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Research to Prevent Blindness

Research Database

Columbia University Research, funded by RPB in 2014 matching Departmental Grant

36 Citations, Sorted by Month and Year

November, 2014
New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.

Xie YA, Lee W, Cai C, Gambin T, Noupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R

Hum Mol Genet. 2014 Nov 1;23(21):5774-80

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

October, 2014
Genetic and clinical analysis of ABCA4-associated disease in african american patients.

Zernant J, Collison FT, Lee W, Fishman GA, Noupuu K, Yuan B, Cai C, Lupski JR, Yannuzzi LA, Tsang SH, Allikmets R

Hum Mutat. 2014 Oct;35(10):1187-94

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.

Cai Z, Grobe K, Zhang X

Dev Dyn. 2014 Oct;243(10):1310-6

Columbia University - Stein Professorship - Zhang, Xin / PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

Structural and genetic assessment of the ABCA4-associated optical gap phenotype.

Noupuu K, Lee W, Zernant J, Tsang SH, Allikmets R

Invest Ophthalmol Vis Sci. 2014 Oct 9;55(11):7217-26

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2014
A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.

Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ

Cell. 2014 Sep 25;159(1):200-14

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway.

Ma W, Paik DC, Barile GR

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6187-93

Columbia University - Departmental Grant

Keyword: Cornea

Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa.

Park SP, Lee W, Bae EJ, Greenstein V, Sin BH, Chang S, Tsang SH

Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct;45(5):469-73

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects.

Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH

Mol Ther. 2014 Sep;22(9):1688-97

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

Late recurrence of myopic foveoschisis after successful repair with primary vitrectomy and incomplete membrane peeling.

Sepulveda G, Chang S, Freund KB, Park S, Hoang QV

Retina. 2014 Sep;34(9):1841-7

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Departmental Grant

Keyword: Myopia/Presbyopia

Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.

Collison FT, Fishman GA, McAnany JJ, Zernant J, Allikmets R

Retina. 2014 Sep;34(9):1888-95

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Whole exome sequencing identifies CRB1 defect in an unusual maculopathy phenotype.

Tsang SH, Burke T, Oll M, Yzer S, Lee W, Xie YA, Allikmets R

Ophthalmology. 2014 Sep;121(9):1773-82

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

August, 2014
Acoustic radiation force for noninvasive evaluation of corneal biomechanical changes induced by cross-linking therapy.

Urs R, Lloyd HO, Silverman RH

J Ultrasound Med. 2014 Aug;33(8):1417-26

Columbia University - Departmental Grant

Keyword: Cornea

The external limiting membrane in early-onset stargardt disease.

Lee W, Noupuu K, Oll M, Duncker T, Burke T, Zernant J, Bearelly S, Tsang SH, Sparrow JR, Allikmets R

Invest Ophthalmol Vis Sci. 2014 Aug 19;55(10):6139-49

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2014
Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.

Schubert C, Pryds A, Zeng S, Xie Y, Freund KB, Spaide RF, Merriam JC, Barbazetto I, Slakter JS, Chang S, Munch IC, Drack AV, Hernandez J, Yzer S, Merriam JE, Linneberg A, Larsen M, Yannuzzi LA, Mullins RF, Allikmets R

Hum Mutat. 2014 Jul;35(7):859-67

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Choroidal and retinal thickening in severe preeclampsia.

Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W, Allikmets R, Bearelly S

Invest Ophthalmol Vis Sci. 2014 Jul 29;55(9):5723-9

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Fundus autofluorescence and photoreceptor cell rosettes in mouse models.

Flynn E, Ueda K, Auran E, Sullivan JM, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Jul 11;55(9):5643-52

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

The value of retinal imaging with infrared scanning laser ophthalmoscopy in patients with stargardt disease.

Chun R, Fishman GA, Collison FT, Stone EM, Zernant J, Allikmets R

Retina. 2014 Jul;34(7):1391-9

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.

Yang J, Li Y, Chan L, Tsai YT, Wu WH, Nguyen HV, Hsu CW, Li X, Brown LM, Egli D, Sparrow JR, Tsang SH

Hum Mol Genet. 2014 Jul 1;23(13):3445-55

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: AMD

Vitamin A dimers trigger the protracted death of retinal pigment epithelium cells.

Mihai DM, Washington I

Cell Death Dis. 2014 Jul 24;5:e1348

Columbia University - Departmental Grant

Keyword: AMD

June, 2014
Notch signaling functions in lymphatic valve formation.

Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J

Development. 2014 Jun;141(12):2446-51

Columbia University - Departmental Grant

Keyword: Cornea

May, 2014
Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina.

Wert KJ, Skeie JM, Bassuk AG, Olivier AK, Tsang SH, Mahajan VB

Hum Mol Genet. 2014 May 15;23(10):2665-77

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Quantitative fundus autofluorescence in recessive stargardt disease.

Burke TR, Duncker T, Woods RL, Greenberg JP, Zernant J, Tsang SH, Smith RT, Allikmets R, Sparrow JR, Delori FC

Invest Ophthalmol Vis Sci. 2014 May 1;55(5):2841-52

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

The photosynthetic eukaryote nannochloris eukaryotum as an intracellular machine to control and expand functionality of human cells.

Black CK, Mihai DM, Washington I

Nano Lett. 2014 May 14;14(5):2720-5

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

April, 2014
Generalized choriocapillaris dystrophy, a distinct phenotype in the spectrum of ABCA4-associated retinopathies.

Bertelsen M, Zernant J, Larsen M, Duno M, Allikmets R, Rosenberg T

Invest Ophthalmol Vis Sci. 2014 Apr 29;55(4):2766-76

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Pharmacologic alternatives to riboflavin photochemical corneal cross-linking: A comparison study of cell toxicity thresholds.

Kim M, Takaoka A, Hoang QV, Trokel SL, Paik DC

Invest Ophthalmol Vis Sci. 2014 Apr 10;55(5):3247-57

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Departmental Grant

Keyword: Cornea

Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia.

Greenberg JP, Sherman J, Zweifel SA, Chen RW, Duncker T, Kohl S, Baumann B, Wissinger B, Yannuzzi LA, Tsang SH

JAMA Ophthalmol. 2014 Apr 1;132(4):437-45

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

March, 2014
Aliphatic beta-nitroalcohols for therapeutic corneoscleral cross-linking: Chemical stability studies using 1H-NMR spectroscopy.

Li X, Li Y, Kim M, Trokel SL, Turro NJ, Paik DC

Photochem Photobiol. 2014 Mar-Apr;90(2):338-43

Columbia University - Departmental Grant

Keyword: Cornea

Epithelial remodeling as basis for machine-based identification of keratoconus.

Silverman RH, Urs R, Roychoudhury A, Archer TJ, Gobbe M, Reinstein DZ

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1580-7

Columbia University - Departmental Grant

Keyword: Cornea

Fine central macular dots associated with childhood-onset stargardt disease.

Fujinami K, Singh R, Carroll J, Zernant J, Allikmets R, Michaelides M, Moore AT

Acta Ophthalmol. 2014 Mar;92(2):e157-9

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Generation of induced pluripotent stem cells from conjunctiva.

Yang J, Li Y, Erol D, Wu WH, Tsai YT, Li XR, Davis RJ, Tsang SH

Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):423-31

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Stem Cell Research/Therapy

Light damage in Abca4 and Rpe65rd12 mice.

Wu L, Ueda K, Nagasaki T, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):1910-8

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.

Hertzler-Schaefer K, Mathew G, Somani AK, Tholpady S, Kadakia MP, Chen Y, Spandau DF, Zhang X

Cell Rep. 2014 Mar 13;6(5):818-26

Columbia University - Stein Professorship - Zhang, Xin / PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

Quantitative fundus autofluorescence and optical coherence tomography in best vitelliform macular dystrophy.

Duncker T, Greenberg JP, Ramachandran R, Hood DC, Smith RT, Hirose T, Woods RL, Tsang SH, Delori FC, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1471-82

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2014
Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene.

Nong E, Lee W, Merriam JE, Allikmets R, Tsang SH

Doc Ophthalmol. 2014 Feb;128(1):59-67

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

From mechanosensitivity to inflammatory responses: New players in the pathology of glaucoma.

Krizaj D, Ryskamp DA, Tian N, Tezel G, Mitchell CH, Slepak VZ, Shestopalov VI

Curr Eye Res. 2014 Feb;39(2):105-19

Columbia University - Departmental Grant

Keyword: Glaucoma

January, 2014
Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP.

Xu C, Zhang J, Mihai DM, Washington I

J Cell Sci. 2014 Jan 15;127(Pt 2):388-99

Columbia University - Departmental Grant

Keyword: Stem Cell Research/Therapy

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