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Research to Prevent Blindness

Research Database

University of Florida Research, funded by RPB from 2012-2014 matching Departmental Grant

113 Citations, Sorted by Month and Year

December, 2014
Flicker cone function in normal and day blind sheep: A large animal model for human achromatopsia caused by CNGA3 mutation.

Ezra-Elia R, Banin E, Honig H, Rosov A, Obolensky A, Averbukh E, Hauswirth WW, Gootwine E, Ofri R

Doc Ophthalmol. 2014 Dec;129(3):141-50

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Oral delivery of angiotensin-converting enzyme 2 and angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.

Shenoy V, Kwon KC, Rathinasabapathy A, Lin S, Jin G, Song C, Shil P, Nair A, Qi Y, Li Q, Francis J, Katovich MJ, Daniell H, Raizada MK

Hypertension. 2014 Dec;64(6):1248-59

University of Florida - Departmental Grant

Keyword: Nanotechnology/Drug Delivery

November, 2014
DICER1/Alu RNA dysmetabolism induces caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7

University of Florida - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

October, 2014
Expression and cellular localization of the mas receptor in the adult and developing mouse retina.

Prasad T, Verma A, Li Q

Mol Vis. 2014 Oct 17;20:1443-55

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR.

Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD

Cold Spring Harb Perspect Med. 2014 Oct 9;5(2):10:e017392

University of Florida - Departmental Grant

Keywords: Retinitis Pigmentosa, Gene Research/Therapy, Retina/Retinal Diseases

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

Ramamurthy V, Jolicoeur C, Koutroumbas D, Muhlhans J, Le YZ, Hauswirth WW, Giessl A, Cayouette M

J Neurosci. 2014 Oct 15;34(42):13976-87

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2014
In vivo knockdown of piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses.

Regus-Leidig H, Fuchs M, Lohner M, Leist SR, Leal-Ortiz S, Chiodo VA, Hauswirth WW, Garner CC, Brandstatter JH

Front Cell Neurosci. 2014 Sep 3;8:259

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Leber congenital amaurosis caused by mutations in GUCY2D.

Boye SE

Cold Spring Harb Perspect Med. 2014 Sep 25;5(1):a017350

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Opsin expression in limulus eyes: A UV opsin is expressed in each eye type and co-expressed with a visible light-sensitive opsin in ventral larval eyes.

Battelle BA, Kempler KE, Harrison A, Dugger DR, Payne R

J Exp Biol. 2014 Sep 1;217(Pt 17):3133-45

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2014
Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas.

Sriram S, Gibson DJ, Robinson P, Pi L, Tuli S, Lewin AS, Schultz G

Exp Eye Res. 2014 Aug;125:173-82

University of Florida - Departmental Grant

Keywords: Cornea, Gene Research/Therapy

Retinal gene therapy using adeno-associated viral vectors: Multiple applications for a small virus.

Hauswirth WW

Hum Gene Ther. 2014 Aug;25(8):671-8

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

July, 2014
Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.

Talla V, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Guy J

Invest Ophthalmol Vis Sci. 2014 Jul 11;55(8):5214-26

University of Florida - Departmental Grant

Keywords: Optic Neuropathy, Gene Research/Therapy

June, 2014
Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

Batenburg WW, Verma A, Wang Y, Zhu P, van den Heuvel M, van Veghel R, Danser AH, Li Q

PLoS One. 2014 Jun 26;9(6):e100954

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Gene therapy: Charting a future course--summary of a national institutes of health workshop, april 12, 2013.

O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J

Hum Gene Ther. 2014 Jun;25(6):488-97

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Genetically targeted binary labeling of retinal neurons.

Zhu Y, Xu J, Hauswirth WW, DeVries SH

J Neurosci. 2014 Jun 4;34(23):7845-61

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.

Ha JH, Shil PK, Zhu P, Gu L, Li Q, Chung S

J Nutr. 2014 Jun;144(6):799-806

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2014
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.

Qiu Y, Shil PK, Zhu P, Yang H, Verma A, Lei B, Li Q

Invest Ophthalmol Vis Sci. 2014 May 22;55(6):3809-18

University of Florida - Departmental Grant

Keywords: Uveitis/Infectious Diseases, Nanotechnology/Drug Delivery

Insights gained from gene therapy in animal models of retGC1 deficiency.

