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Research to Prevent Blindness

Research Database

University of Pennsylvania Research, funded by RPB from 2011-2014 matching Departmental Grant

88 Citations, Sorted by Month and Year

November, 2014
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.

Ratnapriya R, Zhan X, Fariss RN, Branham KE, Jacobson SG, Gorin MB, Klein ML, Allikmets R, Iyengar SK, Weber BH, Haines JL, Léveillard T, Deangelis MM, Stambolian D, Weeks DE, Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A

Hum Mol Genet. 2014 Nov 1;23(21):5827-37.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

October, 2014
A murine rp1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration.

Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL

Am J Pathol. 2014 Oct;184(10):2721-9.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Cost-Effectiveness of Fluocinolone Acetonide Implant versus Systemic Therapy for Noninfectious Intermediate, Posterior, and Panuveitis.

Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Sugar EA, Holbrook JT, Kempen JH, Burke AE, Drye LT, Thorne JE, Louis TA, Jabs DA, Altaweel MM, Frick KD

Ophthalmology. Ophthalmology. 2014 Oct;121(10):1855-62.

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials.

Minella AL, Mowat FM, Willett KL, Sledge D, Bartoe JT, Bennett J, Petersen-Jones SM

Gene Ther. 2014 Oct;21(10):913-20.

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

Late-onset retinal degeneration caused by C1QTNF5 mutation : Sub-retinal pigment epithelium deposits and visual consequences.

Jacobson SG, Cideciyan AV, Sumaroka A, Roman AJ, Wright AF

JAMA Ophthalmol. 2014 Oct 1;132(10):1252-5.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib.

Choe CH, McArthur GA, Caro I, Kempen JH, Amaravadi RK

Am J Ophthalmol. 2014 Oct;158(4):831-837.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis.

Mehta S, Linton MM, Kempen JH

Am J Ophthalmol. 2014 Oct;158(4):676-692.

University of Pennsylvania - Departmental Grant

Keywords: Cataract, Retina/Retinal Diseases, Uveitis/Infectious Diseases

September, 2014
High-Resolution Adaptive Optics Retinal Imaging of Cellular Structure in Choroideremia.

Morgan JI, Han G, Klinman E, Maguire WM, Chung DC, Maguire AM, Bennett J

Invest Ophthalmol Vis Sci. 2014 Sep 4;55(10):6381-97.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Iron upregulates melanogenesis in cultured retinal pigment epithelial cells.

Wolkow N, Li Y, Maminishkis A, Song Y, Alekseev O, Iacovelli J, Song D, Lee JC, Dunaief JL

Exp Eye Res. 2014 Sep 30;128C:92-101.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2014
Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.

Cronin T, Vandenberghe LH, Hantz P, Juttner J, Reimann A, Kacsó AE‘, Huckfeldt RM, Busskamp V, Kohler H, Lagali PS, Roska B, Bennett J

EMBO Mol Med. 2014 Aug 4;6(9):1175-90.

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis.

Khan RS, Dine K, Luna E, Ahlem C, Shindler KS

Invest Ophthalmol Vis Sci. 2014 Aug 19;55(9):5744-51.

University of Pennsylvania - Departmental Grant

Keywords: Optic Neuropathy, Retina/Retinal Diseases

Interobserver agreement in clinical grading of vitreous haze using alternative grading scales.

Hornbeak DM, Payal A, Pistilli M, Biswas J, Ganesh SK, Gupta V, Rathinam SR, Davis JL, Kempen JH

Ophthalmology. 2014 Aug;121(8):1643-8.

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

My career path for developing gene therapy for blinding diseases: the importance of mentors, collaborators, and opportunities.

Bennett J

Hum Gene Ther. 2014 Aug;25(8):663-70.

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

Systemic Administration of the Antioxidant/Iron Chelator α-Lipoic Acid Protects Against Light-Induced Photoreceptor Degeneration in the Mouse Retina.

Zhao L, Wang C, Song D, Li Y, Song Y, Su G, Dunaief JL

Invest Ophthalmol Vis Sci. 2014 Aug 21;55(9):5979-88.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2014
Risk of retinal tear or detachment with oral fluoroquinolone use: a cohort study.

Eftekhari K, Ghodasra DH, Haynes K, Chen J, Kempen JH, VanderBeek BL

Pharmacoepidemiol Drug Saf. 2014 Jul;23(7):745-52.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

TULP1 mutations causing early-onset retinal degeneration: preserved but insensitive macular cones.

