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Research to Prevent Blindness

Research Database

Johns Hopkins University Research, funded by RPB from 2010-2014 matching Senior Scientific Investigator Award

59 Citations, Sorted by Month and Year

October, 2014
A general theoretical framework for interpreting patient-reported outcomes estimated from ordinally scaled item responses.

Massof RW

Stat Methods Med Res. 2014 Oct;23(5):409-29

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Low Vision

August, 2014
Characterizing functional complaints in patients seeking outpatient low-vision services in the united states.

Brown JC, Goldstein JE, Chan TL, Massof R, Ramulu P, Low Vision Research Network Study Group

Ophthalmology. 2014 Aug;121(8):1655,62.e1

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Low Vision

Increased carriage of macrolide-resistant fecal E.

Seidman JC, Coles CL, Silbergeld EK, Levens J, Mkocha H, Johnson LB, Munoz B, West SK

coli following mass distribution of azithromycin for trachoma control. Int J Epidemiol. 2014 Aug;43(4):1105-13

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Uveitis/Infectious Diseases

July, 2014
Automated image alignment and segmentation to follow progression of geographic atrophy in age-related macular degeneration.

Ramsey DJ, Sunness JS, Malviya P, Applegate C, Hager GD, Handa JT

Retina. 2014 Jul;34(7):1296-307

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keyword: AMD

P62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium.

Wang L, Cano M, Handa JT

Biochim Biophys Acta. 2014 Jul;1843(7):1248-58

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

June, 2014
Short-term malaria reduction by single-dose azithromycin during mass drug administration for trachoma, tanzania.

Schachterle SE, Mtove G, Levens JP, Clemens E, Shi L, Raj A, Dumler JS, Munoz B, West S, Sullivan DJ

Emerg Infect Dis. 2014 Jun;20(6):941-9

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Uveitis/Infectious Diseases

May, 2014
Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in niger: A cluster-randomized trial.

Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM

Am J Trop Med Hyg. 2014 May;90(5):846-51

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Uveitis/Infectious Diseases

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells.

Wang L, Kondo N, Cano M, Ebrahimi K, Yoshida T, Barnett BP, Biswal S, Handa JT

Free Radic Biol Med. 2014 May;70:155-66

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells.

Chen C, Cano M, Wang JJ, Li J, Huang C, Yu Q, Herbert TP, Handa JT, Zhang SX

Antioxid Redox Signal. 2014 May 10;20(14):2091-106

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

April, 2014
Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells.

Cano M, Wang L, Wan J, Barnett BP, Ebrahimi K, Qian J, Handa JT

Free Radic Biol Med. 2014 Apr;69:1-14

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

March, 2014
Comparison of time- and spectral-domain optical coherence tomography in management of diabetic macular edema.

Liu MM, Wolfson Y, Bressler SB, Do DV, Ying HS, Bressler NM

Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1370-7

Johns Hopkins University - Physician-Scientist Award - Bressler, Susan B / MD Senior Scientific Investigator Award - Bressler, Neil M / MD

Keywords: Imaging, Retina/Retinal Diseases

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/betaA3/A1-crystallin via V-ATPase-MTORC1 signaling.

Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, Hackett S, Xu G, Lutty GA, Dong L, Sergeev Y, Handa JT, Campochiaro P, Wawrousek E, Zigler JS,Jr, Sinha D

Autophagy. 2014 Mar;10(3):480-96

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

The efficacy of oral azithromycin in clearing ocular chlamydia: Mathematical modeling from a community-randomized trachoma trial.

Liu F, Porco TC, Mkocha HA, Munoz B, Ray KJ, Bailey RL, Lietman TM, West SK

Epidemics. 2014 Mar;6:10-7

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Uveitis/Infectious Diseases

February, 2014
Nrf2 signaling is impaired in the aging RPE given an oxidative insult.

Sachdeva MM, Cano M, Handa JT

Exp Eye Res. 2014 Feb;119:111-4

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.

Cruz-Guilloty F, Saeed AM, Duffort S, Cano M, Ebrahimi KB, Ballmick A, Tan Y, Wang H, Laird JM, Salomon RG, Handa JT, Perez VL

PLoS One. 2014 Feb 19;9(2):e88201

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Gene Research/Therapy

September, 2013
Associations between self-rated vision score, vision tests, and self-reported visual function in the salisbury eye evaluation study.

