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Research to Prevent Blindness

Research Database

University of Nebraska Research, funded by RPB from 2010-2014 matching Departmental Grant

106 Citations, Sorted by Month and Year

November, 2014
Association of retinal vessel caliber and visual outcome in eyes with diabetic macular oedema treated with ranibizumab.

Moradi A, Sepah YJ, Ibrahim MA, Sophie R, Moazez C, Bittencourt MG, Annam RE, Hanout M, Liu H, Ferraz D, Do DV, Nguyen QD

Eye (Lond). 2014 Nov;28(11):1315-20.

University of Nebraska - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging

Hmga2 regulates self-renewal of retinal progenitors.

Parameswaran S, Xia X, Hegde G, Ahmad I

Development. 2014 Nov;141(21):4087-97.

University of Nebraska - Departmental Grant

Keyword: Stem Cell Research/Therapy

Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia.

Ryskamp D, Jo A, Frye A, Vaazquez-Chona F, NacAulay N, Thoreson W, Krizaj D

J Neurosci. 2014 Nov;34(47): 15689-15700.

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Glaucoma

October, 2014
Disparities in visual impairment by immigrant status in the United States.

Wilson FA, Wang Y, Stimpson JP, Kessler AS, Do DV, Britigan DH

Am J Ophthalmol. 2014 Oct;158(4):800,807.e5.

University of Nebraska - Departmental Grant

Keyword: Other: Visual Impairment

Longitudinal comparison of visual acuity as measured by the ETDRS chart and by the potential acuity meter in eyes with macular edema, and its relationship with retinal thickness and sensitivity.

Hatef E, Hanout M, Moradi A, Colantuoni E, Bittencourt M, Liu H, Sepah YJ, Ibrahim M, Do DV, Guyton DL, Nguyen QD

Eye (Lond). 2014 Oct; 28(10):1239-45

University of Nebraska - Departmental Grant

Keywords: Diabetic Retinopathy, Uveitis/Infectious Diseases, Imaging

Ranibizumab for macular telangiectasia type 2 in the absence of subretinal neovascularization.

Do DV, Bressler SB, Cassard SD, Gower EW, Tabandeh H, Jefferys JL, Bressler NM

Retina. 2014 Oct;34(10):2063-71

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Rod Photoreceptor, Other: Endocytosis, Other: electrophysiology

September, 2014
A randomized controlled trial of panretinal photocoagulation with and without intravitreal ranibizumab in treatment-naive eyes with non-high-risk proliferative diabetic retinopathy.

Ferraz DA, Vasquez LM, Preti RC, Motta A, Sophie R, Bittencourt MG, Sepah YJ, Monteiro ML, Nguyen QD, Takahashi WY

Retina. 2014 Sep 30.

University of Nebraska - Departmental Grant

Keywords: Diabetic Retinopathy, Other: Proliferative Diabetic Retinopathy

Assessment of central retinal sensitivity employing two types of microperimetry devices.

Liu H, Bittencourt MG, Wang J, Sophie R, Annam R, Ibrahim MA, Sepah YJ, Moradi A, Scholl HP, Nguyen QD

Transl Vis Sci Technol. 2014 Sep 12;3(5):3.

University of Nebraska - Departmental Grant

Keyword: Other: Visual Acuity

Pharmacotherapy for uveitis: Current management and emerging therapy.

Barry RJ, Nguyen QD, Lee RW, Murray PI, Denniston AK

Clin Ophthalmol. 2014 Sep 22;8:1891-911

University of Nebraska - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection.

Palsamy P, Bidasee KR, Shinohara T

Biochim Biophys Acta. 2014 Sep;1842(9):1794-805.

University of Nebraska - Departmental Grant

Keyword: Cataract

August, 2014
Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription.

Chhunchha B, Fatma N, Kubo E, Singh DP

FEBS J. 2014 Aug;281(15):3357-81

University of Nebraska - Departmental Grant

Keyword: Other: Prdx6

Clinical features and incidence rate of ocular complications in punctate inner choroidopathy.

Leung TG, Moradi A, Liu D, Nguyen QD, Dunn JP, Burkholder B, Butler NJ, Ostheimer T, Thorne JE

Retina. 2014 Aug;34(8):1666-74.

