A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration.

Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL

Am J Pathol. 2014 Oct;184(10):2721-9

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

Characterization of a spontaneous retinal neovascular mouse model.

Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM

PLoS One. 2014 Sep 4;9(9):e106507

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Other: Ocular Neovascularization

EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.

Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG

PLoS One. 2014 Mar 19;9(3):e91849

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Diabetic Retinopathy

Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG

Cell Death Dis. 2014 May 29;5:e1269

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium.

Farkas MH, Lew DS, Sousa ME, Bujakowska K, Chatagnon J, Bhattacharya SS, Pierce EA, Nandrot EF

Am J Pathol. 2014 Oct;184(10):2641-52

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

Strain difference in photoreceptor cell death after retinal detachment in mice.

Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG

Invest Ophthalmol Vis Sci. 2014 May 22;55(7):4165-74

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

The alternative complement pathway regulates pathological angiogenesis in the retina.

Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM

FASEB J. 2014 Jul;28(7):3171-82

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Association of dry eye and inflammatory systemic diseases in a tertiary care-based sample.

Henrich CF, Ramulu PY, Akpek EK

Cornea. 2014 Aug;33(8):819-25

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keyword: Dry Eye

Association of vision loss and work status in the united states.

Sherrod CE, Vitale S, Frick KD, Ramulu PY

JAMA Ophthalmol. 2014 Oct;132(10):1239,42; quiz 1243-6

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keyword: Low Vision

Clinical features and incidence rate of ocular complications in punctate inner choroidopathy.

Leung TG, Moradi A, Liu D, Nguyen QD, Dunn JP, Burkholder B, Butler NJ, Ostheimer T, Thorne JE

Retina. 2014 Aug;34(8):1666-74

Johns Hopkins University - Special Scholar Award

Keyword: Retina/Retinal Diseases

Cost-effectiveness of fluocinolone acetonide implant versus systemic therapy for noninfectious intermediate, posterior, and panuveitis.

Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Sugar EA, Holbrook JT, Kempen JH, Burke AE, Drye LT, Thorne JE, Louis TA, Jabs DA, Altaweel MM, Frick KD

Ophthalmology. 2014 Oct;121(10):1855-62

Johns Hopkins University - Special Scholar Award

Keyword: Uveitis/Infectious Diseases

Driving habits in older patients with central vision loss.

Sengupta S, van Landingham SW, Solomon SD, Do DV, Friedman DS, Ramulu PY

Ophthalmology. 2014 Mar;121(3):727-32

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keyword: Low Vision

Factors predictive of remission of new-onset anterior uveitis.

Artornsombudh P, Pistilli M, Foster CS, Pujari SS, Gangaputra SS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Kempen JH

Ophthalmology. 2014 Mar;121(3):778-84

Johns Hopkins University - Special Scholar Award

Keyword: Uveitis/Infectious Diseases

Fear of falling in age-related macular degeneration.

van Landingham SW, Massof RW, Chan E, Friedman DS, Ramulu PY

BMC Ophthalmol. 2014 Jan 28;14:10,2415-14-10

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keywords: AMD, Low Vision

Glaucomatous visual field loss associated with less travel from home.

Ramulu PY, Hochberg C, Maul EA, Chan ES, Ferrucci L, Friedman DS

Optom Vis Sci. 2014 Feb;91(2):187-93

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keywords: Glaucoma, Low Vision

Incidence of visual improvement in uveitis cases with visual impairment caused by macular edema.

Levin MH, Pistilli M, Daniel E, Gangaputra SS, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Kempen JH, Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study

Ophthalmology. 2014 Feb;121(2):588,95.e1

Johns Hopkins University - Special Scholar Award

Keyword: Uveitis/Infectious Diseases

Reading ability and reading engagement in older adults with glaucoma.

Nguyen AM, van Landingham SW, Massof RW, Rubin GS, Ramulu PY

Invest Ophthalmol Vis Sci. 2014 Jul 22;55(8):5284-90

Johns Hopkins University - Special Scholar Award - Ramulu, Pradeep Y / MD, MHS, PhD

Keywords: Glaucoma, Low Vision

Tattoo-associated uveitis.

Ostheimer TA, Burkholder BM, Leung TG, Butler NJ, Dunn JP, Thorne JE

Am J Ophthalmol. 2014 Sep;158(3):637-43.e1

Johns Hopkins University - Special Scholar Award

Keyword: Uveitis/Infectious Diseases

The role of gender in juvenile idiopathic arthritis-associated uveitis.

Moradi A, Amin RM, Thorne JE

J Ophthalmol. 2014;2014:461078

Johns Hopkins University - Special Scholar Award

Keyword: Uveitis/Infectious Diseases

Transforming growth factor beta and insulin signal changes in stromal fibroblasts of individual keratoconus patients.

