(7):1573-82

University of Missouri - Departmental Grant

Keywords: Pediatric, Other: Lens Development

Profiling of lens protease involved in generation of alphaA-66-80 crystallin peptide using an internally quenched protease substrate.

Hariharapura R, Santhoshkumar P, Krishna Sharma K

Exp Eye Res. 2013 Apr;109:51-9

University of Missouri - Departmental Grant

Keyword: Cataract

January, 2013
GM2 gangliosidosis associated with a HEXA missense mutation in japanese chin dogs: A potential model for tay sachs disease.

Sanders DN, Zeng R, Wenger DA, Johnson GS, Johnson GC, Decker JE, Katz ML, Platt SR, O'Brien DP

Mol Genet Metab. 2013 Jan;108(1):70-5

University of Missouri - Departmental Grant

Keywords: Pediatric, Retina/Retinal Diseases

December, 2012
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.

Madakashira BP, Kobrinski DA, Hancher AD, Arneman EC, Wagner BD, Wang F, Shin H, Lovicu FJ, Reneker LW, Robinson ML

Development. 2012 Dec;139(24):4601-12

University of Missouri - Departmental Grant

Keyword: Other: Lens

September, 2012
Canine corneal fibroblast and myofibroblast transduction with AAV5.

Bosiack AP, Giuliano EA, Gupta R, Mohan RR

Vet Ophthalmol. 2012 Sep;15(5):291-8

University of Missouri - Departmental Grant

Keyword: Cornea

Efficacy and safety of suberoylanilide hydroxamic acid (vorinostat) in the treatment of canine corneal fibrosis.

Bosiack AP, Giuliano EA, Gupta R, Mohan RR

Vet Ophthalmol. 2012 Sep;15(5):307-14

University of Missouri - Departmental Grant

Keyword: Cornea

Short-term use of inhaled and intranasal corticosteroids is not associated with glaucoma progression on optical coherence tomography.

Johnson LN, Soni CR, Johnson MA, Madsen RW

Eur J Ophthalmol. 2012 Sep-Oct;22(5):695-700

University of Missouri - Departmental Grant

Keywords: Glaucoma, Imaging

June, 2012
Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line.

Liu J, Seet LF, Koh LW, Venkatraman A, Venkataraman D, Mohan RR, Praetorius J, Bonanno JA, Aung T, Vithana EN

Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3270-9

University of Missouri - Departmental Grant

Keyword: Cornea

April, 2012
Vorinostat: A potent agent to prevent and treat laser-induced corneal haze.

Tandon A, Tovey JC, Waggoner MR, Sharma A, Cowden JW, Gibson DJ, Liu Y, Schultz GS, Mohan RR

J Refract Surg. 2012 Apr;28(4):285-90

University of Missouri - Departmental Grant

Keyword: Cornea

March, 2012
Small-gauge vitrectomy does not protect against nuclear sclerotic cataract.

Almony A, Holekamp NM, Bai F, Shui YB, Beebe D

Retina. 2012 Mar;32(3):499-505

University of Missouri - Departmental Grant

Keywords: Cataract, Retina/Retinal Diseases

January, 2012
alphaA-crystallin-derived mini-chaperone modulates stability and function of cataract causing alphaAG98R-crystallin.

Raju M, Santhoshkumar P, Sharma KK

PLoS One. 2012;7(9):e44077

University of Missouri - Departmental Grant

Keyword: Cataract

Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-beta type II receptor (sTGFbetaRII) gene transfer.

Sharma A, Rodier JT, Tandon A, Klibanov AM, Mohan RR

Mol Vis. 2012;18:2598-607

University of Missouri - Departmental Grant

Keyword: Cornea

Gene therapy in the cornea: 2005--present.

Mohan RR, Tovey JC, Sharma A, Tandon A

Prog Retin Eye Res. 2012 Jan;31(1):43-64

University of Missouri - Departmental Grant

Keyword: Cornea

October, 2011
A reversal learning task detects cognitive deficits in a dachshund model of late-infantile neuronal ceroid lipofuscinosis.