El-Gasim M, Munoz B, West SK, Scott AW

Invest Ophthalmol Vis Sci. 2013 Sep 27;54(9):6439-45

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Visual Function

Older drivers and rapid deceleration events: Salisbury eye evaluation driving study.

Keay L, Munoz B, Duncan DD, Hahn D, Baldwin K, Turano KA, Munro CA, Bandeen-Roche K, West SK

Accid Anal Prev. 2013 Sep;58:279-85

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Driving, Other: Vision

May, 2013
Functional improvement after one- and two-eye cataract surgery in the salisbury eye evaluation.

Lee BS, Munoz BE, West SK, Gower EW

Ophthalmology. 2013 May;120(5):949-55

Johns Hopkins University - Special Scholar Award Senior Scientific Investigator Award

Keyword: Cataract

April, 2013
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration.

Ebrahimi KB, Fijalkowski N, Cano M, Handa JT

J Pathol. 2013 Apr;229(5):729-42

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Retina/Retinal Diseases

Racial differences in lens opacity incidence and progression: The salisbury eye evaluation (SEE) study.

Storey P, Munoz B, Friedman D, West S

Invest Ophthalmol Vis Sci. 2013 Apr 26;54(4):3010-8

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Cataract, Epidemiology

March, 2013
The decline in attentional visual fields over time among older participants in the salisbury eye evaluation driving study.

Rao P, Munoz B, Turano K, Munro C, West SK

Invest Ophthalmol Vis Sci. 2013 Mar 13;54(3):1839-44

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Low Vision, Other: Driving, Other: Visual Fields

Trachomatous trichiasis clamp vs standard bilamellar tarsal rotation instrumentation for trichiasis surgery: Results of a randomized clinical trial.

Gower EW, West SK, Harding JC, Cassard SD, Munoz BE, Othman MS, Kello AB, Merbs SL

JAMA Ophthalmol. 2013 Mar;131(3):294-301

Johns Hopkins University - Special Scholar Award Senior Scientific Investigator Award

Keywords: Uveitis/Infectious Diseases, Other: Trachoma

February, 2013
Auditory force feedback substitution improves surgical precision during simulated ophthalmic surgery.

Cutler N, Balicki M, Finkelstein M, Wang J, Gehlbach P, McGready J, Iordachita I, Taylor R, Handa JT

Invest Ophthalmol Vis Sci. 2013 Feb 15;54(2):1316-24

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: Retina/Retinal Diseases, Other: Surgical Instruction

January, 2013
A force-sensing microsurgical instrument that detects forces below human tactile sensation.

Sunshine S, Balicki M, He X, Olds K, Kang JU, Gehlbach P, Taylor R, Iordachita I, Handa JT

Retina. 2013 Jan;33(1):200-6

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: Retina/Retinal Diseases, Other: Surgical Instrumentation

A role for Jag2 in promoting uveal melanoma dissemination and growth.

Asnaghi L, Handa JT, Merbs SL, Harbour JW, Eberhart CG

Invest Ophthalmol Vis Sci. 2013 Jan 9;54(1):295-306

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keyword: Ocular Oncology/Pterygium

Retinal microenvironment imbalance in dry age-related macular degeneration: A mini-review.

Barnett BP, Handa JT

Gerontology. 2013;59(4):297-306

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keywords: AMD, Retina/Retinal Diseases

October, 2012
Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials.

Varma R, Bressler NM, Suner I, Lee P, Dolan CM, Ward J, Colman S, Rubio RG, BRAVO and CRUISE Study Groups

Ophthalmology. 2012 Oct;119(10):2108-18

Johns Hopkins University - Senior Scientific Investigator Award - Bressler, Neil M / MD

Keywords: Retinal Vein and Artery Occlusion, Other: Clinical Trials

September, 2012
Refractive error and visual function difficulty in a latino population.

Sandhu RK, Munoz BE, Swenor BK, West SK

Ophthalmology. 2012 Sep;119(9):1731-6

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Other: Refractive Error, Other: Visual Impairment

August, 2012
How does the macula protect itself from oxidative stress?

