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Research to Prevent Blindness

Research Database

University of Florida Research, funded by RPB in 2014 matching Departmental Grant

35 Citations, Sorted by Month and Year

December, 2014
Flicker cone function in normal and day blind sheep: A large animal model for human achromatopsia caused by CNGA3 mutation.

Ezra-Elia R, Banin E, Honig H, Rosov A, Obolensky A, Averbukh E, Hauswirth WW, Gootwine E, Ofri R

Doc Ophthalmol. 2014 Dec;129(3):141-50

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Oral delivery of angiotensin-converting enzyme 2 and angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.

Shenoy V, Kwon KC, Rathinasabapathy A, Lin S, Jin G, Song C, Shil P, Nair A, Qi Y, Li Q, Francis J, Katovich MJ, Daniell H, Raizada MK

Hypertension. 2014 Dec;64(6):1248-59

University of Florida - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

November, 2014
DICER1/Alu RNA dysmetabolism induces caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7

University of Florida - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

October, 2014
Expression and cellular localization of the mas receptor in the adult and developing mouse retina.

Prasad T, Verma A, Li Q

Mol Vis. 2014 Oct 17;20:1443-55

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR.

Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD

Cold Spring Harb Perspect Med. 2014 Oct 9;5(2):10:e017392

University of Florida - Departmental Grant

Keywords: Retinitis Pigmentosa, Gene Research/Therapy, Retina/Retinal Diseases

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

Ramamurthy V, Jolicoeur C, Koutroumbas D, Muhlhans J, Le YZ, Hauswirth WW, Giessl A, Cayouette M

J Neurosci. 2014 Oct 15;34(42):13976-87

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2014
In vivo knockdown of piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses.

Regus-Leidig H, Fuchs M, Lohner M, Leist SR, Leal-Ortiz S, Chiodo VA, Hauswirth WW, Garner CC, Brandstatter JH

Front Cell Neurosci. 2014 Sep 3;8:259

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Leber congenital amaurosis caused by mutations in GUCY2D.

Boye SE

Cold Spring Harb Perspect Med. 2014 Sep 25;5(1):a017350

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Opsin expression in limulus eyes: A UV opsin is expressed in each eye type and co-expressed with a visible light-sensitive opsin in ventral larval eyes.

Battelle BA, Kempler KE, Harrison A, Dugger DR, Payne R

J Exp Biol. 2014 Sep 1;217(Pt 17):3133-45

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2014
Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas.

Sriram S, Gibson DJ, Robinson P, Pi L, Tuli S, Lewin AS, Schultz G

Exp Eye Res. 2014 Aug;125:173-82

University of Florida - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Retinal gene therapy using adeno-associated viral vectors: Multiple applications for a small virus.

Hauswirth WW

Hum Gene Ther. 2014 Aug;25(8):671-8

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

July, 2014
Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.

Talla V, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Guy J

Invest Ophthalmol Vis Sci. 2014 Jul 11;55(8):5214-26

University of Florida - Departmental Grant

Keywords: Optic Neuropathy, Gene Research/Therapy

June, 2014
Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

Batenburg WW, Verma A, Wang Y, Zhu P, van den Heuvel M, van Veghel R, Danser AH, Li Q

PLoS One. 2014 Jun 26;9(6):e100954

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Gene therapy: Charting a future course--summary of a national institutes of health workshop, april 12, 2013.

O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J

Hum Gene Ther. 2014 Jun;25(6):488-97

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Genetically targeted binary labeling of retinal neurons.

Zhu Y, Xu J, Hauswirth WW, DeVries SH

J Neurosci. 2014 Jun 4;34(23):7845-61

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.

Ha JH, Shil PK, Zhu P, Gu L, Li Q, Chung S

J Nutr. 2014 Jun;144(6):799-806

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2014
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.

Qiu Y, Shil PK, Zhu P, Yang H, Verma A, Lei B, Li Q

Invest Ophthalmol Vis Sci. 2014 May 22;55(6):3809-18

University of Florida - Departmental Grant

Keywords: Uveitis/Infectious Diseases, Nanotechnology/Drug Delivery

Insights gained from gene therapy in animal models of retGC1 deficiency.

Boye SE

Front Mol Neurosci. 2014 May 14;7:43

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study.