Boye SE

Front Mol Neurosci. 2014 May 14;7:43

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study.

Furlanetto RL, De Moraes CG, Teng CC, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T, Low-Pressure Glaucoma Treatment Study Group

Am J Ophthalmol. 2014 May;157(5):945-52

University of Florida - Departmental Grant

Keyword: Glaucoma

April, 2014
Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis.

Yang H, Zheng S, Qiu Y, Yang Y, Wang C, Yang P, Li Q, Lei B

Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A.

Dyka FM, Boye SL, Chiodo VA, Hauswirth WW, Boye SE

Hum Gene Ther Methods. 2014 Apr;25(2):166-77

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.

Wilson AM, Chiodo VA, Boye SL, Brecha NC, Hauswirth WW, Di Polo A

PLoS One. 2014 Apr 8;9(4):e94175

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

Probable association of an attack of bilateral acute angle-closure glaucoma with duloxetine.

Shifera AS, Leoncavallo A, Sherwood M

Ann Pharmacother. 2014 Apr 14;48(7):936-9

University of Florida - Departmental Grant

Keyword: Glaucoma

Safety and effects of the vector for the leber hereditary optic neuropathy gene therapy clinical trial.

Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J

JAMA Ophthalmol. 2014 Apr 1;132(4):409-20

University of Florida - Departmental Grant

Keywords: Optic Neuropathy, Gene Research/Therapy

March, 2014
AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice.

Dai X, Han J, Qi Y, Zhang H, Xiang L, Lv J, Li J, Deng WT, Chang B, Hauswirth WW, Pang JJ

Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1724-34

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Natural history of cone disease in the murine model of leber congenital amaurosis due to CEP290 mutation: Determining the timing and expectation of therapy.

Boye SE, Huang WC, Roman AJ, Sumaroka A, Boye SL, Ryals RC, Olivares MB, Ruan Q, Tucker BA, Stone EM, Swaroop A, Cideciyan AV, Hauswirth WW, Jacobson SG

PLoS One. 2014 Mar 26;9(3):e92928

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.

Kohli N, Westerveld DR, Ayache AC, Verma A, Shil P, Prasad T, Zhu P, Chan SL, Li Q, Daniell H

Mol Ther. 2014 Mar;22(3):535-46

University of Florida - Departmental Grant

Keywords: Nanotechnology/Drug Delivery, Retina/Retinal Diseases

February, 2014
Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study).

Netland PA, Sarkisian SR,Jr, Moster MR, Ahmed II, Condon G, Salim S, Sherwood MB, Siegfried CJ

Am J Ophthalmol. 2014 Feb;157(2):433,440.e3

University of Florida - Departmental Grant

Keyword: Glaucoma

January, 2014
Cone specific promoter for use in gene therapy of retinal degenerative diseases.

Dyka FM, Boye SL, Ryals RC, Chiodo VA, Boye SE, Hauswirth WW

Adv Exp Med Biol. 2014;801:695-701

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Investigating the role of retinal muller cells with approaches in genetics and cell biology.

Fu S, Zhu M, Ash JD, Wang Y, Le YZ

Adv Exp Med Biol. 2014;801:401-5

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Scleritis caused by in vitro linezolid-resistant nocardia asteroides.

Gonzalez A, Fakhar K, Gubernick D, Tuli S

Case Rep Ophthalmol Med. 2014;2014:326957

University of Florida - Departmental Grant

Keyword: Cornea

Spectral domain optical coherence tomography findings in CNGB3-associated achromatopsia and therapeutic implications.

McClintock M, Peden MC, Kay CN

Adv Exp Med Biol. 2014;801:551-7

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors.

de Leeuw CN, Dyka FM, Boye SL, Laprise S, Zhou M, Chou AY, Borretta L, McInerny SC, Banks KG, Portales-Casamar E, Swanson MI, D'Souza CA, Boye SE, Jones SJ, Holt RA, Goldowitz D, Hauswirth WW, Wasserman WW, Simpson EM

Mol Ther Methods Clin Dev. 2014 Jan 8;1:5

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach.

