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Research to Prevent Blindness

Research Database

Case Western Reserve University Research, funded by RPB from 2010-2014 matching Departmental Grant

42 Citations, Sorted by Month and Year

August, 2014
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K

FASEB J. 2014 Aug;28(8):3780-91

Case Western Reserve University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

June, 2014
All-trans-retinal induces bax activation via DNA damage to mediate retinal cell apoptosis.

Sawada O, Perusek L, Kohno H, Howell SJ, Maeda A, Matsuyama S, Maeda T

Exp Eye Res. 2014 Jun;123:27-36

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: Implications for human lens aging and cataract formation.

Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH

J Biol Chem. 2014 Jun 13;289(24):17111-23

Case Western Reserve University - Departmental Grant

Keyword: Cataract

April, 2014
Aspergillus and fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.

Taylor PR, Leal SM,Jr, Sun Y, Pearlman E

J Immunol. 2014 Apr 1;192(7):3319-27

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.

Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A

J Immunol. 2014 Apr 15;192(8):3816-27

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.

Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1428-37

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2014
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2.

Taylor PR, Roy S, Leal SM,Jr, Sun Y, Howell SJ, Cobb BA, Li X, Pearlman E

Nat Immunol. 2014 Feb;15(2):143-51

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells.

Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH

Biochim Biophys Acta. 2014 Feb;1842(2):164-74

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

January, 2014
November, 2013
Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human alphaB-crystallin.

Nahomi RB, Huang R, Nandi SK, Wang B, Padmanabha S, Santhoshkumar P, Filipek S, Biswas A, Nagaraj RH

Biochemistry. 2013 Nov 12;52(45):8126-38

Case Western Reserve University - Departmental Grant

Keyword: Cataract

September, 2013
The RodA hydrophobin on aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo.

Carrion Sde J, Leal SM,Jr, Ghannoum MA, Aimanianda V, Latge JP, Pearlman E

J Immunol. 2013 Sep 1;191(5):2581-8

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

May, 2013
Chaperone peptides of alpha-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts.

Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH

J Biol Chem. 2013 May 3;288(18):13022-35

Case Western Reserve University - Departmental Grant

Keyword: Cataract

Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118).

Sun Y, Zhang R, Gadek TR, O'Neill CA, Pearlman E

J Ocul Pharmacol Ther. 2013 May;29(4):395-402

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

Photoreceptor proteins initiate microglial activation via toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A

J Biol Chem. 2013 May 24;288(21):15326-41

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

March, 2013
Autophagy protects the retina from light-induced degeneration.

Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A

J Biol Chem. 2013 Mar 15;288(11):7506-18

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

Kinetic, energetic, and mechanical differences between dark-state rhodopsin and opsin.

Kawamura S, Gerstung M, Colozo AT, Helenius J, Maeda A, Beerenwinkel N, Park PS, Muller DJ

Structure. 2013 Mar 5;21(3):426-37

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2013
Host defense at the ocular surface.

Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A

Int Rev Immunol. 2013 Feb;32(1):4-18

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

January, 2013
Targeting iron acquisition blocks infection with the fungal pathogens aspergillus fumigatus and fusarium oxysporum.

Leal SM,Jr, Roy S, Vareechon C, Carrion S, Clark H, Lopez-Berges MS, Di Pietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E

PLoS Pathog. 2013;9(7):e1003436

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human alpha-crystallin.

Nahomi RB, Oya-Ito T, Nagaraj RH

Biochim Biophys Acta. 2013 Jan;1832(1):195-203

Case Western Reserve University - Departmental Grant

Keywords: Cataract, Diabetic Retinopathy

November, 2012
Cutting edge: IL-1beta processing during pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.

Karmakar M, Sun Y, Hise AG, Rietsch A, Pearlman E

J Immunol. 2012 Nov 1;189(9):4231-5

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

Retinal photodamage mediated by all-trans-retinal(dagger).

Maeda T, Golczak M, Maeda A

Photochem Photobiol. 2012 Nov-Dec;88(6):1309-19

Case Western Reserve University - Departmental Grant

Keywords: AMD, Imaging, Macular Dystrophy

September, 2012
A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids.

Gao SQ, Maeda T, Okano K, Palczewski K

Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6314-23

Case Western Reserve University - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

August, 2012
Inflammatory priming predisposes mice to age-related retinal degeneration.

Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K

J Clin Invest. 2012 Aug 1;122(8):2989-3001

Case Western Reserve University - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Imaging

July, 2012
Fungal antioxidant pathways promote survival against neutrophils during infection.

Leal SM,Jr, Vareechon C, Cowden S, Cobb BA, Latge JP, Momany M, Pearlman E

J Clin Invest. 2012 Jul 2;122(7):2482-98

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

April, 2012
Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage.

Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T

J Neurochem. 2012 Apr;121(1):146-56

Case Western Reserve University - Departmental Grant

Keywords: AMD, Macular Dystrophy

The pathogenic role of maillard reaction in the aging eye.

Nagaraj RH, Linetsky M, Stitt AW

Amino Acids. 2012 Apr;42(4):1205-20

Case Western Reserve University - Departmental Grant

Keywords: Cataract, Diabetic Retinopathy

The role of cytokines and pathogen recognition molecules in fungal keratitis - insights from human disease and animal models.

Leal SM,Jr, Pearlman E

Cytokine. 2012 Apr;58(1):107-11

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

February, 2012
Acetylation of alphaA-crystallin in the human lens: Effects on structure and chaperone function.

Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A

Biochim Biophys Acta. 2012 Feb;1822(2):120-9

Case Western Reserve University - Departmental Grant

Keywords: Cataract, Diabetic Retinopathy

ExoS and ExoT ADP ribosyltransferase activities mediate pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.

Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E

J Immunol. 2012 Feb 15;188(4):1884-95

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.

Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K

J Biol Chem. 2012 Feb 10;287(7):5059-69

Case Western Reserve University - Departmental Grant

Keywords: AMD, Imaging, Macular Dystrophy, Retinitis Pigmentosa

January, 2012
Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: Studies on the structure and chaperone function using mutant mimics.

Nagaraj RH, Panda AK, Shanthakumar S, Santhoshkumar P, Pasupuleti N, Wang B, Biswas A

PLoS One. 2012;7(1):e30257

Case Western Reserve University - Departmental Grant

Keywords: Cataract, Diabetic Retinopathy

TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation.

Chinnery HR, McLenachan S, Binz N, Sun Y, Forrester JV, Degli-Esposti MA, Pearlman E, McMenamin PG

Am J Pathol. 2012 Jan;180(1):209-20

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

November, 2011
Dietary 9-cis-beta,beta-carotene fails to rescue vision in mouse models of leber congenital amaurosis.

Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J

Mol Pharmacol. 2011 Nov;80(5):943-52

Case Western Reserve University - Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2011
Expression of innate and adaptive immune mediators in human corneal tissue infected with aspergillus or fusarium.

Karthikeyan RS, Leal SM,Jr, Prajna NV, Dharmalingam K, Geiser DM, Pearlman E, Lalitha P

J Infect Dis. 2011 Sep 15;204(6):942-50

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

July, 2011
April, 2011
Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice.

Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A

J Biol Chem. 2011 Apr 29;286(17):15543-55

Case Western Reserve University - Departmental Grant

Keywords: AMD, Macular Dystrophy, Retina/Retinal Diseases

January, 2010
A murine model of contact lens-associated fusarium keratitis.

Sun Y, Chandra J, Mukherjee P, Szczotka-Flynn L, Ghannoum MA, Pearlman E

Invest Ophthalmol Vis Sci 2010;51(3):1511-1516

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Other: Keratitis

Distinct roles for Dectin-1 and TLR4 in the pathogenesis of aspergillus fumigatus keratitis.

Leal SM, Jr., Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E

PLoS Pathog 2010;6(7):e1000976

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Other: Keratitis

Lumican is required for neutrophil extravasation following corneal injury and wound healing.

Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW

J Cell Sci 2010;123(17):2987-2995

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Other: Keratitis

Palmitoylation stabilizes unliganded rod opsin.

Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K

Proc Natl Acad Sci USA 2010;107(18):8428-8433

Case Western Reserve University - Departmental Grant

Keyword: AMD

Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient.

Carlson EC, Sun Y, Auletta J, Kao WW, Liu CY, Perez VL, Pearlman E

J Leukoc Biol 2010;88(3):517-522

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Other: Keratitis

TLR4 and TLR5 on corneal macrophages regulate pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.

Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E

J Immunol 2010;185(7):4272-4283

Case Western Reserve University - Departmental Grant

Keywords: Cornea, Other: Keratitis

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