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Research to Prevent Blindness

Research Database

Columbia University Research, funded by RPB from 2012-2014 matching Departmental Grant

94 Citations, Sorted by Month and Year

November, 2014
New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.

Xie YA, Lee W, Cai C, Gambin T, Noupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R

Hum Mol Genet. 2014 Nov 1;23(21):5774-80

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

October, 2014
Genetic and clinical analysis of ABCA4-associated disease in african american patients.

Zernant J, Collison FT, Lee W, Fishman GA, Noupuu K, Yuan B, Cai C, Lupski JR, Yannuzzi LA, Tsang SH, Allikmets R

Hum Mutat. 2014 Oct;35(10):1187-94

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.

Cai Z, Grobe K, Zhang X

Dev Dyn. 2014 Oct;243(10):1310-6

Columbia University - Stein Professorship - Zhang, Xin / PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

Structural and genetic assessment of the ABCA4-associated optical gap phenotype.

Noupuu K, Lee W, Zernant J, Tsang SH, Allikmets R

Invest Ophthalmol Vis Sci. 2014 Oct 9;55(11):7217-26

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

September, 2014
A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.

Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ

Cell. 2014 Sep 25;159(1):200-14

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway.

Ma W, Paik DC, Barile GR

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6187-93

Columbia University - Departmental Grant

Keyword: Cornea

Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa.

Park SP, Lee W, Bae EJ, Greenstein V, Sin BH, Chang S, Tsang SH

Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct;45(5):469-73

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects.

Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH

Mol Ther. 2014 Sep;22(9):1688-97

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retinitis Pigmentosa

Late recurrence of myopic foveoschisis after successful repair with primary vitrectomy and incomplete membrane peeling.

Sepulveda G, Chang S, Freund KB, Park S, Hoang QV

Retina. 2014 Sep;34(9):1841-7

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Departmental Grant

Keyword: Myopia/Presbyopia

Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.

Collison FT, Fishman GA, McAnany JJ, Zernant J, Allikmets R

Retina. 2014 Sep;34(9):1888-95

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Whole exome sequencing identifies CRB1 defect in an unusual maculopathy phenotype.

Tsang SH, Burke T, Oll M, Yzer S, Lee W, Xie YA, Allikmets R

Ophthalmology. 2014 Sep;121(9):1773-82

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

August, 2014
Acoustic radiation force for noninvasive evaluation of corneal biomechanical changes induced by cross-linking therapy.

Urs R, Lloyd HO, Silverman RH

J Ultrasound Med. 2014 Aug;33(8):1417-26

Columbia University - Departmental Grant

Keyword: Cornea

The external limiting membrane in early-onset stargardt disease.

Lee W, Noupuu K, Oll M, Duncker T, Burke T, Zernant J, Bearelly S, Tsang SH, Sparrow JR, Allikmets R

Invest Ophthalmol Vis Sci. 2014 Aug 19;55(10):6139-49

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

July, 2014
Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.

Schubert C, Pryds A, Zeng S, Xie Y, Freund KB, Spaide RF, Merriam JC, Barbazetto I, Slakter JS, Chang S, Munch IC, Drack AV, Hernandez J, Yzer S, Merriam JE, Linneberg A, Larsen M, Yannuzzi LA, Mullins RF, Allikmets R

Hum Mutat. 2014 Jul;35(7):859-67

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Choroidal and retinal thickening in severe preeclampsia.

Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W, Allikmets R, Bearelly S

Invest Ophthalmol Vis Sci. 2014 Jul 29;55(9):5723-9

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Fundus autofluorescence and photoreceptor cell rosettes in mouse models.

Flynn E, Ueda K, Auran E, Sullivan JM, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Jul 11;55(9):5643-52

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

The value of retinal imaging with infrared scanning laser ophthalmoscopy in patients with stargardt disease.

Chun R, Fishman GA, Collison FT, Stone EM, Zernant J, Allikmets R

Retina. 2014 Jul;34(7):1391-9

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.

Yang J, Li Y, Chan L, Tsai YT, Wu WH, Nguyen HV, Hsu CW, Li X, Brown LM, Egli D, Sparrow JR, Tsang SH

Hum Mol Genet. 2014 Jul 1;23(13):3445-55

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: AMD

Vitamin A dimers trigger the protracted death of retinal pigment epithelium cells.

Mihai DM, Washington I

Cell Death Dis. 2014 Jul 24;5:e1348

Columbia University - Departmental Grant

Keyword: AMD

June, 2014
Notch signaling functions in lymphatic valve formation.

Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J

Development. 2014 Jun;141(12):2446-51

Columbia University - Departmental Grant

Keyword: Cornea

May, 2014
Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina.

Wert KJ, Skeie JM, Bassuk AG, Olivier AK, Tsang SH, Mahajan VB

Hum Mol Genet. 2014 May 15;23(10):2665-77

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

Quantitative fundus autofluorescence in recessive stargardt disease.

Burke TR, Duncker T, Woods RL, Greenberg JP, Zernant J, Tsang SH, Smith RT, Allikmets R, Sparrow JR, Delori FC

Invest Ophthalmol Vis Sci. 2014 May 1;55(5):2841-52

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

The photosynthetic eukaryote nannochloris eukaryotum as an intracellular machine to control and expand functionality of human cells.

Black CK, Mihai DM, Washington I

Nano Lett. 2014 May 14;14(5):2720-5

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

April, 2014
Generalized choriocapillaris dystrophy, a distinct phenotype in the spectrum of ABCA4-associated retinopathies.

Bertelsen M, Zernant J, Larsen M, Duno M, Allikmets R, Rosenberg T

Invest Ophthalmol Vis Sci. 2014 Apr 29;55(4):2766-76

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Pharmacologic alternatives to riboflavin photochemical corneal cross-linking: A comparison study of cell toxicity thresholds.

Kim M, Takaoka A, Hoang QV, Trokel SL, Paik DC

Invest Ophthalmol Vis Sci. 2014 Apr 10;55(5):3247-57

Columbia University - Career Development Award - Hoang, Quan V / MD, PhD Departmental Grant

Keyword: Cornea

Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia.

Greenberg JP, Sherman J, Zweifel SA, Chen RW, Duncker T, Kohl S, Baumann B, Wissinger B, Yannuzzi LA, Tsang SH

JAMA Ophthalmol. 2014 Apr 1;132(4):437-45

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

March, 2014
Aliphatic beta-nitroalcohols for therapeutic corneoscleral cross-linking: Chemical stability studies using 1H-NMR spectroscopy.

Li X, Li Y, Kim M, Trokel SL, Turro NJ, Paik DC

Photochem Photobiol. 2014 Mar-Apr;90(2):338-43

Columbia University - Departmental Grant

Keyword: Cornea

Epithelial remodeling as basis for machine-based identification of keratoconus.

Silverman RH, Urs R, Roychoudhury A, Archer TJ, Gobbe M, Reinstein DZ

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1580-7

Columbia University - Departmental Grant

Keyword: Cornea

Fine central macular dots associated with childhood-onset stargardt disease.

Fujinami K, Singh R, Carroll J, Zernant J, Allikmets R, Michaelides M, Moore AT

Acta Ophthalmol. 2014 Mar;92(2):e157-9

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Generation of induced pluripotent stem cells from conjunctiva.

Yang J, Li Y, Erol D, Wu WH, Tsai YT, Li XR, Davis RJ, Tsang SH

Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):423-31

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Stem Cell Research/Therapy

Light damage in Abca4 and Rpe65rd12 mice.

Wu L, Ueda K, Nagasaki T, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):1910-8

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.

Hertzler-Schaefer K, Mathew G, Somani AK, Tholpady S, Kadakia MP, Chen Y, Spandau DF, Zhang X

Cell Rep. 2014 Mar 13;6(5):818-26

Columbia University - Stein Professorship - Zhang, Xin / PhD Departmental Grant

Keyword: Ocular Oncology/Pterygium

Quantitative fundus autofluorescence and optical coherence tomography in best vitelliform macular dystrophy.

Duncker T, Greenberg JP, Ramachandran R, Hood DC, Smith RT, Hirose T, Woods RL, Tsang SH, Delori FC, Sparrow JR

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1471-82

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Retina/Retinal Diseases

February, 2014
Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene.

Nong E, Lee W, Merriam JE, Allikmets R, Tsang SH

Doc Ophthalmol. 2014 Feb;128(1):59-67

Columbia University - Physician-Scientist Award - Tsang, Stephen / MD, PhD Departmental Grant

Keyword: Gene Research/Therapy

From mechanosensitivity to inflammatory responses: New players in the pathology of glaucoma.

Krizaj D, Ryskamp DA, Tian N, Tezel G, Mitchell CH, Slepak VZ, Shestopalov VI

Curr Eye Res. 2014 Feb;39(2):105-19

Columbia University - Departmental Grant

Keyword: Glaucoma

January, 2014
Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP.