Furlanetto RL, De Moraes CG, Teng CC, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T, Low-Pressure Glaucoma Treatment Study Group

Am J Ophthalmol. 2014 May;157(5):945-52

University of Florida - Departmental Grant

Keyword: Glaucoma

April, 2014
Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis.

Yang H, Zheng S, Qiu Y, Yang Y, Wang C, Yang P, Li Q, Lei B

Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A.

Dyka FM, Boye SL, Chiodo VA, Hauswirth WW, Boye SE

Hum Gene Ther Methods. 2014 Apr;25(2):166-77

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.

Wilson AM, Chiodo VA, Boye SL, Brecha NC, Hauswirth WW, Di Polo A

PLoS One. 2014 Apr 8;9(4):e94175

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

Probable association of an attack of bilateral acute angle-closure glaucoma with duloxetine.

Shifera AS, Leoncavallo A, Sherwood M

Ann Pharmacother. 2014 Apr 14;48(7):936-9

University of Florida - Departmental Grant

Keyword: Glaucoma

Safety and effects of the vector for the leber hereditary optic neuropathy gene therapy clinical trial.

Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J

JAMA Ophthalmol. 2014 Apr 1;132(4):409-20

University of Florida - Departmental Grant

Keywords: Optic Neuropathy, Gene Research/Therapy

March, 2014
AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice.

Dai X, Han J, Qi Y, Zhang H, Xiang L, Lv J, Li J, Deng WT, Chang B, Hauswirth WW, Pang JJ

Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1724-34

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Natural history of cone disease in the murine model of leber congenital amaurosis due to CEP290 mutation: Determining the timing and expectation of therapy.

Boye SE, Huang WC, Roman AJ, Sumaroka A, Boye SL, Ryals RC, Olivares MB, Ruan Q, Tucker BA, Stone EM, Swaroop A, Cideciyan AV, Hauswirth WW, Jacobson SG

PLoS One. 2014 Mar 26;9(3):e92928

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.

Kohli N, Westerveld DR, Ayache AC, Verma A, Shil P, Prasad T, Zhu P, Chan SL, Li Q, Daniell H

Mol Ther. 2014 Mar;22(3):535-46

University of Florida - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Retina/Retinal Diseases

February, 2014
Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study).

Netland PA, Sarkisian SR,Jr, Moster MR, Ahmed II, Condon G, Salim S, Sherwood MB, Siegfried CJ

Am J Ophthalmol. 2014 Feb;157(2):433,440.e3

University of Florida - Departmental Grant

Keyword: Glaucoma

January, 2014
Cone specific promoter for use in gene therapy of retinal degenerative diseases.

Dyka FM, Boye SL, Ryals RC, Chiodo VA, Boye SE, Hauswirth WW

Adv Exp Med Biol. 2014;801:695-701

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Investigating the role of retinal muller cells with approaches in genetics and cell biology.

Fu S, Zhu M, Ash JD, Wang Y, Le YZ

Adv Exp Med Biol. 2014;801:401-5

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Scleritis caused by in vitro linezolid-resistant nocardia asteroides.

Gonzalez A, Fakhar K, Gubernick D, Tuli S

Case Rep Ophthalmol Med. 2014;2014:326957

University of Florida - Departmental Grant

Keyword: Cornea

Spectral domain optical coherence tomography findings in CNGB3-associated achromatopsia and therapeutic implications.

McClintock M, Peden MC, Kay CN

Adv Exp Med Biol. 2014;801:551-7

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors.

de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, Borretta L, McInerny SC, Banks KG, Portales-Casamar E, Swanson MI, D'Souza CA, Boye SE, Jones SJ, Holt RA, Goldowitz D, Hauswirth WW, Wasserman WW, Simpson EM

Mol Ther Methods Clin Dev. 2014 Jan 8;1:5

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach.

Mowat FM, Gornik KR, Dinculescu A, Boye SL, Hauswirth WW, Petersen-Jones SM, Bartoe JT

Gene Ther. 2014 Jan;21(1):96-105

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Very long chain polyunsaturated fatty acids and rod cell structure and function.

Marchette LD, Sherry DM, Brush RS, Chan M, Wen Y, Wang J, Ash JD, Anderson RE, Mandal NA

Adv Exp Med Biol. 2014;801:637-45

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

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