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Research to Prevent Blindness

Research Database

Washington University Research, funded by RPB in 2013 & 2014 matching Departmental Grant

45 Citations, Sorted by Month and Year

November, 2014
The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

Masuda T, Zhang X, Berlinicke C, Wan J, Yerrabelli A, Conner EA, Kjellstrom S, Bush R, Thorgeirsson SS, Swaroop A, Chen S, Zack DJ

J Neurosci. 2014 Nov 12;34(46):15356-68

Washington University - Departmental Grant

Keywords: Retina/Retinal Diseases, Macular Dystrophy, Gene Research/Therapy

October, 2014
Mechanisms of blindness: Animal models provide insight into distinct CRX-associated retinopathies.

Tran NM, Chen S

Dev Dyn. 2014 Oct;243(10):1153-66

Washington University - Departmental Grant

Keywords: Retina/Retinal Diseases, Macular Dystrophy, Gene Research/Therapy

Retrograde plasticity and differential competition of bipolar cell dendrites and axons in the developing retina.

Johnson RE, Kerschensteiner D

Curr Biol. 2014 Oct 6;24(19):2301-6

Washington University - Career Development Award - Kerschensteiner, Daniel / MD Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Retinal Development

September, 2014
Endothelial cell FGF signaling is required for injury response but not for vascular development or homeostasis.

Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM

Pro Natl Acad Sci. 2014 Sep; 111(37):13379-84

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinitis Pigmentosa, Stem Cell Research/Therapy

August, 2014
Chromophore supply rate-limits mammalian photoreceptor dark adaptation.

Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ

J Neurosci. 2014 Aug; 34:11212-11221

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2014
FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.

Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC

Development. 2014 Jul;141(13):2691-701

Washington University - Departmental Grant

Keywords: Dry Eye, Cornea, Gene Research/Therapy

May, 2014
Bai.

Beebe D, Shui YB, Siegfried C, Holekamp B and F

Preserve the (intraocular) environment: The importance of maintaining normal oxygen gradients in the eye. Japanese J Ophthalmol. 2014 May;58(3):225-31

Washington University - Departmental Grant

Keywords: Cataract, Glaucoma

Retaining clinician-scientists: Nature versus nurture.

Culican SM, Rupp JD, Margolis TP

Invest Ophthalmol Vis Sci. 2014 May 27;55(5):3219-22

Washington University - Departmental Grant

Keywords: Other: Career Development, Other: Education

April, 2014
Application of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticles.

Pham CT, Thomas DG, Beiser J, Mitchell LM, Huang JL, Senpan A, Hu G, Gordon M, Baker NA, Pan D, Lanza GM, Hourcade DE

Nanomedicine. 2014 Apr;10(3):651-60

Washington University - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

In vivo substrates of the lens molecular chaperones αA- and αB-crystallin.

Andley UP, Malone JP, Townsend RR

PLoS One. 2014 Apr 23;9(4):e95507

Washington University - Departmental Grant

Keyword: Cataract

Temporal and tissue-specific disruption of LINC complexes in vivo.

Razafsky D, Hodzic D

Genesis. 2014 Apr;52(4):359-65

Washington University - Departmental Grant

Keywords: Imaging, Retina/Retinal Diseases

March, 2014
Eyeballing cholesterol efflux and macrophage function in disease pathogenesis.

Sene A, Apte RS

Trends Endocrinol Metab. 2014 Mar;25(3):107-14

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinitis Pigmentosa, Stem Cell Research/Therapy

February, 2014
Mechanistically distinct mouse models for CRX-associated retinopathy.

Tran NM, Zhang A, Zhang X, Huecker JB, Hennig AK, and Chen S

PLoS Genet. 2014 Feb;10(2):e1004111

Washington University - Departmental Grant

Keywords: Retina/Retinal Diseases, Macular Dystrophy, Gene Research/Therapy

January, 2014
DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K

FASEB J. 2014;28:3780-3791

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

Enzymatic degradation identifies components responsible for the structural properties of the vitreous body.

