Recent RPB Research & Archives

Welcome to the RPB Research Archive.  Each year, more than 800 scientific studies are published citing RPB grant support, so you should be aware that your search request may produce extensive results, requiring you to scroll through them until you locate a result of specific relevance.  You can click on any of the article titles produced by your search to find an abstract providing an overview of the research.

Search instructions
To search the entire RPB Research Archive for scientific papers on a specific topic, by a specific author, or for bibliographies by eye disease, enter keywords in the box and click Search. 

To browse bibliographies by year, click on the links below and use the search capacity within each downloaded document (Word or PDF) to find specific terms.

232 citations match:

Recent Research

An fMRI Study of Word-Level Recognition and Processing in Patients with Age-Related Macular Degeneration

Janet P. Szlyk and Deborah M. Little
Invest. Ophthalmol. Vis. Sci. 2009 50: 4487-4495

Association Between Dietary Fat Intake and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): An Ancillary Study of the Women's Health Initiative

Niyati Parekh; Rickie P. Voland; Suzen M. Moeller; Barbara A. Blodi; Cheryl Ritenbaugh; Richard J. Chappell; Robert B. Wallace; Julie A. Mares; for the CAREDS Research Study Group
Arch Ophthalmol, Nov 2009; 127: 1483 - 1493.

Association of Risk Factors for Choroidal Neovascularization in Age-Related Macular Degeneration With Decreased Foveolar Choroidal Circulation , 20 May 2010

Wei Xu, Juan E. Grunwald, Tatyana I. Metelitsina, Joan C. DuPont, Gui-Shuang Ying, E. Revell Martin, Joshua L. Dunaief, Alexander J. Brucker
American Journal of Ophthalmology
July 2010 (Vol. 150, Issue 1, Pages 40-47.e2)

A Targeted Inhibitor of the Alternative Complement Pathway Reduces Angiogenesis in a Mouse Model of Age-Related Macular Degeneration

Bärbel Rohrer, Qin Long, Beth Coughlin, R. Brooks Wilson, Yuxiang Huang, Fei Qiao, Peter H. Tang, Kannan Kunchithapautham, Gary S. Gilkeson, and Stephen Tomlinson
Invest. Ophthalmol. Vis. Sci. 2009 50: 3056-3064.

A Variable-dosing Regimen with Intravitreal Ranibizumab for Neovascular Age-related Macular Degeneration: Year 2 of the PrONTO Study , 20 April 2009

Geeta A. Lalwani, Philip J. Rosenfeld, Anne E. Fung, Sander R. Dubovy, Stephen Michels, William Feuer, Janet L. Davis, Harry W. Flynn, Maria Esquiabro
American Journal of Ophthalmology
July 2009 (Vol. 148, Issue 1, Pages 43-58.e1)

Characterization of Retinal and Blood Mitochondrial DNA from Age-Related Macular Degeneration Patients

M. Cristina Kenney, Shari R. Atilano, David Boyer, Marilyn Chwa, Garrick Chak, Sahmon Chinichian, Pinar Coskun, Douglas C. Wallace, Anthony B. Nesburn, and Nitin S. Udar
Invest. Ophthalmol. Vis. Sci. 2010 51: 4289-4297. 

Complement Component 3 (C3) Haplotypes and Risk of Advanced Age-Related Macular Degeneration

Kyu Hyung Park, Brooke L. Fridley, Euijung Ryu, Nirubol Tosakulwong, and Albert O. Edwards
Invest. Ophthalmol. Vis. Sci. 2009 50: 3386-3393.

Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants With Respect to Phenotype in Advanced Age-Related Macular Degeneration , 01 October 2009

Michael T. Andreoli, Margaux A. Morrison, Ben J. Kim, Ling Chen, Scott M. Adams, Joan W. Miller, Margaret M. DeAngelis, Ivana K. Kim
American Journal of Ophthalmology
December 2009 (Vol. 148, Issue 6, Pages 869-874)

Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants with Respect to Phenotype in Advanced Age-related Macular Degeneration Corrected Proof, 01 October 2009

Michael T. Andreoli, Margaux A. Morrison, Ben J. Kim, Ling Chen, Scott M. Adams, Joan W. Miller, Margaret M. DeAngelis, Ivana K. Kim
American Journal of Ophthalmology
DOI: 10.1016/j.ajo.2009.07.002

Contribution of Copy Number Variation in the Regulation of Complement Activation Locus to Development of Age-Related Macular Degeneration

Katharina E. Schmid-Kubista, Nirubol Tosakulwong, Yanhong Wu, Euijung Ryu, Laura A. Hecker, Keith H. Baratz, William L. Brown, and Albert O. Edwards
Invest. Ophthalmol. Vis. Sci. 2009 50: 5070-5079.

Effects of Vitrectomy on Age-Related Macular Degeneration , 22 February 2010

A. Brock Roller, Vinit B. Mahajan, H. Culver Boldt, Michael D. Abramoff, Stephen R. Russell, James C. Folk
Ophthalmology
July 2010 (Vol. 117, Issue 7, Pages 1381-1386)

Effects of Vitrectomy on Age-Related Macular Degeneration Corrected Proof, 22 February 2010

A. Brock Roller, Vinit B. Mahajan, H. Culver Boldt, Michael D. Abramoff, Stephen R. Russell, James C. Folk
Ophthalmology
DOI: 10.1016/j.ophtha.2009.11.007

Evaluation of Injection Frequency and Visual Acuity Outcomes for Ranibizumab Monotherapy in Exudative Age-related Macular Degeneration , 29 July 2009

Hajir Dadgostar, Alexandre A.C.M. Ventura, Jeffrey Y. Chung, Sumit Sharma, Peter K. Kaiser
Ophthalmology
September 2009 (Vol. 116, Issue 9, Pages 1740-1747)

Evaluation of Potential Therapies for a Mouse Model of Human Age-Related Macular Degeneration Caused by Delayed all-trans-Retinal Clearance

Tadao Maeda, Akiko Maeda, Melissa Matosky, Kiichiro Okano, Satsumi Roos, Johnny Tang, and Krzysztof Palczewski
Invest. Ophthalmol. Vis. Sci. 2009 50: 4917-4925.

Excess Lead in the Neural Retina in Age-Related Macular Degeneration , 07 September 2009

Jay C. Erie, Jonathan A. Good, John A. Butz
American Journal of Ophthalmology
December 2009 (Vol. 148, Issue 6, Pages 890-894)

Four-Year Incidence and Progression of Age-Related Macular Degeneration: The Los Angeles Latino Eye Study

Rohit Varma, Athena W.P. Foong, Mei-Ying Lai, Farzana Choudhury, Ronald Klein, Stanley P. Azen, Los Angeles Latino Eye Study Group
American Journal of Ophthalmology
May 2010 (Vol. 149, Issue 5, Pages 741-751)

Inverse Association of Female Hormone Replacement Therapy with Age-Related Macular Degeneration and Interactions with ARMS2 Polymorphisms

Digna R. Velez Edwards, Paul Gallins, Monica Polk, Juan Ayala-Haedo, Stephen G. Schwartz, Jaclyn L. Kovach, Kylee Spencer, Gaofeng Wang, Anita Agarwal, Eric A. Postel, Jonathan L. Haines, Margaret Pericak-Vance, and William K. Scott
Invest. Ophthalmol. Vis. Sci. 2010 51: 1873-1879.

Mitochondrial DNA Haplogroups Associated with Age-Related Macular Degeneration

Nitin Udar, Shari R. Atilano, Masood Memarzadeh, David S. Boyer, Marilyn Chwa, Stephanie Lu, Barak Maguen, Jonathan Langberg, Pinar Coskun, Douglas C. Wallace, Anthony B. Nesburn, Nikan Khatibi, Dieter Hertzog, Khoi Le, Daniel Hwang, and M. Cristina Kenney
Invest. Ophthalmol. Vis. Sci. 2009 50: 2966-2974.

Natural History of Predominantly Classic, Minimally Classic, and Occult Subgroups in Exudative Age-related Macular Degeneration , 09 July 2009

Ankoor R. Shah, Lucian V. Del Priore
Ophthalmology
October 2009 (Vol. 116, Issue 10, Pages 1901-1907)

Ocular Risk Factors for Age-Related Macular Degeneration: The Los Angeles Latino Eye Study (LALES) Corrected Proof, 08 February 2010

Samantha Fraser-Bell, Farzana Choudhury, Ronald Klein, Stanley Azen, Rohit Varma, Los Angeles Latino Eye Study Group
American Journal of Ophthalmology
DOI: 10.1016/j.ajo.2009.11.013

Ocular Risk Factors for Age-Related Macular Degeneration: The Los Angeles Latino Eye Study , 08 February 2010

Samantha Fraser-Bell, Farzana Choudhury, Ronald Klein, Stanley Azen, Rohit Varma, Los Angeles Latino Eye Study Group
American Journal of Ophthalmology
May 2010 (Vol. 149, Issue 5, Pages 735-740)

Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables

Johanna M. Seddon, Robyn Reynolds, Julian Maller, Jesen A. Fagerness, Mark J. Daly, and Bernard Rosner
Invest. Ophthalmol. Vis. Sci. 2009 50: 2044-2053.

Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration Corrected Proof, 09 April 2010

Michael L. Klein, Frederick L. Ferris, Peter J. Francis, Anne S. Lindblad, Emily Y. Chew, Sara C. Hamon, Jurg Ott
Ophthalmology
DOI: 10.1016/j.ophtha.2009.12.012

Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration 

Michael L. Klein, Frederick L. Ferris, Peter J. Francis, Anne S. Lindblad, Emily Y. Chew, Sara C. Hamon, Jurg Ott 
Ophthalmology 
August 2010 (Vol. 117, Issue 8, Pages 1554-1559.e1)

Protective Effect of Paraoxonase 1 Gene Variant Gln192Arg in Age-Related Macular Degeneration , 30 December 2009

Gayle J.T. Pauer, Gwen M. Sturgill, Neal S. Peachey, Stephanie A. Hagstrom, Clinical Genomic And Proteomic AMD Study Group
American Journal of Ophthalmology
March 2010 (Vol. 149, Issue 3, Pages 513-522)

Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration

D. Scott McLeod, Rhonda Grebe, Imran Bhutto, Carol Merges, Takayuki Baba, and Gerard A. Lutty
Invest. Ophthalmol. Vis. Sci. 2009 50: 4982-4991.

Statin Use and the Incidence of Advanced Age-related Macular Degeneration in the Complications of Age-related Macular Degeneration Prevention Trial , 22 October 2009

Maureen G. Maguire, Gui-shuang Ying, Colin A. McCannel, Chengcheng Liu, Yang Dai, Complications of Age-related Macular Degeneration Prevention Trial (CAPT) Research Group
Ophthalmology
December 2009 (Vol. 116, Issue 12, Pages 2381-2385)

The Association of Smoking and Alcohol Use With Age-related Macular Degeneration in the Oldest Old: The Study of Osteoporotic Fractures , 01 October 2009

Anne L. Coleman, Robin L. Seitzman, Steven R. Cummings, Fei Yu, Jane A. Cauley, Kristine E. Ensrud, Katie L. Stone, Marc C. Hochberg, Kathryn L. Pedula, Edgar L. Thomas, Carol M. Mangione, The Study Of Osteoporotic Fractures Research Group
American Journal of Ophthalmology
January 2010 (Vol. 149, Issue 1, Pages 160-169)

The Association of Smoking and Alcohol Use with Age-related Macular Degeneration in the Oldest Old: The Study of Osteoporotic Fractures Corrected Proof, 01 October 2009

Anne L. Coleman, Robin L. Seitzman, Steven R. Cummings, Fei Yu, Jane A. Cauley, Kristine E. Ensrud, Katie L. Stone, Marc C. Hochberg, Kathryn L. Pedula, Edgar L. Thomas, Carol M. Mangione, Study Of Osteoporotic Fractures Research Group
American Journal of Ophthalmology
DOI: 10.1016/j.ajo.2009.07.025

The Complement Component 5 Gene and Age-Related Macular Degeneration , 21 December 2009

Dominique C. Baas, Lintje Ho, Sarah Ennis, Joanna E. Merriam, Michael W.T. Tanck, André G. Uitterlinden, Paulus T.V.M. de Jong, Angela J. Cree, Helen L. Griffiths, Fernando Rivadeneira, Albert Hofman, Cornelia van Duijn, R. Theodore Smith, Gaetano R. Barile, Theo G.M.F. Gorgels, Johannes R. Vingerling, Caroline C.W. Klaver, Andrew J. Lotery, Rando Allikmets, Arthur A.B. Bergen
Ophthalmology
March 2010 (Vol. 117, Issue 3, Pages 500-511)

The Prevalence of Age-Related Macular Degeneration and Associated Risk Factors

Ronald Klein; Karen J. Cruickshanks; Scott D. Nash; Elizabeth M. Krantz; F. Javier Nieto; Guan H. Huang; James S. Pankow; Barbara E. K. Klein
Arch Ophthalmol, Jun 2010; 128: 750 - 758.

Three Major Loci Involved in Age-Related Macular Degeneration Are Also Associated with Polypoidal Choroidal Vasculopathy Corrected Proof, 08 April 2010

Luiz H. Lima, Carl Schubert, Daniela C. Ferrara, Joanna E. Merriam, Yutaka Imamura, K. Bailey Freund, Richard F. Spaide, Lawrence A. Yannuzzi, Rando Allikmets
Ophthalmology
DOI: 10.1016/j.ophtha.2009.12.018

Three Major Loci Involved in Age-Related Macular Degeneration Are Also Associated with Polypoidal Choroidal Vasculopathy , 08 April 2010 

Luiz H. Lima, Carl Schubert, Daniela C. Ferrara, Joanna E. Merriam, Yutaka Imamura, K. Bailey Freund, Richard F. Spaide, Lawrence A. Yannuzzi, Rando Allikmets 
Ophthalmology 
August 2010 (Vol. 117, Issue 8, Pages 1567-1570)

 

2009 Research Archive

Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins

Curcio CA, Johnson M, Huang JD, Rudolf M
Progress in Retinal & Eye Research 2009;28:393-422 (Univ. of Alabama at Birmingham – Unres. Grant) Keyword(s): Retina/Retinal Diseases

Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers

Gu J, Pauer GJT, Yue X, Narendra U, Sturgill GM, Peachey NS, Salomon RG, Hagstrom SA, Crabb JW, The Clinical Genomic and Proteomic AMD Study Group
Mol Cell Proteomics 2009;8:1338-1349 (Cleveland Clinic Lerner College of Medicine – Unres. Grant, Sybil B. Harrington Scholar and Sr. Scientific Inv. Awd) Keyword(s): AMD, Genetics

Association between dietary fat intake and age-related macular degeneration in the carotenoids in age-related eye disease study (CAREDS): an ancillary study of the women's health initiative

Parekh N, Voland RP, Moeller SM, Blodi BA, Ritenbaugh C, Chappell RJ, Wallace RB, Mares JA; CAREDS Research Study Group
Arch Ophthalmol 2009;127(11):1483-93 (Univ. of Wisconsin – Unres. Grant and Research Sabbatical Grant) Keyword(s): AMD

Association of complement factor H and LOC287715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy

Brantley Jr MA, Edelstein SL, King JM, Plotzke MR, Apte RS, Kymes SM, Shiels A
Eye 2009;23:626-631 (Washington Univ. – Challenge Grant) Keyword(s): AMD, Genetics

A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration

Rohrer B, Long Q, Coughlin B, Wilson RB, Huang Y, Qiao F, Tang PH, Kunchithapautham K, Gilkeson GS, Tomlinson S
Invest Ophthalmol Vis Sci 2009;50:3056-3064 (Medical Univ. of South Carolina – Unres. Grant) Keyword(s): AMD

Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

Wang AL, Lukas TJ, Yuan M, Du N, Tso MO, Neufeld AH
PLoS ONE 2009;4:e4160 (Northwestern Univ. – Unres. Grant) Keyword(s): AMD

A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study

Lalwani GA, Rosenfeld PJ, Fung AE, Dubovy SR, Michels S, Feuer W, Davis JL, Flynn Jr HW, Esquiabro M
Am J Ophthalmol. 2009;148(1):43-58 (Univ. of Miami, FL - Unres. Grant) Keyword(s): AMD

CCR3 is a target for age-related macular degeneration diagnosis and therapy

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J
Nature 2009;460(7252):225-230 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

CCR3 is a target for age-related macular degeneration diagnosis and therapy

Takeda A, Baffi JZ, Kleinman M, Cho W, Nozaki M, Yamada K, Kaneko H, Raisler BJ, Geisen P, Ambati BK, Albuquerque R, Ishibashi T, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J
Nature 2009;460:225-230 (Univ. of Kentucky – Unres. Grant, Lew R. Wasserman Merit Awd, Physician-Scientist Awd and Career Development Awd) Keyword(s): AMD

CCR3 is a target for age-related macular degeneration diagnosis and therapy

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J
Nature 2009;460:225-231 (Univ. of North Carolina – Unres. Grant) Keyword(s): AMD, Retina/Retinal Diseases

Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration

Wang AL, Lukas TJ, Yuan M, Du N, Handa JT, Neufeld AH
PLoS ONE 2009;4:e5304 (Northwestern Univ. – Unres. Grant) Keyword(s): AMD

Common vairabion in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects

Park KH, Ryu E, Tosakulwong N, Wu Y, Edwards AO
Mol Vis 2009;15:200-207 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Comparison of intravitreal bevacizumab followed by ranibizumab for the treatment of neovascular age-related macular degeneration

Stepien KE, Rosenfeld PJ, Puliafito CA, Feuer W, Shi W, Al-Attar L, Dubovy SR, Murray TG, Davis JL, Lee WH, Schwartz SG, Smiddy WE, Berrocal AM, Flynn Jr HW
Retina 2009;29(8):1067-1073 (Univ. of Miami, FL - Unres. Grant) Keyword(s): AMD

Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration

Park KH, Fridley BL, Ryu E, Tosakulwong N, Edwards AO
Invest Ophthalmol Vis Sci 2009;50:3386-3393. (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Comprehensive Analysis of Complement Factor H and LOC38775/ARMS2/HTRA1 Variants with Repsect to Phenotype in Advanced Age-related Macular Degeneration

Andreoli MT, Morrison MA, Kim BJ, Chen L, Adams SM, Miller JW, DeAngelis MM, Kim IK
Am J Ophthalmol 2009;148:869-874 (Harvard Medical School – Unres. Grant and Physician-Scientist Awd) Keywords: AMD, Genetics

Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration

Schmid-Kubista KE, Tosakulwong N, Wu Y, Ryu E, Hecker LA, Baratz KH, Brown WL, Edwards AO
Invest Ophthalmol Vis Sci 2009;50:5070-5079 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Elov14 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin

Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R
Exp Eye Res 2009;89:905-912 (Univ. of Tennessee Health Science Center – Unres. Grant) Keyword(s): Macular Dystropy, Retina/Retinal Diseases

Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin

Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R
Exp Eye Res 2009;89:905-912 (Univ. of California, San Diego - Unres. Grant) Keyword(s): Retina, Macular Dystrophy

Evaluation of Potential Therapies for a Mouse Model of Human Age-Related Macular Degeneration Caused by Delayed all-trans- Retinal Clearance

Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, Palczewski K
Invest Ophthalmol Vis Sci 2009;50(10):4917-4925 (Case Western Reserve Univ. - Unres. Grant) Keyword(s): Retinal Degeneration

Excess lead in the neural retina in age-related macular degeneration

Erie JC, Good JA, Butz JA
Am J Ophthalmol 2009;148:890-894 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration

Narendra U, Pauer GJT, Hagstrom SA
Mol Vis 2009;15:731-736 (Cleveland Clinic Lerner College of Medicine – Unres. Grant and Sybil B. Harrington Scholar) Keyword(s): AMD, Genetics

Geographic Atrophy in Age-Related Macular Degeneration and TLR3

Allikmets R, Bergen AA, Dean M, Guymer RH, Hageman GS, Klaver CC, Stefansson K, Weber BH, The International AMD Genetics Consortium
New Engl J Med 2009;360:2252-2254 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration

SanGiovanni JP, Arking DE, Iyengar SK, Elashoff M, Clemons TE, Reed GF, Henning AK, Sivakumaran TA, Xu X, DeWan A, Agrón E, Rochtchina E, Sue CM, Wang JJ, Mitchell P, Hoh J, Francis PJ, Klein ML, Chew EY, Chakravarti A
PLoS One 2009;4(5):e5508 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD, Genetics

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

Bertram K, Baglole C, Phipps R, Libby R
Am J Physiol Cell Physiol 2009;2997:C1200-C1210 (Univ. of Rochester - Unres. Grant and Career Development Awd) Keyword(s): AMD

Multilocus analysis of age-related macular degeneraion

Berferon-Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, Allikmets R, Dean M
Eur J Hum Genet 2009;89:16-24 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

Natural History of Predominantly Classic, Minimally Classic, and Occult Subgroups in Exudative Age-Related Macular Degeneration

Shah AR, Del Priore LV
Ophthalmology 2009;116:1901-1907 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab

Lee AY, Raya AK, Kymes SM, Shiels A, Brantley Jr MA
Br J Ophthalmol 2009;93:610-613 (Washington Univ. – Challenge Grant) Keyword(s): AMD, Genetics

Physician assessment of changing lesion size of predominantly classic choroidal neovascular membranes in age-related macular degeneration

Covert DJ, Han DP, Kim JE, Wirostko WJ, Connor TB, Moon SJ, Hamilton R
Ophthalmic Surg Lasers Imaging. 2009;40:554-560 (Medical College of Wisconsin – Unres. Grant) Keyword(s): Imaging

Plasma Complement Components and Activation Fragments: Associations with Age-Related Macular Degeneration Genotypes and Phenotypes

Reynolds R, Hartnett ME, Atkinson JP, Giclas PC, Rosner B, Seddon JM
Invest Ophthalmol Vis Sci 2009;50:5818-5827 (Tufts Univ. - Challenge Grant) Keyword(s): AMD, Genetics

Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration

Ni J, Yuan X, Gu J, Yue X, Gu X, Nagaraj RH, Crabb JW
Mol Cell Proteomics 2009;8:1921-1933 (Cleveland Clinic Lerner College – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration

Ni J, Yuan X, Gu J, Yue X, Gu X, Nagaraj RH, Crabb JW, The Clinical Genomic and Proteomic AMD Study Group
Mol Cell Proteomics 2009;8.8:1921-1933 (Case Western Reserve Univ. - Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): Macular Degeneration

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss

Francis PJ, Hamon SC, Ott J, Weleber RG, Klein ML
J Med Genet 2009;46(5):300-307 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables

Seddon JM, Reynolds R, Maller J, Fagerness JA, Daly MJ, Rosner B
Invest Ophthalmol Vis Sci 2009;50:2044-2053 (Tufts Univ. - Challenge Grant) Keyword(s): AMD, Genetics

Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration

Gorczynska I, Srinivasan VJ, Vuong LN, Chen RW, Liu JJ, Reichel E, Wojtkowski M, Schuman JS, Fujimoto JG
Br J Ophthalmol 2009;93:603-609 (Tufts Univ. – Challenge Grant) Keyword(s): Retina, AMD

Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration

Erie JC, Good JA, Butz JA, Pulido JS
Am J Ophthalmol 2009;147:276-282 (Mayo Medical School – Unres. Grant) Keyword(s):AMD

Relationship between RPE and choriocapillaris in age-related macular degeneration

Mc Leod DS, Grebe R, Bhutto I, Merges C, Baba T, Lutty GA
Invest Ophthalmol Vis Sci 2009;50:4982-4991 (Johns Hopkins Univ. – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degeneration

Bakri SJ, Couch SM, McCannel CA, Edwards AO
Retina 2009;29:573-578. (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Serum cystatin C, kidney disease markers, and the incidence of age-related macular degeneration: the beaver dam eye Study

Klein R, Knudtson MD, Lee KE, Klein BEK
Arch Ophthalmol 2009;127(2):193-9 (Univ. of Wisconsin – Unres. Grant, Sr. Scientific Inv. Awd and Physician-Scientist Awd) Keyword(s): AMD

Statin use and the incidence of advanced age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial

Maguire M, Ying G-S, McCannel CA, Liu C, Dai Y
Ophthalmol 2009;116:2381-2385 (Univ. of Pennsylvania – Unres. Grant) Keyword(s): AMD

Subfoveal exudative age-related macular degeneration: evidence for preoccult disease

Shah AR, Del Priore LV
Curr Opin Ophthalmol 2009;20:182-187 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Surgical drainage of a pigment epithelial detachment in Neovascular age-related macular degeneration

Ernst BJ, Chiranand P, Akduman L
J Retinal & Vitreous Diseases 2009;29:704-707 (Saint Louis Univ. – Unres. Grant) Keyword(s): AMD

The SERPING1 gene and age-related macular degeneration

Allikmets R, Dean M, Hageman GS, Baird PN, Klaver CC, Bergen AA, Weber BH and the International AMD Genetics Consortium
Lancet 2009;374:875-876 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Three-dimensional optical coherence tomography (3D-OCT) image enhancement with segmentation-free contour modeling C-mode

Ishikawa H, Kim J, Friberg TR, Wollstein G, Kagemann L, Gabriele ML, Townsend KA, Sung KR, Duker JS, Fujimoto JG, Schuman JS
Invest Ophthalmol Vis Sci 2009;50:1344-1349 (Univ. of Pittsburgh Medical School - Unres. Grant) Keyword(s): Macular Degeneration

Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

Swaroop A, Chew EY, Bowes Rickman C, Abecasis GR
Annu Rev Genomics Hum Genet. 2009;10:19-43 (Duke Univ. – Unres. Grant) Keyword(s): AMD

 

2008 Research Archive

Age-period-cohort effect on the incidence of age-related macular degeneration: the Beaver Dam Eye Study

Klein R, Knudtson MD, Lee KE, Gangnon R, Klein BEK
Ophthalmology 2008;115(9):1460-7 (Univ. of Wisconsin - Unres. Grant and Physician-Scientist Awd and Sr. Scientific Inv. Awd) Keyword(s): AMD

Age-related macular degeneration and the aging eye

Ehrlich R, Harris A, Kheradiya N, Winston DM, Ciulla TA, Wirostko B
Clin Interventions Aging 2008;3:473-482 (Indiana Univ. – Unres. Grant) Keyword(s): AMD

Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration

DeAngelis MM, Ji F, Adams SM, Morrison MA, Harring AJ, Sweeney MO, Capone A, Miller JW, Dryja, TP, and Kim, IK
Ophthalmology 2008;115:1209-1215 (Harvard Medical School – Unres. Grant) Keyword(s): AMD

Analysis of major alleles associated with age-related macular degeneration in patients with Multifocal Choroiditis: Strong association with Complement Factor H

Ferrara DC, Merriam JE, Freund KB, Spaide RF, Takahashi BS, Zhitomirsky I, Fine HF, Yannuzzi LA, Allikmets R
Arch Ophthalmol 2008;126:1562-1566 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

An FMRI study of saccadic and smooth-pursuit eye movement control in patients with age-related macular degeneration

Little DM, Thulborn KR, Szlyk JP
Invest Ophthalmol Vis Sci 2008;49:1728-1735 (Univ. of Illinois at Chicago - Unres. Grant) Keyword(s): AMD

Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration

Chen H, Yang Z, Gibbs D, Yang X, Hau V, Zhao P, Ma X, Zeng J, Luo L, Pearson E, Constantine R, Kaminoh Y, Harmon J, Tong Z, Stratton CA, Cameron DJ, Tang S, Zhang K
Vis Res 2008;48(5):690-694 (Univ. of Utah - Unres. Grant) Keyword(s): AMD, Cone Dystrophy

Associations of plasma-soluble fas ligand with aging and age-related macular degeneration

Jiang S, Moriarty-Craige SE, Li C, Lynn MJ, Cai J, Jones DP, Sternberg P
Invest Ophthalmol Vis Sci 2008;49:1345-49 (Vanderbilt Univ. – Unres. Grant and Lew R. Wasserman Merit Awd) Keyword(s): AMD

Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization

Renganathan K, Ebrahem Q, Vasanji A, Gu X, Lu L, Sears J, Salomon RG, Anand-Apte B, Crabb JW
Advances in Experimental Medicine and Biology 2008;613:261-7 (Cleveland Clinic Lerner College of Medicine – Challenge Grant and Lew R. Wasserman Merit Awd) Keyword(s): AMD

Cardiovascular risk factors and age-related macular degeneration: The Los Angeles Latino Eye Study

Fraser-Bell S, Wu J, Klein R, Azen SP, Hooper C, Foong AW, Varma R
Am J Ophthalmol 2008;145:308-316 (Univ. of Southern California – Unres. Grant, Sybil B. Harrington Scholar) Keyword(s): AMD

CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration

Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon SC, Schultz DW, Ott J, Seddon JM
Opthalmology 2008;115:1019-1025 (Tufts Univ. - Challenge Grant) Keyword(s): AMD

CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration

Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon SC, Schultz DW, Ott J, Seddon JM
Ophthalmology 2008;115:1019-1025 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration

Kim IK, Ji F, Morrison MA, Adams SM, Zhang Q, Lane AM, Capone A, Dryja TP, Ott J, Miller JW, DeAngelis MM
Mol Vis 2008;14:1487-1495 (Harvard Medical School – Unres. Grant) Keyword(s): AMD

Comprehensive analysis of the candidate genes CCL2, CCR2 and TLR4 in age-related macular degeneration

Despriet DDG, Bergen AAB, Merriam JE, Zernant J, Barile GR, Smith RT, Barbazetto IA, van Soest S, Bakker A, de Jong PTVM, Allikmets R, Klaver CCW
Invest Ophthalmol Vis Sci 2008;49:364-371 (Columbia Univ. – Unres. Grant) Keyword(s): AMD

Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration

Marc RE, Jones BW, Watt CB, Vazquez-Chona F, Vaughan DK, Organisciak DT
Mol Vis 2008;14:782-805 (Univ. of Utah - Unres. Grant) Keyword(s): AMD

Familial aggregation of age-related macular degeneration in the Utah population

Luo L, Harmon J, Yang Z, Chen H, Patel S, Mineau G, Yang Z, Constantine R, Buehler J, Kaminoh Y, Ma X, Wong TY, Zhang M, Zhang K
Vis Res 2008;48(3):494-500 (Univ. of Utah - Unres. Grant and Lew R. Wasserman Merit Awd) Keyword(s): AMD, Cone Dystrophy

Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration

Metelitsina TI, Grunwald JE, DuPont JC, Ying G-S, Brucker AJ, Dunaief JL
Invest Ophthalmol Vis Sci 2008;49:358-363 (Univ. of Pennsylvania – Unres. Grant and Wm. and Mary Greve Scholar) Keyword(s): AMD

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration

Gibbs D, Yang Z, Constantine R, Ma X, Camp NJ, Yang X, Chen H, Jorgenson A, Hau V, DeWan A, Zeng J, Harmon J, Beuhler J, Brand JM, Hoh J, Cameron DJ, Dixit M, Tong Z, Zhang K
Vis Res 2008;48(5):685-689 (Univ. of Utah - Unres. Grant) Keyword(s): AMD, Cone Dystrophy

Intravenous bevacizumab causes regression of choroidal neovascularization secondary to diseases other than age-related macular degeneration

Nguyen QD, Shah SM, Hafiz G, Do DV, Haller JA, Pili R, Zimmer-Galler IE, Janjua K, Symons RC, Campochiaro PA
Am J Ophthalmol 2008;145:257-266 (Johns Hopkins Univ. – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration?

Schaal S, Kaplan HJ, Tezel TH
Amer Acad of Ophthal; 2008;115(12):2199-2205 (Univ. of Louisville – Unres. Grant and Career Development Awd) Keyword(s): Uveitis

Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration

Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci 2008;49:2848-2855 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration

Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci. 2008;49;7:2448-2855 (Emory Univ. Eye Center - Unres. Grant) Keyword(s): AMD

Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hung DM
J Clin Invest 2008;118(8):2908-2916 (Univ. of Utah - Unres. Grant) Keyword(s): Acular Dystrophy, Cone Dystrophy

Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K
J Clin Invest 2008;118(8):2908-2916 (Univ. of California, Los Angeles – Unres. Grant and Jules & Doris Stein RPB Prof.) Keyword(s): Macular Dystrophy

Oxidative damage-induced inflammation initiates age-related macular degeneration

Hollyfield J, Bonilha V, Rayborn M, Yang X, Shadrach K, Lu L, Ufret R, Salomon R, Perez V
Nat Med. 2008;14:194-198 (Univ. of Texas, Southwestern - Unres. Grant) Keyword(s): Macular Degeneration

Oxidative damage-induced inflammation initiates age-related macular degeneration

Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, Lu L, Ufret RL, Salomon RG, Perez VL
Nature Medicine. 2008;14(2):194-8 (Cleveland Clinic Lerner College of Medicine – Challenge Grant) Keyword(s): AMD

PPAR-alpha ligands as potential therapeutic agents for wet age-related macular degeneration

Del V Cano M, Gehlbach PL
PPAR Res 2008;821592 (Johns Hopkins Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

Racial differences and other risk factors for incidence and progression of age-related macular degeneration: Salisbury Eye Evaluation (SEE) Project

Chang MA, Bressler SB, Munoz B, West SK
Invest Ophthalmol Vis Sci 2008;49:2395-2402 (Johns Hopkins Univ. – Unres. Grant, Olga Keith Weiss Scholar and Sr. Scientific Inv. Awd) Keyword(s): AMD

Racial differences in the prevalence of age-related macular degeneration: the Salisbury Eye Evaluation (SEE) Project

Bressler SB, Muñoz B, Solomon SD, West SK; Salisbury Eye Evaluation (SEE) Study Team
Arch Ophthalmol 2008;126:241-245 (Johns Hopkins Univ. – Unres. Grant, Olga Keith Weiss Scholar and Sr. Scientific Inv. Awd) Keyword(s): AMD

Reorganization of visual processing is related to eccentric viewing in patients with macular degeneration

Schumacher EH, Jacko JA, Primo SA, Main KL, Moloney KP, Kinzel EN, Ginn J
Restorative Neurology and Neuroscience 2008;26;391-402. (Emory Univ. Eye Center - Unres. Grant). Keyword(s): AMD

Retinal precursors and the development of geographic atrophy in age-related macular degeneration

Klein ML, Ferris FL 3rd, Armstrong J, Hwang TS, Chew EY, Bressler SB, Chandra SR; AREDS Research Group
Ophthalmology 2008;115(6):1026-31 (Univ. of Wisconsin – Unres. Grant) Keyword(s): AMD

The aged retinal pigment epithelium/choroid: A potential substratum for the pathogenesis of age-related macular degeneration

Chen H, Liu B, Lukas TJ, Neufeld, AH
PLoS ONE 2008;3(6):e2339 (Northwestern Univ. – Unres. Grant) Keyword(s): AMD

The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples

Tuo J, Ross RJ, Reed GF, Yan Q, Wang JJ, Bojanowski CM, Chew EY, Feng X, Olsen TW, Ferris FL, Mitchell P, Chan CC
Ophthalmology 2008;115:1891-1898 (Emory Univ. Eye Center - Unres. Grant) Keyword(s): AMD

The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration

Zhang H, Morrison MA, DeWan A, Adams SM, Andreoli M, Huynh N, Regan M, Brown A, Miller JW, Kim IK, Hoh J, DeAngelis MM
BMC Med Genet 2008;9:51-60 (Harvard Medical School – Unres. Grant) Keyword(s): AMD

The role of abnormal vitreomacular adhesion in age-related macular degeneration: Spectral optical coherence tomography and surgical results

Mojana F, Cheng L, Bartsch DU, Silva GA, Kozak I, Nigam N, Freeman WR
Am J Ophthalmol 2008;146(2):218-227 (Univ. of California, San Diego - Unres. Grant) Keyword(s): OCT, Age-Related Macular Degeneration, Choroidal Neovascularization

Toll-like Receptor 3 and geographic atrophy in age-related macular degeneration

Yang Z, Stratton C, Francis PJ, Kleinman ME, Perciliz LT, Gibbs D, et al
N Engl J Med 2008;359:1456-1463 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration

Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K
N Engl J Med 2008;359:1456-1463 (Johns Hopkins Univ. – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration

Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma Z, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B,Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K
New England J Medicine 2008;359:1456-1463 (Univ. of Kentucky – Challenge Grant) Keyword(s): AMD, Geographic Atrophy

Toll-like receptor polymorphisms and age-relaed macular degeneration

Edwards AO, Chen D, Fridley BL, James KM, Wu Y, Abecasis G, Swaroop A, Othman M, Branbam K, Iyengar SK, Sivakumaran TA, Klein R, Klein BE, Tosakulwong N
Invest Ophthalmol Vis Sci 2008;49:1652-9 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

Toll-like receptor polymorphisms and age-related macular degeneration

Edwards AO, Chen D, Fridley BL, James KM, Wu Y, Abecasis G, Swaroop A, Othman M, Branham K, Iyengar SK, Sivakumaran TA, Klein R, Klein BE, Tosakulwong N
Invest Ophthalmol Vis Sci. 2008;49(4):1652-9 (Univ. of Wisconsin - Unres. Grant and Physician-Scientist Awd and Sr. Scientific Inv. Awd) Keyword(s): AMD, Genetics

 

2007 Research Archive

Adult retinal pigment epithelial transplantation in exudative age-related macular degeneration

Tezel TH, Del Priore LV, Berger AS, Kaplan HJ
Am J Ophthalmology. 2007;143:584-595 (Univ. of Louisville – Unres. Grant and Career Development Awd) Keyword(s): Macular Dystrophy, AMD