University of Nebraska - Departmental Grant

Keyword: Other: Punctuate Inner Choroidopathy

Simultaneous recording of mouse retinal ganglion cells during epiretinal or subretinal stimulation.

Sim SL, Szalewski RJ, Johnson LJ, Akah LE, Shoemaker LE, Thoreson WB, Margalit E

Vision Res. 2014 Aug;101:41-50.

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2014
Intravitreal aflibercept for diabetic macular edema.

Korobelnik JF, Do DV, Schmidt-Erfurth U, Boyer DS, Holz FG, Heier JS, Midena E, Kaiser PK, Terasaki H, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, Schmelter T, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Zeitz O, Metzig C, Brown DM

Ophthalmology. 2014 Jul 8.

University of Nebraska - Departmental Grant

Keyword: Diabetic Retinopathy

Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.

Palsamy P, Bidasee KR, Ayaki M, Augusteyn RC, Chan JY, Shinohara T

Free Radic Biol Med. 2014 Jul;72:134-48.

University of Nebraska - Departmental Grant

Keyword: Cataract

June, 2014
Daytime and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension.

Fan S, Agrawal A, Gulati V, Neely DG, Toris CB

J Glaucoma. 2014 Jun-Jul;23(5):276-81.

University of Nebraska - Departmental Grant

Keyword: Glaucoma

FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys.

Sharif NA, Katoli P, Scott D, Li L, Kelly C, Xu S, Husain S, Toris C, Crosson C

Drug Dev Res. 2014 Jun;75(4):211-23.

University of Nebraska - Departmental Grant

Keyword: Glaucoma

May, 2014
Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium.

Cork KM, Thoreson WB

Vis Neurosci. 2014 May;31(3):227-35

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2014
Examination of VLC-PUFA-deficient photoreceptor terminals.

Bennett LD, Hopiavuori BR, Brush RS, Chan M, Van Hook MJ, Thoreson WB, Anderson RE

Invest Ophthalmol Vis Sci. 2014 Apr 24;55(7):4063-72.

University of Nebraska - Departmental Grant

Keywords: Macular Dystrophy, Other: Juvenile-onset autosomal dominant Stargardt-like macular dystrophy

Fundus autofluorescence imaging: Fundamentals and clinical relevance.

Sepah YJ, Akhtar A, Sadiq MA, Hafeez Y, Nasir H, Perez B, Mawji N, Dean DJ, Ferraz D, Nguyen QD

Saudi J Ophthalmol. 2014 Apr;28(2):111-6.

University of Nebraska - Departmental Grant

Keywords: Retina, Imaging

Sumoylation differentially regulates Sp1 to control cell differentiation.

Gong L, Ji WK, Hu XH, Hu WF, Tang XC, Huang ZX, Li L, Liu M, Xiang SH, Wu E, Woodward Z, Liu YZ, Nguyen QD, Li DW

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5574-9.

University of Nebraska - Departmental Grant

Keyword: Other: Transcription Regulation

March, 2014
Comparison of time- and spectral-domain optical coherence tomography in management of diabetic macular edema.

Liu MM, Wolfson Y, Bressler SB, Do DV, Ying HS, Bressler NM

Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1370-7.

University of Nebraska - Departmental Grant

Keyword: Diabetic Retinopathy

Driving habits in older patients with central vision loss.

Sengupta S, van Landingham SW, Solomon SD, Do DV, Friedman DS, Ramulu PY

Ophthalmology. 2014 Mar;121(3):727-32.

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab.

Channa R, Sophie R, Khwaja AA, Do DV, Hafiz G, Nguyen QD, Campochiaro PA, READ-2 Study Group

Eye (Lond). 2014 Mar;28(3):269-78.

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Diabetic Macular Edema

Improvement in outflow facility by two novel microinvasive glaucoma surgery implants.

Hays CL, Gulati V, Fan S, Samuelson TW, Ahmed II, Toris CB

Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):1893-900.

University of Nebraska - Departmental Grant

Keyword: Glaucoma

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors.

Fu D, Lv X, Hua G, He C, Dong J, Lele SM, Li DW, Zhai Q, Davis JS, Wang C

Endocr Relat Cancer. 2014 Mar 4;21(2):297-310.

University of Nebraska - Departmental Grant

Keyword: Other: Transcription Regulation

February, 2014
A phase ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophy.

