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Research to Prevent Blindness

Research Database

Wayne State University Research, funded by RPB from 2010-2014 matching Departmental Grant

105 Citations, Sorted by Month and Year

October, 2014
Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy.

Mishra M, Zhong Q, Kowluru RA

Invest Ophthalmol Vis Sci 2014 Oct 10. 55:7256–7265.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Non-invasive imaging of visual arrestin 1 and its translocation.

Berkowitz BA, Gorgis J, Patel A, Baameur F, Gurevich VV, Craft CM, Kefalov VJ, Roberts R

FASEB J. 2014 Oct 28. pii: fj.14-254953.

Wayne State University - Departmental Grant

Keyword: Imaging

September, 2014
Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia.

Mishra M, Kowluru RA

Invest Ophthalmol Vis Sci 2014 Sep 23. 55:6960–6967.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

June, 2014
Sirt1, A negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.

Kowluru RA, Santos JM, Zhong Q

Invest Ophthalmol Vis Sci. 2014 Jun 3;55(9):5653-60.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

May, 2014
Tiam1-Rac1 signaling axis mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.

Kowluru RA, Kowluru A, Mohammad G, Syed I, Santos JM, Mishra M

Diabetologia. 2014 May;57(5):1047-56.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

April, 2014
February, 2014
January, 2014
, N.

Liu, X

Gao, C. Dong, L. Zhou, Q. S. Mi, T. J. Standiford, and F. S. Yu. 2014. Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection. Eur J Immunol 44:2667-2679.

Wayne State University - Departmental Grant

Keywords: Other: Fungal Keratitis, Other: Innate Immunity

Antibacterial response of retinal Muller glia: production of antimicrobial peptides, oxidative burst and phagocytosis.

Singh PK, Shisha MJ, and Kumar A

Journal of Neuroinflammation 2014, 18; 11(1): 33.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Antimicrobial Peptides

Beneficial effects of carotenoids on diabetic retinopathy.

Kowluru RA, Zhong Q, Santos JM, Thandampallayam M, Putt D, Gierhart SL

Nutrition & Metabolism. (Lond) 2014 Jan 30;11(1):8.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration.

Pan Z-H, Ganjawala TH, Lu Q, Ivanova E, Zhang Z

PloS One, 2014 9(6):e98924

Wayne State University - Departmental Grant

Keywords: Artificial Vision, Other: Optogenetics

Epigenetic modifications and potential new treatment targets in diabetic retinopathy.

Perrone L, Matrone C, Singh LP

J Ophthalmol. 2014;2014:789120.

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Epigenetics, Other: Histone and DNA Methylation, Other: Histone Acetylation

Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis.

Singh PK, Donovan DM, and Kumar A

Antimicrobial Agents and Chemotherapy 2014, 58:4621-9.

Wayne State University - Departmental Grant Special Scholar Award - Kumar, Ashok / PhD

Keyword: Other: Endophthalmitis

MicroRNA-146 inhibits thrombin-induced NF-κB activation and subsequent inflammatory responses in human retinal endothelial cells.

Cowan C, Muraleedharan CK, O’Donnell JJ, Singh PK, Lum H, Kumar A, and Xu S

Invest Ophthalmol Vis Sci. 2014, 55(8): 4944-51.

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Pathogenicity of ocular isolates of acinetobacter baumannii in a mouse model of bacterial endophthalmitis.

Talreja D, Kaye KS, Yu FS, Walia SK, and Kumar A

Invest Ophthalmol Vis Sci 2014, 55: 2392-402.

Wayne State University - Departmental Grant

Keyword: Other: Endophthalmitis

Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina.

Ichinose T, Fyk-Kolodziej B, Cohn J

Journal of Neuroscience 2014 34(26): 8761-8771

Wayne State University - Departmental Grant

Keyword: Other: Bipolar Cell

Virulence properties of multidrug resistant ocular isolates of Acinetobacter baumannii.

Talreja D, Muraleedharan C, Gunathilaka G, Zhang Y, Kaye KS, Walia SK, and Kumar A

Current Eye Research 2014, 39: 695-704.