Mowat FM, Gornik KR, Dinculescu A, Boye SL, Hauswirth WW, Petersen-Jones SM, Bartoe JT

Gene Ther. 2014 Jan;21(1):96-105

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Very long chain polyunsaturated fatty acids and rod cell structure and function.

Marchette LD, Sherry DM, Brush RS, Chan M, Wen Y, Wang J, Ash JD, Anderson RE, Mandal NA

Adv Exp Med Biol. 2014;801:637-45

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

December, 2013
Light-dependent phosphorylation of bardet-biedl syndrome 5 in photoreceptor cells modulates its interaction with arrestin1.

Smith TS, Spitzbarth B, Li J, Dugger DR, Stern-Schneider G, Sehn E, Bolch SN, McDowell JH, Tipton J, Wolfrum U, Smith WC

Cell Mol Life Sci. 2013 Dec;70(23):4603-16

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

October, 2013
Influence of eye size and beam entry angle on dose to non-targeted tissues of the eye during stereotactic x-ray radiosurgery of AMD.

Cantley JL, Hanlon J, Chell E, Lee C, Smith WC, Bolch WE

Phys Med Biol. 2013 Oct 7;58(19):6887-96

University of Florida - Departmental Grant

Keywords: AMD, Glaucoma

NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS.

Talla V, Yu H, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J

Mol Ther. 2013 Oct;21(10):1876-88

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of leber congenital amaurosis 12.

Molday LL, Djajadi H, Yan P, Szczygiel L, Boye SL, Chiodo VA, Gregory-Evans K, Sarunic MV, Hauswirth WW, Molday RS

Hum Mol Genet. 2013 Oct 1;22(19):3894-905

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: Analysis of serotype-dependent retinal effects.

Guziewicz KE, Zangerl B, Komaromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD

PLoS One. 2013 Oct 15;8(10):e75666

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

August, 2013
A rare cause of blindness.

Parker JJ, Svingos RS, Reeder DN, Grieser E

J Emerg Med. 2013 Aug;45(2):e27-30

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus.

Lopes VS, Boye SE, Louie CM, Boye S, Dyka F, Chiodo V, Fofo H, Hauswirth WW, Williams DS

Gene Ther. 2013 Aug;20(8):824-33

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

July, 2013
Cone phosphodiesterase-6alpha' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6beta-deficient rd10 mouse.

Deng WT, Sakurai K, Kolandaivelu S, Kolesnikov AV, Dinculescu A, Li J, Zhu P, Liu X, Pang J, Chiodo VA, Boye SL, Chang B, Ramamurthy V, Kefalov VJ, Hauswirth WW

J Neurosci. 2013 Jul 17;33(29):11745-53

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Formation of lipofuscin-like material in the RPE cell by different components of rod outer segments.

Lei L, Tzekov R, McDowell JH, Smith WC, Tang S, Kaushal S

Exp Eye Res. 2013 Jul;112:57-67

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid.

Bhalla S, Joshi D, Bhullar S, Kasuga D, Park Y, Kay CN

Br J Ophthalmol. 2013 Jul;97(7):895-9

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.

Yu H, Mehta A, Wang G, Hauswirth WW, Chiodo V, Boye SL, Guy J

Mol Vis. 2013 Jul 14;19:1482-91

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

Pain and decreased vision in a teenager.

Tuli SY, Kelly M, Giordano B, Fillipps DJ, Tuli SS

J Pediatr Health Care. 2013 Jul-Aug;27(4):304-7

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Retinal pigment epithelial detachment in ABCA4-associated stargardt's disease.

Cohen J, Bhullar S, Kasuga D, Boye S, Elhalis H, Kay CN

Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug;44(4):401-4

University of Florida - Departmental Grant

Keywords: Retinal Detachment, Retina/Retinal Diseases

The progression of haze formation in rabbit corneas following phototherapeutic keratectomy.

Gibson DJ, Tuli SS, Schultz GS

Invest Ophthalmol Vis Sci. 2013 Jul 16;54(7):4776-81

University of Florida - Departmental Grant

Keyword: Cornea

June, 2013
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.

Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murca TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C, Raizada MK

Hypertension. 2013 Jun;61(6):1328-33

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.

Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK

Elife. 2013 Jun 18;2:e00324

University of Florida - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.

Watson RS, Broome TA, Levings PP, Rice BL, Kay JD, Smith AD, Gouze E, Gouze JN, Dacanay EA, Hauswirth WW, Nickerson DM, Dark MJ, Colahan PT, Ghivizzani SC

Gene Ther. 2013 Jun;20(6):670-7

University of Florida - Departmental Grant

Keyword: Gene Research/Therapy

Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia.

Komaromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD

Mol Ther. 2013 Jun;21(6):1131-41

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

May, 2013
Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.

Ruan Q, Xi L, Boye SL, Han S, Chen ZJ, Hauswirth WW, Lewin AS, Boulton ME, Law BK, Jiang WG, Jiang H, Cai J

Cancer Lett. 2013 May 10;332(1):120-9

University of Florida - Departmental Grant

Keywords: Diabetic Retinopathy, Gene Research/Therapy

April, 2013
Elimination of infusion bubbles and uncontrolled reflux in the alcon constellation vitrectomy vision system.

Russell SR, Sohn EH, Boldt HC, Folk JC, Tarantola RM, Kay CN, Mahajan VB

Retina. 2013 Apr;33(4):803-6

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.

Weitz AC, Behrend MR, Lee NS, Klein RL, Chiodo VA, Hauswirth WW, Humayun MS, Weiland JD, Chow RH

J Neurophysiol. 2013 Apr;109(7):1979-88

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Imaging

Reactivation of herpes zoster keratitis in an adult after varicella zoster vaccination.

Hwang CW,Jr, Steigleman WA, Saucedo-Sanchez E, Tuli SS

Cornea. 2013 Apr;32(4):508-9

University of Florida - Departmental Grant

Keyword: Cornea

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

Kay CN, Ryals RC, Aslanidi GV, Min SH, Ruan Q, Sun J, Dyka FM, Kasuga D, Ayala AE, Van Vliet K, Agbandje-McKenna M, Hauswirth WW, Boye SL, Boye SE

PLoS One. 2013 Apr 26;8(4):e62097

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

March, 2013
A comprehensive review of retinal gene therapy.

Boye SE, Boye SL, Lewin AS, Hauswirth WW

Mol Ther. 2013 Mar;21(3):509-19

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L,Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50

University of Florida - Departmental Grant

Keyword: Glaucoma

Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.

Hazra S, Jarajapu YP, Stepps V, Caballero S, Thinschmidt JS, Sautina L, Bengtsson N, Licalzi S, Dominguez J, Kern TS, Segal MS, Ash JD, Saban DR, Bartelmez SH, Grant MB

Diabetologia. 2013 Mar;56(3):644-53

University of Florida - Departmental Grant

Keywords: Diabetic Retinopathy, Stem Cell Research/Therapy

Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-kappaB-cytokine signaling in the spontaneously hypertensive rat.

Zubcevic J, Jun JY, Lamont G, Murca TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z

Hypertension. 2013 Mar;61(3):622-7

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa.

Conlon TJ, Deng WT, Erger K, Cossette T, Pang JJ, Ryals R, Clement N, Cleaver B, McDoom I, Boye SE, Peden MC, Sherwood MB, Abernathy CR, Alkuraya FS, Boye SL, Hauswirth WW

Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

February, 2013
AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of leber congenital amaurosis.

Boye SL, Peshenko IV, Huang WC, Min SH, McDoom I, Kay CN, Liu X, Dyka FM, Foster TC, Umino Y, Karan S, Jacobson SG, Baehr W, Dizhoor A, Hauswirth WW, Boye SE

Hum Gene Ther. 2013 Feb;24(2):189-202

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Effective arrestin-specific immunotherapy of experimental autoimmune uveitis with RTL: A prospect for treatment of human uveitis.

Kyger M, Worley A, Huan J, McDowell H, Smith WC, Burrows GG, Mattapallil MJ, Caspi RR, Adamus G

Transl Vis Sci Technol. 2013 Feb;2(2):1

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Human retinal gene therapy for leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.

Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komaromy AM, Hauswirth WW, Aguirre GD

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E517-25

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (sonepcizumab) in a rabbit model.