Xu C, Zhang J, Mihai DM, Washington I

J Cell Sci. 2014 Jan 15;127(Pt 2):388-99

Columbia University - Departmental Grant

Keyword: Stem Cell Research/Therapy

November, 2013
Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells.

van der Burght BW, Hansen M, Olsen J, Zhou J, Wu Y, Nissen MH, Sparrow JR

Acta Ophthalmol. 2013 Nov;91(7):e537-45

Columbia University - Departmental Grant

Keyword: Macular Dystrophy

Outcome of ABCA4 disease-associated alleles in autosomal recessive retinal dystrophies: Retrospective analysis in 420 spanish families.

Riveiro-Alvarez R, Lopez-Martinez MA, Zernant J, Aguirre-Lamban J, Cantalapiedra D, Avila-Fernandez A, Gimenez A, Lopez-Molina MI, Garcia-Sandoval B, Blanco-Kelly F, Corton M, Tatu S, Fernandez-San Jose P, Trujillo-Tiebas MJ, Ramos C, Allikmets R, Ayuso C

Ophthalmology. 2013 Nov;120(11):2332-7

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

October, 2013
ABCA4 gene screening by next-generation sequencing in a british cohort.

Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K, Webster AR, Moore AT, Allikmets R, Michaelides M

Invest Ophthalmol Vis Sci. 2013 Oct 11;54(10):6662-74

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Disruption of the human cone photoreceptor mosaic from a defect in NR2E3 transcription factor function in young adults.

Park SP, Hong IH, Tsang SH, Lee W, Horowitz J, Yzer S, Allikmets R, Chang S

Graefes Arch Clin Exp Ophthalmol. 2013 Oct;251(10):2299-309

Columbia University - Departmental Grant

Keyword: Imaging

Distinct characteristics of inferonasal fundus autofluorescence patterns in stargardt disease and retinitis pigmentosa.

Duncker T, Lee W, Tsang SH, Greenberg JP, Zernant J, Allikmets R, Sparrow JR

Invest Ophthalmol Vis Sci. 2013 Oct 17;54(10):6820-6

Columbia University - Departmental Grant

Keyword: Macular Dystrophy

Expanded clinical spectrum of enhanced S-cone syndrome.

Yzer S, Barbazetto I, Allikmets R, van Schooneveld MJ, Bergen A, Tsang SH, Jacobson SG, Yannuzzi LA

JAMA Ophthalmol. 2013 Oct;131(10):1324-30

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Outer retinal tubulation in degenerative retinal disorders.

Goldberg NR, Greenberg JP, Laud K, Tsang S, Freund KB

Retina. 2013 Oct;33(9):1871-6

Columbia University - Departmental Grant

Keyword: Imaging

Reticular pseudodrusen in early age-related macular degeneration are associated with choroidal thinning.

Garg A, Oll M, Yzer S, Chang S, Barile GR, Merriam JC, Tsang SH, Bearelly S

Invest Ophthalmol Vis Sci. 2013 Oct 29;54(10):7075-81

Columbia University - Departmental Grant

Keyword: AMD

September, 2013
Inclusion of genotype with fundus phenotype improves accuracy of predicting choroidal neovascularization and geographic atrophy.

Perlee LT, Bansal AT, Gehrs K, Heier JS, Csaky K, Allikmets R, Oeth P, Paladino T, Farkas DH, Rawlings PL, Hageman GS

Ophthalmology. 2013 Sep;120(9):1880-92

Columbia University - Departmental Grant

Keyword: AMD

Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of goldmann-favre syndrome.

Wang NK, Lai CC, Liu CH, Yeh LK, Chou CL, Kong J, Nagasaki T, Tsang SH, Chien CL

Dis Model Mech. 2013 Sep;6(5):1113-22

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2013
Age-related macular degeneration: Choroidal ischaemia?

Coleman DJ, Silverman RH, Rondeau MJ, Lloyd HO, Khanifar AA, Chan RV

Br J Ophthalmol. 2013 Aug;97(8):1020-3

Columbia University - Departmental Grant

Keyword: AMD

Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa.

Acton JH, Greenberg JP, Greenstein VC, Marsiglia M, Tabacaru M, Theodore Smith R, Tsang SH

Exp Eye Res. 2013 Aug;113:41-8

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

Quantitative fundus autofluorescence in healthy eyes.

