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Research to Prevent Blindness

Research Database

University of Pittsburgh Research, funded by RPB in 2014 matching Departmental Grant

44 Citations, Sorted by Month and Year

December, 2014
Human limbal biopsy-derived stromal stem cells prevent corneal scarring.

Basu S, Hertsenberg AJ, Funderburgh ML, Burrow MK, Mann MM, Du Y, Lathrop KL, Syed-Picard FN, Adams SM, Birk DE, Funderburgh, JL

Sci.Transl.Med. 2014 Dec 10;6(266):266ra172.

University of Pittsburgh - Departmental Grant

Keyword: Cornea

Splenectomy Promotes Indirect Elimination of Intraocular Tumors by CD8+ T Cells That Is Associated with IFNgamma- and Fas/FasL-Dependent Activation of Intratumoral Macrophages.

Miller MR, Mandell JB, Beatty KM, Harvey SA, Rizzo MJ, Previte DM, Thorne SH, McKenna KC

Cancer Immunol.Res. 2014 Dec;2(12):1175-85.

University of Pittsburgh - Departmental Grant

Keyword: Ocular Oncology/Pterygium

October, 2014
Acute corneal edema with subsequent thinning and hyperopic shift following selective laser trabeculoplasty.

Knickelbein JE, Singh A, Flowers BE, Nair UK, Eisenberg M, Davis R, Raju LV, Schuman JS, Conner IP

J.Cataract Refract.Surg. 2014 Oct;40(10):1731-5.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

Dexamethasone Diffusion Across Contact Lenses Is Inhibited by Staphylococcus epidermidis Biofilms in Vitro.

Brothers KM, Nau AC, Romanowski EG, Shanks RM

Cornea 2014 Oct;33(10):1083-7.

University of Pittsburgh - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children.

Avery RA, Cnaan A, Schuman JS, Chen CL, Glaug NC, Packer RJ, Quinn GE, Ishikawa H

Am.J.Ophthalmol. 2014 Oct;158(4):780-7.

University of Pittsburgh - Departmental Grant

Keywords: Imaging, Pediatric

September, 2014
Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading.

Ho LC, Sigal IA, Jan NJ, Squires A, Tse Z, Wu EX, Kim SG, Schuman JS, Chan KC

Invest Ophthalmol.Vis.Sci. 2014 Sep;55(9):5662-72.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Glaucoma

August, 2014
28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres.

Fedorchak MV, Conner IP, Medina CA, Wingard JB, Schuman JS, Little SR

Exp.Eye Res. 2014 Aug;125:210-6.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

Correlations in V1 are reduced by stimulation outside the receptive field.

Snyder AC, Morais MJ, Kohn A, Smith MA

J.Neurosci. 2014 Aug 20;34(34):11222-7.

University of Pittsburgh - Career Development Award - Smith, Matthew A / PhD Departmental Grant

Keyword: Neuro-Ophthalmology

Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle, JP, Coyne, CV, Sadovsky Y

Am.J.Obstet.Gynecol. 2014 Aug 6.

University of Pittsburgh - Departmental Grant

Keyword: Gene Research/Therapy

July, 2014
ABCB5 is a limbal stem cell gene required for corneal development and repair.

Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Winston WYK, Call MK, Tucker BA, Zhan A, Murphy GF, Lathrop KA, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY

Nature 2014 Jul 17;511(7509):353-7.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Stem Cell Research/Therapy

Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts.

Markus A, Waldman Ben-Asher H, Kinchington PR, Goldstein RS

J.Virol. 2014 Jul;88(13):7674-7.

University of Pittsburgh - Departmental Grant

Keywords: Gene Research/Therapy, Stem Cell Research/Therapy

Characterisation of Schlemm's canal cross-sectional area.

Kagemann L, Nevins JE, Jan NJ, Wollstein G, Ishikawa H, Kagemann J, Sigal IA, Nadler Z, Ling Y, Schuman JS

Br.J.Ophthalmol. 2014 Jul;98 Suppl 2:ii10-ii14.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Imaging

Imaging of the optic nerve and retinal nerve fiber layer: an essential part of glaucoma diagnosis and monitoring.

Kotowski J, Wollstein G, Ishikawa H, Schuman JS

Surv.Ophthalmol. 2014 Jul;59(4):458-67.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Imaging

Intra- and Inter-visit Reproducibility of Ganglion Cell-Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children With Optic Pathway Gliomas.

Avery RA, Cnaan A, Schuman JS, Chen CL, Glaug NC, Packer RJ, Quinn GE, Ishikawa H

Am.J.Ophthalmol. 2014 Jul 25.

