netbook
desktop
mobile
tablet-landscape
tablet
phone-landscape
phone
Research to Prevent Blindness

Research Database

University of Kentucky Research, funded by RPB from 2010-2014 matching Departmental Grant

16 Citations, Sorted by Month and Year

November, 2014
DICER1/Alu RNA dysmetabolism induces caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7

University of Kentucky - Departmental Grant

Keywords: AMD, Other: Dicer1

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J

Science. 2014 Nov 21;346(6212):1000-3

University of Kentucky - Departmental Grant

Keyword: Other: Nucleoside Reverse Transcriptase Inhibitors

November, 2013
TLR-independent and P2X7-dependent signaling mediate alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J

Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401

University of Kentucky - Departmental Grant

Keyword: AMD

October, 2013
Retinal angiogenesis suppression through small molecule activation of p53.

Chavala SH, Kim Y, Tudisco L, Cicatiello V, Milde T, Kerur N, Claros N, Yanni S, Guaiquil VH, Hauswirth WW, Penn JS, Rafii S, De Falco S, Lee TC, Ambati J

J Clin Invest. 2013 Oct 1;123(10):4170-81

University of Kentucky - Departmental Grant

Keyword: AMD

June, 2013
Immunology of age-related macular degeneration.

Ambati J, Atkinson JP, Gelfand BD

Nat Rev Immunol. 2013 Jun;13(6):438-51

University of Kentucky - Departmental Grant

Keyword: AMD

January, 2013
Clocking in on diabetic retinopathy.

Kleinman ME, Ambati J

Diabetes. 2013 Jan;62(1):29-30

University of Kentucky - Career Development Award - Kleinman, Mark E / MD Departmental Grant

Keyword: Diabetic Retinopathy

August, 2012
ERK1/2 activation is a therapeutic target in age-related macular degeneration.

Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6

University of Kentucky - Departmental Grant

Keyword: AMD

January, 2012
A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina.

Kleinman ME, Ambati J

Adv Exp Med Biol. 2012;723:3-9

University of Kentucky - Departmental Grant

Keyword: AMD

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.

Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J

Mol Ther. 2012 Jan;20(1):101-8

University of Kentucky - Departmental Grant

Keyword: AMD

April, 2011
Age-related macular degeneration and the other double helix.

Ambati J

the cogan lecture. Invest Ophthalmol Vis Sci. 2011 Apr 6;52(5):2165-9

University of Kentucky - Departmental Grant

Keywords: Other: Angiogenesis, Other: apoptosis, Other: Cell Death, Other: Neovascularization

March, 2011
DICER1 deficit induces alu RNA toxicity in age-related macular degeneration.

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Kariko K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J

Nature. 2011 Mar 17;471(7338):325-30

University of Kentucky - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Geographic Atrophy, Other: microRNA

January, 2010
Endothelial cell capture of heparin-binding growth factors under flow.

Zhao B, Zhang C, Forsten-Williams K, Zhang J, Fannon M

PLoS Comput Biol 2010;6(10):e1000971

University of Kentucky - Departmental Grant

Keywords: Other: Angiogenesis, Other: Cancer

Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.

Becker J, Pavlakovic H, Ludewig F, Wilting F, Weich HA, Albuquerque R, Ambati J, Wilting J

Clin Cancer Res 2010;16(5):1431-1441

University of Kentucky - Departmental Grant

Keywords: Other: Lymphangiogenesis, Other: Metastasis, Other: Vascular Endothelial Growth Factor Receptor-2

The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model.

Shibata MA, Ambati J, Shibata E, Albuquerque RJ, Morimoto J, Ito Y, Otsuki Y

BMC Med 2010;3;8:69

University of Kentucky - Departmental Grant

Keywords: Other: Lymphangiogenesis, Other: Metastasis, Other: Vascular Endothelial Growth Factor Receptor-2

Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prostate cancer cells.

Gregory KJ, Zhao B, Bielenberg DR, Dridi S, Wu J, Jiang W, Huang B, Pirie-Shepherd S, Fannon M

PLoS ONE 2010;5(10):e13428

University of Kentucky - Departmental Grant

Keywords: Other: Angiogenesis, Other: Cancer

Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis.

Bargagna-Mohan P, Paranthan RR, Hamza A, Dimova N, Trucchi B, Srinivasan C, Elliott GI, Zhan CG, Lau DL, Zhu H, Kasahara K, Inagaki M, Cambi F, Mohan R

J Biol Chem 2010;285(10):7657-7669

University of Kentucky - Departmental Grant

Keywords: Other: Gliosis, Other: Injury, Other: repair

Subscribe

Get our email updates filled with the latest news from our researchers about preventing vision loss, treating eye disease and even restoring sight. Unsubscribe at any time. Under our privacy policy, we'll never share your contact information with a third party.