netbook
desktop
mobile
tablet-landscape
tablet
phone-landscape
phone
Research to Prevent Blindness

Research Database

Johns Hopkins University Research, funded by RPB from 2012-2014 matching Departmental Grant

40 Citations, Sorted by Month and Year

November, 2014
Rare and common variants in extracellular matrix gene fibrillin 2 (FBN2) are associated with macular degeneration.

Ratnapriya R, Zhan X, Fariss RN, Branham KE, Zipprer D, Chakarova CF, Sergeev YV, Campos MM, Othman M, Friedman JS, Maminishkis A, Waseem NH, Brooks M, Rajasimha HK, Edwards AO, Lotery A, Klein BE, Truitt BJ, Li B, Schaumberg DA, Morgan DJ, Morrison MA, Souied E, Tsironi EE, Grassmann F, Fishman GA, Silvestri G, Scholl HP, Kim IK, Ramke J, Tuo J, Merriam JE, Merriam JC, Park KH, Olson LM, Farrer LA, Johnson MP, Peachey NS, Lathrop M, Baron RV, Igo RP,Jr, Klein R, Hagstrom SA, Kamatani Y, Martin TM, Jiang Y, Conley Y, Sahel JA, Zack DJ, Chan CC, Pericak-Vance MA, Jacobson SG, Gorin MB, Klein ML, Allikmets R, Iyengar SK, Weber BH, Haines JL, Leveillard T, Deangelis MM, Stambolian D, Weeks DE, Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A

Hum Mol Genet. 2014 Nov 1;23(21):5827-37

Johns Hopkins University - Departmental Grant

Keywords: AMD, Gene Research/Therapy

October, 2014
N-acetylcysteine increases corneal endothelial cell survival in a mouse model of fuchs endothelial corneal dystrophy.

Kim EC, Meng H, Jun AS

Exp Eye Res. 2014 Oct;127:20-5

Johns Hopkins University - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Retinal macroglia changes in a triple transgenic mouse model of alzheimer's disease.

Edwards MM, Rodriguez JJ, Gutierrez-Lanza R, Yates J, Verkhratsky A, Lutty GA

Exp Eye Res. 2014 Oct;127:252-60

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

September, 2014
On the origin of 'guttae'.

Son HS, Villarreal G,Jr, Meng H, Eberhart CG, Jun AS

Br J Ophthalmol. 2014 Sep;98(9):1308-10

Johns Hopkins University - Departmental Grant

Keyword: Cornea

August, 2014
The demethylating agent 5-aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma.

Rajaii F, Asnaghi L, Enke R, Merbs SL, Handa JT, Eberhart CG

Invest Ophthalmol Vis Sci. 2014 Aug 21;55(10):6178-86

Johns Hopkins University - Departmental Grant

Keyword: Ocular Oncology

June, 2014
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs.

Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV

Nat Commun. 2014 Jun 10;5:4047

Johns Hopkins University - Departmental Grant

Keywords: Retina/Retinal Diseases, Stem Cell Research/Therapy

May, 2014
A multi-function force sensing instrument for variable admittance robot control in retinal microsurgery.

He X, Balicki M, Gehlbach P, Handa J, Taylor R, Iordachita I

IEEE Int Conf Robot Autom. 2014 May;2014:1411-8

Johns Hopkins University - Departmental Grant

Keyword: Retina/Retinal Diseases

Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium.

Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N

J Biol Chem. 2014 May 2;289(18):12908-21

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

April, 2014
The Pex1-G844D mouse: A model for mild human zellweger spectrum disorder.

Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ

Mol Genet Metab. 2014 Apr;111(4):522-32

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

February, 2014
A submillimetric 3-DOF force sensing instrument with integrated fiber bragg grating for retinal microsurgery.

He X, Handa J, Gehlbach P, Taylor R, Iordachita I

IEEE Trans Biomed Eng. 2014 Feb;61(2):522-34

Johns Hopkins University - Departmental Grant

Keyword: Retina/Retinal Diseases

Development and validation of an improved neurological hemifield test to identify chiasmal and postchiasmal lesions by automated perimetry.

