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Research to Prevent Blindness

Research Database

Harvard Medical School Research, funded by RPB in 2013 & 2014 matching Physician-Scientist Award

23 Citations, Sorted by Month and Year

December, 2014
Effects of metformin on retinoblastoma growth in vitro and in vivo.

Brodowska K, Theodoropoulou S, Meyer Zu Horste M, Paschalis EI, Takeuchi K, Scott G, Ramsey DJ, Kiernan E, Hoang M, Cichy J, Miller JW, Gragoudas ES, Vavvas DG

Int J Oncol. 2014 Dec;45(6):2311-24

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

September, 2014
Characterization of a spontaneous retinal neovascular mouse model.

Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM

PLoS One. 2014 Sep 4;9(9):e106507

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

LKB1 and AMPK regulate synaptic remodeling in old age.

Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR

Nat Neurosci. 2014 Sep;17(9):1190-7

Harvard Medical School - Innovative Ophthalmic Research Award - Sanes, Joshua R / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

Removal of silicone oil from intraocular lens using novel surgical materials.

Paschalis EI, Eliott D, Vavvas DG

Transl Vis Sci Technol. 2014 Sep 12;3(5):4

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD

Keyword: Retinal Detachment

July, 2014
Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-kappaB pathway.

Hu Y, Lin H, Dib B, Atik A, Bouzika P, Lin C, Yan Y, Tang S, Miller JW, Vavvas DG

Discov Med. 2014 Jul-Aug;18(97):7-14

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD

Keyword: Retina/Retinal Diseases

Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Other: Ocular Neovascularization

Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms.

Kim LA, Amarnani D, Gnanaguru G, Tseng WA, Vavvas DG, D'Amore PA

Invest Ophthalmol Vis Sci. 2014 Jul 3;55(8):4747-58

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD

Keyword: Retina/Retinal Diseases

May, 2014
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG

Cell Death Dis. 2014 May 29;5:e1269

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Strain difference in photoreceptor cell death after retinal detachment in mice.

Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG

Invest Ophthalmol Vis Sci. 2014 May 22;55(7):4165-74

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

April, 2014
Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas TD, Marmalidou A, Ksander BR, Miller JW, Gragoudas E, Vavvas DG

Invest Ophthalmol Vis Sci. 2014 Apr 29;55(7):4175-85

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD

Keyword: Ocular Oncology/Pterygium

March, 2014
EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.

Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG

PLoS One. 2014 Mar 19;9(3):e91849

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Diabetic Retinopathy

February, 2014
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.

Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL

Ophthalmology. 2014 Feb;121(2):508-16

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

November, 2013
Photoreceptor cell death and rescue in retinal detachment and degenerations.

Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG

Prog Retin Eye Res. 2013 Nov;37:114-40

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Macular Dystrophy, Retina/Retinal Diseases, Retinitis Pigmentosa

October, 2013
Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: A novel treatment.

Ziaei A, Schmedt T, Chen Y, Jurkunas UV

Invest Ophthalmol Vis Sci. 2013 Oct 15;54(10):6724-34

Harvard Medical School - Physician-Scientist Award - Jurkunas, Ula V / MD

Keyword: Cornea

September, 2013
Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open angle glaucoma.

Feke GT, Rhee DJ, Turalba AV, Pasquale LR

J Ocul Pharmacol Ther. 2013 Sep;29(7):639-45

Harvard Medical School - Physician-Scientist Award

Keywords: Glaucoma, Retina/Retinal Diseases

Investigation of known genetic risk factors for primary open angle glaucoma in two populations of african ancestry.

Liu Y, Hauser MA, Akafo SK, Qin X, Miura S, Gibson JR, Wheeler J, Gaasterland DE, Challa P, Herndon LW, International Consortium of African Ancestry REsearch in Glaucoma, Ritch R, Moroi SE, Pasquale LR, Girkin CA, Budenz DL, Wiggs JL, Richards JE, Ashley-Koch AE, Allingham RR

Invest Ophthalmol Vis Sci. 2013 Sep 17;54(9):6248-54

Harvard Medical School - Physician-Scientist Award

Keywords: Gene Research/Therapy, Glaucoma

Retinal detachment model in rodents by subretinal injection of sodium hyaluronate.

Matsumoto H, Miller JW, Vavvas DG

J Vis Exp. 2013 Sep 11(79)

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

July, 2013
AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-abl and Prdx1 proteins in endothelial cells.

Takeuchi K, Morizane Y, Kamami-Levy C, Suzuki J, Kayama M, Cai W, Miller JW, Vavvas DG

J Biol Chem. 2013 Jul 12;288(28):20581-91

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Vein and Artery Occlusion

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the united states.

Pasquale LR, Loomis SJ, Weinreb RN, Kang JH, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Scott WK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL

Mol Vis. 2013 Jul 12;19:1471-81

Harvard Medical School - Physician-Scientist Award

Keywords: Gene Research/Therapy, Glaucoma

May, 2013
A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features.

Shah M, Lee G, Lefebvre DR, Kronberg B, Loomis S, Brauner SC, Turalba A, Rhee DJ, Freitag SK, Pasquale LR

PLoS One. 2013 May 1;8(5):e61638

Harvard Medical School - Medical Student Eye Research Fellowship - Shah, Mamta

Keyword: Glaucoma

February, 2013
CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the united states.

Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL

Am J Ophthalmol. 2013 Feb;155(2):342-53.e5

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

January, 2013
Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis.

Theodoropoulou S, Brodowska K, Kayama M, Morizane Y, Miller JW, Gragoudas ES, Vavvas DG

PLoS One. 2013;8(1):e52852

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Ocular Oncology/Pterygium, Pediatric

Soluble guanylate cyclase alpha1-deficient mice: A novel murine model for primary open angle glaucoma.

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR

PLoS One. 2013;8(3):e60156

Harvard Medical School - Physician-Scientist Award

Keywords: Gene Research/Therapy, Glaucoma

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