Handa JT

Mol Aspects Med. 2012 Aug;33(4):418-35

Johns Hopkins University - Senior Scientific Investigator Award - Handa, James T / MD

Keyword: AMD

June, 2012
April, 2012
Mass distribution of azithromycin for trachoma control is associated with short-term reduction in risk of acute lower respiratory infection in young children.

Coles CL, Levens J, Seidman JC, Mkocha H, Munoz B, West S

Pediatr Infect Dis J. 2012 Apr;31(4):341-6

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Trachoma

March, 2012
Global prevalence and major risk factors of diabetic retinopathy.

Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY, Meta-Analysis for Eye Disease (META-EYE) Study Group

Diabetes Care. 2012 Mar;35(3):556-64

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Diabetic Retinopathy

February, 2012
Two-day dosing versus one-day dosing of azithromycin in children with severe trachoma in tanzania.

Campbell JP, Mkocha H, Munoz B, West SK

Ophthalmic Epidemiol. 2012 Feb;19(1):38-42

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Trachoma

January, 2012
Definitions and standardization of a new grading scheme for eyelid contour abnormalities after trichiasis surgery.

Gower EW, West SK, Cassard SD, Munoz BE, Harding JC, Merbs SL

PLoS Negl Trop Dis. 2012;6(6):e1713

Johns Hopkins University - Special Scholar Award Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Trachoma

Discrepancies in the concordance of self-reported vision status and visual acuity in the salisbury eye evaluation study.

El-Gasim M, Munoz B, West SK, Scott AW

Ophthalmology. 2012 Jan;119(1):106-11

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Visual Acuity

Relationship between immediate post-operative appearance and 6-week operative outcome in trichiasis surgery.

Merbs SL, Harding JC, Cassard SD, Munoz BE, West SK, Gower EW

PLoS Negl Trop Dis. 2012;6(7):e1718

Johns Hopkins University - Special Scholar Award Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Trachoma

Trachoma and antibiotic use: The 'A' in SAFE.

West S

Expert Rev Anti Infect Ther. 2012 Jan;10(1):75-83

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Epidemiology, Other: Trachoma

November, 2011
Can clinical signs of trachoma be used after multiple rounds of mass antibiotic treatment to indicate infection?

Munoz B, Stare D, Mkocha H, Gaydos C, Quinn T, West SK

Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8806-10

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Other: Drug Therapy, Other: Trachoma

October, 2011
Association of mass treatment with azithromycin in trachoma-endemic communities with short-term reduced risk of diarrhea in young children.

Coles CL, Seidman JC, Levens J, Mkocha H, Munoz B, West S

Am J Trop Med Hyg. 2011 Oct;85(4):691-6

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

September, 2011
C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration.

Bhutto IA, Baba T, Merges C, Juriasinghani V, McLeod DS, Lutty GA

Br J Ophthalmol. 2011 Sep;95(9):1323-30

Johns Hopkins University - Departmental Grant

Keyword: AMD

Understanding and reporting visual acuity measurements in publications of clinical research.

Lopes MS, Zayit-Soudry S, Moshiri A, Bressler SB, Bressler NM

Arch Ophthalmol. 2011 Sep;129(9):1228-9

Johns Hopkins University - Senior Scientific Investigator Award - Bressler, Neil M / MD

Keyword: Other: Visual Acuity

July, 2011
Do infants increase the risk of re-emergent infection in households after mass drug administration for trachoma?

West SK, Stare D, Mkocha H, Munoz B, Gaydos C, Quinn TC

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):6040-2

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in tanzania.

West SK, Munoz B, Mkocha H, Gaydos CA, Quinn TC

J Infect Dis. 2011 Jul 15;204(2):268-73

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

June, 2011
A cross-sectional survey of water and clean faces in trachoma endemic communities in tanzania.

Rog M, Swenor B, Cajas-Monson LC, Mchiwe W, Kiboko S, Mkocha H, West S

BMC Public Health. 2011 Jun 24;11:495

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

May, 2011
Impact of trichiasis surgery on physical functioning in ethiopian patients: STAR trial.

Wolle MA, Cassard SD, Gower EW, Munoz BE, Wang J, Alemayehu W, West SK

Am J Ophthalmol. 2011 May;151(5):850-7

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trichiasis

Uncorrected refractive error in a latino population: Proyecto VER.