McCoy AN, Quigley HA, Wang J, Miller NR, Subramanian PS, Ramulu PY, Boland MV

Invest Ophthalmol Vis Sci. 2014 Feb 20;55(2):1017-23

Johns Hopkins University - Departmental Grant

Keywords: Glaucoma, Neuro-Ophthalmology

January, 2014
Endothelial cell microRNA expression in human late-onset fuchs' dystrophy.

Matthaei M, Hu J, Kallay L, Eberhart CG, Cursiefen C, Qian J, Lackner EM, Jun AS

Invest Ophthalmol Vis Sci. 2014 Jan 9;55(1):216-25

Johns Hopkins University - Departmental Grant

Keyword: Cornea

Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature.

Park TS, Bhutto I, Zimmerlin L, Huo JS, Nagaria P, Miller D, Rufaihah AJ, Talbot C, Aguilar J, Grebe R, Merges C, Reijo-Pera R, Feldman RA, Rassool F, Cooke J, Lutty G, Zambidis ET

Circulation. 2014 Jan 21;129(3):359-72

Johns Hopkins University - Departmental Grant

Keywords: Retina/Retinal Diseases, Stem Cell Research/Therapy

November, 2013
VEGF secreted by hypoxic muller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy.

Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A

Diabetes. 2013 Nov;62(11):3863-73

Johns Hopkins University - Career Development Award - Sodhi, Akrit / MD, PhD Departmental Grant

Keyword: Diabetic Retinopathy

October, 2013
Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs.

Wan J, Oliver VF, Zhu H, Zack DJ, Qian J, Merbs SL

Nucleic Acids Res. 2013 Oct;41(18):8503-14

Johns Hopkins University - Departmental Grant

Keyword: Gene Research/Therapy

September, 2013
Hypoxic retinal muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.

Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34

Johns Hopkins University - Career Development Award - Welsbie, Derek / MD, PhD Career Development Award - Sodhi, Akrit / MD, PhD Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

August, 2013
Lithium treatment increases endothelial cell survival and autophagy in a mouse model of fuchs endothelial corneal dystrophy.

Kim EC, Meng H, Jun AS

Br J Ophthalmol. 2013 Aug;97(8):1068-73

Johns Hopkins University - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Seidel and india ink tests assessment of different clear cornea side-port incision configurations.

Kashiwabuchi FK, Khan YA, Rodrigues MW,Jr, Wang J, McDonnell PJ, Daoud YJ

Graefes Arch Clin Exp Ophthalmol. 2013 Aug;251(8):1961-5

Johns Hopkins University - Departmental Grant

Keyword: Cornea

June, 2013
A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples.

Oliver VF, Wan J, Agarwal S, Zack DJ, Qian J, Merbs SL

Epigenetics Chromatin. 2013 Jun 7;6(1):17,8935-6-17

Johns Hopkins University - Departmental Grant

Keyword: Gene Research/Therapy

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.

Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N

Mol Vis. 2013 Jun 17;19:1371-86

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

April, 2013
Ex vivo electroporation of retinal cells: A novel, high efficiency method for functional studies in primary retinal cultures.

Vergara MN, Gutierrez C, O'Brien DR, Canto-Soler MV

Exp Eye Res. 2013 Apr;109:40-50

Johns Hopkins University - Departmental Grant

Keyword: Retina/Retinal Diseases

Modified femtosecond laser-assisted sutureless anterior lamellar keratoplasty.

Bonfadini G, Moreira H, Jun AS, Campos M, Kim EC, Arana E, Zapparoli M, Ribas Filho JM, McDonnell PJ

Cornea. 2013 Apr;32(4):533-7

Johns Hopkins University - Departmental Grant

Keyword: Cornea

Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo.

Xu Q, Boylan NJ, Suk JS, Wang YY, Nance EA, Yang JC, McDonnell PJ, Cone RA, Duh EJ, Hanes J

J Control Release. 2013 Apr 10;167(1):76-84

Johns Hopkins University - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Other: Vitreous Body

Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in fuchs dystrophy.

Matthaei M, Lackner EM, Meng H, Hicks JL, Meeker AK, Eberhart CG, Jun AS

Cornea. 2013 Apr;32(4):473-8

Johns Hopkins University - Departmental Grant

Keywords: Cornea, Other: Tissue Microassay

March, 2013
Endothelial cell whole genome expression analysis in a mouse model of early-onset fuchs' endothelial corneal dystrophy.