Foster J, Wu WH, Scott SG, Bassi M, Mohan D, Daoud Y, Stark WJ, Jun AS, Chakravarti S

PLoS One. 2014 Sep 23;9(9):e106556

Johns Hopkins University - Special Scholar Award

Keyword: Cornea

Trends over time and regional variations in the rate of laser trabeculoplasty in the medicare population.

Jampel HD, Cassard SD, Friedman DS, Shekhawat NS, Whiteside-de Vos J, Quigley HA, Gower EW

JAMA Ophthalmol. 2014 Jun;132(6):685-90

Johns Hopkins University - Special Scholar Award

Keyword: Glaucoma

Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial.

Repka MX, Kraker RT, Holmes JM, Summers AI, Glaser SR, Barnhardt CN, Tien DR

JAMA Ophthalmol. 2014 Jul;132(7):799-805

Mayo Medical School - Departmental Grant

Keywords: Pediatric, Strabismus/Amblyopia/Eye Movement Disorders

Bourne WM, Patel SV.

Trousdale ER, Hodge DO, Baratz KH, Maguire LJ

Vision-related quality of life before and after keratoplasty for Fuchs’ endothelial dystrophy. 2014 Nov;121(11):2147-52

Mayo Medical School - Departmental Grant

Keyword: Cornea

Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.

Wieben ED, Aleff RA, Eckloff BW, Atkinson EJ, Baheti S, Middha S, Brown WL, Patel SV, Kocher JP, Baratz KH

Invest Ophthalmol Vis Sci 2014. Aug;55(9):6101-7

Mayo Medical School - Departmental Grant

Keyword: Cornea

Corneal abnormalities early in the course of Fuchs’ endothelial dystrophy.

Amin SR, Baratz KH, McLaren JW, Patel SV

Ophthalmology. 2014 Dec;121(12):2325-33

Mayo Medical School - Departmental Grant

Keyword: Cornea

Depressive symptoms associated with poor health-related quality of life in adults with strabismus.

Hatt SR, Leske DA, Liebermann L, Philbrick KL, Holmes JM

Ophthalmology. 2014 Oct;121(10):2070-1

Mayo Medical School - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

Improvement in specific function-related quality-of-life concerns after strabismus surgery in nondiplopic adults.

Liebermann L, Hatt SR, Leske DA, Holmes JM

J AAPOS. 2014 Apr;18(2):105-9

Mayo Medical School - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

Incidence, types, and lifetime risk of adult-onset strabismus.

Martinez-Thompson JM, Diehl NN, Holmes JM, Mohney BG

Ophthalmology. 2014 Apr;121(4):877-82

Mayo Medical School - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

Intraocular pressure variations: Causes and clinical significance.

Sit AJ

Can J Ophthalmol. 2014 Dec;49(6):484-8

Mayo Medical School - Departmental Grant

Keyword: Glaucoma

In vivo confocal microscopy of the ocular surface: from bench to bedside.

Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M

Curr Eye Res. 2014 Mar;39(3):213-31

Mayo Medical School - Departmental Grant

Keyword: Cornea

Long-term trends in glaucoma-related blindness in Olmsted County, Minnesota.

Malihi M, Moura Filho ER, Hodge DO, Sit AJ

Ophthalmology. 2014 Jan;121(1):134-41

Mayo Medical School - Departmental Grant

Keyword: Glaucoma

Objective assessment of the corneal endothelium in Fuchs' endothelial dystrophy.

McLaren JW, Bachman LA, Kane KM, Patel SV

Invest Ophthalmol Vis Sci. 2014 Feb;55(2):1184-90

Mayo Medical School - Departmental Grant

Keyword: Cornea

Scleral lenses in the management of ocular surface disease.

Schornack MM, Pyle J, Patel SV

Ophthalmology. 2014 Jul;121(7):1398-405

Mayo Medical School - Departmental Grant

Keyword: Cornea

Successful treatment of diplopia with prism improves health-related quality of life.

Hatt SR, Leske DA, Liebermann L, Holmes JM

Am J Ophthalmol. 2014 Jun;157(6):1209-13

Mayo Medical School - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

Sustained improvement of reading symptoms following botulinum toxin A injection for convergence insufficiency.

Saunte JP, Holmes JM

Strabismus. 2014 Sep;22(3):95-9

Mayo Medical School - Departmental Grant

Keyword: Strabismus/Amblyopia/Eye Movement Disorders

Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells.

Aga M, Bradley JM, Wanchu R, Yang YF, Acott TS, Keller KE

Invest Ophthalmol Vis Sci. 2014 Aug 7;55(9):5497-509.

Oregon Health & Science University - Special Scholar Award - Keller, Kate E / PhD Departmental Grant

Keyword: Glaucoma

Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.

Keller KE, Yang YF, Sun YY, Sykes R, Gaudette ND, Samples JR, Acott TS, Wirtz MK

J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):267-76.

Oregon Health & Science University - Special Scholar Award - Keller, Kate E / PhD Departmental Grant

Keyword: Glaucoma

Intraocular pressure homeostasis: Maintaining balance in a high-pressure environment.