Do DV, Pieramici DJ, van Lookeren Campagne M, Beres T, Friesenhahn M, Zhang Y, Strauss EC, Phase Ia Investigators

Retina. 2014 Feb;34(2):313-20.

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Effects of a schlemm canal scaffold on collector channel ostia in human anterior segments.

Johnstone MA, Saheb H, Ahmed II, Samuelson TW, Schieber AT, Toris CB

Exp Eye Res. 2014 Feb;119:70-6.

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Intracellular calcium stores drive slow non-ribbon vesicle release from rod photoreceptors.

Chen M, Krizaj D, Thoreson WB

Front Cell Neurosci. 2014 Feb 3;8:20

University of Nebraska - Departmental Grant

Keywords: Other: Calcium-Induced Calcium Release, Other: Ribbon Synapse, Other: Synaptic Vesicle

Retina-simulating phantom for optical coherence tomography.

Baxi J, Calhoun W, Sepah YJ, Hammer DX, Ilev I, Pfefer TJ, Nguyen QD, Agrawal A

J Biomed Opt. 2014 Feb;19(2):21106

University of Nebraska - Departmental Grant

Keyword: Other: Optical Coherence Tomography

January, 2014
Author reply: to PMID 23084240.

Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, Kirchof B, Ho A, Ogura Y, Schmidt-Erfuth U

Ophthalmology. 2014 Jan;121(1):e5-e6.

University of Nebraska - Departmental Grant

Keyword: AMD

Cytologic features in vitreous preparations of patients with suspicion of intraocular lymphoma.

Rodriguez EF, Sepah YJ, Jang HS, Ibrahim M, Nguyen QD, Rodriguez FJ

Diagn Cytopathol. 2014 Jan;42(1):37-44.

University of Nebraska - Departmental Grant

Keyword: Other: Intraocular Lymphoma

Dual application versus simple application of povidone-iodine in reducing surgical site contamination during strabismus surgery.

Benson CE, Rogers KL, Suh DW

Journal of American Association for Pediatric Ophthalmology and Strabismus 2014 Jan;18(4):347-50.

University of Nebraska - Departmental Grant

Keyword: Pediatric

Emerging therapies for noninfectious uveitis: What may be coming to the clinics.

Maya JR, Sadiq MA, Zapata LJ, Hanout M, Sarwar S, Rajagopalan N, Guinn KE, Sepah YJ, Nguyen QD

J Ophthalmol. 2014;2014:310329.

University of Nebraska - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Intravitreal aflibercept injection for neovascular age-related macular degeneration: Ninety-six-week results of the VIEW studies.

Schmidt-Erfurth U, Kaiser PK, Korobelnik JF, Brown DM, Chong V, Nguyen QD, Ho AC, Ogura Y, Simader C, Jaffe GJ, Slakter JS, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Soo Y, Anderesi M, Sowade O, Zeitz O, Norenberg C, Sandbrink R, Heier JS

Ophthalmology. 2014 Jan;121(1):193-201.

University of Nebraska - Departmental Grant

Keyword: AMD

November, 2013
Management of retained subretinal perfluorocarbon liquid.

Shulman M, Sepah YJ, Chang S, Abrams GW, Do DV, Nguyen QD

Ophthalmic Surg Lasers Imaging Retina. 2013 Nov 1;44(6):577-83

University of Nebraska - Departmental Grant

Keyword: Other: Perfluorocarbon Fluid

October, 2013
Adult ciliary epithelial stem cells generate functional neurons and differentiate into both early and late born retinal neurons under non-cell autonomous influences.

Del Debbio CB, Peng X, Xiong H, Ahmad I

BMC Neurosci. 2013 Oct 22;14(1):130

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Stem Cell Research/Therapy

HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1.

Shah A, Kumar S, Simon SD, Singh DP, Kumar A

Cell Death Dis. 2013 Oct 10;4:e850

University of Nebraska - Departmental Grant

Keyword: Other: Oxidative Stress

Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36-month results from two phase III trials: RISE and RIDE.

Brown DM, Nguyen QD, Marcus DM, Boyer DS, Patel S, Feiner L, Schlottmann PG, Rundle AC, Zhang J, Rubio RG, Adamis AP, Ehrlich JS, Hopkins JJ, RIDE and RISE Research Group

Ophthalmology. 2013 Oct;120(10):2013-22

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Diabetic Macular Edema

September, 2013
An experimental steroid responsive model of ocular inflammation in rabbits using an SLT frequency doubled Q switched nd:YAG laser.