Greenberg JP, Duncker T, Woods RL, Smith RT, Sparrow JR, Delori FC

Invest Ophthalmol Vis Sci. 2013 Aug 21;54(8):5684-93

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Therapeutic margins in a novel preclinical model of retinitis pigmentosa.

Davis RJ, Hsu CW, Tsai YT, Wert KJ, Sancho-Pelluz J, Lin CS, Tsang SH

J Neurosci. 2013 Aug 14;33(33):13475-83

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

July, 2013
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP

Cell. 2013 Jul 18;154(2):452-64

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

Potential pitfalls in measuring the thickness of small choroidal melanocytic tumors with ultrasonography.

Mrejen S, Fung AT, Silverman RH, Kendall C, Freund KB

Retina. 2013 Jul-Aug;33(7):1293-9

Columbia University - Departmental Grant

Keyword: Ocular Oncology/Pterygium

June, 2013
Transduction of photoreceptors with equine infectious anemia virus lentiviral vectors: Safety and biodistribution of StarGen for stargardt disease.

Binley K, Widdowson P, Loader J, Kelleher M, Iqball S, Ferrige G, de Belin J, Carlucci M, Angell-Manning D, Hurst F, Ellis S, Miskin J, Fernandes A, Wong P, Allikmets R, Bergstrom C, Aaberg T, Yan J, Kong J, Gouras P, Prefontaine A, Vezina M, Bussieres M, Naylor S, Mitrophanous KA

Invest Ophthalmol Vis Sci. 2013 Jun 12;54(6):4061-71

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2013
In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3.

Qin Q, Knapinska A, Dobri N, Madoux F, Chase P, Hodder P, Petrukhin K

J Ocul Pharmacol Ther. 2013 Apr;29(3):298-309

Columbia University - Departmental Grant

Keyword: Macular Dystrophy

Quantitative fundus autofluorescence in mice: Correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness.

Sparrow JR, Blonska A, Flynn E, Duncker T, Greenberg JP, Secondi R, Ueda K, Delori FC

Invest Ophthalmol Vis Sci. 2013 Apr 17;54(4):2812-20

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Seven new loci associated with age-related macular degeneration.

Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP,Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Said S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Leveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR, AMD Gene Consortium

Nat Genet. 2013 Apr;45(4):433-9.e1-2

Columbia University - Departmental Grant

Keyword: AMD

March, 2013
A study of factors affecting the human cone photoreceptor density measured by adaptive optics scanning laser ophthalmoscope.

Park SP, Chung JK, Greenstein V, Tsang SH, Chang S

Exp Eye Res. 2013 Mar;108:1-9

Columbia University - Departmental Grant

Keyword: Imaging

Measurement of choroidal perfusion and thickness following systemic sildenafil (viagra((R)) ).

Kim DY, Silverman RH, Chan RV, Khanifar AA, Rondeau M, Lloyd H, Schlegel P, Coleman DJ

Acta Ophthalmol. 2013 Mar;91(2):183-8

Columbia University - Departmental Grant

Keyword: Imaging

Synthesis of antioxidants for prevention of age-related macular degeneration.

Joshi D, Field J, Murphy J, Abdelrahim M, Schonherr H, Sparrow JR, Ellestad G, Nakanishi K, Zask A

J Nat Prod. 2013 Mar 22;76(3):450-4

Columbia University - Departmental Grant

Keyword: AMD

February, 2013
Aliphatic beta-nitroalcohols for therapeutic corneoscleral cross-linking: Corneal permeability considerations.

Wen Q, Trokel SL, Kim M, Paik DC

Cornea. 2013 Feb;32(2):179-84

Columbia University - Departmental Grant

Keyword: Cornea

January, 2013
A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.

Dobri N, Qin Q, Kong J, Yamamoto K, Liu Z, Moiseyev G, Ma JX, Allikmets R, Sparrow JR, Petrukhin K

Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):85-95

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Author response: Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene.

Burke TR, Allikmets R

Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):521-11528

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Choroidal thickness and biometric markers for the screening of lacquer cracks in patients with high myopia.

Wang NK, Lai CC, Chou CL, Chen YP, Chuang LH, Chao AN, Tseng HJ, Chang CJ, Wu WC, Chen KJ, Tsang SH

PLoS One. 2013;8(1):e53660

Columbia University - Departmental Grant

Keyword: Myopia/Presbyopia

Comparison of artemis 2 ultrasound and visante optical coherence tomography corneal thickness profiles.

