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Research to Prevent Blindness

Research Database

Wayne State University Research, funded by RPB in 2013 & 2014 matching Departmental Grant

39 Citations, Sorted by Month and Year

October, 2014
Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy.

Mishra M, Zhong Q, Kowluru RA

Invest Ophthalmol Vis Sci 2014 Oct 10. 55:7256–7265.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Non-invasive imaging of visual arrestin 1 and its translocation.

Berkowitz BA, Gorgis J, Patel A, Baameur F, Gurevich VV, Craft CM, Kefalov VJ, Roberts R

FASEB J. 2014 Oct 28. pii: fj.14-254953.

Wayne State University - Departmental Grant

Keyword: Imaging

September, 2014
Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.

Mishra M, Kowluru RA

Invest Ophthalmol Vis Sci 2014 Sep 23. 55:6960–6967.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

June, 2014
Sirt1, A negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.

Kowluru RA, Santos JM, Zhong Q

Invest Ophthalmol Vis Sci. 2014 Jun 3;55(9):5653-60.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

May, 2014
Tiam1-Rac1 signaling axis mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.

Kowluru RA, Kowluru A, Mohammad G, Syed I, Santos JM, Mishra M

Diabetologia. 2014 May;57(5):1047-56.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

April, 2014
February, 2014
January, 2014
, N.

Liu, X

Gao, C. Dong, L. Zhou, Q. S. Mi, T. J. Standiford, and F. S. Yu. 2014. Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection. Eur J Immunol 44:2667-2679.

Wayne State University - Departmental Grant

Keywords: Other: Fungal Keratitis, Other: Innate Immunity

Antibacterial response of retinal Muller glia: production of antimicrobial peptides, oxidative burst and phagocytosis.

Singh PK, Shisha MJ, and Kumar A

Journal of Neuroinflammation 2014, 18; 11(1): 33.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Antimicrobial Peptides

Beneficial effects of carotenoids on diabetic retinopathy.

Kowluru RA, Zhong Q, Santos JM, Thandampallayam M, Putt D, Gierhart SL

Nutrition & Metabolism. (Lond) 2014 Jan 30;11(1):8.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration.

Pan Z-H, Ganjawala TH, Lu Q, Ivanova E, Zhang Z

PloS One, 2014 9(6):e98924

Wayne State University - Departmental Grant

Keywords: Artificial Vision, Other: Optogenetics

Epigenetic modifications and potential new treatment targets in diabetic retinopathy.

Perrone L, Matrone C, Singh LP

J Ophthalmol. 2014;2014:789120.

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Epigenetics, Other: Histone and DNA Methylation, Other: Histone Acetylation

Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis.

Singh PK, Donovan DM, and Kumar A

Antimicrobial Agents and Chemotherapy 2014, 58:4621-9.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Endophthalmitis

MicroRNA-146 inhibits thrombin-induced NF-κB activation and subsequent inflammatory responses in human retinal endothelial cells.

Cowan C, Muraleedharan CK, O’Donnell JJ, Singh PK, Lum H, Kumar A, and Xu S

Invest Ophthalmol Vis Sci. 2014, 55(8): 4944-51.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Pathogenicity of ocular isolates of acinetobacter baumannii in a mouse model of bacterial endophthalmitis.

Talreja D, Kaye KS, Yu FS, Walia SK, and Kumar A

Invest Ophthalmol Vis Sci 2014, 55: 2392-402.

Wayne State University - Departmental Grant

Keyword: Other: Endophthalmitis

Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina.

Ichinose T, Fyk-Kolodziej B, Cohn J

Journal of Neuroscience 2014 34(26): 8761-8771

Wayne State University - Departmental Grant

Keyword: Other: Bipolar Cell

Virulence properties of multidrug resistant ocular isolates of Acinetobacter baumannii.

Talreja D, Muraleedharan C, Gunathilaka G, Zhang Y, Kaye KS, Walia SK, and Kumar A

Current Eye Research 2014, 39: 695-704.

Wayne State University - Departmental Grant

Keywords: Other: Corneal Epithelium, Other: Ocular Infection

November, 2013
Interferon regulatory factor-1 in flagellin-induced reprogramming: Potential protective role of CXCL10 in cornea innate defense against pseudomonas aeruginosa infection.

Yoon GS, Dong C, Gao N, Kumar A, Standiford TJ, Yu FS

Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7510-21

Wayne State University - Departmental Grant

Keywords: Other: Innate Immunity, Other: Interferon Regulatory Factor-1, Other: Microbial Keratitis

October, 2013
A novel light damage paradigm for use in retinal regeneration studies in adult zebrafish.

Thomas JL, Thummel R

J Vis Exp. 2013 Oct 24(80):e51017

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Photoreceptor, Other: Regeneration, Other: Zebrafish

Retinal regeneration in adult zebrafish requires regulation of TGFbeta signaling.