Wayne State University - Departmental Grant

Keywords: Other: Corneal Epithelium, Other: Ocular Infection

November, 2013
Interferon regulatory factor-1 in flagellin-induced reprogramming: Potential protective role of CXCL10 in cornea innate defense against pseudomonas aeruginosa infection.

Yoon GS, Dong C, Gao N, Kumar A, Standiford TJ, Yu FS

Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7510-21

Wayne State University - Departmental Grant

Keywords: Other: Innate Immunity, Other: Interferon Regulatory Factor-1, Other: Microbial Keratitis

October, 2013
A novel light damage paradigm for use in retinal regeneration studies in adult zebrafish.

Thomas JL, Thummel R

J Vis Exp. 2013 Oct 24(80):e51017

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Photoreceptor, Other: Regeneration, Other: Zebrafish

Retinal regeneration in adult zebrafish requires regulation of TGFbeta signaling.

Lenkowski JR, Qin Z, Sifuentes CJ, Thummel R, Soto CM, Moens CB, Raymond PA

Glia. 2013 Oct;61(10):1687-97

Wayne State University - Departmental Grant

Keywords: Other: Muller Glia, Other: Photoreceptor, Other: six3b, Other: tgif1

September, 2013
Genome-wide transcriptional analysis of differentially expressed genes in flagellin-pretreated mouse corneal epithelial cells in response to pseudomonas aeruginosa: Involvement of S100A8/A9.

Gao N, Sang Yoon G, Liu X, Mi X, Chen W, Standiford TJ, Yu FS

Mucosal Immunol. 2013 Sep;6(5):993-1005

Wayne State University - Departmental Grant

Keywords: Other: cDNA Array, Other: Innate Immunity, Other: Microbial Keratitis

Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

Santos JM, Tewari S, Lin JY, Kowluru RA

Biochem Biophys Res Commun. 2013 Sep 6;438(4):760-4

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Epigenetics, Other: Matrix Metalloproteinase, Other: Mitochondria

August, 2013
Thioredoxin interacting protein (TXNIP) and pathogenesis of diabetic retinopathy.

Singh LP

J Clin Exp Ophthalmol. 2013 Aug 5;4:287

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Inflammation, Other: Mitochondrial Dysfunction, Other: ROS/RNS Stress, Other: TXNIP

July, 2013
MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy.

Berkowitz BA, Bissig D, Dutczak O, Corbett S, North R, Roberts R

Expert Opin Med Diagn. 2013 Jul;7(4):393-403

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging, Retina/Retinal Diseases

Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy.

Zhong Q, Kowluru RA

Diabetes. 2013 Jul;62(7):2559-68

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Gene Research/Therapy (Epigenetics), Other: Matrix Metalloproteinase

June, 2013
Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-cre transgenic mouse line.

Ivanova E, Lee P, Pan ZH

J Comp Neurol. 2013 Jun 15;521(9):2165-80

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Bistratified Retinal Ganglion Cells, Other: Cre-transgenic Mouse

Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing cre transgenic mouse lines.

Lu Q, Ivanova E, Ganjawala TH, Pan ZH

Mol Vis. 2013 Jun 12;19:1310-20

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Cre-transgenic Mouse, Other: Retinal Bipolar Cells

rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo.

Wu C, Ivanova E, Zhang Y, Pan ZH

PLoS One. 2013 Jun 14;8(6):e66332

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Optogenetics

Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy.

Zhong Q, Mishra M, Kowluru RA

Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3941-8

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Oxidative Stress, Other: Nrf2

May, 2013
Assessment of the AAV-mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling.

Shimano T, Fyk-Kolodziej B, Mirza N, Asako M, Tomoda K, Bledsoe S, Pan ZH, Molitor S, Holt AG

Brain Res. 2013 May 20;1511:138-52

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Gene Expression

Diabetes, diabetic retinopathy, and age-related macular degeneration: An unexpected relationship.

Frank RN

Retina. 2013 May;33(5):899-900

Wayne State University - Departmental Grant

Keywords: AMD, Macular Dystrophy

April, 2013
Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy.