Jacobson SG, Cideciyan AV, Huang WC, Sumaroka A, Roman AJ, Schwartz SB, Luo X, Sheplock R, Dauber JM, Swider M, Stone EM

Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5354-64.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2014
The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.

Song D, Zhao L, Li Y, Hadziahmetovic M, Song Y, Connelly J, Spino M, Dunaief JL

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4525-32.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2014
Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models.

Black A, Vasireddy V, Chung DC, Maguire AM, Gaddameedi R, Tolmachova T, Seabra Ml, Bennett J

J Gen Med. 2014 May-Jun 16(5-6):122-30.

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized study.

Sheppard JD, Toyos MM, Kempen JH, Kaur P, Foster CS

Invest Ophthalmol Vis Sci. 2014 May 6;55(5):2993-3002.

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

March, 2014
Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.

Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD

PLoS One. 2014 Mar 5;9(3):e90390.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Factors predictive of remission of new-onset anterior uveitis.Ophthalmology.

Artornsombudh P, Pistilli M, Foster CS, Pujari SS, Gangaputra SS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Kempen JH

Ophthalmology. 2014 Mar;121(3):778-84.

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Inner and outer retinal changes in retinal degenerations associated with ABCA4 mutations.

Huang WC, Cideciyan AV, Roman AJ, Sumaroka A, Sheplock R, Schwartz SB, Stone EM, Jacobson SG

Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1810-2.

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.

Boye SE, Huang WC, Roman AJ, Sumaroka A, Boye SL, Ryals RC, Olivares MB, Ruan Q, Tucker BA, Stone EM, Swaroop A, Cideciyan AV, Hauswirth WW, Jacobson SG

PLoS One. 2014 Mar 26;9(3):e92928.

University of Pennsylvania - Departmental Grant

Keyword: Other: Leber Congenital Amaurosis

NEI’s audacious goals initiative.

Salowe RJ, O'Brien JM

Ophthalmology. 2014 Mar;121(3):615-6.

University of Pennsylvania - Departmental Grant

Keyword: Other: Vision Research

Tear osmolarity and dry eye symptoms in diabetics.

Fuerst N, Langelier N, Massaro-Giordano M, Pistilli M, Stasi K, Burns C, Cardillo S, Bunya VY

Clin Ophthalmol. 2014 Mar 10;8:507-15.

University of Pennsylvania - Departmental Grant

Keyword: Dry Eye

February, 2014
Incidence of visual improvement in uveitis cases with visual impairment caused by macular edema.

Levin MH, Pistilli M, Daniel E, Gangaputra SS, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Kempen JH, Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study

Ophthalmology. 2014 Feb;121(2):588-95.

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

January, 2014
fMRI of retina-originated phosphenes experienced by patients with Leber congenital amaurosis.

Ashtari M, Cyckowski L, Yazdi A, Viands A, Marshall K, Bókkon I, Maguire A, Bennett J

PLoS One. 2014 Jan 21;9(1): e86068.

University of Pennsylvania - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Leber Congenital Amaurosis

SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease.

Khan RS, Dine K, Das Sarma J, Shindler KS

Acta Neuropathol Commun. 2014 Jan 2;2:3.

University of Pennsylvania - Departmental Grant

Keyword: Optic Neuropathy

October, 2013
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.

Drivas TG, Holzbaur EL, Bennett J

J Clin Invest. 2013 Oct 1;123(10):4525-39

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Mitochondrial sequence variation in african-american primary open-angle glaucoma patients.

Collins DW, Gudiseva HV, Trachtman BT, Jerrehian M, Gorry T, Merritt Iii WT, Rhodes AL, Sankar PS, Regina M, Miller-Ellis E, O'Brien JM

PLoS One. 2013 Oct 1;8(10):e76627

University of Pennsylvania - Departmental Grant

Keywords: Glaucoma, Gene Research/Therapy

September, 2013
Risk of choroidal neovascularization among the uveitides.

Baxter SL, Pistilli M, Pujari SS, Liesegang TL, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Kempen JH

Am J Ophthalmol. 2013 Sep;156(3):468-77.e2

University of Pennsylvania - Departmental Grant

Keywords: Retina/Retinal Diseases, Uveitis/Infectious Diseases

August, 2013
Response of pediatric uveitis to tumor necrosis factor-alpha inhibitors.