Filas BA, Zhang Q, Okamoto RJ, Shui YB, Beebe DC

Invest Ophthalmol Vis Sci. 2014 Jan 3;55(1):55-63

Washington University - Departmental Grant

Keywords: Retinal Detachment, Retina/Retinal Diseases, Cataract

Ex Vivo ERG analysis of photoreceptors using an In Vivo ERG system.

Vinberg F, Kolesnikov AV, Kefalov VJ

Vision Res. 2014;101C:108-117

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma.

Bennett TM, Mackay DS, Siegfried CJ, Shiels A

PLoS One. 2014; 9:e104000

Washington University - Departmental Grant

Keywords: Cataract, Glaucoma

Nuclear envelope in nuclear positioning and cell migration.

Razafsky D, Wirtz D, Hodzic D

Adv Exp Med Biol. 2014;773:471-90

Washington University - Departmental Grant

Keywords: Imaging, Retina/Retinal Diseases

P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis.

Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K

Hum Mol Genet. 2014;23:1723-1741

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

R9AP overexpression alters phototransduction kinetics in iCre75 mice.

Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K

Invest Ophthalmol Vis Sci. 2014;55:1339-47

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

Science research conference on biology and chemistry of vision.

Kefalov VJ, Arshavsky VY

FASEB J. 2014;28:2395-2397

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

December, 2013
Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300.

Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A

Nucleic Acids Res. 2013 Dec;41(22):10199-214

Washington University - Departmental Grant

Keywords: Cataract, Gene Research/Therapy

October, 2013
Computational model for oxygen transport and consumption in human vitreous.

Filas BA, Shui YB, Beebe DC

Invest Ophthalmol Vis Sci. 2013 Oct 15;54(10):6549-59

Washington University - Departmental Grant

Keywords: Cataract, Glaucoma, Retina/Retinal Diseases

p62 expression and autophagy in alphaB-crystallin R120G mutant knock-in mouse model of hereditary cataract.

Wignes JA, Goldman JW, Weihl CC, Bartley MG, Andley UP

Exp Eye Res. 2013 Oct;115:263-73

Washington University - Departmental Grant

Keyword: Cataract

UV-B-induced DNA damage and repair in the mouse lens.

Mesa R, Bassnett S

Invest Ophthalmol Vis Sci. 2013 Oct 17;54(10):6789-97

Washington University - Departmental Grant

Keyword: Cataract

September, 2013
Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis.

Razafsky DS, Ward CL, Kolb T, Hodzic D

Nucleus. 2013 Sep-Oct;4(5):399-409

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2013
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration.

Zhao H, Roychoudhury J, Doggett TA, Apte RS, Ferguson TA

Invest Ophthalmol Vis Sci. 2013 Aug 7;54(8):5321-31

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

July, 2013
Cone phosphodiesterase-6alpha' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6beta-deficient rd10 mouse.

Deng WT, Sakurai K, Kolandaivelu S, Kolesnikov AV, Dinculescu A, Li J, Zhu P, Liu X, Pang J, Chiodo VA, Boye SL, Chang B, Ramamurthy V, Kefalov VJ, Hauswirth WW

J Neurosci. 2013 Jul 17;33(29):11745-53

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

Intersecting circuits generate precisely patterned retinal waves.

Akrouh A, Kerschensteiner D

Neuron. 2013 Jul 24;79(2):322-34

Washington University - Career Development Award - Kerschensteiner, Daniel / MD Departmental Grant

Keywords: Imaging, Other: Retinal Development

NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina.

Soto F, Watkins KL, Johnson RE, Schottler F, Kerschensteiner D

J Neurosci. 2013 Jul 17;33(29):11949-59

Washington University - Career Development Award - Kerschensteiner, Daniel / MD Departmental Grant

Keywords: Gene Research/Therapy, Imaging

Noncanonical autophagy promotes the visual cycle.