Lukowski ZL, Min J, Beattie AR, Meyers CA, Levine MA, Stoller G, Schultz GS, Samuelson DA, Sherwood MB

J Glaucoma. 2013 Feb;22(2):145-51

University of Florida - Departmental Grant

Keyword: Glaucoma

January, 2013
Comparison of the transduction efficiency of tyrosine-mutant adeno-associated virus serotype vectors in kidney.

Qi YF, Li QH, Shenoy V, Zingler M, Jun JY, Verma A, Katovich MJ, Raizada MK

Clin Exp Pharmacol Physiol. 2013 Jan;40(1):53-5

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

Bramall AN, Szego MJ, Pacione LR, Chang I, Diez E, D'Orleans-Juste P, Stewart DJ, Hauswirth WW, Yanagisawa M, McInnes RR

PLoS One. 2013;8(2):e58023

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs.

Bruewer AR, Mowat FM, Bartoe JT, Boye SL, Hauswirth WW, Petersen-Jones SM

PLoS One. 2013;8(4):e60218

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Newborn with an absent red reflex.

Tuli SY, Giordano BP, Kelly M, Fillipps D, Tuli SS

J Pediatr Health Care. 2013 Jan;27(1):51-5

University of Florida - Departmental Grant

Keyword: Cataract

RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model.

Jiang L, Li TZ, Boye SE, Hauswirth WW, Frederick JM, Baehr W

PLoS One. 2013;8(3):e57676

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

November, 2012
Comparison of single versus multiple injections of the protein saratin for prolonging bleb survival in a rabbit model.

Min J, Lukowski ZL, Levine MA, Meyers CA, Beattie AR, Schultz GS, Samuelson DA, Sherwood MB

Invest Ophthalmol Vis Sci. 2012 Nov 19;53(12):7625-30

University of Florida - Departmental Grant

Keyword: Glaucoma

Wound modulation after filtration surgery.

Seibold LK, Sherwood MB, Kahook MY

Surv Ophthalmol. 2012 Nov;57(6):530-50

University of Florida - Departmental Grant

Keyword: Glaucoma

October, 2012
A multicenter analysis of the ophthalmic knowledge assessment program and american board of ophthalmology written qualifying examination performance.

Lee AG, Oetting TA, Blomquist PH, Bradford G, Culican SM, Kloek C, Krishnan C, Lauer AK, Levi L, Naseri A, Rubin SE, Scott IU, Tao J, Tuli S, Wright MM, Wudunn D, Zimmerman MB

Ophthalmology. 2012 Oct;119(10):1949-53

University of Florida - Departmental Grant

Keyword: Other: Resident Training

Morning glory disc anomaly and optic nerve coloboma.

Knape RM, Motamarry SP, Clark CL,3rd, Bohsali KI, Khuddus N

Clin Pediatr (Phila). 2012 Oct;51(10):991-3

University of Florida - Departmental Grant

Keyword: Pediatric

Regenerative medicine for the special senses: Restoring the inputs.

Bermingham-McDonogh O, Corwin JT, Hauswirth WW, Heller S, Reed R, Reh TA

J Neurosci. 2012 Oct 10;32(41):14053-7

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.

Boye SE, Alexander JJ, Boye SL, Witherspoon CD, Sandefer KJ, Conlon TJ, Erger K, Sun J, Ryals R, Chiodo VA, Clark ME, Girkin CA, Hauswirth WW, Gamlin PD

Hum Gene Ther. 2012 Oct;23(10):1101-15

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

September, 2012
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.

Chollangi S, Mather T, Rodgers KK, Ash JD

J Biol Chem. 2012 Sep 21;287(39):32848-59

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy.

Yellowlees Douglas J, Bhatwadekar AD, Li Calzi S, Shaw LC, Carnegie D, Caballero S, Li Q, Stitt AW, Raizada MK, Grant MB

Prog Retin Eye Res. 2012 Sep;31(5):481-94

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Organizational motifs for ground squirrel cone bipolar cells.

Light AC, Zhu Y, Shi J, Saszik S, Lindstrom S, Davidson L, Li X, Chiodo VA, Hauswirth WW, Li W, DeVries SH

J Comp Neurol. 2012 Sep 1;520(13):2864-87

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2012
A 6-year-old girl with restricted upward gaze of her right eye.