Sanders DN, Kanazono S, Wininger FA, Whiting RE, Flournoy CA, Coates JR, Castaner LJ, O'Brien DP, Katz ML

Genes Brain Behav. 2011 Oct;10(7):798-804

University of Missouri - Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2011
Degenerative myelopathy in a bernese mountain dog with a novel SOD1 missense mutation.

Wininger FA, Zeng R, Johnson GS, Katz ML, Johnson GC, Bush WW, Jarboe JM, Coates JR

J Vet Intern Med. 2011 Sep-Oct;25(5):1166-70

University of Missouri - Departmental Grant

Keyword: Other: neurodegeneration

Mitomycin C: A promising agent for the treatment of canine corneal scarring.

Gupta R, Yarnall BW, Giuliano EA, Kanwar JR, Buss DG, Mohan RR

Vet Ophthalmol. 2011 Sep;14(5):304-12

University of Missouri - Departmental Grant

Keyword: Cornea

August, 2011
Early diabetes mellitus or hypertension is not significantly associated with severity of vision loss in nonarteritic anterior ischemic optic neuropathy.

Odette JD, Okorodudu DO, Johnson LN

Arch Ophthalmol. 2011 Aug;129(8):1106-7

University of Missouri - Departmental Grant

Keyword: Optic Neuropathy

Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea.

Sharma A, Tandon A, Tovey JC, Gupta R, Robertson JD, Fortune JA, Klibanov AM, Cowden JW, Rieger FG, Mohan RR

Nanomedicine. 2011 Aug;7(4):505-13

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

July, 2011
Significant inhibition of corneal scarring in vivo with tissue-selective, targeted AAV5 decorin gene therapy.

Mohan RR, Tandon A, Sharma A, Cowden JW, Tovey JC

Invest Ophthalmol Vis Sci. 2011 Jul 1;52(7):4833-41

University of Missouri - Departmental Grant

Keyword: Cornea

June, 2011
A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in tibetan terriers.

Farias FH, Zeng R, Johnson GS, Wininger FA, Taylor JF, Schnabel RD, McKay SD, Sanders DN, Lohi H, Seppala EH, Wade CM, Lindblad-Toh K, O'Brien DP, Katz ML

Neurobiol Dis. 2011 Jun;42(3):468-74

University of Missouri - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

May, 2011
Identification and characterization of a copper-binding site in alphaA-crystallin.

Raju M, Santhoshkumar P, Henzl TM, Sharma KK

Free Radic Biol Med. 2011 May 15;50(10):1429-36

University of Missouri - Departmental Grant

Keyword: Cataract

April, 2011
Activation of unfolded protein response in transgenic mouse lenses.

Reneker LW, Chen H, Overbeek PA

Invest Ophthalmol Vis Sci. 2011 Apr 4;52(5):2100-8

University of Missouri - Departmental Grant

Keyword: Other: Lens

alphaA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of alpha-crystallin and induces lens protein aggregation.

Santhoshkumar P, Raju M, Sharma KK

PLoS One. 2011 Apr 28;6(4):e19291

University of Missouri - Departmental Grant

Keyword: Cataract

Efficacious and safe tissue-selective controlled gene therapy approaches for the cornea.

Mohan RR, Sinha S, Tandon A, Gupta R, Tovey JC, Sharma A

PLoS One. 2011 Apr 12;6(4):e18771

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

January, 2011
Cataract-causing alphaAG98R-crystallin mutant dissociates into monomers having chaperone activity.

Raju M, Santhoshkumar P, Sharma KK

Mol Vis. 2011 Jan 5;17:7-15

University of Missouri - Departmental Grant

Keyword: Cataract

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo.

Mohan RR, Tovey JC, Sharma A, Schultz GS, Cowden JW, Tandon A

PLoS One. 2011;6(10):e26432

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

January, 2010
AAV serotype influences gene transfer in corneal stroma in vivo.