Devi TS, Hosoya K, Terasaki T, Singh LP

Exp Cell Res. 2013 Apr 15;319(7):1001-12

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Oxidative Stress, Other: Pericyte Apoptosis, Other: TXNIP

March, 2013
Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy.

Santos JM, Kowluru RA

Diabetes Metab Res Rev. 2013 Mar;29(3):204-13

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Metabolic Memory, Other: Mitochondria

February, 2013
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.

Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Wayne State University - Departmental Grant

Keyword: Other: Retinal Degeneration

January, 2013
Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.

Bissig D, Goebel D, Berkowitz BA

PLoS One. 2013;8(2):e56340

Wayne State University - Departmental Grant

Keyword: Other: Aging

Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation.

Zhong Q, Kowluru RA

Invest Ophthalmol Vis Sci. 2013 Jan 14;54(1):244-50

Wayne State University - Departmental Grant

Keywords: Gene Research/Therapy, Other: Epigenetics, Other: Metabolic Memory, Other: Mitochondria

Mitochondria damage in the pathogenesis of diabetic retinopathy and in the metabolic memory associated with its continued progression.

Kowluru RA

Curr Med Chem. 2013;20(26):3226-33

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Metabolic Memory, Other: Mitochondria

Muller glia in retinal innate immunity: A perspective on their roles in endophthalmitis.

Kumar A, Pandey RK, Miller LJ, Singh PK, Kanwar M

Crit Rev Immunol. 2013;33(2):119-35

Wayne State University - Departmental Grant

Keywords: Other: Endophthalmitis, Other: Muller Glial Cells, Other: Retinal Innate Immunity

December, 2012
Reduced innervation and delayed re-innervation after epithelial wounding in type 2 diabetic goto-kakizaki rats.

Wang F, Gao N, Yin J, Yu FS

Am J Pathol. 2012 Dec;181(6):2058-66

Wayne State University - Departmental Grant

Keyword: Other: Diabetic Keratopathy and Neuropathy

November, 2012
A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy.

Santos JM, Tewari S, Kowluru RA

Free Radic Biol Med. 2012 Nov 1;53(9):1729-37

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Expression of CaV3.2 T-type ca(2)(+) channels in a subpopulation of retinal type-3 cone bipolar cells.

Cui J, Ivanova E, Qi L, Pan ZH

Neuroscience. 2012 Nov 8;224:63-9

Wayne State University - Departmental Grant

Keyword: Gene Research/Therapy

October, 2012
Light-dependent changes in outer retinal water diffusion in rats in vivo.

Bissig D, Berkowitz BA

Mol Vis. 2012 Oct;18:2561-77

Wayne State University - Departmental Grant

Keyword: Imaging

August, 2012
Damaged mitochondrial DNA replication system and the development of diabetic retinopathy.

Tewari S, Santos JM, Kowluru RA

Antioxid Redox Signal. 2012 Aug 1;17(3):492-504

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

July, 2012
Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy.

Tewari S, Zhong Q, Santos JM, Kowluru RA

Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

June, 2012
Matrix metalloproteinases in diabetic retinopathy: Potential role of MMP-9.

Kowluru RA, Zhong Q, Santos JM

Expert Opin Investig Drugs. 2012 Jun;21(6):797-805

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

May, 2012
Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment.

Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH

J Biol Chem. 2012 May 11;287(20):16424-34

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Glaucoma, Imaging, Uveitis/Infectious Diseases

April, 2012
Characterization of multiple light damage paradigms reveals regional differences in photoreceptor loss.

Thomas JL, Nelson CM, Luo X, Hyde DR, Thummel R

Exp Eye Res. 2012 Apr;97(1):105-16

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Retinal Degeneration, Other: Retinal Regeneration

March, 2012
Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.

Mohammad G, Kowluru RA

J Cell Physiol. 2012 Mar;227(3):1052-61

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

January, 2012
Acute systemic 11-cis-retinal intervention improves abnormal outer retinal ion channel closure in diabetic mice.

Berkowitz BA, Bissig D, Patel P, Bhatia A, Roberts R

Mol Vis. 2012;18:372-6

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging

Evidence for diffuse central retinal edema in vivo in diabetic male sprague dawley rats.