Ursea R, Feng M, Urs R, RoyChoudhury A, Silverman RH

J Refract Surg. 2013 Jan;29(1):36-41

Columbia University - Departmental Grant

Keyword: Cornea

Comparison of near-infrared and short-wavelength autofluorescence in retinitis pigmentosa.

Duncker T, Tabacaru MR, Lee W, Tsang SH, Sparrow JR, Greenstein VC

Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):585-91

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

DFPE, partially fluorinated ether: A novel approach for experimental intravitreal tamponade.

Santos RA, Keegan DJ, Fuchs BS, Song BJ, Avila MP, Simpson N, Sparrow JR, Chang S

Retina. 2013 Jan;33(1):120-7

Columbia University - Departmental Grant

Keyword: Retinal Detachment

Effect of ultrasound radiation force on the choroid.

Silverman RH, Urs R, Lloyd HO

Invest Ophthalmol Vis Sci. 2013 Jan 10;54(1):103-9

Columbia University - Departmental Grant

Keyword: Imaging

Mcph1-deficient mice reveal a role for MCPH1 in otitis media.

Chen J, Ingham N, Clare S, Raisen C, Vancollie VE, Ismail O, McIntyre RE, Tsang SH, Mahajan VB, Dougan G, Adams DJ, White JK, Steel KP

PLoS One. 2013;8(3):e58156

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

September, 2012
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA,Jr, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM

Ophthalmology. 2012 Sep;119(9):1874-85

Columbia University - Departmental Grant

Keyword: AMD

Non-planar pad-printed thick-film focused high-frequency ultrasonic transducers for imaging and therapeutic applications.

Lethiecq M, Lou-Moeller R, Ketterling J, Levassort F, Tran-Huu-Hue LP, Filoux E, Silverman RH, Wolny WW

IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Sep;59(9):1976-82

Columbia University - Departmental Grant

Keyword: Imaging

Visualization of the optic fissure in short-wavelength autofluorescence images of the fundus.

Duncker T, Greenberg JP, Sparrow JR, Smith RT, Quigley HA, Delori FC

Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6682-6

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

August, 2012
Complement dysregulation in AMD: RPE-bruch's membrane-choroid.

Sparrow JR, Ueda K, Zhou J

Mol Aspects Med. 2012 Aug;33(4):436-45

Columbia University - Departmental Grant

Keyword: AMD

Fundus autofluorescence findings in a mouse model of retinal detachment.

Secondi R, Kong J, Blonska AM, Staurenghi G, Sparrow JR

Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5190-7

Columbia University - Departmental Grant

Keyword: Retinal Detachment

Identification of a potential susceptibility locus for macular telangiectasia type 2.

Parmalee NL, Schubert C, Figueroa M, Bird AC, Peto T, Gillies MC, Bernstein PS, Kiryluk K, Terwilliger JD, Allikmets R, MacTel Project

PLoS One. 2012 Aug;7(8):e24268

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

Structural mechanism for alteration of collagen gel mechanics by glutaraldehyde crosslinking.

Chandran PL, Paik DC, Holmes JW

Connect Tissue Res. 2012 Aug;53(4):285-97

Columbia University - Departmental Grant

Keyword: Cornea

July, 2012
A novel source of methylglyoxal and glyoxal in retina: Implications for age-related macular degeneration.

Yoon KD, Yamamoto K, Ueda K, Zhou J, Sparrow JR

PLoS One. 2012 Jul;7(7):e41309

Columbia University - Departmental Grant

Keyword: AMD

Comparison between MP-1 and humphrey visual field defects in glaucoma and retinitis pigmentosa.

Acton JH, Smith RT, Greenberg JP, Greenstein VC

Optom Vis Sci. 2012 Jul;89(7):1050-8

Columbia University - Departmental Grant

Keyword: Glaucoma

Hyperautofluorescent ring in autoimmune retinopathy.

Lima LH, Greenberg JP, Greenstein VC, Smith RT, Sallum JM, Thirkill C, Yannuzzi LA, Tsang SH

Retina. 2012 Jul;32(7):1385-94

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene.

Burke TR, Fishman GA, Zernant J, Schubert C, Tsang SH, Smith RT, Ayyagari R, Koenekoop RK, Umfress A, Ciccarelli ML, Baldi A, Iannaccone A, Cremers FP, Klaver CC, Allikmets R

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4458-67

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

Unilateral retinitis pigmentosa: A proposal of genetic pathogenic mechanisms.