Tuli S, Tuli S

Pediatr Rev. 2012 Aug;33(8):e53-6

University of Florida - Departmental Grant

Keyword: Pediatric

CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators.

Pi L, Shenoy AK, Liu J, Kim S, Nelson N, Xia H, Hauswirth WW, Petersen BE, Schultz GS, Scott EW

FASEB J. 2012 Aug;26(8):3365-79

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

ERK1/2 activation is a therapeutic target in age-related macular degeneration.

Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6

University of Florida - Departmental Grant

Keywords: AMD, Gene Research/Therapy, Retina/Retinal Diseases

July, 2012
Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.

Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD

J Biol Chem. 2012 Jul 13;287(29):24092-102

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Microcephaly, lymphedema, chorioretinal dysplasia (MLCRD) syndrome.

Kelly MN, Khuddus N, Motamarry S, Tuli S

J Pediatr Health Care. 2012 Jul-Aug;26(4):306-11

University of Florida - Departmental Grant

Keyword: Pediatric

June, 2012
A connective tissue growth factor signaling receptor in corneal fibroblasts.

Blalock TD, Gibson DJ, Duncan MR, Tuli SS, Grotendorst GR, Schultz GS

Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3387-94

University of Florida - Departmental Grant

Keyword: Cornea

ER stress is involved in T17M rhodopsin-induced retinal degeneration.

Kunte MM, Choudhury S, Manheim JF, Shinde VM, Miura M, Chiodo VA, Hauswirth WW, Gorbatyuk OS, Gorbatyuk MS

Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3792-800

University of Florida - Departmental Grant

Keywords: Retina/Retinal Diseases, Retinitis Pigmentosa

May, 2012
DICER1 loss and alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Nunez G, Baffi JZ, Kleinman ME, Ambati J

Cell. 2012 May 11;149(4):847-59

University of Florida - Departmental Grant

Keywords: AMD, Retina/Retinal Diseases

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses leber's hereditary optic neuropathy in a mouse model.

Yu H, Koilkonda RD, Chou TH, Porciatti V, Ozdemir SS, Chiodo V, Boye SL, Boye SE, Hauswirth WW, Lewin AS, Guy J

Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1238-47

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment.

Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH

J Biol Chem. 2012 May 11;287(20):16424-34

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2012
Gene therapy for retinitis pigmentosa caused by MFRP mutations: Human phenotype and preliminary proof of concept.

Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG

Hum Gene Ther. 2012 Apr;23(4):367-76

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases, Retinitis Pigmentosa

Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice.

Mao H, Gorbatyuk MS, Rossmiller B, Hauswirth WW, Lewin AS

Hum Gene Ther. 2012 Apr;23(4):356-66

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases, Retinitis Pigmentosa

Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

Deng WT, Dinculescu A, Li Q, Boye SL, Li J, Gorbatyuk MS, Pang J, Chiodo VA, Matthes MT, Yasumura D, Liu L, Alkuraya FS, Zhang K, Vollrath D, LaVail MM, Hauswirth WW

Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1895-904

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

March, 2012
Blepharoptosis: Assessment and management.

Tuli SY, Kelly M, Giordano B, Fillipps DJ, Tuli SS

J Pediatr Health Care. 2012 Mar;26(2):149-54

University of Florida - Departmental Grant

Keywords: Pediatric, Plastic Surgery

Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane.

Wang H, Murphy R, Taaffe D, Yin S, Xia L, Hauswirth WW, Bance M, Robertson GS, Wang J

Gene Ther. 2012 Mar;19(3):255-63

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

The tube versus trabeculectomy study: Interpretation of results and application to clinical practice.

Gedde SJ, Singh K, Schiffman JC, Feuer WJ, Tube Versus Trabeculectomy Study Group

Curr Opin Ophthalmol. 2012 Mar;23(2):118-26

University of Florida - Departmental Grant

Keyword: Glaucoma

Three-dimensional distribution of the vitelliform lesion, photoreceptors, and retinal pigment epithelium in the macula of patients with best vitelliform macular dystrophy.