Adult retinal pigment epithelial transplantation in exudative age-related macular degeneration

Tezel TH, Del Priore LV, Berger AS, Kaplan HJ
Am J Ophthalmol 2007;143:584-595 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal

Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci 2007;48:3469-3479 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Alcohol consumption and the 15-year cumulative incidence of age-related macular degeneration (AMD)

Knudtson MD, Klein R, Klein BEK
Am J Ophthalmol 2007;143:1026-1029 (Univ. of Wisconsin – Unres. Grant, Sr. Scientific Inv. Awd and Physician-Scientist Awd) Keyword(s): AMD

An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration

Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ, Puliafito CA, Davis JL, Flynn HW Jr, Esquiabro M
Am J Ophthalmol 2007;143:566-83 (Univ. of Miami – Unres. Grant) Keyword(s): Macular Degeneration

Apolipoprotein E epsilon 4 offers protection against age-related macular degeneration

Friedman DA, Lukiw WJ, Hill JM
Med Hypotheses 2007;68:1047-1055 (Louisiana State Univ. – Challenge Grant) Keyword(s): AMD

Association between vitamin D and age-related macular degeneration in the third national health and nutrition examination survey, 1988 through 1994

Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA
Arch Ophthalmol 2007;125:661-669 (Univ. of Wisconsin – Unres. Grant) Keyword(s): AMD

Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration

Seddon JM, Francis PJ, George S, Schultz DW, Rosner B, Klein ML
JAMA 2007;297:1793-1800 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

Association of cfh y402h and loc387715 a695 with progression of age-related macular degeneration

Seddon JM, Francis PJ, George S, Schultz DW, Rosner B, Klein ML
JAMA 2007;297:1793-1800 (Tufts Univ. – Challenge Grant) Keyword(s): AMD

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

Kanda A, Chen W, Othman M, Branham KE, Brooks M, Khanna R, He S, Lyons R, Abecasis GR, Swaroop A
Proc Natl Acad Sci U S A. 2007;104:16227-32 (Univ. of Michigan – Unres. Grant) Keyword(s): AMD

Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: women’s health initiative sight exam ancillary study

Klein R, Deng Y, Klein BEK, Lyman L, Seddon J, Frank RN, Wallace RB, Hendrix SL, Kuppermann BD, Langer RD, Kuller L, Brunner R, Johnson KC, Thomas AM, Haan M
Am J Ophthalmol 2007;143:473-483 (Univ. of Wisconsin – Unres. Grant and Physician-Scientist Awd) Keyword(s): AMD

Changes in select redox proteins of the retinal pigment epithelium in age related macular degeneration

Decanini A, Nordgaard CL, Feng X, Ferrington DA, Olsen TW
Am J Ophthalmol 2007;143:607-615 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Cigarette smoking, CFH, APO, ELOVL4, and risk of neovascular age-related macular degeneration

DeAngelis MM, Ji F, Kim IK, Adams S, Capone A Jr, Ott J, Miller JW, Dryja TP
Arch Ophthalmol 2007;125:49-54 (Harvard Univ. – Unres. Grant) Keyword(s): AMD

Complement factor H polymorphism in age-related macular degeneration

Narayanan R, Butani V, Boyer DS, Atilano SR, Resende GP, Kim DS, Chakrabarti S, Kuppermann BD, Khatibi N, Chwa M, Nesburn AB, Kenney MC
Ophthalmol 2007;114:1327-1331 (Univ. of California Irvine - Challenge Grant) Keyword(s): AMD

Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration

Moriarty-Craige SE, Ha KN, Sternberg, Jr., P, Lynn M, Bressler S, Gensler G, Jones DP
Am J Ophthalmol 2007;143:206-211 (Vanderbilt Univ. – Challenge Grant and Medical Student Fellowship) Keyword(s): AMD, Retina

Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema

Emerson MV, Lauer AK
BioDrugs 2007;21:245-257 (Oregon Health & Science Univ. – Unres. Grant) Keyword(s): AMD, Diabetic Retinopathy

Enhanced accumulation of a2e in individuals homozygous or heterozygous for mutations in best1(vmd2)

Bakall B, Radu RA, Stanton JB, Burke JM, McKay BS, Wadelius C, Mullins RF, Stone EM, Travis GH, Marmorstein AD
Exp Eye Res 2007;85:34-43 (Univ. of California, Los Angeles – Unres. Grant and Jules & Doris Stein RPB Prof.) Keyword(s): Macular Degeneration, Retinal Pigment Epithelium

Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration

Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD
Hum Mol Genet 2007;16:2423-2432 (Univ. of Arizona – Unres. Grant ) Keyword(s): AMD

Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration

Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD
Hum Mol Genet 2007;16:2423-2432 (Cleveland Clinic Lerner College of Medicine – Challenge Grant) Keyword(s): AMD

Functionalizing cell-based therapy for age-related macular degeneration

Zarbin MA
Am J Ophthalmol 2007;142:681–682 (Univ. of Medicine & Dentistry of NJ - Unres. Grant) Keyword(s): AMD

Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits

Swaroop A, Branham KE, Chen W, Abecasis G
Hum Mol Genet. 2007;16:R174-82 (Univ. of Michigan – Unres. Grant) Keyword(s): Macular Dystrophy

Histopathological findings in postmortem eyes after photodynamic therapy for choroidal neovascularization in age-related macular degeneration: report of two cases

Kang SJ, Schmack I, Benson HE, Grossniklaus HE
Br J Ophthalmol 2007;91:1602-1606 (Emory Univ. – Unres. Grant and Sr. Scientific Inv. Awd.) Keyword(s): Macular Degeneration

Intravitreal bevacizumab (Avastin) treatment of neovascular age-related macular degeneration

Emerson MV, Lauer AK, Flaxel CJ, Wilson DJ, Francis PJ, Stout JT, Emerson GG, Schlesinger TK, Nolte SK, Klein ML
Retina 2007;27:439-444 (Oregon Health & Science Univ. –Unres. Grant, Career Development Awd and Robert E. McCormick Scholar) Keyword(s): AMD

Lack of Fibulin-3 causes early aging and herniation, but not macular degeneration in mice

Precious J, McLaughlin PJ, Bakall B, Choi J, Liu Z, Sasaki T, Davis EC, Marmorstein AD, Marmorstein LY
Hum Mol Genet;16:3059-3070 (Univ. of Arizona – Unres. Grant ) Keyword(s): AMD

Macular pigment and lutein supplementation in abca4-associated retinal degenerations

Aleman TS, Cideciyan AV, Windsor EA, Schwartz SB, Swider M, Chico JD, Sumaroka A, Pantelyat AY, Duncan KG, Gardner LM, Emmons JM, Steinberg JD, Stone EM, Jacobson SG
Invest Ophthalmol Vis Sci 2007;48:1319-1329 (Univ. of Iowa - Unres. Grant) Keyword(s): Retinal Disorders

New molecular histopathologic insights into the pathogenesis of age-related macular degeneration

Handa JT
Int Ophthalmol Clin 2007;47:15-50 (Johns Hopkins Univ. – Unres. Grant and Physician-Scientist Awd) Keyword(s): AMD

Optical coherence tomography findings during pegaptanib therapy for neovascular age-related macular degeneration

Emerson GG, Flaxel CJ, Lauer AK, Stout JT, Emerson MV, Nolte S, Wilson DJ, Klein ML
Retina 2007;27:724-729 (Oregon Health & Science Univ. – Unres. Grant and Robert E. McCormick Scholar) Keyword(s): AMD

Overview of progress in the epidemiology of age-related macular degeneration

Klein R
Ophthalmic Epidemiol 2007;14:184-187 (Univ. of Wisconsin – Unres. Grant and Physician-Scientist Awd) Keyword(s): AMD

Oxidative damage in age-related macular degeneration

Shen JK, Dong A, Hackett SF, Bell WR, Green WR, Campochiaro PA
Histol Histopathol 2007;22:1301-1308 (Johns Hopkins Univ. – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Photodynamic therapy and high-dose intravitreal triamcinolone to treat exudative age-related macular degeneration

Ruiz-Moreno JM, Montero JA, Zarbin MA
Retina 2007;27:458–461 (Univ. of Medicine & Dentistry of NJ - Unres. Grant) Keyword(s): AMD

Population-based study of early age-related macular degeneration - role of the complement factor HY402H polymorphism in bilateral but not unilateral disease

Tedeschi-Blok N, Buckley J, Varma R, Triche TJ, Hinton DR
Ophthalmology 2007;114:99-103 (Univ. of Southern California – Unres. Grant) Keyword(s): AMD

Progressive visual loss in subfoveal exudation in age-related macular degeneration: a meta-analysis using lineweaver-burke plots

Shah AR, Del Priore LV
Am J Ophthalmol 2007;143:83-89 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Dystrophy

Relationship between age-related macular degeneration-associated variants of complement factor H and LOC387715 with coronary artery disease

Pulido JS, McConnell JP, Lennon RJ, Bryant SC, Peterson LM, Berger PB, Somers V, Highsmith EW
Mayo Clin Proc 2007;82:301-307 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

RPE tears after pegaptanib treatment in age-related macular degeneration

Chang LK, Flaxel CJ, Lauer AK, Sarraf D
Retina 2007;27:857-863 (Univ. of California, Los Angeles - Unres. Grant) Keyword(s): AMD

Statin use and the 15-year incidence and progression of age-related macular degeneration