Berkowitz BA, Bissig D, Ye Y, Valsadia P, Kern TS, Roberts R

PLoS One. 2012;7(1):e29619

Wayne State University - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging

Human tumor cell proliferation evaluated using manganese-enhanced MRI.

Braun RD, Bissig D, North R, Vistisen KS, Berkowitz BA

PLoS One. 2012;7(2):e30572

Wayne State University - Departmental Grant

Keyword: Imaging

Refractive development in the "ROP rat".

Chui TY, Bissig D, Berkowitz BA, Akula JD

J Ophthalmol. 2012;2012:956705

Wayne State University - Departmental Grant

Keywords: Imaging, Myopia/Presbyopia, Pediatric

Retinal muller glia initiate innate response to infectious stimuli via toll-like receptor signaling.

Kumar A, Shamsuddin N

PLoS One. 2012;7(1):e29830

Wayne State University - Special Scholar Award - Kumar, Ashok / PhD Departmental Grant

Keyword: Uveitis/Infectious Diseases

TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal muller glia under chronic hyperglycemia: Implications for diabetic retinopathy.

Devi TS, Lee I, Huttemann M, Kumar A, Nantwi KD, Singh LP

Exp Diabetes Res. 2012;2012:438238

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Using the tg(nrd:Egfp)/albino zebrafish line to characterize in vivo expression of neurod.

Thomas JL, Ochocinska MJ, Hitchcock PF, Thummel R

PLoS One. 2012;7(1):e29128

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Retinal Degeneration, Other: Retinal Regeneration

November, 2011
Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage.

Kowluru RA, Mohammad G, dos Santos JM, Zhong Q

Diabetes. 2011 Nov;60(11):3023-33

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Beyond AREDS: Is there a place for antioxidant therapy in the prevention/treatment of eye disease?

Kowluru RA, Zhong Q

Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8665-71

Wayne State University - Departmental Grant

Keyword: AMD

Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair.

Gao N, Yin J, Yoon GS, Mi QS, Yu FS

Am J Pathol. 2011 Nov;179(5):2243-53

Wayne State University - Departmental Grant

Keywords: Cornea, Other: Innate Immunity

Diabetic retinopathy and damage to mitochondrial structure and transport machinery.

Zhong Q, Kowluru RA

Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8739-46

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish.

Qin Z, Kidd AR,3rd, Thomas JL, Poss KD, Hyde DR, Raymond PA, Thummel R

Exp Eye Res. 2011 Nov;93(5):726-34

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Regeneration

Mitochondrial biogenesis and the development of diabetic retinopathy.

Santos JM, Tewari S, Goldberg AF, Kowluru RA

Free Radic Biol Med. 2011 Nov 15;51(10):1849-60

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.

Santos JM, Kowluru RA

Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8791-8

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

October, 2011
Same-session functional assessment of rat retina and brain with manganese-enhanced MRI.

Bissig D, Berkowitz BA

Neuroimage. 2011 Oct 1;58(3):749-60

Wayne State University - Departmental Grant

Keywords: Imaging, Retina/Retinal Diseases

September, 2011
August, 2011
Corneal complications in streptozocin-induced type I diabetic rats.

Yin J, Huang J, Chen C, Gao N, Wang F, Yu FS

Invest Ophthalmol Vis Sci. 2011 Aug 22;52(9):6589-96

Wayne State University - Departmental Grant

Keyword: Other: Diabetic Keratopathy

June, 2011
Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation.

Yamazaki A, Hayashi F, Matsuura I, Bondarenko VA

FEBS J. 2011 Jun;278(11):1854-72

Wayne State University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Physiology

Novel role of mitochondrial matrix metalloproteinase-2 in the development of diabetic retinopathy.

Mohammad G, Kowluru RA

Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3832-41

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa.

Wang Q, Song SK, Zhang H, Berkowitz BA, Chen S, Wickline SA, Chen J

Magn Reson Med. 2011 Jun;65(6):1793-8

Wayne State University - Departmental Grant

Keywords: Imaging, Retina/Retinal Diseases

Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK.