Lerman MA, Burnham JM, Chang PY, Daniel E, Foster CS, Hennessy S, Jabs DA, Joffe MM, Kacmaz RO, Levy-Clarke GA, Mills MD, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Kempen JH

J Rheumatol. 2013 Aug;40(8):1394-403

University of Pennsylvania - Departmental Grant

Keywords: Pediatric, Uveitis/Infectious Diseases

Risk of elevated intraocular pressure and glaucoma in patients with uveitis: Results of the multicenter uveitis steroid treatment trial.

Friedman DS, Holbrook JT, Ansari H, Alexander J, Burke A, Reed SB, Katz J, Thorne JE, Lightman SL, Kempen JH, MUST Research Group

Ophthalmology. 2013 Aug;120(8):1571-9

University of Pennsylvania - Departmental Grant

Keywords: Glaucoma, Uveitis/Infectious Diseases

July, 2013
SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.

Zuo L, Khan RS, Lee V, Dine K, Wu W, Shindler KS

Invest Ophthalmol Vis Sci. 2013 Jul 26;54(7):5097-102

University of Pennsylvania - Departmental Grant

Keywords: Neuro-Ophthalmology, Optic Neuropathy, Retina/Retinal Diseases

June, 2013
Retinal iron homeostasis in health and disease.

Song D, Dunaief JL

Front Aging Neurosci. 2013 Jun 28;5:24

University of Pennsylvania - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with leber congenital amaurosis type 2.

Testa F, Maguire AM, Rossi S, Pierce EA, Melillo P, Marshall K, Banfi S, Surace EM, Sun J, Acerra C, Wright JF, Wellman J, High KA, Auricchio A, Bennett J, Simonelli F

Ophthalmology. 2013 Jun;120(6):1283-91

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Other: Leber Congenital Amaurosis

May, 2013
AAV-mediated gene therapy for choroideremia: Preclinical studies in personalized models.

Vasireddy V, Mills JA, Gaddameedi R, Basner-Tschakarjan E, Kohnke M, Black AD, Alexandrov K, Zhou S, Maguire AM, Chung DC, Mac H, Sullivan L, Gadue P, Bennicelli JL, French DL, Bennett J

PLoS One. 2013 May 7;8(5):e61396

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Other: Choroideremia

April, 2013
Full-field electroretinography under general anesthesia in retinoblastoma.

Sachidanandam R, Krishnakumar S, Gopal L, O'Brien JM, Khetan V, Sen P

Doc Ophthalmol. 2013 Apr;126(2):149-57

University of Pennsylvania - Departmental Grant

Keywords: Ocular Oncology/Pterygium, Other: Retinoblastoma

March, 2013
Abnormal thickening as well as thinning of the photoreceptor layer in intermediate age-related macular degeneration.

Sadigh S, Cideciyan AV, Sumaroka A, Huang WC, Luo X, Swider M, Steinberg JD, Stambolian D, Jacobson SG

Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1603-12

University of Pennsylvania - Departmental Grant

Keyword: AMD

Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration.

Morgan JI, Pugh EN,Jr

Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2048-59

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Seeing the light.

Wojno AP, Pierce EA, Bennett J

Sci Transl Med. 2013 Mar 6;5(175):175fs8

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Other: Leber Congenital Amaurosis

February, 2013
Intervisit variability of visual parameters in leber congenital amaurosis caused by RPE65 mutations.

Roman AJ, Cideciyan AV, Schwartz SB, Olivares MB, Heon E, Jacobson SG

Invest Ophthalmol Vis Sci. 2013 Feb 15;54(2):1378-83

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Other: Leber Congenital Amaurosis

Retinopathy and cognitive impairment in adults with CKD.

Yaffe K, Ackerson L, Hoang TD, Go AS, Maguire MG, Ying GS, Daniel E, Bazzano LA, Coleman M, Cohen DL, Kusek JW, Ojo A, Seliger S, Xie D, Grunwald JE, CRIC Study Investigators

Am J Kidney Dis. 2013 Feb;61(2):219-27

University of Pennsylvania - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Chronic Kidney Disease

January, 2013
AAV9 targets cone photoreceptors in the nonhuman primate retina.

Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM

PLoS One. 2013;8(1):e53463

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human leber congenital amaurosis en route to therapy: Residual cone-photoreceptor vision correlates with biochemical properties of the mutants.

