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Research to Prevent Blindness

Research Database

Harvard Medical School Research, funded by RPB from 2010-2014 matching Departmental Grant

69 Citations, Sorted by Month and Year

December, 2014
Effects of metformin on retinoblastoma growth in vitro and in vivo.

Brodowska K, Theodoropoulou S, Meyer Zu Horste M, Paschalis EI, Takeuchi K, Scott G, Ramsey DJ, Kiernan E, Hoang M, Cichy J, Miller JW, Gragoudas ES, Vavvas DG

Int J Oncol. 2014 Dec;45(6):2311-24

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

October, 2014
A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration.

Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL

Am J Pathol. 2014 Oct;184(10):2721-9

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium.

Farkas MH, Lew DS, Sousa ME, Bujakowska K, Chatagnon J, Bhattacharya SS, Pierce EA, Nandrot EF

Am J Pathol. 2014 Oct;184(10):2641-52

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

September, 2014
Characterization of a spontaneous retinal neovascular mouse model.

Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM

PLoS One. 2014 Sep 4;9(9):e106507

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

UV cross-linking of donor corneas confers resistance to keratolysis.

Arafat SN, Robert MC, Shukla AN, Dohlman CH, Chodosh J, Ciolino JB

Cornea. 2014 Sep;33(9):955-9

Harvard Medical School - Senior Scientific Investigator Award - Chodosh, James / MD, MPH Career Development Award - Ciolino, Joseph Bowers / MD Departmental Grant

Keyword: Cornea

July, 2014
Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Other: Ocular Neovascularization

The alternative complement pathway regulates pathological angiogenesis in the retina.

Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM

FASEB J. 2014 Jul;28(7):3171-82

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2014
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG

Cell Death Dis. 2014 May 29;5:e1269

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Strain difference in photoreceptor cell death after retinal detachment in mice.

Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG

Invest Ophthalmol Vis Sci. 2014 May 22;55(7):4165-74

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

March, 2014
EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.

Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG

PLoS One. 2014 Mar 19;9(3):e91849

Harvard Medical School - Special Scholar Award - Connor, Kip M / PhD Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Diabetic Retinopathy

February, 2014
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.

Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL

Ophthalmology. 2014 Feb;121(2):508-16

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

November, 2013
Photoreceptor cell death and rescue in retinal detachment and degenerations.

Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG

Prog Retin Eye Res. 2013 Nov;37:114-40

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Macular Dystrophy, Retina/Retinal Diseases, Retinitis Pigmentosa

October, 2013
Caveolin-1 associated adenovirus entry into human corneal cells.

Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J

PLoS One. 2013 Oct 11;8(10):e77462

Harvard Medical School - Senior Scientific Investigator Award - Chodosh, James / MD, MPH Departmental Grant

Keywords: Cornea, Uveitis/Infectious Diseases

September, 2013
Retinal detachment model in rodents by subretinal injection of sodium hyaluronate.

Matsumoto H, Miller JW, Vavvas DG

J Vis Exp. 2013 Sep 11(79)

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: AMD, Retina/Retinal Diseases, Retinal Detachment

July, 2013
AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-abl and Prdx1 proteins in endothelial cells.

Takeuchi K, Morizane Y, Kamami-Levy C, Suzuki J, Kayama M, Cai W, Miller JW, Vavvas DG

J Biol Chem. 2013 Jul 12;288(28):20581-91

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Vein and Artery Occlusion

February, 2013
CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the united states.

Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL

Am J Ophthalmol. 2013 Feb;155(2):342-53.e5

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

January, 2013
Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis.

Theodoropoulou S, Brodowska K, Kayama M, Morizane Y, Miller JW, Gragoudas ES, Vavvas DG

PLoS One. 2013;8(1):e52852

Harvard Medical School - Physician-Scientist Award - Vavvas, Demetrios G / MD, PhD Departmental Grant

Keywords: Ocular Oncology/Pterygium, Pediatric

September, 2012
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration.

Murakami Y, Matsumoto H, Roh M, Suzuki J, Hisatomi T, Ikeda Y, Miller JW, Vavvas DG

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14598-603

Harvard Medical School - Departmental Grant

Keyword: Retinitis Pigmentosa

July, 2012
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.

Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE, Hawthorne F, Budenz DL, Friedman DS, Gaasterland D, Haines J, Kang JH, Lee R, Lichter P, Liu Y, Pasquale LR, Pericak-Vance M, Realini A, Schuman JS, Singh K, Vollrath D, Weinreb R, Wollstein G, Zack DJ, Zhang K, Young T, Allingham RR, Wiggs JL, Ashley-Koch A, Hauser MA

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4468-74

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

May, 2012
Evidence for baseline retinal pigment epithelium pathology in the Trp1-cre mouse.

Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG

Am J Pathol. 2012 May;180(5):1917-27

Harvard Medical School - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

April, 2012
Oral acetazolamide after boston keratoprosthesis in stevens-johnson syndrome.

Kumar R, Dohlman CH, Chodosh J

BMC Res Notes. 2012 Apr 30;5:205

Harvard Medical School - Departmental Grant

Keywords: Cornea, Glaucoma

January, 2012
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL

PLoS Genet. 2012;8(4):e1002654

Harvard Medical School - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

Complement involvement in neovascular ocular diseases.

Yanai R, Thanos A, Connor KM

Adv Exp Med Biol. 2012;946:161-83

Harvard Medical School - Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Retina/Retinal Diseases

Computational and serologic analysis of novel and known viruses in species human adenovirus D in which serology and genomics do not correlate.

Liu EB, Wadford DA, Seto J, Vu M, Hudson NR, Thrasher L, Torres S, Dyer DW, Chodosh J, Seto D, Jones MS

PLoS One. 2012;7(3):e33212

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Demographic and geographic features of exfoliation glaucoma in 2 united states-based prospective cohorts.

Kang JH, Loomis S, Wiggs JL, Stein JD, Pasquale LR

Ophthalmology. 2012 Jan;119(1):27-35

Harvard Medical School - Departmental Grant

Keywords: Epidemiology, Glaucoma

Etanercept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma.

Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, Benowitz LI, Miller JW

PLoS One. 2012;7(7):e40065

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

Five genome sequences of subspecies B1 human adenoviruses associated with acute respiratory disease.

Dehghan S, Liu EB, Seto J, Torres SF, Hudson NR, Kajon AE, Metzgar D, Dyer DW, Chodosh J, Jones MS, Seto D

J Virol. 2012 Jan;86(1):635-6

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

December, 2011
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in caucasians from the USA.

Wiggs JL, Kang JH, Yaspan BL, Mirel DB, Laurie C, Crenshaw A, Brodeur W, Gogarten S, Olson LM, Abdrabou W, DelBono E, Loomis S, Haines JL, Pasquale LR, GENEVA Consortium

Hum Mol Genet. 2011 Dec 1;20(23):4707-13

Harvard Medical School - Departmental Grant

Keywords: Genetics, Glaucoma

November, 2011
Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.

Stahl A, Krohne TU, Sapieha P, Chen J, Hellstrom A, Chew E, Holz FG, Smith LE

Br J Ophthalmol. 2011 Nov;95(11):1496-501

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

October, 2011
Wnt signaling mediates pathological vascular growth in proliferative retinopathy.

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE

Circulation. 2011 Oct 25;124(17):1871-81

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2011
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: The candidate gene association resource (CARe).

Sobrin L, Green T, Sim X, Jensen RA, Tai ES, Tay WT, Wang JJ, Mitchell P, Sandholm N, Liu Y, Hietala K, Iyengar SK, Family Investigation of Nephropathy and Diabetes-Eye Research Group, Brooks M, Buraczynska M, Van Zuydam N, Smith AV, Gudnason V, Doney AS, Morris AD, Leese GP, Palmer CN, Wellcome Trust Case Control Consortium 2, Swaroop A, Taylor HA,Jr, Wilson JG, Penman A, Chen CJ, Groop PH, Saw SM, Aung T, Klein BE, Rotter JI, Siscovick DS, Cotch MF, Klein R, Daly MJ, Wong TY

Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7593-602

Harvard Medical School - Departmental Grant

Keywords: Diabetic Retinopathy, Genetics

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA,Jr, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM

Hum Mol Genet. 2011 Sep 15;20(18):3699-709

Harvard Medical School - Departmental Grant

Keywords: AMD, Genetics

August, 2011
Effect of brimonidine on retinal blood flow autoregulation in primary open-angle glaucoma.

Feke GT, Hazin R, Grosskreutz CL, Pasquale LR

J Ocul Pharmacol Ther. 2011 Aug;27(4):347-52

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

Geographic and climatic factors associated with exfoliation syndrome.

Stein JD, Pasquale LR, Talwar N, Kim DS, Reed DM, Nan B, Kang JH, Wiggs JL, Richards JE

Arch Ophthalmol. 2011 Aug;129(8):1053-60

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

July, 2011
Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a.

Zaniolo K, Sapieha P, Shao Z, Stahl A, Zhu T, Tremblay S, Picard E, Madaan A, Blais M, Lachapelle P, Mancini J, Hardy P, Smith LE, Ong H, Chemtob S

Invest Ophthalmol Vis Sci. 2011 Jul 23;52(8):5376-86

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

June, 2011
Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: Interactions with hypertension, alcohol intake, and cigarette smoking.

