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Dry eye is a chronic medical condition that develops when the eye's tear film does not lubricate and protect the eye's outer surface.
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Grant Type:
Individual
Award Name:
Physician-Scientist Award
Year:
2024
Amount:
$300,000.00
Research Area:
* RPB / Mary Tyler Moore Vision Initiative Physician-Scientist Award Will explore the role of a protein (Runt-related transcription factor 1, or RUNX1) in creating resistance in patients with diabetic retinopathy (DR) to the current standard treatment for the disease, called anti-vascular endothelial growth factor (anti-VEGF). Anti-VEGF therapy stops the growth of abnormal blood vessels in the eye, but it doesn’t work for 5 – 10% of patients with DR, who are resistant to it. The researcher will use messenger ribonucleic acid (also called mRNA), the same technology used in the COVID-19 vaccine, inside the eye to produce therapeutic proteins that could be used to inhibit RUNX1.
*Grant Amounts Listed Reflect Awards That Were Approved By The RPB Board of Trustees
*Grantees Shown Below Are For The Current Grant Year Only.