Jacobson SG, Cideciyan AV, Peshenko IV, Sumaroka A, Olshevskaya EV, Cao L, Schwartz SB, Roman AJ, Olivares MB, Sadigh S, Yau KW, Heon E, Stone EM, Dizhoor AM

Hum Mol Genet. 2013 Jan 1;22(1):168-83

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Other: Leber Congenital Amaurosis

Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice.

Kishore A, Kanaujia A, Nag S, Rostami AM, Kenyon LC, Shindler KS, Das Sarma J

Biomed Res Int. 2013;2013:589048

University of Pennsylvania - Departmental Grant

Keywords: Neuro-Ophthalmology, Other: Multiple Sclerosis

November, 2012
Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome.

Kempen JH, Sugar EA, Lyon AT, Lewis RA, Jabs DA, Heinemann MH, Dunn JP, Studies of Ocular Complications of AIDS Research Group

Ophthalmology. 2012 Nov;119(11):2343-50

University of Pennsylvania - Departmental Grant

Keywords: Cataract, Uveitis/Infectious Diseases

Risk of hypotony in noninfectious uveitis.

Daniel E, Pistilli M, Pujari SS, Kacmaz RO, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Kempen JH

Ophthalmology. 2012 Nov;119(11):2377-85

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

September, 2012
Retinopathy and chronic kidney disease in the chronic renal insufficiency cohort (CRIC) study.

Grunwald JE, Alexander J, Ying GS, Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Jaar BG, CRIC Study Group

Arch Ophthalmol. 2012 Sep 1;130(9):1136-44

University of Pennsylvania - Departmental Grant

Keyword: Other: Retinopathy

August, 2012
Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.

Hadziahmetovic M, Kumar U, Song Y, Grieco S, Song D, Li Y, Tobias JW, Dunaief JL

Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5231-41

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases.

Udoetuk JD, Dai Y, Ying GS, Daniel E, Gangaputra S, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Kempen JH, Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group

Ophthalmology. 2012 Aug;119(8):1569-74

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

RPGR-associated retinal degeneration in human X-linked RP and a murine model.

Huang WC, Wright AF, Roman AJ, Cideciyan AV, Manson FD, Gewaily DY, Schwartz SB, Sadigh S, Limberis MP, Bell P, Wilson JM, Swaroop A, Jacobson SG

Invest Ophthalmol Vis Sci. 2012 Aug 15;53(9):5594-608

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.

Guha S, Baltazar GC, Tu LA, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH

J Neurochem. 2012 Aug;122(4):823-33

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2012
Association between retinopathy and cardiovascular disease in patients with chronic kidney disease (from the chronic renal insufficiency cohort [CRIC] study).

Grunwald JE, Ying GS, Maguire M, Pistilli M, Daniel E, Alexander J, Whittock-Martin R, Parker C, Mohler E, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Coleman M, Keane MG, Chronic Renal Insufficiency Cohort (CRIC) Study Group

Am J Cardiol. 2012 Jul 15;110(2):246-53

University of Pennsylvania - Departmental Grant

Keyword: Other: Retinopathy

Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.

Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH

Am J Physiol Cell Physiol. 2012 Jul 15;303(2):C160-9

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

In vivo detection of experimental optic neuritis by pupillometry.

Shindler KS, Revere K, Dutt M, Ying GS, Chung DC

Exp Eye Res. 2012 Jul;100:1-6

University of Pennsylvania - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optic Neuritis

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina.

Song D, Song Y, Hadziahmetovic M, Zhong Y, Dunaief JL

Free Radic Biol Med. 2012 Jul 1;53(1):64-71

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2012
The diagnostic and economic yield of neuroimaging in neuro-ophthalmology.

Mehta S, Loevner LA, Mikityansky I, Langlotz C, Ying GS, Tamhankar MA, Shindler KS, Volpe NJ

J Neuroophthalmol. 2012 Jun;32(2):139-44

University of Pennsylvania - Departmental Grant

Keywords: Imaging, Neuro-Ophthalmology

April, 2012
DNA methylation is associated with altered gene expression in AMD.

Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, Dezoeten E, Dunaief JL

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105

University of Pennsylvania - Departmental Grant

Keyword: AMD

Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.

Wolkow N, Song D, Song Y, Chu S, Hadziahmetovic M, Lee JC, Iacovelli J, Grieco S, Dunaief JL

Am J Pathol. 2012 Apr;180(4):1614-24

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Gene therapy for retinitis pigmentosa caused by MFRP mutations: Human phenotype and preliminary proof of concept.

Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG

Hum Gene Ther. 2012 Apr;23(4):367-76

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

March, 2012
Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial.

Frick KD, Drye LT, Kempen JH, Dunn JP, Holland GN, Latkany P, Rao NA, Sen HN, Sugar EA, Thorne JE, Wang RC, Holbrook JT, Multicenter Uveitis Steroid Treatment-MUST Trial Research Group

Invest Ophthalmol Vis Sci. 2012 Mar 9;53(3):1169-76

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

February, 2012
AAV2 gene therapy readministration in three adults with congenital blindness.

Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM

Sci Transl Med. 2012 Feb 8;4(120):120ra15

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

Macular function in macular degenerations: Repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials.

Cideciyan AV, Swider M, Aleman TS, Feuer WJ, Schwartz SB, Russell RC, Steinberg JD, Stone EM, Jacobson SG

Invest Ophthalmol Vis Sci. 2012 Feb 21;53(2):841-52

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keyword: AMD

Understanding pRb: Toward the necessary development of targeted treatments for retinoblastoma.

Sachdeva UM, O'Brien JM

J Clin Invest. 2012 Feb 1;122(2):425-34

University of Pennsylvania - Departmental Grant

Keywords: Ocular Oncology/Pterygium, Retina/Retinal Diseases, Other: Retinoblastoma

January, 2012
Gene delivery to the retina: From mouse to man.

Bennett J, Chung DC, Maguire A

Methods Enzymol. 2012;507:255-74

University of Pennsylvania - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Regeneration of cone outer segments induced by CNTF.

Wen R, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM, Li Y

Adv Exp Med Biol. 2012;723:93-9

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis.

Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS

Front Neurol. 2012;3:84

University of Pennsylvania - Departmental Grant

Keyword: Optic Neuropathy

The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration.

Berenberg TL, Metelitsina TI, Madow B, Dai Y, Ying GS, Dupont JC, Grunwald L, Brucker AJ, Grunwald JE

Retina. 2012 Jan;32(1):25-31

University of Pennsylvania - Departmental Grant

Keyword: AMD

December, 2011
Evidence of association of APOE with age-related macular degeneration: A pooled analysis of 15 studies.

McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG, Weber BH, Keilhauer CN, Lotery AJ, Ennis S, Klein ML, Francis PJ, Stambolian D, Orlin A, Gorin MB, Weeks DE, Kuo CL, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Wright AF, Hayward C, Baird PN, Guymer RH, Attia J, Thakkinstian A, Silvestri G

Hum Mutat. 2011 Dec;32(12):1407-16

University of Pennsylvania - Departmental Grant

Keyword: AMD

November, 2011
Aceruloplasminemia: Retinal histopathologic manifestations and iron-mediated melanosome degradation.

Wolkow N, Song Y, Wu TD, Qian J, Guerquin-Kern JL, Dunaief JL

Arch Ophthalmol. 2011 Nov;129(11):1466-74

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

New grading criteria allow for earlier detection of geographic atrophy in clinical trials.

Brader HS, Ying GS, Martin ER, Maguire MG, Complications of Age-Related Macular Degeneration Prevention Trial-CAPT Research Group

Invest Ophthalmol Vis Sci. 2011 Nov 29;52(12):9218-25

University of Pennsylvania - Departmental Grant

Keyword: AMD

October, 2011
Retinal disease course in usher syndrome 1B due to MYO7A mutations.

Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS

Invest Ophthalmol Vis Sci. 2011 Oct 7;52(11):7924-36

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2011
Diagnosis and treatment of microsporidial keratoconjunctivitis: Literature review and case series.

Taju S, Tilahun Y, Ayalew M, Fikrie N, Schneider J, Kempen JH

J Ophthalmic Inflamm Infect. 2011 Sep;1(3):105-10

University of Pennsylvania - Departmental Grant

Keyword: Cornea

Success of prisms in the management of diplopia due to fourth nerve palsy.

Tamhankar MA, Ying GS, Volpe NJ

J Neuroophthalmol. 2011 Sep;31(3):206-9

University of Pennsylvania - Departmental Grant

Keyword: Other: Diplopia

August, 2011
Human CRB1-associated retinal degeneration: Comparison with the rd8 Crb1-mutant mouse model.