Qiu P, Wheater MK, Qiu Y, Sosne G

FASEB J. 2011 Jun;25(6):1815-26

Wayne State University - Departmental Grant

Keywords: Cornea, Other: Inflammation

TLR2 mediates the innate response of retinal muller glia to staphylococcus aureus.

Shamsuddin N, Kumar A

J Immunol. 2011 Jun 15;186(12):7089-97

Wayne State University - Special Scholar Award - Kumar, Ashok / PhD Departmental Grant

Keywords: Other: Endophthalmitis, Other: Toll-Like Receptor

May, 2011
Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats.

Xu K, Yu FS

Invest Ophthalmol Vis Sci. 2011 May 17;52(6):3301-8

Wayne State University - Departmental Grant

Keyword: Other: Diabetic Keratopathy

The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism.

Thomas JL, Vihtelic TS, Dendekker AD, Willer G, Luo X, Murphy TR, Gregg RG, Hyde DR, Thummel R

Invest Ophthalmol Vis Sci. 2011 May 27;52(6):3119-28

Wayne State University - Departmental Grant

Keyword: Retina/Retinal Diseases

Topical flagellin-mediated innate defense against candida albicans keratitis.

Gao N, Kumar A, Guo H, Wu X, Wheater M, Yu FS

Invest Ophthalmol Vis Sci. 2011 May 10;52(6):3074-82

Wayne State University - Departmental Grant

Keywords: Cornea, Other: Infection

April, 2011
Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy.

Zhong Q, Kowluru RA

Diabetes. 2011 Apr;60(4):1304-13

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

The role of raf-1 kinase in diabetic retinopathy.

Mohammad G, Kowluru RA

Expert Opin Ther Targets. 2011 Apr;15(4):357-64

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

March, 2011
The optic UK lecture: Bench-to-bedside adventures of a diabetes researcher: Results past, results present.

Frank RN

Eye (Lond). 2011 Mar;25(3):331-41

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

February, 2011
The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells.

Kennedy A, Frank RN

Curr Eye Res. 2011 Feb;36(2):168-77

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

January, 2011
Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity.

Berkowitz BA, Bissig D, Bergman D, Bercea E, Kasturi VK, Roberts R

Mol Vis. 2011;17:2516-26

Wayne State University - Departmental Grant

Keyword: Other: Retinopathy of Prematurity

January, 2010
Analysis of postnatal eye development in the mouse with high-resolution small animal magnetic resonance imaging.

Tkatchenko TV, Shen Y, Tkatchenko AV

Invest Ophthalmol Vis Sci 2010;51(1):21-27

Wayne State University - Departmental Grant

Keyword: Retinal Development

Corneal dystrophies: Molecular genetics to therapeutic intervention--fifth ARVO/Pfizer ophthalmics research institute conference.

Weiss JS

Invest Ophthalmol Vis Sci 2010;51(11):5391-5402

Wayne State University - Departmental Grant

Keywords: Cornea, Genetics

Evidence for a critical role of panretinal pathophysiology in experimental ROP.

Berkowitz BA, Roberts R

Doc Ophthalmol 2010;120(1):13-24

Wayne State University - Departmental Grant

Keyword: Retinal Imaging

Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kB–independent and EGFR-dependent pathway.

Gao N, Kumar A, Jyot J, Yu FS

PLoS ONE 2010;5(2):e9351

Wayne State University - Departmental Grant

Keyword: Other: Corneal Innate Immunity

Glyceraldehyde 3 phosphate dehydrogenase in retinal microvasculature: Implications for the development and progression of diabetic retinopathy.

Madsen-Bouterse S, Mohammad G, Kowluru RA

Invest Ophthalmol Vis Sci 2010;51(3):1765-1772

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy.

Perrone L, Devi TS, Hosoya K-I, Terasaki T, Singh LP

Cell Death and Disease 2010;1:e65

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Intravitreous delivery of the corticosteroid fluocinolone acetonide attenuates retinal degeneration in S334ter-4 rats.

Glybina IV, Kennedy A, Ashton P, Abrams GW, Iezzi R

Invest Ophthalmol Vis Sci 2010;51(8):4243-4252

Wayne State University - Departmental Grant

Keyword: Other: Neuroretinal Protection

Ketamine-xylazine anesthesia causes hyperopic refractive shift in mice.