Kim JY, Zhao H, Martinez J, Doggett TA, Kolesnikov AV, Tang PH, Ablonczy Z, Chan CC, Zhou Z, Green DR, Ferguson TA

Cell. 2013 Jul 18;154(2):365-76

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.

Hennig AK, Peng GH, Chen S

PLoS One. 2013 Jul 26;8(7):e69721

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2013
Oxidative responses induced by pharmacologic vitreolysis and/or long-term hyperoxia treatment in rat lenses.

Li Q, Yan H, Ding TB, Han J, Shui YB, Beebe DC

Curr Eye Res. 2013 Jun;38(6):639-48

Washington University - Departmental Grant

Keywords: Cataract, Retina/Retinal Diseases

The rate of structural change: The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study.

Zangwill LM, Jain S, Dirkes K, He F, Medeiros FA, Trick GL, Brandt JD, Cioffi GA, Coleman AL, Liebmann JM, Piltz-Seymour JR, Gordon MO, Kass MA, Weinreb RN, Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

Am J Ophthalmol. 2013 Jun;155(6):971-82

Washington University - Departmental Grant

Keywords: Glaucoma, Imaging

May, 2013
Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors.

Lai CW, Kolesnikov AV, Frederick JM, Blake DR, Jiang L, Stewart JS, Chen CK, Barrow JR, Baehr W, Kefalov VJ, Willardson BM

J Neurosci. 2013 May 1;33(18):7941-51

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2013
Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins alphaA- and alphaB-crystallin.

Andley UP, Malone JP, Hamilton PD, Ravi N, Townsend RR

Biochemistry. 2013 Apr 30;52(17):2933-48

Washington University - Departmental Grant

Keyword: Cataract

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

Shi Y, Tu Y, De Maria A, Mecham RP, Bassnett S

Invest Ophthalmol Vis Sci. 2013 Apr 1;54(4):2504-15

Washington University - Departmental Grant

Keywords: Pediatric, Other: Marfan Syndrome

Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals.

Schubert T, Hoon M, Euler T, Lukasiewicz PD, Wong RO

Neuron. 2013 Apr 10;78(1):124-37

Washington University - Departmental Grant

Keyword: Other: Retinal Neuroscience

Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS

Cell Metab. 2013 Apr 2;17(4):549-61

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Noncoding variation of the gene for ferritin light chain in hereditary and age-related cataract.

Bennett TM, Maraini G, Jin C, Sun W, Hejtmancik JF, Shiels A

Mol Vis. 2013 Apr 11;19:835-44

Washington University - Departmental Grant

Keywords: Cataract, Gene Research/Therapy

February, 2013
Series length used during trend analysis affects sensitivity to changes in progression rate in the ocular hypertension treatment study.

Gardiner SK, Demirel S, De Moraes CG, Liebmann JM, Cioffi GA, Ritch R, Gordon MO, Kass MA, Ocular Hypertension Treatment Study Group

Invest Ophthalmol Vis Sci. 2013 Feb 15;54(2):1252-9

Washington University - Departmental Grant

Keyword: Glaucoma

January, 2013
Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K

J Clin Invest. 2013 Jan 2;123(1):121-37

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

Cruz-Guilloty F, Saeed AM, Echegaray JJ, Duffort S, Ballmick A, Tan Y, Betancourt M, Viteri E, Ramkhellawan GC, Ewald E, Feuer W, Huang D, Wen R, Hong L, Wang H, Laird JM, Sene A, Apte RS, Salomon RG, Hollyfield JG, Perez VL

Int J Inflam. 2013;2013:503725

Washington University - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.

Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, Vitenzon A, Zheng D, Gotz M, Beebe DC, Zavadil J, Cvekl A

PLoS One. 2013;8(1):e54507

Washington University - Departmental Grant

Keywords: Cataract, Gene Research/Therapy

Reprogramming of adult rod photoreceptors prevents retinal degeneration.

Montana CL, Kolesnikov AV, Shen SQ, Myers CA, Kefalov VJ, Corbo JC

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1732-7

Washington University - Departmental Grant

Keyword: Retina/Retinal Diseases

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