Lenkowski JR, Qin Z, Sifuentes CJ, Thummel R, Soto CM, Moens CB, Raymond PA

Glia. 2013 Oct;61(10):1687-97

Wayne State University - Departmental Grant

Keywords: Other: Muller Glia, Other: Photoreceptor, Other: six3b, Other: tgif1

September, 2013
Genome-wide transcriptional analysis of differentially expressed genes in flagellin-pretreated mouse corneal epithelial cells in response to pseudomonas aeruginosa: Involvement of S100A8/A9.

Gao N, Sang Yoon G, Liu X, Mi X, Chen W, Standiford TJ, Yu FS

Mucosal Immunol. 2013 Sep;6(5):993-1005

Wayne State University - Departmental Grant

Keywords: Other: cDNA Array, Other: Innate Immunity, Other: Microbial Keratitis

Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

Santos JM, Tewari S, Lin JY, Kowluru RA

Biochem Biophys Res Commun. 2013 Sep 6;438(4):760-4

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Epigenetics, Other: Matrix Metalloproteinase, Other: Mitochondria

August, 2013
Thioredoxin interacting protein (TXNIP) and pathogenesis of diabetic retinopathy.

Singh LP

J Clin Exp Ophthalmol. 2013 Aug 5;4:287

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Inflammation, Other: Mitochondrial Dysfunction, Other: ROS/RNS Stress, Other: TXNIP

July, 2013
MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy.

Berkowitz BA, Bissig D, Dutczak O, Corbett S, North R, Roberts R

Expert Opin Med Diagn. 2013 Jul;7(4):393-403

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging, Retina/Retinal Diseases

Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy.

Zhong Q, Kowluru RA

Diabetes. 2013 Jul;62(7):2559-68

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Gene Research/Therapy (Epigenetics), Other: Matrix Metalloproteinase

June, 2013
Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-cre transgenic mouse line.

Ivanova E, Lee P, Pan ZH

J Comp Neurol. 2013 Jun 15;521(9):2165-80

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Bistratified Retinal Ganglion Cells, Other: Cre-transgenic Mouse

Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing cre transgenic mouse lines.

Lu Q, Ivanova E, Ganjawala TH, Pan ZH

Mol Vis. 2013 Jun 12;19:1310-20

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Cre-transgenic Mouse, Other: Retinal Bipolar Cells

rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo.

Wu C, Ivanova E, Zhang Y, Pan ZH

PLoS One. 2013 Jun 14;8(6):e66332

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Optogenetics

Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy.

Zhong Q, Mishra M, Kowluru RA

Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3941-8

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Oxidative Stress, Other: Nrf2

May, 2013
Assessment of the AAV-mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling.

Shimano T, Fyk-Kolodziej B, Mirza N, Asako M, Tomoda K, Bledsoe S, Pan ZH, Molitor S, Holt AG

Brain Res. 2013 May 20;1511:138-52

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Gene Expression

Diabetes, diabetic retinopathy, and age-related macular degeneration: An unexpected relationship.

Frank RN

Retina. 2013 May;33(5):899-900

Wayne State University - Departmental Grant

Keywords: AMD, Macular Dystrophy

April, 2013
Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy.

Devi TS, Hosoya K, Terasaki T, Singh LP

Exp Cell Res. 2013 Apr 15;319(7):1001-12

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Oxidative Stress, Other: Pericyte Apoptosis, Other: TXNIP

March, 2013
Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy.

Santos JM, Kowluru RA

Diabetes Metab Res Rev. 2013 Mar;29(3):204-13

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Metabolic Memory, Other: Mitochondria

February, 2013
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.

Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Wayne State University - Departmental Grant

Keyword: Other: Retinal Degeneration

January, 2013
Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.

Bissig D, Goebel D, Berkowitz BA

PLoS One. 2013;8(2):e56340

Wayne State University - Departmental Grant

Keyword: Other: Aging

Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation.

Zhong Q, Kowluru RA

Invest Ophthalmol Vis Sci. 2013 Jan 14;54(1):244-50

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Epigenetics, Other: Metabolic Memory, Other: Mitochondria

Mitochondria damage in the pathogenesis of diabetic retinopathy and in the metabolic memory associated with its continued progression.

Kowluru RA

Curr Med Chem. 2013;20(26):3226-33

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Metabolic Memory, Other: Mitochondria

Muller glia in retinal innate immunity: A perspective on their roles in endophthalmitis.

Kumar A, Pandey RK, Miller LJ, Singh PK, Kanwar M

Crit Rev Immunol. 2013;33(2):119-35

Wayne State University - Departmental Grant

Keywords: Other: Endophthalmitis, Other: Muller Glial Cells, Other: Retinal Innate Immunity

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