Aleman TS, Cideciyan AV, Aguirre GK, Huang WC, Mullins CL, Roman AJ, Sumaroka A, Olivares MB, Tsai FF, Schwartz SB, Vandenberghe LH, Limberis MP, Stone EM, Bell P, Wilson JM, Jacobson SG

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6898-910

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2011
3D alignment and change detection from uncalibrated eye images.

Kuthirummal S, Bansal M, Sawhney H, Eledath J, Pearson DJ, Stone RA

HISB. 2011 Jul 26-29:299-306

University of Pennsylvania - Departmental Grant

Keyword: Imaging

Image defocus and altered retinal gene expression in chick: Clues to the pathogenesis of ametropia.

Stone RA, McGlinn AM, Baldwin DA, Tobias JW, Iuvone PM, Khurana TS

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5765-77

University of Pennsylvania - Departmental Grant

Keyword: Other: Refractive Error

June, 2011
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.

Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J

Sci Transl Med. 2011 Jun 22;3(88):88ra54

University of Pennsylvania - Departmental Grant

Keyword: Gene Research/Therapy

Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus.

Shindler KS, Chatterjee D, Biswas K, Goyal A, Dutt M, Nassrallah M, Khan RS, Das Sarma J

J Neuropathol Exp Neurol. 2011 Jun;70(6):470-80

University of Pennsylvania - Departmental Grant

Keyword: Other: Optic Neuritis

Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.

McKay GJ, Silvestri G, Chakravarthy U, Dasari S, Fritsche LG, Weber BH, Keilhauer CN, Klein ML, Francis PJ, Klaver CC, Vingerling JR, Ho L, De Jong PT, Dean M, Sawitzke J, Baird PN, Guymer RH, Stambolian D, Orlin A, Seddon JM, Peter I, Wright AF, Hayward C, Lotery AJ, Ennis S, Gorin MB, Weeks DE, Kuo CL, Hingorani AD, Sofat R, Cipriani V, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Yates JR, Webster AR, Moore AT, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Young IS, Fletcher AE, Patterson CC

Am J Epidemiol. 2011 Jun 15;173(12):1357-64

University of Pennsylvania - Departmental Grant

Keyword: Other: Aging Eye

April, 2011
Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: Generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy.

Cideciyan AV, Rachel RA, Aleman TS, Swider M, Schwartz SB, Sumaroka A, Roman AJ, Stone EM, Jacobson SG, Swaroop A

Hum Mol Genet. 2011 Apr 1;20(7):1411-23

University of Pennsylvania - Senior Scientific Investigator Award - Cideciyan, Artur, V / PhD Departmental Grant

Keyword: Gene Research/Therapy

Population-based prevalence of uveitis in southern india.

Rathinam SR, Krishnadas R, Ramakrishnan R, Thulasiraj RD, Tielsch JM, Katz J, Robin AL, Kempen JH, Aravind Comprehensive Eye Survey Research Group

Br J Ophthalmol. 2011 Apr;95(4):463-7

University of Pennsylvania - Departmental Grant

Keyword: Uveitis/Infectious Diseases

March, 2011
DICER1 deficit induces alu RNA toxicity in age-related macular degeneration.

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Kariko K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J

Nature. 2011 Mar 17;471(7338):325-30

University of Pennsylvania - Departmental Grant

Keyword: AMD

January, 2011
Adult hypertropia: A guide to diagnostic evaluation based on review of 300 patients.

Tamhankar MA, Kim JH, Ying GS, Volpe NJ

Eye (Lond). 2011 Jan;25(1):91-6

University of Pennsylvania - Departmental Grant

Keyword: Other: Refractive Error

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM, Vollrath D

J Clin Invest. 2011 Jan;121(1):369-83

University of Pennsylvania - Departmental Grant

Keyword: Retina/Retinal Diseases

Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis.

Quinn TA, Dutt M, Shindler KS

Front Neurol. 2011;2:50

University of Pennsylvania - Departmental Grant

Keywords: Other: Optic Neuritis, Other: Multiple Sclerosis

Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and senior-loken syndrome.

Stone EM, Cideciyan AV, Aleman TS, Scheetz TE, Sumaroka A, Ehlinger MA, Schwartz SB, Fishman GA, Traboulsi EI, Lam BL, Fulton AB, Mullins RF, Sheffield VC, Jacobson SG

Arch Ophthalmol. 2011 Jan;129(1):81-7

University of Pennsylvania - Departmental Grant

Keyword: Other: Leber Congenital Amaurosis

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