Matthaei M, Hu J, Meng H, Lackner EM, Eberhart CG, Qian J, Hao H, Jun AS

Invest Ophthalmol Vis Sci. 2013 Mar 15;54(3):1931-40

Johns Hopkins University - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L,Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

L450W and Q455K Col8a2 knock-in mouse models of fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.

Meng H, Matthaei M, Ramanan N, Grebe R, Chakravarti S, Speck CL, Kimos M, Vij N, Eberhart CG, Jun AS

Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):1887-97

Johns Hopkins University - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

October, 2012
betaA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.

Sinha D, Valapala M, Bhutto I, Patek B, Zhang C, Hose S, Yang F, Cano M, Stark WJ, Lutty GA, Zigler JS, Wawrousek EF

Transgenic Res. 2012 Oct;21(5):1033-42

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

September, 2012
MITF-M, a 'melanocyte-specific' isoform, is expressed in the adult retinal pigment epithelium.

Maruotti J, Thein T, Zack DJ, Esumi N

Pigment Cell Melanoma Res. 2012 Sep;25(5):641-4

Johns Hopkins University - Departmental Grant

Keyword: Gene Research/Therapy

August, 2012
June, 2012
Co-expression of endothelial and neuronal nitric oxide synthases in the developing vasculatures of the human fetal eye.

McLeod DS, Baba T, Bhutto IA, Lutty GA

Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):839-48

Johns Hopkins University - Departmental Grant

Keywords: Other: Development, Other: Retinal Blood Vessels

Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma.

Kalesnykas G, Oglesby EN, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Quigley HA

Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3847-57

Johns Hopkins University - Departmental Grant

Keywords: Glaucoma, Retina/Retinal Diseases

April, 2012
Latent dry eye disease state variable.

Massof RW, McDonnell PJ

Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1905-16

Johns Hopkins University - Departmental Grant

Keyword: Dry Eye

March, 2012
The deletion of Math5 disrupts retinal blood vessel and glial development in mice.

Edwards MM, McLeod DS, Li R, Grebe R, Bhutto I, Mu X, Lutty GA

Exp Eye Res. 2012 Mar;96(1):147-56

Johns Hopkins University - Departmental Grant

Keywords: Other: Development, Other: Retinal Blood Vessels

VEGF 165 b in the developing vasculatures of the fetal human eye.

Baba T, McLeod DS, Edwards MM, Merges C, Sen T, Sinha D, Lutty GA

Dev Dyn. 2012 Mar;241(3):595-607

Johns Hopkins University - Departmental Grant

Keywords: Other: Development, Other: Retinal Blood Vessels

February, 2012
Notch signaling promotes growth and invasion in uveal melanoma.

Asnaghi L, Ebrahimi KB, Schreck KC, Bar EE, Coonfield ML, Bell WR, Handa J, Merbs SL, Harbour JW, Eberhart CG

Clin Cancer Res. 2012 Feb 1;18(3):654-65

Johns Hopkins University - Departmental Grant

Keywords: Gene Research/Therapy, Ocular Oncology/Pterygium

January, 2012
Beyond the definitions of the phenotypic complications of sickle cell disease: An update on management.

Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I, Wang WC, Hoppe C, Hagar W, Darbari DS, Malik P

ScientificWorldJournal. 2012;2012:949535

Johns Hopkins University - Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Sickle Cell

Cell-specific DNA methylation patterns of retina-specific genes.

Merbs SL, Khan MA, Hackler L,Jr, Oliver VF, Wan J, Qian J, Zack DJ

PLoS One. 2012;7(3):e32602

Johns Hopkins University - Departmental Grant

Keyword: Gene Research/Therapy

Dynamics of regulatory networks in the developing mouse retina.

Hwang W, Hackler L,Jr, Wu G, Ji H, Zack DJ, Qian J

PLoS One. 2012;7(10):e46521

Johns Hopkins University - Departmental Grant

Keyword: Gene Research/Therapy

Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo.

Sunshine JC, Sunshine SB, Bhutto I, Handa JT, Green JJ

PLoS One. 2012;7(5):e37543

Johns Hopkins University - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

Subscribe

Get our email updates filled with the latest news from our researchers about preventing vision loss, treating eye disease and even restoring sight. Unsubscribe at any time. Under our privacy policy, we'll never share your contact information with a third party.

Follow Us