Gulati V, Pahuja S, Fan S, Toris CB

J Ocul Pharmacol Ther. 2013 Sep;29(7):663-9

University of Nebraska - Departmental Grant

Keyword: Other: Ocular Inflammation

Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens.

Kubo E, Hasanova N, Sasaki H, Singh DP

J Cell Mol Med. 2013 Sep;17(9):1146-59

University of Nebraska - Departmental Grant

Keyword: Cataract

Longitudinal spectral domain optical coherence tomography changes in eyes with intraocular lymphoma.

Jang HS, Sepah YJ, Sophie R, Bittencourt MG, Ferraz D, Hanout M, Liu H, Do DV, Nguyen QD

J Ophthalmic Inflamm Infect. 2013 Sep 8;3(1):59,5760-3-59

University of Nebraska - Departmental Grant

Keyword: Other: Ocular Lymphoma

July, 2013
Adverse events and complications associated with intravitreal injection of anti-VEGF agents: A review of literature.

Falavarjani KG, Nguyen QD

Eye (Lond). 2013 Jul;27(7):787-94

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2013
Biosynthesis, characterization, and efficacy in retinal degenerative diseases of lens epithelium-derived growth factor fragment (LEDGF1-326), a novel therapeutic protein.

Baid R, Upadhyay AK, Shinohara T, Kompella UB

J Biol Chem. 2013 Jun 14;288(24):17372-83

University of Nebraska - Departmental Grant

Keywords: AMD, Retinitis Pigmentosa

Simultaneous whole-cell recordings from photoreceptors and second-order neurons in an amphibian retinal slice preparation.

Van Hook MJ, Thoreson WB

J Vis Exp. 2013 Jun 1(76)

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2013
Putting theories and results into practice: Managing cases.

Nguyen QD, Do DV, Haller JA, Heier JS, Kaiser PK

Ophthalmology. 2013 May;120(5 Suppl):S16-22

University of Nebraska - Departmental Grant

Keyword: AMD

April, 2013
Corticosteroids as adjuvant therapy for ocular toxoplasmosis.

Jasper S, Vedula SS, John SS, Horo S, Sepah YJ, Nguyen QD

Cochrane Database Syst Rev. 2013 Apr 30;4:CD007417

University of Nebraska - Departmental Grant

Keyword: Other: Corticosteroids

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-kappaB regulation.

Chhunchha B, Fatma N, Kubo E, Rai P, Singh SP, Singh DP

Am J Physiol Cell Physiol. 2013 Apr 1;304(7):C636-55

University of Nebraska - Departmental Grant

Keywords: Other: Oxidative Stress, Other: Peroxiredoxin 6

March, 2013
A novel 8-mm schlemm's canal scaffold reduces outflow resistance in a human anterior segment perfusion model.

Gulati V, Fan S, Hays CL, Samuelson TW, Ahmed II, Toris CB

Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1698-704

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.

Bhargavan B, Chhunchha B, Fatma N, Kubo E, Kumar A, Singh DP

Epigenetics. 2013 Mar;8(3):268-80

University of Nebraska - Departmental Grant

Keywords: Other: Epigenetics, Other: LEDGF

February, 2013
Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis: Primary 6-month results of the SAVE study.

Nguyen QD, Ibrahim MA, Watters A, Bittencourt M, Yohannan J, Sepah YJ, Dunn JP, Naor J, Shams N, Shaikh O, Leder HA, Do DV

J Ophthalmic Inflamm Infect. 2013 Feb 11;3(1):32,5760-3-32

University of Nebraska - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Oral proton pump inhibitors disrupt horizontal cell-cone feedback and enhance visual hallucinations in macular degeneration patients.

Hanneken AM, Babai N, Thoreson WB

Invest Ophthalmol Vis Sci. 2013 Feb 27;54(2):1485-9

University of Nebraska - Departmental Grant

Keyword: AMD

Ranibizumab for edema of the macula in diabetes study: 3-year outcomes and the need for prolonged frequent treatment.