Klein R, Knudtson MD, Klein BEK
Am J Opthalmol 2007;144:1-6 (Univ. of Wisconsin – Unres. Grant, Sr. Scientific Inv. Awd and Physician-Scientist Awd) Keyword(s): AMD

Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multi-racial cohort: the multi-ethnic study of atherosclerosis

Klein R, Klein BEK, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR
Arch Opthalmol 2007;125:534-543 (Univ. of Wisconsin – Unres. Grant, Sr. Scientific Inv. Awd. and Physician-Scientist Awd) Keyword(s): AMD

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model

Kim SR, Jang YP, Jockusch S, Fishkin NE, Turro NJ, Sparrow JR
Proc Natl Acad Sci USA 2007;104:19273-19278 (Columbia Univ. – Unres. Grant) Keyword(s): Macular Degeneration

The challenge of modeling macular degeneration in mice

Marmorstein AD, Marmorstein LY
Trends Genet 2007;23:225-231 (Univ. of Arizona –Unres. Grant ) Keyword(s): AMD

The coexistence of age-related macular degeneration and retinitis pigmentosa in three unrelated families

Sarraf D, Salib DM, Jain A, Quiram PA
Semin Ophthalmol 2007;22:155-161 (Univ. of California, Los Angeles - Unres. Grant) Keyword(s): ARMD, Retinitis Pigmentosa

The fifteen-year cumulative incidence of age-related macular degeneration: the beaver dam eye study

Klein R, Klein BEK, Knudtson MD, Meuer SM, Swift M, Gangnon R
Ophthalmology 2007;114:253-62. (Univ. of Wisconsin – Unres. Grant, Sr. Scientific Inv. Awd. and Physician-Scientist Awd) Keyword(s): AMD

The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration

Francis PJ, George S, Schultz DW, Rosner B, Hamon S, Ott J, Weleber RG, Klein ML, Seddon JM
Hum Hered 2007;63:212-218 (Oregon Health & Science Univ. – Unres. Grant and Career Development Awd) Keyword(s): AMD

The long-term natural history of geographic atrophy from age-related macular degeneration

Sunness J, Margalit E, Srikumaran D, Applegate C, Tian Y, Perry D, Hawkins B, Bressler N
Ophthalmology 2007;114:271-277 (Univ.of Nebraska – Unres. Grant) Keyword(s): AMD

The relationship between retrobulbar and choroidal hemodynamics in non-neovascular age-related macular degeneration

Rechtman E, Harris A, Siesky B, Kagemann L, Danis RP, Sines D, Ciulla TA
Ophthalmic Surg Lasers Imaging 2007;38:219-225 (Univ. of Pittsburgh – Unres. Grant) Keyword(s): Macular Degeneration

The relationship between retrobulbar and choroidal hemodynamics in non-neovascular age-related macular degeneration

Rechtman E, Harris A, Siesky B, Kagemann L, Danis RP, Sines D, Ciulla TA
Ophthalmic Surgery, Lasers & Imaging 2007;38:219-225 (Indiana Univ. – Unres. Grant) Keyword(s): AMD

Transformation of the proteosome with age-related macular degeneration

Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA
FEBS Letters 2007;581:885-90 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Treatment of exudative age-related macular degeneration: many factors to consider

Olsen TW
Am J Ophthalmol 2007;144:281-83 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Urinary cadmium and age-related macular degeneration

Erie JC, Good JA, Butz JA, Hodge DO, Pulido JS
Am J Ophthalmol 2007;144:414-418 (Mayo Medical School – Unres. Grant) Keyword(s): AMD

 

2006 Research Archive

Age-Related Macular Degeneration-Emerging Pathogenetic And Therapeutic Concepts

Gehrs KM, Anderson DH, Johnson LV, Hageman GS
Ann Med 2006;38:450-71 (Univ. of Iowa - Unres. Grant) Keyword(s): AMD

Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age- Related Eye Disease Study (CAREDS)

Moeller SM, Parekh N, Tinker L, Rittenbaugh C, Blodi B, Wallace RB, Mares JA, Careds Research Study Group
Arch Ophthalmol 2006;124(8):1151-1162 (Univ. of Wisconsin – Unres. Grant) Keyword(s): AMD

A Variant Of The HTRA1 Gene Increases Susceptibility To Age-Related Macular Degeneration

Yang A, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, DeWan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K
Science 2006;314:992-993 (Univ. of Utah - Unres. Grant) Keyword(s): AMD

C-reactive Protein and Homocysteine are Associated with Dietary and Behavioral Risk Factors for Age-related Macular Degeneration

Seddon JM, Gensler G, Klein ML, Milton RC
Nutrition 2006;22:441-443 (Oregon Health & Science Univ. – Unres. Grant) Keyword(s): AMD

CFH Gene Variant, Y402H, and Smoking, Body Mass Index, Environmental Associations with Advanced Age-Related Macular Degeneration

Seddon JM, George S, Rosner B, Klein ML
Human Heredity 2006;61:157-165 (Oregon Health & Science Univ. – Unres. Grant) Keyword(s): AMD

CFH Haplotypes Without The Y402H Coding Variant Show Strong Association With Susceptibility To Age-Related Macular Degeneration

Li M, Atmaca-Sonmez P, Othman M, Branham K, Khanna R, Wade M, Li Y, LIang L, Zareparsi S, Swaroop A, Abacasis G
Nature Genetics 2006;38:9:1049-1054 (Univ. of Michigan – Unres. Grant) Keyword(s): Retinal Degeneration

Characterization of Native Retinal Fluorophores Involved in Biosynthesis of A2E and Lipofuscin-Associated Retinopathies

Bui T, Han Y, Radu R, Travis G, Mata N
J. Bio Chem. 2006;281: 18112-18119 (Univ. of California, Los Angeles – Unres. Grant and Jules & Doris Stein RPB Prof.) Keyword(s): Visual Cycle, Macular Degeneration

Cone-Mediated Multifocal Electroretinogram in Age-Related Macular Degeneration: Progression Over a Long-term Follow-up

Gerth C, Delahunt PB, Alam S, Morse LS Werner JS
Arch Ophthalmol 2006;124:345-352 (Univ. of California, Davis – Unres. Grant and Jules & Doris Stein RPB Prof.) Keyword(s): AMD

Diet And Age-Related Macular Degeneration: Expanding Our View

Mares JA, Moeller SM
Am J Clin Nutr 2006;83:733-734 (Univ. of Wisconsin – Unres. Grant) Keyword(s): AMD

Drusen Complement Components C3a and C5a Promote Choroidal Neovascularization PNAS 2006;103(7):2328-2333 (Univ

Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lamabris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J
of Kentucky – Challenge Grant) Keyword(s): Innate Immunity; Macular Degeneration

Focus Groups with Persons Who Have Age-Related Macular Degeneration: Emotional Issues

Owsley C, McGwin G Jr, Scilley K, Dreer LE, Bray CR, Mason JO
Rehab Psych 2006;51:23-29 (Univ. of Alabama at Birmingham - Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Iron Induced Oxidative Damage As a Potential Factor in Age-Related Macular Degeneration

Dunaief J
Invest Ophthalmol Vis Sci 2006;47(11):4660-4663 (Univ. of Pennsylvania – Wm. and Mary Greve Scholar and Unres. Grant) Keyword(s): AMD

Loss of SPARC-mediated VEGFR-1 Suppression After Injury Reveals a Novel Antiangiogenic Activity of VEGF-A

Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J
The Journal of Clinical Investigation 2006;116(2):422-429 (Univ. of Kentucky - Challenge Grant) Keyword(s): Macular Degeneration; Extracellular Matrix

Macrophages Inhibit Neovascularization in a Murine Model of Age-Related Macular Degeneration

Apte RS, Richter J, Herndon J, Ferguson TA
PLoS Med 2006;3(8)1371-1381 (Washington Univ. – Unres. Grant and Career Development Award) Keyword(s): AMD

Macular Thickness Mapping in Exudative Age-related Macular Degeneration

Shakoor A, Shahidi M, Blair NP, Gieser JP, Zelkha R
Retina 2006;26:44-8 (Univ. of Illinois at Chicago - Unres. Grant) Keyword(s): AMD

Maculoplasty For Age-Related Macular Degeneration: Reengineering Bruch’s Membrane And The Human Macula

Del Priore LV, Tezel TH, Kaplan HJ
Prog Ret Eye Res 2006;25:539-562 (Univ. of Louisville – Unres. Grant and Career Development Awd) Keyword(s): AMD

Maculoplasty for Age-Related Macular Degeneration: Reengineering Bruch’s Membrane and the Human Macula

Del Priore LV, Tezel TH, Kaplan HJ
Prog Retin Eye Res 2006;25:539-562 (Columbia Univ. – Unres. Grant) Keyword(s): AMD, Macular Dystrophy

Migration and Proliferation of Retinal Pigment Epithelium on Extracellular Matrix Ligands

Wang H, Van Oatten Y, Sugino I, Zarbin MA
JRRD 2006;43:713–722 (Univ. of Medicine & Dentistry of NJ - Unres. Grant) Keyword(s): Retinal Pigment Epithelium, Age-Related Macular Degeneration

Predictive Value of Fundus Autofluorescence for Development of Geographic Atrophy in Age-Related Macular Degeneration

Hwang JC, Chan J, Chang S, Smith RT
Invest Ophthalmol Vis Sci 2006;47:2655-2661 (Columbia Univ. – Unres. Grant) Keyword(s): AMD, Macular Dystrophy

Prophylactic Treatment of Age-Related Macular Degeneration Report Number 1: 810-Nanometer Laser to Eyes with Drusen