Kay CN, Abramoff MD, Mullins RF, Kinnick TR, Lee K, Eyestone ME, Chung MM, Sohn EH, Stone EM

Arch Ophthalmol. 2012 Mar;130(3):357-64

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2012
AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice.

Tuo J, Pang JJ, Cao X, Shen D, Zhang J, Scaria A, Wadsworth SC, Pechan P, Boye SL, Hauswirth WW, Chan CC

Neurobiol Aging. 2012 Feb;33(2):433.e1-10

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Gamma-secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.

Qi X, Cai J, Ruan Q, Liu L, Boye SL, Chen Z, Hauswirth WW, Ryals RC, Shaw L, Caballero S, Grant MB, Boulton ME

Invest Ophthalmol Vis Sci. 2012 Feb 1;53(2):574-85

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.

Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Roman AJ, Deng WT, Swider M, Aleman TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2132-7

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases, Retinitis Pigmentosa

January, 2012
AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.

Pang JJ, Deng WT, Dai X, Lei B, Everhart D, Umino Y, Li J, Zhang K, Mao S, Boye SL, Liu L, Chiodo VA, Liu X, Shi W, Tao Y, Chang B, Hauswirth WW

PLoS One. 2012;7(4):e35250

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

ACE2 and ang-(1-7) confer protection against development of diabetic retinopathy.

Verma A, Shan Z, Lei B, Yuan L, Liu X, Nakagawa T, Grant MB, Lewin AS, Hauswirth WW, Raizada MK, Li Q

Mol Ther. 2012 Jan;20(1):28-36

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Caspase inhibition with XIAP as an adjunct to AAV vector gene-replacement therapy: Improving efficacy and prolonging the treatment window.

Yao J, Jia L, Khan N, Zheng QD, Moncrief A, Hauswirth WW, Thompson DA, Zacks DN

PLoS One. 2012;7(5):e37197

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Functional rescue of P23H rhodopsin photoreceptors by gene delivery.

Gorbatyuk MS, Gorbatyuk OS, LaVail MM, Lin JH, Hauswirth WW, Lewin AS

Adv Exp Med Biol. 2012;723:191-7

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases, Retinitis Pigmentosa

Gene delivery of wild-type rhodopsin rescues retinal function in an autosomal dominant retinitis pigmentosa mouse model.

Mao H, Gorbatyuk MS, Hauswirth WW, Lewin AS

Adv Exp Med Biol. 2012;723:199-205

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases, Retinitis Pigmentosa

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: Safety and efficacy in 15 children and adults followed up to 3 years.

Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW

Arch Ophthalmol. 2012 Jan;130(1):9-24

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury.

Qi Y, Li H, Shenoy V, Li Q, Wong F, Zhang L, Raizada MK, Sumners C, Katovich MJ

Exp Physiol. 2012 Jan;97(1):89-101

University of Florida - Departmental Grant

Keyword: Diabetic Retinopathy

Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.

Yu H, Ozdemir SS, Koilkonda RD, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J

Mol Vis. 2012;18:1668-83

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Optic Neuropathy

Orbital aspergillosis: Voriconazole - the new standard treatment?

Ohlstein DH, Hooten C, Perez J, Clark CL,3rd, Samy H

Case Report Ophthalmol. 2012 Jan;3(1):46-53

University of Florida - Departmental Grant

Keyword: Uveitis/Infectious Diseases

Prevention of ocular scarring post glaucoma filtration surgery using the inflammatory cell and platelet binding modulator saratin in a rabbit model.

Min J, Lukowski ZL, Levine MA, Meyers CA, Beattie AR, Schultz GS, Samuelson DA, Sherwood MB

PLoS One. 2012;7(4):e35627

University of Florida - Departmental Grant

Keyword: Glaucoma

Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector.

Petrs-Silva H, Yasumura D, Matthes MT, LaVail MM, Lewin AS, Hauswirth WW

Adv Exp Med Biol. 2012;723:215-23

University of Florida - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

The 5HT1a receptor agonist 8-oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium.

Thampi P, Rao HV, Mitter SK, Cai J, Mao H, Li H, Seo S, Qi X, Lewin AS, Romano C, Boulton ME

PLoS One. 2012;7(4):e34468

University of Florida - Departmental Grant

Keyword: Retina/Retinal Diseases

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