Sharma A, Tovey JCK, Ghosh A, Mohan RR

Exp Eye Res 2010;91(3):440-448

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a dachshund.

Sanders DN, Farias FH, Johnson GS, Chiang V, Cook JR, O’Brien DP, Hofmann SL, Lu JY, Katz ML

Mol Genetics Metab 2010;100(4):349-356

University of Missouri - Departmental Grant

Keywords: Retina/Retinal Diseases, Gene Research/Therapy

An ADAMSTS17 splice donor site mutation in dogs with primary lens luxation.

Farias FHG, Johnson GS, Taylor JF, Giuliano E, Katz ML, Sanders DN, Schnabel RD, McKay SD, Khan S, Gharahkhani P, O’Leary CA, Pettitt L, Forman OP, Boursnell M, McLaughlin B, Ahonen S, Lohi H, Hernandez-Merino E, Gould DJ, Sargan DR, Mellersh C

Invest Ophthalmol Vis Sci 2010;51(9):4716-4721

University of Missouri - Departmental Grant

Keywords: Genetics, Other: Lens

Common denominators in retained orbital wooden foreign bodies.

Liu D

Ophthal Plast Reconstr Surg 2010;26(6):454-458

University of Missouri - Departmental Grant

Keyword: Plastic Surgery

Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts.

Mohan RR, Gupta R, Mehan MK, Cowden JW, Sinha S

Exp Eye Res 2010;91(2):238-245

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Efficacy and safety of mitomycin C as an agent to treat corneal scarring in horses using an in vitro model.

Buss DG, Sharma A, Giuliano EA, Mohan RR

Vet Ophthalmol 2010;13(4):211-218

University of Missouri - Departmental Grant

Keyword: Cornea

Gene delivery in the equine cornea: A novel therapeutic strategy.

Buss DG, Giuliano E, Sharma A, Mohan RR

Vet Ophthalmol 2010;13(5):301-306

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Gene therapy for the cornea, conjunctiva and lacrimal gland.

Sharma A, Ghosh A, Siddappa C, Mohan RR

Encyclopedia Eye 2010;2:185-194

University of Missouri - Departmental Grant

Keyword: Gene Research/Therapy

Induction of corneal myofibroblasts by lens-derived transforming growth factor β1 (TGFβ1): A transgenic mouse model.

Reneker LW, Bloch A, Xie L, Overbeek PA, Ash JD

Brain Res Bull 2010;81(2-3):287-296

University of Missouri - Departmental Grant

Keyword: Other: Lens

Isolation and cultivation of equine corneal keratocytes, fibroblasts and myofibroblasts.

Buss DG, Giuliano EA, Sharma A, Mohan RR

Vet Ophthalmol 2010;13(1):37-42

University of Missouri - Departmental Grant

Keyword: Cornea

Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo.

Sharma A, Bettis DI, Cowden JW, Mohan RR

Mol Vis 2010;16:720-728

University of Missouri - Departmental Grant

Keyword: Cornea

Role of transforming growth factor beta in corneal function, biology and pathology.

Tandon A, Tovey JCK, Sharma A, Gupta R, Mohan RR

Curr Mol Med 2010;10(6):565-578

University of Missouri - Departmental Grant

Keyword: Cornea

Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

Sharma A, Ghosh A, Hansen ET, Newman JM, Mohan RR

Brain Res Bull 2010;81(2-3):273-278

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Vector delivery technique affects gene transfer in the cornea in vivo.

Mohan RR, Sharma A, Cebulko TC, Tandon A

Mol Vis 2010;16:2494-2501

University of Missouri - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Visual neuropraxia and progressive vision loss from thyroid-associated stretch optic neuropathy.

Soni CR, Johnson LN

Eur J Ophthalmol 2010;20(2):429-436

University of Missouri - Departmental Grant

Keyword: Optic Neuropathy

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