Friberg TR, Musch DC, Lim JI, Morse L, Freeman W, Sinclair S
Unilaterally Eligible Patients. Ophthalmology 2006;113:612-622 (Univ. of Southern California – Unres. Grant) Keyword(s): AMD

Prophylactic Treatment of Age-Related Macular Degeneration Report Number 1: 810-Nanometer Laser to Eyes with Drusen

Friberg TR, Musch DC, Lim JI, Morse L, Freeman W, Sinclair S
Unilaterally Eligible Patients. Ophthalmology 2006;113:612-622 (Univ. of Pittsburgh – Unres. Grant) Keyword(s): Visual Acuity

Prophylactic Treatment of Age-Related Macular Degeneration Report Number 1: 810-Nanometer Laser to Eyes with Drusen

Friberg TR, Musch DC, Lim JI, Morse LS, Freeman W, Sinclair S; PTAMD Study Group
Unilaterally Eligible Patients. Ophthalmology 2006;113:612-622 (Univ. of California, Davis – Unres. Grant) Keyword(s): AMD, Retina and Retinal Diseases

Proteomics of the Retinal Pigment Epithelium Reveals Altered Protein Expression at Progressive Stages of Age-Related Macular Degeneration

Nordgaard CL, Berg KM, Kapphahn RJ, Reilly C, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci 2006; 47:815-822 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Retention of Function without Normal Disc Morphogenesis Occurs in Cone but not Rod Photoreceptors

Farjo R, Skaggs JS, Nagel BA, Quiambao AB, Nash ZA, Fliesler SJ and Naash MI
J Cell Bio 2006;173:59-68 (Saint Louis Univ. – Challenge Grant) Keyword(s): AMD, Macular Degeneration

Short-Term Safety And Efficacy Of Intravitreal Bevacizumab (Avastin) For Neovascular Age-Related Macular Degeneration

Rich RM, Rosenfeld PJ, Puliafito CA, Dubovy SR, Davis JL, Flynn HW Jr, Gonzalez S, Feuer WJ, Lin RC, Lalwani GA, Nguyen JK, Kumar G
Retina 2006;26(5):495-511 (Univ. of Miami - Unres. Grant) Keyword(s): AMD

Smoking, Alcohol Intake, Estrogen Use, and Age-Related Macular Degeneration in Latinos: The Los Angeles Latino Eye Study

Fraser-Bell S, Wu J, Klein R, Azen SP, Varma R
Am J Ophthalmol 2006;141:79-87 (Univ. of Southern California – Unres. Grant and Sybil B. Harrington Scholar) Keyword(s): AMD

Systemic Bevacizumab (Avastin) Therapy for Neovascular Age-Related Macular Degeneration: Twenty-Four-Week Results of an Uncontrolled Open-Label Clinical Study

Moshfeghi AA, Rosenfeld PJ, Puliafito CA, Michels S, Marcus EN, Lenchus JD, Venkatraman AS
Ophthalmology 2006;113(11):2002.e1-12 (Univ. of Miami - Unres. Grant) Keyword(s): AMD

The Iron Carrier Transferrin Is Upregulated in Retinas from Patients with Age-Related Macular Degeneration

Chowers I, Wong R, Dentchev T, Farkas RH, Iacovelli J, Gunatilaka TL, Medeiros NE, Presley JB, Campochiaro PA, Curcio CA, Dunaief JL, Zack DL
Invest Ophthalmol Vis Sci 2006;47(5):2135-2140 (Univ. of Pennsylvania – Unres. Grant and Wm. and Mary Greve Scholar) Keyword(s): AMD

The Iron Carrier Transferrin is Upregulated in Retinas From Patients with Age-Related Macular Degeneration

Chowers I, Wong R, Dentchev T, Farkas RH, Iacovelli J, Gunatilaka TL, Medeiros NE, Presley JB, Campochiaro PA, Curcio CA, Dunaief JL, Zack DJ
Invest Ophthalmol Vis Sci 2006;47:2135-2140 (Johns Hopkins Univ. – Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

The Iron Carrier Transferrin is Upregulated in Retinas from Patients with Age-Related Macular Degeneration

Chowers I, Wong R, Dentchev T, Farkas RH, Iacovelli J, Gunatilaka TL, Medeiros NE, Presley JB, Campochiaro PA, Curcio CA, Dunaief JL, Zack DJ
Invest Ophthalmol Vis Sci 2006;47:2135-2149 (Univ. of Alabama at Birmingham – Unres. Grant) Keyword(s): AMD

The Proteome of Central and Peripheral Retina with Progression of Age-related Macular Degeneration

Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci 2006;47:2280-2290 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

The Scotopic Sensitivity Tester-1 And The Detection Of Early Age-Related Macular Degeneration

Jackson GR, Felix T, Owsley C
Ophthal Physiol Opt 2006;26:431-437 (Univ. of Alabama at Birmingham - Unres. Grant and Sr. Scientific Inv. Awd) Keyword(s): AMD

Transpupillary Thermotherapy with Indocyanine Green Dye Enhancement for the Treatment of Occult Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration

Kim JE, Shah KB, Han DP, Connor TB Jr
Ophthalmic Surg Lasers Imaging 2006;37:272-277 (Medical College of Wisconsin – Unres. Grant) Keyword(s): Retinal and Retinal Diseases, AMD

Use Of Iris Pigment Epithelium To Replace Retinal Pigment Epithelium In Age-Related Macular Degeneration: A Gene Expression Analysis

Cai H, Shin MC, Tezel TH, Kaplan HJ, Del Priore LV
Arch Ophthalmology 2006;124:1276-1285 (Univ. of Louisville – Unres. Grant and Career Development Awd) Keyword(s): AMD

Use of Iris Pigment Epithelium to Replace Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Gene Expression Analysis

Cai H, Shin MC, Tezel TH, Kaplan HJ, Del Priore LV
Arch Ophthalmol 2006;124:1276-1285 (Columbia Univ. – Unres. Grant) Keyword(s): AMD, Gene Therapy

Variation in Factor B (BF) and Complement Component 2 (C2) Genes is Associated with Age-Related Macular Degeneration

Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, AMD Genetics Clinical Study Group, Hageman GS, Dean M, Allikmets R
Nature Genetics 2006;38:458-462 (Columbia Univ. – Unres. Grant) Keyword(s) AMD, Macular Dystrophy

 

2005 Research Archive

A Common Haplotype in the Complement Regulatory Gene, Factor H (HF1/CFH), Predisposes Individuals to Age- Related Macular Degeneration

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CCW, Barbazetto I, Chang S, Yannuzzi L.A, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R
Proc Natl Acad Sci USA, 2005;102:7227-7232 (Columbia Univ. and Univ. of Iowa – Unres. Grants) Keyword(s):AMD/Eye Movement Disorders

A Common Haplotype in the Complement Regulatory Gene Factor H (HF1/CFH) Predisposes Individuals to Age- Related Macular Degeneration

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R
Proc Natl Acad Sci USA 2005;102:7227-7232 (Univ. of Iowa and Columbia Univ. - Unres. Grants) Keyword(s): AMD, Gene Therapy

A Phase I Trial of Stereotactic External Beam Radiation for Subfoveal Choroidal Neovascular Membranes in Age-Related Macular Degeneration

Barak A, Hauser D, Yipp P, Morse L, Leigh B, Kubo D, Goldberg Z, Earle J, Handa JT
Br J Radiol 2005;78:827- 831 (Johns Hopkins Univ. and Univ. of California, Davis - Unres. Grants) Keyword(s): Age- Related Macular Degeneration

Candidate Gene Analysis Suggest Roles for Fatty Acid Biosynthesis, Extracellular Matrix Integrity and Regulation of the Complement System in the Etiology of Age-Related Maculopathy

Conley YP, Weeks DE, Thalamuthu A, Jakobsdottir J, Mah TS, Ferrell RE, Gorin MB
Hum Mol Genet 2005;14:1991-2002 (Univ. of Pittsburgh - Unres. Grant) Keyword(s): Other - Macular Degeneration, Genetics

Complement Factor H Polymorphism and Age-Related Macular Degeneration

Edwards AO, Ritter III R, Abel KJ, Manning A, Panhuysen C, Farrer LA
Science 2005;308:421-424 (Univ. of Texas Southwestern – Unres. Grant) Keyword(s): AMD

Current Treatment Options for Neovascular Age-Related Macular Degeneration

Park SS
Vision Pan-America 2005;4:2-5 (Univ. of California, Davis – Unres. Grant) Keyword(s): AMD, Retinal and Retinal Diseases

Declines in Arrestin and Rhodopsin in the Macula with Progression of Age-Related Macular Degeneration

Ethen CM, Feng X, Olsen TW, Ferrington DA
Invest Ophthalmol Vis Sci 2005;46:769-775 (Univ. of Minnesota – Unres. Grant) Keyword(s): AMD

Decreased Thickness and Integrity of the Macular Elastic Layer of Bruch's Membrane Correspond to the Distribution of Lesions Associated with Age-Related Macular Degeneration

Chong NH, Keonin J, Luthert PJ, Frennesson CI, Weingeist DM, Wolf RL, Mullins RF, Hageman GS
Am J Pathol 2005;166:241-251 (Univ. of Iowa - Unres. Grant and Lew R. Wasserman Merit Awd.) Keyword(s): AMD

Early-Onset Macular Degeneration with Drusen in a Cynomolgus Monkey (Macaca Fascicularis) Pedigree: Exclusion of 13 Candidate Genes and Loci