Do DV, Nguyen QD, Khwaja AA, Channa R, Sepah YJ, Sophie R, Hafiz G, Campochiaro PA, READ-2 Study Group

JAMA Ophthalmol. 2013 Feb;131(2):139-45

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Diabetic Macular Edema

January, 2013
Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease.

Harms NV, Toris CB

Expert Opin Pharmacother. 2013 Jan;14(1):105-13

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells.

Kubo E, Hasanova N, Fatma N, Sasaki H, Singh DP

J Cell Mol Med. 2013 Jan;17(1):212-21

University of Nebraska - Departmental Grant

Keyword: Cataract

Lateral mobility of L-type calcium channels in synaptic terminals of retinal bipolar cells.

Thoreson WB, Mercer AJ, Cork KM, Szalewski RJ

Mol Vis. 2013;19:16-24

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.

Chen M, Van Hook MJ, Zenisek D, Thoreson WB

J Neurosci. 2013 Jan 30;33(5):2071-86

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Therapies for neovascular age-related macular degeneration: Current approaches and pharmacologic agents in development.

Hanout M, Ferraz D, Ansari M, Maqsood N, Kherani S, Sepah YJ, Rajagopalan N, Ibrahim M, Do DV, Nguyen QD

Biomed Res Int. 2013;2013:830837.

University of Nebraska - Departmental Grant

Keyword: AMD

Tracking quantum dot-tagged calcium channels at vertebrate photoreceptor synapses: Retinal slices and dissociated cells.

Mercer AJ, Thoreson WB

Curr Protoc Neurosci. 2013 Jan;Chapter 2:Unit 2.18

University of Nebraska - Departmental Grant

Keyword: Other: Ribbon Synapse

December, 2012
Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina.

Van Hook MJ, Thoreson WB

J Neurosci. 2012 Dec 12;32(50):18112-23

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Rod and Cone Photoreceptors

November, 2012
CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway.

Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S, Zheng J

Stem Cells. 2012 Nov;30(11):2571-83

University of Nebraska - Departmental Grant

Keywords: Stem Cell Research/Therapy, Other: Neural Stem Cell

October, 2012
Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection.

Elanchezhian R, Palsamy P, Madson CJ, Lynch DW, Shinohara T

Chem Biol Interact. 2012 Oct 25;200(1):1-10

University of Nebraska - Departmental Grant

Keywords: Cataract, Other: Age-Related

September, 2012
A novel schlemm's canal scaffold increases outflow facility in a human anterior segment perfusion model.

Camras LJ, Yuan F, Fan S, Samuelson TW, Ahmed IK, Schieber AT, Toris CB

Invest Ophthalmol Vis Sci. 2012 Sep 12;53(10):6115-21

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Lateral interactions in the outer retina.

Thoreson WB, Mangel SC

Prog Retin Eye Res. 2012 Sep;31(5):407-41

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Rod and Cone Photoreceptors

Lens epithelium-derived growth factor deSumoylation by sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.

Ishihara K, Fatma N, Bhargavan B, Chhunchha B, Kubo E, Dey S, Takamura Y, Kumar A, Singh DP

FEBS J. 2012 Sep;279(17):3048-70

University of Nebraska - Departmental Grant

Keywords: Gene Research/Therapy, Other: Lens Epithelium-Derived Growth Factor

July, 2012
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.

Palsamy P, Ayaki M, Elanchezhian R, Shinohara T

Biochem Biophys Res Commun. 2012 Jul 6;423(3):542-8

University of Nebraska - Departmental Grant

Keywords: Cataract, Other: Age-Related

June, 2012
Diurnal and nocturnal variations in aqueous humor dynamics of patients with ocular hypertension undergoing medical therapy.

Gulati V, Fan S, Zhao M, Maslonka MA, Gangahar C, Toris CB

Arch Ophthalmol. 2012 Jun;130(6):677-84

University of Nebraska - Departmental Grant

Keywords: Glaucoma, Other: Ocular Hypertension

Regulation of presynaptic strength by controlling Ca2+ channel mobility: Effects of cholesterol depletion on release at the cone ribbon synapse.

Mercer AJ, Szalewski RJ, Jackman SL, Van Hook MJ, Thoreson WB

J Neurophysiol. 2012 Jun;107(12):3468-78

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Cone Photoreceptor

May, 2012
LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.

Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh DP

Cell Death Dis. 2012 May 31;3:e316

University of Nebraska - Departmental Grant

Keywords: Gene Research/Therapy, Other: Lens Epithelium-Derived Growth Factor

April, 2012
Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells.

Elanchezhian R, Palsamy P, Madson CJ, Mulhern ML, Lynch DW, Troia AM, Usukura J, Shinohara T

Cell Death Dis. 2012 Apr 19;3:e301

University of Nebraska - Departmental Grant

Keywords: Cataract, Other: Age-Related

March, 2012
A comparison of optical and electrophysiological methods for recording retinal ganglion cells during electrical stimulation.

Luo J, Boosalis BJ, Thoreson WB, Margalit E

Curr Eye Res. 2012 Mar;37(3):218-27

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

January, 2012
Endoplasmic reticulum stress associated retinal photoreceptor cell death in the transgenic mutant rhodopsin S334ter-3 rats.

Mulhern ML, Madson CJ, Troia A, Elanchezhian R, Palsamy P, Shinohara T

Biomedicine & Aging Pathology. 2012;2(4):143-50

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Retinitis Pigmentosa

Nucleic acid and non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency.

Parameswaran S, Balasubramanian S, Babai N, DelDebbio CB, Harms DW, Gurumurthy CB, Rao MS, Sharp JG, Ahmad I

PLoS One. 2012;7(10):e46734

University of Nebraska - Departmental Grant

Keyword: Stem Cell Research/Therapy

Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter.

Singh DP, Bhargavan B, Chhunchha B, Kubo E, Kumar A, Fatma N

PLoS One. 2012;7(5):e37012

University of Nebraska - Departmental Grant

Keywords: Gene Research/Therapy, Other: Lens Epithelium-Derived Growth Factor

December, 2011
Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few ca(2+) channels.

Bartoletti TM, Jackman SL, Babai N, Mercer AJ, Kramer RH, Thoreson WB

J Neurophysiol. 2011 Dec;106(6):2922-35

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

November, 2011
Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.

Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A, Singh DP

Cell Death Dis. 2011 Nov 24;2:e234

University of Nebraska - Departmental Grant

Keyword: Cataract

October, 2011
Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis.

Fatma N, Singh P, Chhunchha B, Kubo E, Shinohara T, Bhargavan B, Singh DP

Am J Physiol Cell Physiol. 2011 Oct;301(4):C954-67

University of Nebraska - Departmental Grant

Keyword: Cataract

September, 2011
Aqueous humor dynamics during the day and night in volunteers with ocular hypertension.

Fan S, Hejkal JJ, Gulati V, Galata S, Camras CB, Toris CB

Arch Ophthalmol. 2011 Sep;129(9):1162-6

University of Nebraska - Departmental Grant

Keyword: Glaucoma

July, 2011
Concise review: Non-cell autonomous reprogramming: A nucleic acid-free approach to induction of pluripotency.

Parameswaran S, Balasubramanian S, Rao MS, Ahmad I

Stem Cells. 2011 Jul;29(7):1013-20

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Muller glia: A promising target for therapeutic regeneration.

Ahmad I, Del Debbio CB, Das AV, Parameswaran S

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5758-64

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2011
A positive feedback synapse from retinal horizontal cells to cone photoreceptors.

Jackman SL, Babai N, Chambers JJ, Thoreson WB, Kramer RH

PLoS Biol. 2011 May;9(5):e1001057

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Center/surround organization of retinal bipolar cells: High correlation of fundamental responses of center and surround to sinusoidal contrasts.

Burkhardt DA, Bartoletti TM, Thoreson WB

Vis Neurosci. 2011 May;28(3):183-92

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Regulation of ocular angiogenesis by notch signaling: Implications in neovascular age-related macular degeneration.

Ahmad I, Balasubramanian S, Del Debbio CB, Parameswaran S, Katz AR, Toris C, Fariss RN

Invest Ophthalmol Vis Sci. 2011 May 2;52(6):2868-78

University of Nebraska - Departmental Grant

Keyword: AMD

April, 2011
Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.

Bartoletti TM, Thoreson WB

Mol Vis. 2011 Apr 12;17:920-31

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

March, 2011
Aqueous humor dynamics during the day and night in healthy mature volunteers.

Liu H, Fan S, Gulati V, Camras LJ, Zhan G, Ghate D, Camras CB, Toris CB

Arch Ophthalmol. 2011 Mar;129(3):269-75

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Inner and outer retinal mechanisms engaged by epiretinal stimulation in normal and rd mice.