Kang JH, Wiggs JL, Rosner BA, Haines J, Abdrabou W, Pasquale LR

Arch Ophthalmol. 2011 Jun;129(6):773-80

Harvard Medical School - Departmental Grant

Keywords: Genetics, Glaucoma

Genome partitioning of genetic variation for complex traits using common SNPs.

Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, Cunningham JM, de Andrade M, Feenstra B, Feingold E, Hayes MG, Hill WG, Landi MT, Alonso A, Lettre G, Lin P, Ling H, Lowe W, Mathias RA, Melbye M, Pugh E, Cornelis MC, Weir BS, Goddard ME, Visscher PM

Nat Genet. 2011 Jun;43(6):519-25

Harvard Medical School - Departmental Grant

Keywords: Genetics, Other: Epidemiology

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honore JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beausejour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P

Blood. 2011 Jun 2;117(22):6024-35

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Optic nerve involvement with panuveitis in sweet syndrome.

Lobo AM, Stacy R, Cestari D, Stone JH, Jakobiec FA, Sobrin L

Ocul Immunol Inflamm. 2011 Jun;19(3):167-70

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

The relationship between diabetes mellitus and exfoliation syndrome in a united states veterans affairs population: A case-control study.

Wood SD, Asefzadeh B, Fisch B, Jiwani A, Lee RK, Conlin PR, Pasquale LR

J Glaucoma. 2011 Jun-Jul;20(5):278-81

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

May, 2011
Female reproductive factors and primary open-angle glaucoma in the nurses' health study.

Pasquale LR, Kang JH

Eye (Lond). 2011 May;25(5):633-41

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

April, 2011
LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S.

Fan BJ, Pasquale LR, Rhee D, Li T, Haines JL, Wiggs JL

caucasian population. Invest Ophthalmol Vis Sci. 2011 Apr 12;52(5):2372-8

Harvard Medical School - Departmental Grant

Keywords: Genetics, Glaucoma

Phenotype harmonization and cross-study collaboration in GWAS consortia: The GENEVA experience.

Bennett SN, Caporaso N, Fitzpatrick AL, Agrawal A, Barnes K, Boyd HA, Cornelis MC, Hansel NN, Heiss G, Heit JA, Kang JH, Kittner SJ, Kraft P, Lowe W, Marazita ML, Monroe KR, Pasquale LR, Ramos EM, van Dam RM, Udren J, Williams K, GENEVA Consortium

Genet Epidemiol. 2011 Apr;35(3):159-73

Harvard Medical School - Departmental Grant

Keyword: Other: Epidemiology

Resveratrol inhibits pathologic retinal neovascularization in vldlr(-/-) mice.

Hua J, Guerin KI, Chen J, Michan S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE

Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2809-16

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

March, 2011
Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US caucasian population.

Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL

Invest Ophthalmol Vis Sci. 2011 Mar 28;52(3):1788-92

Harvard Medical School - Departmental Grant

Keywords: Genetics, Glaucoma

February, 2011
5-lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids.

Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE

Sci Transl Med. 2011 Feb 9;3(69):69ra12

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.

Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein PS, Souied EH, Daly MJ, Seddon JM

Am J Ophthalmol. 2011 Feb;151(2):345,52.e3

Harvard Medical School - Departmental Grant

Keywords: AMD, Genetics

January, 2011
Reproductive factors and NOS3 variant interactions in primary open-angle glaucoma.

Kang JH, Wiggs JL, Haines J, Abdrabou W, Pasquale LR

Mol Vis. 2011;17:2544-51

Harvard Medical School - Departmental Grant

Keywords: Genetics, Glaucoma

January, 2010
Acute retinal necrosis after intraocular triamcinolone acetonide injection.

Chang S, Weissgold DJ, Singer JA, Sobrin L

Retinal Cases & Brief Reports 2010;4(4):306-308

Harvard Medical School - Departmental Grant

Keyword: Uveitis/Infectious Diseases

An eye for discovery.

Stahl A, Smith LE

J Clin Invest 2010;120(9):3008-3011

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.

Raychaudhuri S, Ripke S, Li M, Neale BM, Fagerness J, Reynolds R, Sobrin L, Swaroop A, Abecasis G, Seddon JM, Daly MJ

Nat Genet 2010;42(7):553-555

Harvard Medical School - Departmental Grant

Keywords: AMD, Genetics

Calpain activation in experimental glaucoma.