Umeda S, Ayyagari R, Allikmets R, Suzuki MT, Karoukis AJ, Ambasudhan R, Zernant J, Okamoto H, Ono F, Terao K, Mizota A, Yoshikawa Y, Tanaka Y, Iwata T
Invest Ophthalmol Vis Sci 2005;46:683-691 (Univ. of Michigan and Columbia Univ. - Unres. Grants) Keyword(s): Retina and Retinal Diseases

Early-Onset Macular Degeneration with Drusen in a Cynomolgus Monkey (Macaca fascicularis) Pedigree: Exclusion of 13 Candidate Genes and Loci

Umeda S, Ayyagari R, Allikmets R, Suzuki MT, Karoukis AJ, Ambasudhan R, Zernant J, Okamoto H, Ono F, Terao K, Mizota A, Yoshikawa Y, Tanaka Y, Iwata T
Invest Ophthalmol Vis Sci 2005;46:683-691 (Columbia Univ. and Univ. of Michigan – Unres. Grants) Keyword(s): AMD/Eye Movement Disorders, Retina and Retinal Diseases

Eye-Movement Training for Reading in Patients with Age-Related Macular Degeneration

Seiple W, Szlyk JP, McMahon T, Pulido J, Fishman GA
Invest Ophthalmol Vis Sci 2005;46:2886-2896 (Univ. of Illinois at Chicago - Unres. Grant) Keyword(s): AMD/Eye Movement Disorders

Future Pharmacological Treatment Options for Non-exudative and Exudative Age-related Macular Degeneration

Comer GM, Ciulla TA, Heier JS, Criswell MH
Exp Opin Emerging Drugs 2005;10:119-135 (Indiana Univ. Unres. Grant and Career Development Awd.) Keyword(s): AMD, Retina & Retinal Diseases

Late-Onset Macular Degeneration and Long Anterior Lens Zonules Result from a Ctrp5 Gene Mutation

Ayyagari R, Mandal MN, Karoukis AJ, Chen L, McLaren NC, Lichter M, Wong DT, Hitchcock PF, Caruso RC, Moroi SE, Maumenee IH, Sieving PA
Invest Ophthalmol Vis Sci 2005;46:3363-3371 (Univ. of Michigan and Johns Hopkins Univ. – Unres. Grants) Keyword(s): Retina and Retinal Diseases

Lipofuscin Accumulation, Abnormal Electrophysiology, and Photoreceptor Degeneration in Mutant ELOVL4 Transgenic Mice: A Model for Macular Degeneration

Karan G, Lillo C, Yang Z, Cameron DJ, Locke KG, Zhao Y, Thirumalaichary S, Li C, Birch DG, Vollmer-Snarr HR, Williams DS, Zhang K
Proc Natl Acad Sci USA 2005;102:4164-4169 (Univ. of Utah - Unres. Grant) Keyword(s): AMD, Retina and Retinal Diseases

Macular Degeneration in a Patient with Aceruloplasminemia, A Disease Associated with Retinal Iron Overload

Dunaief JL, Richa C, Franks EP, Schultze RL, Aleman TS, Schenck JF, Zimmerman EA, Brooks DG
Ophthalmology 2005;112:1062-1065 (Univ. of Pennsylvania – Unres. Grant and Career Development Awd.) Keyword(s): AMD

Meta-Analysis of Genome Scans of Age-Related Macular Degeneration

Fisher SA, Abecasis GR, Yashar BM, Zareparsi S, Swaroop A, Iyengar SK, Klein BEK, Klein R, Lee KE, Majewski J, Schultz DW, Klein ML, Seddon JM, Santangelo SL, Weeks DE, Conley YP, Mah TS, Schmidt S, Haines JL, Pericek-Vance MA, Gorin MB, Schultz HL, Pardi F, Lewis CM, Weber BHF
Hum Mol Genet 2005;14:2257-2264 (Univ. of Michigan, Univ. of Wisconsin, Oregon Health & Science Univ. and Univ. of Pittsburg – Unres. Grants) Keyword(s): Retinal and Retinal Diseases

Meta-Analysis of Genome Scans of Age-Related Macular Degeneration

Fisher SA, Abecasis GR, Yashar BM, Zareparsi S, Swaroop A, Iyengar SK, Klein B, Klein R, Lee KE, Majewski J, Schultz DW, Klein ML, Seddon JM, Santangelo SL, Weeks DE, Conley YP, Mah T, Schmidt S, Haines, JL, Pericak-Vance MA, Gorin MB, Schulz HL, Pardi F, Lewis CM, Weber BHF
Hum Mol Genet 2005;14:2257-2264 (Univ. of Wisconsin, Univ of Michigan, Oregon Health & Science Univ. and Univ. of Pittsburgh – Unres. Grant) Keyword(s): AMD

Meta-Analysis Of Genome Scans of Age-Related Macular Degeneration

Fisher SA, Abecasis GR, Yashar BM, Zareparsi S, Swaroop A, Iyengar SK, Klein BEK, Klein R, Lee KE Majewski J, Schultz DW, Klein ML, Seddon JM, Santangelo SL, Weeks DE, Conley YP, Mah TS, Schmidt S, Haines JL, Pericak-Vance MA, Gorin MB, Schultz HL, Pardi F, Lewis CM, Weber BHF
Hum Mol Genet 2005 Aug 1;14:2257-2264 (Univ. of Pittsburgh, Univ. of Michigan, Univ. of Wisconsin and Oregon Health & Science Univ. - Unres. Grant) Keyword(s): Other - Macular Degeneration, Genetics

Mouse Models May Provide New Insight into the Relation between Cholesterol and Age Related Macular Degeneration

Duncan, JL
Br J Ophthalmol 2005;89:1549-1551 (Univ. of California, San Francisco – Unres. Grant and Career Development Awd.) Keyword(s): Retina and Retinal Diseases, AMD

Prevalence of Age-Related Macular Degeneration in a Population-Based Sample of Hispanic People in Arizona: Proyecto VER

Munoz B, Klein R, Rodriguez J, Snyder R, West SK
Arch Ophthalmol 2005;123:1575-1580 (Johns Hopkins Univ., Univ. of Wisconsin and Univ. of Arizona – Unres. Grants and Sr. Scientific Inv. Awd.) Keyword(s): Age-Related Macular Degeneration

Rapid Recurrence of Geographic Atrophy after Full Macular Translocation for Nonexudative Age-Related Macular Degeneration

Khurana RN, Fujii GY, Walsh AC, Humayun MS, de Juan E, Jr., Sadda SR
Ophthalmology 2005;112:1586-1591 (Univ of Southern California - Unres. Grant) Keyword(s): AMD/Eye Movement Disorders, Retina and Retinal Diseases

Sociodemographic Factors and Age-Related Macular Degeneration in Latinos: The Los Angeles Latino Eye Study

Fraser-Bell S, Donofrio J, Wu J, Klein R, Azen SP, Varma R
Am J Ophthalmol 2005;139:30-38 (Univ of Southern California and Univ. of Wisconsin - Unres. Grants and Sybil B. Harrington Scholar) Keyword(s): AMD/Eye Movement Disorders, Retina and Retinal Diseases, Other: Epidemiology

Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-related Macular Degeneration

Zareparsi S, Branham KEH, Li M, Shah S, Klein RJ, Ott J, Hoh J, Abecasis GR, Swaroop A
Am J Hum Genet 2005;77:149-153 (Univ. of Michigan – Unres. Grant) Keyword(s): Retinal and Retinal Diseases

Suppression and Regression of Choroidal Neovascularization by Polyamine Analogues

Lima e Silva R, Saishin Y, Saishin Y, Akiyama H, Kachi S, Aslam S, Rogers B, Deering T, Gong YY, Hackett SF, Lai H, Frydman BJ, Valasinas A, Marton LJ, Campochiaro PA
Invest Ophthalmol Vis Sci 2005;46:3323-3330 (Johns Hopkins Univ. – Unres. Grant and Lew R. Wasserman Merit Awd.) Keyword(s): Age-Related Macular Degeneration

Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26

Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB
Am J Hum Genet 2005;77:389-407 (Univ. of Pittsburgh - Unres. Grant and Sr. Scientific Inv. Awd.) Keyword(s): Other - Macular Degeneration, Genetics

Systemic Bevacizumab (Avastin) Therapy for Neovascular Age-Related Macular Degeneration; Twelve-Week Results of an Uncontrolled Open-Label Clinical Study

Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS
Ophthalmology 2005;112:1035-1047 (Univ. of Miami - Unres. Grant) Keyword(s): Retina and Retinal Diseases

The Relation Between C Reactive Protein and Age Related Macular Degeneration in the Cardiovascular Health Study

McGwin G, Hall T, Xie A, Owsley C
Br J Ophthalmol 2005;9:1166-1170 (Univ. of Alabama – Unres. Grant and Sr. Scientific Inv Awd.) Keyword(s): Age Related Macular Degeneration, Retinal Pigmented Epithelium, C Reactive Protein, Systemic Inflammatory Disease

The Use of Cholesterol-Lowering Medication and Age- Related Macular Degeneration

McGwin GJr, Xie A, Owsley C
Ophthalmology 2005;112:488-494 (Univ. of Alabama - Unres. Grant and Sr. Scientific Inv. Awd.) Keyword(s): AMD

Toll-Like Receptor 4 Variant D299G is Associated with Susceptibility to Age-related Macular Degeneration

Zareparsi S, Buraczynska M, Branham KEH, Shah S, Eng D, Li M, Pawar H, Yashar BM, Moroi SE, Lichter PR, Petty HR, Richards JE, Abecasis GR, Elner VM, Swaroop A
Hum Mol Genet 2005;14:1449-1455 (Univ. of Michigan – Unres. Grant) Keyword(s): Retinal and Retinal Diseases