Uribe JA, Swenor BK, Munoz BE, West SK

Ophthalmology. 2011 May;118(5):805-11

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Visual Acuity

March, 2011
Retinal and optic nerve head pathology in susac's syndrome.

McLeod DS, Ying HS, McLeod CA, Grebe R, Lubow M, Susac JO, Lutty GA

Ophthalmology. 2011 Mar;118(3):548-52

Johns Hopkins University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optic Nerve

February, 2011
Design and baseline data of a randomized trial to evaluate coverage and frequency of mass treatment with azithromycin: The partnership for rapid elimination of trachoma (PRET) in tanzania and the gambia.

Stare D, Harding-Esch E, Munoz B, Bailey R, Mabey D, Holland M, Gaydos C, West S

Ophthalmic Epidemiol. 2011 Feb;18(1):20-9

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

Understanding rasch and item response theory models: Applications to the estimation and validation of interval latent trait measures from responses to rating scale questionnaires.

Massof RW

Ophthalmic Epidemiol. 2011 Feb;18(1):1-19

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Other: Quality of Life, Other: Visual Function Questionnaires

January, 2010
A rat model for choroidal neovascularization using subretinal lipidhydroperoxide injection.

Baba T, Bhutto IA, Merges C, Grebe R, Emmert D, McLeod DS, Armstrong D, Lutty GA

Am J Pathol 2010;176(6):3085-3097

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: AMD, Retina/Retinal Diseases

Change in function and spectacle-use 2 months after providing presbyopic spectacles in rural Tanzania.

Patel I, Munoz B, Mkocha H, Schwarzwalder AW, McHiwa W, West SK

Br J Ophthalmol 2010;94(6):685-689

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Cornea, Other: Presbyopia

How much is not enough? A community randomized trial of a water and health education programme for trachoma and ocular c.

Abdou A, Munoz BE, Nassirou B, Kadri B, Moussa F, Baar I, Riverson J, Opong E, West SK

trachomatis infection in Niger. Trop Med Int Health 2010;15(1):98-104

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies.

Barcelona PF, Luna JD, Chiabrando GA, Juarez CP, Bhutto IA, Baba T, McLeod DS, Sanchez MC, Lutty GA

Exp Eye Res 2010;91(2):264-272

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Diabetic Retinopathy, Retina/Retinal Diseases

Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD).

Bhutto IA, Baba T, Merges C, McLeod DS, Lutty GA

Exp Eye Res 2010;90(1):155-167

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: AMD

Mass treatment with azithromycin for trachoma control: Participation clusters in households.

Ssemanda EN, Munoz B, Harding-Esch EM, Edwards T, Mkocha H, Bailey RL, Sillah A, Stare D, Mabey DC, West SK; PRET Project Team

PLoS Negl Trop Dis 2010;4(10):e838

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Other: Trachoma

Older drivers and failure to stop at red lights.

West SK, Hahn DV, Baldwin KC, Duncan DD, Munoz BE, Turano KA, Hassan SE, Munro CA, Bandeen-Roche K

J Gerontol A Biol Sci Med Sci 2010;65A(2):179-183

Johns Hopkins University - Senior Scientific Investigator Award

Keyword: Low Vision

Predictors of lane-change errors in older drivers.

Munro CA, Jefferys J, Gower EW, Munoz BE, Lyketsos CG, Keay L, Turano KA, Bandeen-Roche K, West SK

J Am Geriatr Soc 2010;58(3):457-464

Johns Hopkins University - Special Scholar Award Senior Scientific Investigator Award

Keyword: Low Vision

Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy.

Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, Yamamoto M, Reddy SP, Lutty GA

Exp Eye Res 2010;90(4):493-500

Johns Hopkins University - Senior Scientific Investigator Award

Keywords: Diabetic Retinopathy, Retina/Retinal Diseases

The impact of fish and shellfish consumption on age-related macular degeneration.

Swenor BK, Bressler S, Caulfield L, West SK

Ophthalmology 2010;117(12):2395-2401

Johns Hopkins University - Senior Scientific Investigator Award - Bressler, Neil M / MD

Keyword: AMD

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