Acott TS, Kelley MJ, Keller KE, Vranka JA, Abu-Hassan DW, Li X, Aga M, Bradley JM

J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):94-101.

Oregon Health & Science University - Special Scholar Award - Keller, Kate E / PhD Departmental Grant

Keyword: Glaucoma

IKK2 inhibition attenuates laser-induced choroidal neovascularization.

Lu H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ, Li Q

PloS One. 2014 Jan;9(1):e87530.

University of Louisville - Special Scholar Award - Li, Qiutang / PhD Special Scholar Award - Lu, Qingxian / PhD Departmental Grant

Keyword: Other: Neovascularization

Cell and gene therapy.

Rao RC, Zacks DN

Dev Ophthalmol. 2014 53:167-77

University of Michigan - Special Scholar Award

Keyword: Gene Research/Therapy

Circadian and non-circadian modulation of autophagy in photoreceptors and retinal pigment epithelium.

Yao J, Jia L, Shelby SJ, Ganios AM, Feathers K, Thompson DA, Zacks DN

Invest Ophthalmol Vis Sci. 2014 Apr;55(5):3237-46

University of Michigan - Departmental Grant

Keywords: Retina/Retinal Diseases, AMD, Retinitis Pigmentosa

Control of photoreceptor autophagy after retinal detachment: the switch from survival to death.

Chinskey ND, Zheng QD, Zacks DN

Invest Ophthalmol Vis Sci. 2014 Feb;55(2):688-95

University of Michigan - Special Scholar Award

Keywords: Retina/Retinal Diseases, Retinal Detachment

Retinal cell death and current strategies in retinal neuroprotection.

Chinskey ND, Besirli CG, Zacks DN

Curr Opin Ophthalmol. 2014 May;25(3):228-33

University of Michigan - Special Scholar Award

Keywords: Retina/Retinal Diseases, Retinal Detachment

Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.

Chen H, Chan AY, Stone DU, Mandal NA

Surv Ophthalmol. 2014 Jan; 59(1):64-76.

University of Oklahoma Health Sciences Center - Special Scholar Award - Mandal, Nawajes / PhD

Keywords: Retina/Retinal Diseases, Gene Research/Therapy, AMD, Diabetic Retinopathy

Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation.

Li X, Gu X, Boyce TM, Zheng M, Reagan AM, Qi H, Mandal N, Cohen AW, Callegan MC, Carr, DJ, Elliott MH

Invest Ophthalmol Vis Sci 2014 Oct;55(10): 6224-6234.

University of Oklahoma Health Sciences Center - Special Scholar Award - Mandal, Nawajes / PhD Special Scholar Award - Elliott, Michael H / PhD Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Uveitis/Infectious Diseases

In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.

Mandal NA, Tran JT, Zheng L, Wilkerson JL, Brush RS, McRae J, Agbaga MP, Zhang K, Petrukhin K, Ayyagari R, Anderson RE

Invest Ophthalmol Vis Sci. 2014 Apr;55(4):2705-13.

University of Oklahoma Health Sciences Center - Special Scholar Award - Mandal, Nawajes / PhD

Keywords: Retina/Retinal Diseases, Gene Research/Therapy, AMD

Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration.

Gu X, Fliesler SJ, Zhao Y, Stallcup WB, Cohen AW, Elliott MH

Am J Path. 2014 Feb;184(2):541-555.

University of Oklahoma Health Sciences Center - Special Scholar Award - Elliott, Michael H / PhD Departmental Grant

Keywords: Diabetic Retinopathy, Glaucoma, Retinal Vein and Artery Occlusion

Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes.

May JM, Jayagopal A, Qu ZC, Parker WH

Biochem Biophys Res Commun. 2014 Sep 12;452(1):112-7.

Vanderbilt University - Special Scholar Award - Jayagopal, Ashwath / PhD Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Engineering of nanoscale contrast agents for optical coherence tomography.

Gordon AY, Jayagopal A

J Nanomed Nanotechnol. 2014 Jan 30;Suppl 5:004.

Vanderbilt University - Special Scholar Award - Jayagopal, Ashwath / PhD Departmental Grant

Keyword: Imaging

Molecular probes for imaging of hypoxia in the retina.

Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A

Bioconjug Chem. 2014 Nov;25(11):2030-37.

Vanderbilt University - Special Scholar Award - Jayagopal, Ashwath / PhD Departmental Grant

Antibacterial response of retinal Muller glia: production of antimicrobial peptides, oxidative burst and phagocytosis.

Singh PK, Shisha MJ, and Kumar A

Journal of Neuroinflammation 2014, 18; 11(1): 33.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Antimicrobial Peptides

Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis.

Singh PK, Donovan DM, and Kumar A

Antimicrobial Agents and Chemotherapy 2014, 58:4621-9.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Endophthalmitis