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Research to Prevent Blindness

Research Database

Harvard Medical School Research, funded by RPB from 2012-2014 matching Departmental Grant

27 Citations, Sorted by Month and Year

December, 2014
Effects of metformin on retinoblastoma growth in vitro and in vivo.

Brodowska K, Theodoropoulou S, Meyer Zu Horste M, Paschalis EI, Takeuchi K, Scott G, Ramsey DJ, Kiernan E, Hoang M, Cichy J, Miller JW, Gragoudas ES, Vavvas DG

Int J Oncol. 2014 Dec;45(6):2311-24

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

October, 2014
A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration.

Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL

Am J Pathol. 2014 Oct;184(10):2721-9

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium.

Farkas MH, Lew DS, Sousa ME, Bujakowska K, Chatagnon J, Bhattacharya SS, Pierce EA, Nandrot EF

Am J Pathol. 2014 Oct;184(10):2641-52

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

September, 2014
Characterization of a spontaneous retinal neovascular mouse model.

Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM

PLoS One. 2014 Sep 4;9(9):e106507

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

UV cross-linking of donor corneas confers resistance to keratolysis.

Arafat SN, Robert MC, Shukla AN, Dohlman CH, Chodosh J, Ciolino JB

Cornea. 2014 Sep;33(9):955-9

Harvard Medical School - Senior Scientific Investigator Award - Chodosh, James / MD, MPH Career Development Award - Ciolino, Joseph Bowers / MD Departmental Grant

Keyword: Cornea

July, 2014
Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Other: Ocular Neovascularization

The alternative complement pathway regulates pathological angiogenesis in the retina.

Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM

FASEB J. 2014 Jul;28(7):3171-82

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2014
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG

Cell Death Dis. 2014 May 29;5:e1269

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Strain difference in photoreceptor cell death after retinal detachment in mice.

Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG

Invest Ophthalmol Vis Sci. 2014 May 22;55(7):4165-74

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

March, 2014
EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.

Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG

PLoS One. 2014 Mar 19;9(3):e91849

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Diabetic Retinopathy

February, 2014
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.

Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL

Ophthalmology. 2014 Feb;121(2):508-16

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

November, 2013
Photoreceptor cell death and rescue in retinal detachment and degenerations.

Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG

Prog Retin Eye Res. 2013 Nov;37:114-40

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Macular Dystrophy, Retina/Retinal Diseases, Retinitis Pigmentosa

October, 2013
Caveolin-1 associated adenovirus entry into human corneal cells.

Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J

PLoS One. 2013 Oct 11;8(10):e77462

Harvard Medical School - Senior Scientific Investigator Award - Chodosh, James / MD, MPH Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

September, 2013
Retinal detachment model in rodents by subretinal injection of sodium hyaluronate.

Matsumoto H, Miller JW, Vavvas DG

J Vis Exp. 2013 Sep 11(79)

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

July, 2013
AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-abl and Prdx1 proteins in endothelial cells.

Takeuchi K, Morizane Y, Kamami-Levy C, Suzuki J, Kayama M, Cai W, Miller JW, Vavvas DG

J Biol Chem. 2013 Jul 12;288(28):20581-91

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Vein and Artery Occlusion

February, 2013
CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the united states.

Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL

Am J Ophthalmol. 2013 Feb;155(2):342-53.e5

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

January, 2013
Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis.

Theodoropoulou S, Brodowska K, Kayama M, Morizane Y, Miller JW, Gragoudas ES, Vavvas DG

PLoS One. 2013;8(1):e52852

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Ocular Oncology/Pterygium, Pediatric

September, 2012
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration.

Murakami Y, Matsumoto H, Roh M, Suzuki J, Hisatomi T, Ikeda Y, Miller JW, Vavvas DG

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14598-603

Harvard Medical School - Departmental Grant

Keyword: Retinitis Pigmentosa

July, 2012
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.

Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE, Hawthorne F, Budenz DL, Friedman DS, Gaasterland D, Haines J, Kang JH, Lee R, Lichter P, Liu Y, Pasquale LR, Pericak-Vance M, Realini A, Schuman JS, Singh K, Vollrath D, Weinreb R, Wollstein G, Zack DJ, Zhang K, Young T, Allingham RR, Wiggs JL, Ashley-Koch A, Hauser MA

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4468-74

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

May, 2012
Evidence for baseline retinal pigment epithelium pathology in the Trp1-cre mouse.

Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG

Am J Pathol. 2012 May;180(5):1917-27

Harvard Medical School - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

April, 2012
Oral acetazolamide after boston keratoprosthesis in stevens-johnson syndrome.

Kumar R, Dohlman CH, Chodosh J

BMC Res Notes. 2012 Apr 30;5:205

Harvard Medical School - Departmental Grant

Keywords: Cornea, Glaucoma

January, 2012
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL

PLoS Genet. 2012;8(4):e1002654

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

Complement involvement in neovascular ocular diseases.

Yanai R, Thanos A, Connor KM

Adv Exp Med Biol. 2012;946:161-83

Harvard Medical School - Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Retina/Retinal Diseases

Computational and serologic analysis of novel and known viruses in species human adenovirus D in which serology and genomics do not correlate.

Liu EB, Wadford DA, Seto J, Vu M, Hudson NR, Thrasher L, Torres S, Dyer DW, Chodosh J, Seto D, Jones MS

PLoS One. 2012;7(3):e33212

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Demographic and geographic features of exfoliation glaucoma in 2 united states-based prospective cohorts.

Kang JH, Loomis S, Wiggs JL, Stein JD, Pasquale LR

Ophthalmology. 2012 Jan;119(1):27-35

Harvard Medical School - Departmental Grant

Keywords: Epidemiology, Glaucoma

Etanercept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma.

Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, Benowitz LI, Miller JW

PLoS One. 2012;7(7):e40065

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

Five genome sequences of subspecies B1 human adenoviruses associated with acute respiratory disease.

Dehghan S, Liu EB, Seto J, Torres SF, Hudson NR, Kajon AE, Metzgar D, Dyer DW, Chodosh J, Jones MS, Seto D

J Virol. 2012 Jan;86(1):635-6

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

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