University of Pittsburgh - Departmental Grant

Keywords: Imaging, Pediatric

OCT for glaucoma diagnosis, screening and detection of glaucoma progression.

Bussel II, Wollstein G, Schuman JS

Br.J.Ophthalmol. 2014 Jul;98 Suppl 2:ii15-ii19.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy

Recent advances in OCT imaging of the lamina cribrosa.

Sigal IA, Wang B, Strouthidis NG, Akagi T, Girard MJ

Br.J.Ophthalmol. 2014 Jul;98 Suppl 2:ii34-ii39.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Imaging, Optic Neuropathy

Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin.

Guedon JM, Zhang M, Glorioso JC, Goins WF, Kinchington PR

Gene Ther. 2014 Jul;21(7):694-702.

University of Pittsburgh - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis.

Yun H, Rowe AM, Lathrop KL, Harvey SA, Hendricks RL

J.Virol. 2014 Jul;88(14):7870-80.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

June, 2014
A method to estimate biomechanics and mechanical properties of optic nerve head tissues from parameters measurable using optical coherence tomography.

Sigal IA, Grimm JL, Schuman JS, Kagemann L, Ishikawa H, Wollstein G

IEEE Trans.Med.Imaging 2014 Jun;33(6):1381-9.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.

Ho LC, Conner IP, Do CW, Kim SG, Wu EX, Wollstein G, Schuman JS, Chan KC

Invest Ophthalmol.Vis.Sci. 2014 Jun;55(6):3747-57.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Imaging

May, 2014
Characterization of porcine corneal endothelium for xenotransplantation.

Lee SE, Mehra R, Fujita M, Roh DS, Long C, Lee W, Funderburgh JL, Ayares DL, Cooper DK, Hara H

Semin.Ophthalmol. 2014 May;29(3):127-35.

University of Pittsburgh - Departmental Grant

Keyword: Cornea

Cyclic-AMP inhibition of fimbriae and prodigiosin production by Serratia marcescens is strain-dependent.

Stella NA, Shanks RM

Arch.Microbiol. 2014 May;196(5):323-30.

University of Pittsburgh - Departmental Grant

Keywords: Gene Research/Therapy, Uveitis/Infectious Diseases

Techniques and outcomes of minimally invasive trabecular ablation and bypass surgery.

Kaplowitz K, Schuman JS, Loewen NA

Br.J.Ophthalmol. 2014 May;98(5):579-85.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

Varicella-zoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected.

Sloutskin A, Yee MB, Kinchington PR, Goldstein RS

J.Virol. 2014 May;88(9):5079-86.

University of Pittsburgh - Departmental Grant

Keywords: Uveitis/Infectious Diseases, Other: virology

April, 2014
Corneal stromal bioequivalents secreted on patterned silk substrates.

Wu J, Rnjak-Kovacina J, Du Y, Funderburgh ML, Kaplan DL, Funderburgh JL

Biomaterials 2014 Apr;35(12):3744-55.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

In vivo visuotopic brain mapping with manganese-enhanced MRI and resting-state functional connectivity MRI.

Chan KC, Fan SJ, Chan RW, Cheng JS, Zhou IY, Wu EX

Neuroimage. 2014 Apr 15;90:235-45.

University of Pittsburgh - Departmental Grant

Keyword: Imaging

Predatory prokaryotes wage war against eye infections.

Shanks RM, Kadouri DE

Future.Microbiol. 2014 Apr;9(4):429-32.

University of Pittsburgh - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography.

Nadler Z, Wang B, Wollstein G, Nevins JE, Ishikawa H, Bilonick R, Kagemann L, Sigal IA, Ferguson RD, Patel A, Hammer DX, Schuman JS

Biomed.Opt.Express 2014 Apr 1;5(4):1114-23.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Imaging

March, 2014
Combining information from 3 anatomic regions in the diagnosis of glaucoma with time-domain optical coherence tomography.

Wang M, Lu AT, Varma R, Schuman JS, Greenfield DS, Huang D

J.Glaucoma. 2014 Mar;23(3):129-35.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Retina

Corneal stromal stem cells versus corneal fibroblasts in generating structurally appropriate corneal stromal tissue.

Wu J, Du Y, Mann MM, Funderburgh JL, Wagner WR

Exp.Eye Res. 2014 Mar;120:71-81.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Handheld optical coherence tomography during sedation in young children with optic pathway gliomas.

Avery RA, Hwang EI, Ishikawa H, Acosta MT, Hutcheson KA, Santos D, Zand DJ, Kilburn LB, Rosenbaum KN, Rood BR, Schuman JS, Packer, RJ

JAMA Ophthalmol. 2014 Mar;132(3):265-71.