Margalit E, Babai N, Luo J, Thoreson WB

Vis Neurosci. 2011 Mar;28(2):145-54

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses.

Mercer AJ, Chen M, Thoreson WB

J Neurosci. 2011 Mar 23;31(12):4397-406

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2011
Correlations between parameters of aqueous humor dynamics and the influence of central corneal thickness.

Gulati V, Ghate DA, Camras CB, Toris CB

Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):920-6

University of Nebraska - Departmental Grant

Keyword: Glaucoma

January, 2011
Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors.

Krizaj D, Mercer AJ, Thoreson WB, Barabas P

Am J Physiol Cell Physiol. 2011 Jan;300(1):C187-97

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.

Mercer AJ, Rabl K, Riccardi GE, Brecha NC, Stella SL,Jr, Thoreson WB

J Neurophysiol. 2011 Jan;105(1):321-35

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

January, 2010
Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells.

Babai N, Kanevsky N, Dascal N, Rozanski GJ, Singh DP, Fatma N, Thoreson WB

PLoS ONE 2010;5(1):e8602

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Aqueous humor dynamics during the day and night in juvenile and adult rabbits.

Zhao M, Hejkal JJ, Camras CB, Toris CB

Invest Ophthalmol Vis Sci 2010;51(6):3145-3151

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension.

Toris CB, Risma JM, Gonzales-Martin J, McLaughlin MA, Dawson WW

Exp Eye Res 2010;91(6):860-865

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Aqueous humor dynamics in pigment dispersion syndrome.

Toris CB, Haecker NR, Teasley LA, Zhan G, Gulati V, Camras CB

Arch Ophthalmol 2010;128(9):1115-1118

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Calcium regulates vesicle replenishment at the cone ribbon synapse.

Babai N, Bartoletti TM, Thoreson WB

J Neurosci 2010;30(47):15866-15877

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

Duration of anesthesia affects intraocular pressure, but not outflow facility in mice.

Camras LJ, Sufficool KE, Camras CB, Fan S, Liu H, Toris CB

Curr Eye Res 2010;35(9):819-827

University of Nebraska - Departmental Grant

Keyword: Glaucoma

Induced pluripotent stem cells (iPSCs) generate both retinal ganglion cells and photoreceptors: Therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration.

Parameswaran S, Balasubramanian S, Babai N, Qiu F, Eudy JD, Thoreson WB, Ahmad I

Stem Cells 2010;28(4):695-703

University of Nebraska - Departmental Grant

Keywords: Glaucoma, Macular Dystrophy, Retina/Retinal Diseases

Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications.

Lane JT, Larson L, Fan S, Stoner JA, Margalit E, Toris CB

BMC Ophthalmol 2010;10:19

University of Nebraska - Departmental Grant

Keywords: Diabetic Retinopathy, Glaucoma

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage.

Tulsawani R, Kelly LS, Fatma N, Chhunchha B, Kubo E, Kumar A, Singh DP

BMC Neurosci 2010;11:125

University of Nebraska - Departmental Grant

Keywords: Glaucoma, Retina/Retinal Diseases

Notch and Wnt signaling mediated rod photoreceptor regeneration by muller cells in adult mammalian retina.

Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I

PLoS ONE 2010;5(8):e12425

University of Nebraska - Departmental Grant

Keywords: Macular Dystrophy, Retina/Retinal Diseases

Quantitative analysis of synaptic release at the photoreceptor synapse.

Duncan G, Rabl K, Gemp I, Heidelberger R, Thoreson WB

Biophys J 2010;98(10):2102-2110

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

The safety of intraocular linezolid in rabbits.

Duke SL, Kump LI, Yuan Y, West WW, Sachs AJ, Haider NB, Margalit E

Invest Ophthalmol Vis Sci 2010;51(6):3115-3119

University of Nebraska - Departmental Grant

Keywords: Retina/Retinal Diseases, Uveitis/Infectious Diseases

Vesicle pool size at the salamander cone ribbon synapse.

Bartoletti TM, Babai N, Thoreson WB

J Neurophysiol 2010;103(1):419-428

University of Nebraska - Departmental Grant

Keyword: Retina/Retinal Diseases

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