Tkatchenko TV, Tkatchenko AV

J Neurosci Methods 2010;193(1):67-71

Wayne State University - Departmental Grant

Keyword: Other: Retinal Development

Light-dependant intraretinal ion regulation by melanopsin in young awake and free moving mice evaluated with manganese-enhanced MRI.

Berkowitz BA, Roberts R, Bissig D

Mol Vis 2010;16:1776-1780

Wayne State University - Departmental Grant

Keyword: Other: Retinal Imaging

LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas.

Yin J, Yu FS

Invest Ophthalmol Vis Sci 2010;51(4):1891-1897

Wayne State University - Departmental Grant

Keyword: Other: Corneal Wound Healing

Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction.

Mohammad G, Kowluru RA

Lab Invest 2010;90(9):1365-1372

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Mechanism for the regulation of mammalian cGMP phosphodiesterase6.1: Identification of its inhibitory subunit complexes and their roles.

Yamazaki A, Bondarenko VA, Matsuura I, Tatsumi M, Kurono S, Komori N, Matsumoto H, Hayashi F, Yamazaki RK, Usukura J

Mol Cell Biochem 2010;339(1-2):215-233

Wayne State University - Departmental Grant

Keyword: Retina/Retinal Diseases

Mechanism for the regulation of mammalian cGMP phosphodiesterase6.2: Isolation and characterization of the transducin-activated form.

Yamazaki A, Tatsumi M, Bondarenko VA, Kurono S, Komori N, Matsumoto H, Matsuura I, Hayashi F, Yamazaki RK, Usukura J

Mol Cell Biochem 2010;339(1-2):235-251

Wayne State University - Departmental Grant

Keyword: Retina/Retinal Diseases

Metabolic memory and diabetic retinopathy: Role of inflammatory mediators in retinal pericytes.

Kowluru RA, Zhong Q, Kanwar M

Exp Eye Res 2010;90(5):617-623

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Metabolic memory in diabetes–from in vitro oddity to in vivo problem: Role of apoptosis.

Kowluru RA, Chan PS

Brain Res Bull 2010;81(2-3):297-302

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Mouse experimental myopia has features of primate myopia.

Tkatchenko TV, Shen Y, Tkatchenko AV

Invest Ophthalmol Vis Sci 2010;51(3):1297-1303

Wayne State University - Departmental Grant

Keyword: Other: Retinal Development

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase.

Madsen-Bouterse SA, Zhong Q, Mohammad G, Ho YS, Kowluru RA

Free Rad Research 2010;44(3):313-321

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: Novel mechanism for metabolic memory.

Chan PS, Kanwar M, Kowluru RA

J Diabetes & Complications 2010;24(1):55-63

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Retinal channelrhodopsin-2-mediated activity in vivo evaluated with manganese-enhanced magnetic resonance imaging.

Ivanova E, Roberts R, Bissig D, Pan ZH, Berkowitz BA

Mol Vis 2010;16:1059-1067

Wayne State University - Departmental Grant

Keyword: Other: Retinal Imaging

Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon.

Zhong Q, Kowluru RA

J of Cell Biochem 2010;110(6):1306-1313

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras.

Kowluru RA

Invest Ophthalmol Vis Sci 2010;51(8):4320-4326

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression.

Madsen-Bouterse SA, Mohammad G, Kanwar M, Kowluru RA

Antioxid Redox Signal 2010;13(6):797-805

Wayne State University - Departmental Grant

Keyword: Diabetic Retinopathy

Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis.

Kumar A, Singh CN, Glybina IV, Mahmoud TH, Yu FS

J Infect Dis 2010;201(1):255-263

Wayne State University - Departmental Grant

Keywords: Other: Ocular Infection, Other: Immunity

Topical flagellin protects the injured corneas from pseudomonas aeruginosa infection.

Kumar A, Gao N, Standiford TJ, Gallo RL, Yu FS

Microbes Infect 2010;12(12-13):978-989

Wayne State University - Departmental Grant

Keyword: Other: Corneal Innate Immunity

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