University of Pittsburgh - Departmental Grant

Keywords: Optic Neuropathy, Pediatric

IOP elevation reduces Schlemm's canal cross-sectional area.

Kagemann L, Wang B, Wollstein G, Ishikawa H, Nevins JE, Nadler Z, Sigal IA, Bilonick RA, Schuman JS

Invest Ophthalmol.Vis.Sci. 2014 Mar;55(3):1805-9.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

February, 2014
Deep sequencing of viral genomes provides insight into the evolution and pathogenesis of varicella zoster virus and its vaccine in humans.

Depledge DP, Kundu S, Jensen NJ, Gray ER, Jones M, Steinberg S, Gershon A, Kinchington PR, Schmid DS, Balloux F, Nichols RA, Breuer J

Mol.Biol.Evol. 2014 Feb;31(2):397-409.

University of Pittsburgh - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Outflow tract ablation using a conditionally cytotoxic feline immunodeficiency viral vector.

Zhang Z, Dhaliwal AS, Tseng H, Kim JD, Schuman JS, Weinreb RN, Loewen NA

Invest Ophthalmol.Vis.Sci. 2014 Feb;55(2):935-40.

University of Pittsburgh - Departmental Grant

Keywords: Gene Expression, Stem Cell Research/Therapy

January, 2014
A laser-induced mouse model with long-term intraocular pressure elevation.

Yun H, Lathrop KL, Yang E, Sun M, Kagemann L, Fu V, Stolz DB, Schuman JS, Du Y

PLoS.One. 2014;9(9):e107446.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells.

Karamichos D, Funderburgh ML, Hutcheon AE, Zieske JD, Du Y, Wu J, Funderburgh JL

PLoS.One. 2014;9(1):e86260.

University of Pittsburgh - Departmental Grant

Keywords: Cornea, Stem Cell Research/Therapy

Eye-specific IOP-induced displacements and deformations of human lamina cribrosa.

Sigal IA, Grimm JL, Jan NJ, Reid K, Minckler DS, Brown DJ

Invest Ophthalmol.Vis.Sci. 2014 Jan;55(1):1-15.

University of Pittsburgh - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy

Gold nanorods as a contrast agent for Doppler optical coherence tomography.

Wang B, Kagemann L, Schuman JS, Ishikawa H, Bilonick RA, Ling Y, Sigal IA, Nadler Z, Francis A, Sandrian MG, Wollstein, G

PLoS.One. 2014;9(3):e90690.

University of Pittsburgh - Departmental Grant

Keyword: Imaging

In vivo three-dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography.

Nadler Z, Wang B, Schuman JS, Ferguson RD, Patel A, Hammer DX, Bilonick RA, Ishikawa H, Kagemann L, Sigal IA, Wollstein G

Invest Ophthalmol.Vis.Sci. 2014;55(10):6459-66.

University of Pittsburgh - Departmental Grant

Keyword: Imaging

Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.

Butterworth MB, Zhang L, Liu X, Shanks RM, Thibodeau PH

PLoS.One. 2014;9(6):e100313.

University of Pittsburgh - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Reproducibility of in-vivo OCT measured three-dimensional human lamina cribrosa microarchitecture.

Wang B, Nevins JE, Nadler Z, Wollstein G, Ishikawa H, Bilonick RA, Kagemann L, Sigal IA, Grulkowski I, Liu JJ, Kraus M, Lu CD, Hornegger J, Fujimoto JG, Schuman JS

PLoS.One. 2014;9(4):e95526.

University of Pittsburgh - Departmental Grant

Keyword: Glaucoma

RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation.

Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, Kellam P, Hollinshead M, Kinchington PR, O'Toole EA, Breuer J

PLoS.Pathog. 2014 Jan;10(1):e1003896.

University of Pittsburgh - Departmental Grant

Keyword: Gene Research/Therapy

SLURP-1 Modulates Corneal Homeostasis by Serving as a Soluble Scavenger of Urokinase-Type Plasminogen Activator.

Swamynathan S, Swamynathan SK

Invest Ophthalmol.Vis.Sci. 2014;55(10):6251-61.

University of Pittsburgh - Departmental Grant

Keyword: Cornea

Successful tactile based visual sensory substitution use functions independently of visual pathway integrity.

Lee VK, Nau AC, Laymon C, Chan KC, Rosario BL, Fisher C

Front Hum.Neurosci. 2014;8:291.

University of Pittsburgh - Departmental Grant

Keyword: Artificial Vision

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