Huang W, Fileta J, Rawe I, Qu J, Grosskreutz CL

Invest Ophthalmol Vis Sci 2010;51(6):3049-3054

Harvard Medical School - Departmental Grant

Keyword: Glaucoma

Feasibility of high-throughput genome-wide genotyping using DNA from stored buccal cell samples.

Loomis SJ, Olson LM, Pasquale LR, Wiggs J, Mirel D, Crenshaw A, Parkin M, Rahhal B, Tetreault S, Kraft P, Tworoger SS, Haines JL, Kang JH

Biomark Insights 2010;5:49-55

Harvard Medical School - Departmental Grant

Keyword: Gene Research/Therapy

Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: A novel analytic approach.

Sobrin L, Maller JB, Neale BM, Reynolds RC, Fagerness JA, Daly MJ, Seddon JM

Eur J Hum Genet 2010;18(4):496-501

Harvard Medical School - Departmental Grant

Keywords: AMD, Genetics

Genome-wide scan of advanced age-related macular degeneration suggests a role of the hepatic lipase gene (LIPC).

Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan P, Oh EC, Merriam JE, Souied E, Bersntein PS, Li B, Frederick JM, Zhang K, Brantley MA, Lee AY, Zack DJ, Campochiaro B. Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM

Proc Natl Acad Sci USA 2010;107(16):7395-7400

Harvard Medical School - Departmental Grant

Keywords: AMD, Genetics

Localization of vascular adhesion protein-1 (VAP-1) in the human eye.

Almuki L, Noda K, Nakao S, Hisatomi T, Thomas K, Hafezi-Moghadam A

Exper Eye Res 2010;90(1):26-32

Harvard Medical School - Departmental Grant

Keywords: Retina/Retinal Diseases, Uveitis/Infectious Diseases

Lymphangiogenesis and angiogenesis: Concurrence and/or dependence? Studies in inbred mouse strains.

Nakao S, Maruyama k, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A

FASEB J 2010;24:504-513

Harvard Medical School - Departmental Grant

Keyword: Cornea

Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy.

Hoang MV, Smith LEH, Senger DR

Angiogenesis 2010;13(3):269-277

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Mortality after diagnosis of small melanocytic lesions of the choroid.

Lane AM, Egan KM, Kim IK, Gragoudas ES

Arch Ophthalmol 2010;128(8):996-1000

Harvard Medical School - Departmental Grant

Keyword: Ocular Oncology Melanoma

Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma.

Kim IK, Lane AM, Egan KM, Munzenrider J, Gragoudas ES

Ophthalmology 2010;117(8):1617-1622

Harvard Medical School - Departmental Grant

Keywords: Ocular Oncology Melanoma, Optic Neuropathy

Postnatal weight gain modifies severity and functional outcome of oxygen-induced retinopathy.

Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LEH

American Journal of Pathology 2010;177(6):2715-2723.

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

PPARγ mediates a direct anti-angiogenic effect of ω3-PUFAs in proliferative retinopathy.

Stahl A, Sapieha P, Connor KM, SanGiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE

Circ Res 2010;107(4):495-500

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis.

Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG

Proc Natl Acad Sci USA 2010;107(50):21695-21700

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

Theodoropoulou S, Kolovou PE, Morizane Y, Kayama M, Nicolaou F, Miller JW, Gragoudas E, Ksander BR, Vavvas DG

FASEB J 2010 24:2620-2630

Harvard Medical School - Departmental Grant

Keyword: Other: Intraocular Tumors

Superior sensitivity of novel molecular imaging probe: Simultaneously targeting two types of endothelial injury markers.

Sun D, Nakao S, Xie F, Zandi S, Schering A, Hafezi-Moghadam

FASEB J 2010;24:1532-1540

Harvard Medical School - Departmental Grant

Keyword: Imaging

Survival in patients with presymptomatic diagnosis of metastatic uveal melanoma.

Kim IK, Lane AM, Gragoudas ES

Arch Ophthalmol 2010;128(7):871-875

Harvard Medical School - Departmental Grant

Keyword: Ocular Oncology Melanoma

Synaptic input of ON-Bipolar cells onto the dopaminergic neurons of the mouse retina.

Contini M, Lin B, Kobayashi K, Okano H, Masland RH, Raviola E

J Comp Neurol 2010;518:2035-2050

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

The mouse retina as an angiogenesis model.

Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, Hua J, Löfqvist C, Hellström A, Smith LE

Invest Ophthalmol Vis Sci. 2010;51(6): 2813-2826

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema.

Stahl A, Buchwald A, Martin G, Junker B, Chen J, Hansen L, Agostini H, Smith LEH, Feltgen N

Retina 2010;30(9):1524-1529

Harvard Medical School - Departmental Grant

Keyword: Retina/Retinal Diseases

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