Marsiglia M, Duncker T, Peiretti E, Brodie SE, Tsang SH

Eur J Ophthalmol. 2012 Jul-Aug;22(4):654-60

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

June, 2012
Toward an understanding of bisretinoid autofluorescence bleaching and recovery.

Yamamoto K, Zhou J, Hunter JJ, Williams DR, Sparrow JR

Invest Ophthalmol Vis Sci. 2012 Jun 8;53(7):3536-44

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

May, 2012
Infrared imaging and optical coherence tomography reveal early-stage astrocytic hamartomas not detectable by fundoscopy.

Xu L, Burke TR, Greenberg JP, Mahajan VB, Tsang SH

Am J Ophthalmol. 2012 May;153(5):883-9.e2

Columbia University - Departmental Grant

Keyword: Imaging

Mice with a D190N mutation in the gene encoding rhodopsin: A model for human autosomal-dominant retinitis pigmentosa.

Sancho-Pelluz J, Tosi J, Hsu CW, Lee F, Wolpert K, Tabacaru MR, Greenberg JP, Tsang SH, Lin CS

Mol Med. 2012 May 9;18:549-55

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

Preservation of retinotopic map in retinal degeneration.

Xie J, Wang GJ, Yow L, Humayun MS, Weiland JD, Cela CJ, Jadvar H, Lazzi G, Dhrami-Gavazi E, Tsang SH

Exp Eye Res. 2012 May;98:88-96

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

April, 2012
Progressive constriction of the hyperautofluorescent ring in retinitis pigmentosa.

Lima LH, Burke T, Greenstein VC, Chou CL, Cella W, Yannuzzi LA, Tsang SH

Am J Ophthalmol. 2012 Apr;153(4):718-27.e1-2

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

March, 2012
Disruption in bruch membrane in patients with stargardt disease.

Park SP, Chang S, Allikmets R, Smith RT, Burke TR, Gregory-Roberts E, Tsang SH

Ophthalmic Genet. 2012 Mar;33(1):49-52

Columbia University - Departmental Grant

Keyword: Macular Dystrophy

Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration.

Baas DC, Ho L, Tanck MW, Fritsche LG, Merriam JE, van het Slot R, Koeleman BP, Gorgels TG, van Duijn CM, Uitterlinden AG, de Jong PT, Hofman A, ten Brink JB, Vingerling JR, Klaver CC, Dean M, Weber BH, Allikmets R, Hageman GS, Bergen AA

Mol Vis. 2012 Mar;18:657-74

Columbia University - Departmental Grant

Keyword: AMD

The bisretinoids of retinal pigment epithelium.

Sparrow JR, Gregory-Roberts E, Yamamoto K, Blonska A, Ghosh SK, Ueda K, Zhou J

Prog Retin Eye Res. 2012 Mar;31(2):121-35

Columbia University - Departmental Grant

Keyword: AMD

February, 2012
Structural and functional changes associated with normal and abnormal fundus autofluorescence in patients with retinitis pigmentosa.

Greenstein VC, Duncker T, Holopigian K, Carr RE, Greenberg JP, Tsang SH, Hood DC

Retina. 2012 Feb;32(2):349-57

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

January, 2012
Autofluorescence imaging and spectral-domain optical coherence tomography in incomplete congenital stationary night blindness and comparison with retinitis pigmentosa.

Chen RW, Greenberg JP, Lazow MA, Ramachandran R, Lima LH, Hwang JC, Schubert C, Braunstein A, Allikmets R, Tsang SH

Am J Ophthalmol. 2012 Jan;153(1):143-54.e2

Columbia University - Departmental Grant

Keyword: Retinitis Pigmentosa

Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.

Tsang SH, Woodruff ML, Lin CS, Jacobson BD, Naumann MC, Hsu CW, Davis RJ, Cilluffo MC, Chen J, Fain GL

Cell Signal. 2012 Jan;24(1):181-8

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

Familial discordance in stargardt disease.

Burke TR, Tsang SH, Zernant J, Smith RT, Allikmets R

Mol Vis. 2012 Jan;18:227-33

Columbia University - Departmental Grant

Keyword: Gene Research/Therapy

Pulse-encoded ultrasound imaging of the vitreous with an annular array.

Silverman RH, Ketterling JA, Mamou J, Lloyd HO, Filoux E, Coleman DJ

Ophthalmic Surg Lasers Imaging. 2012 Jan-Feb;43(1):82-6

Columbia University - Departmental Grant

Keyword: Imaging

The susceptibility of the retina to photochemical damage from visible light.

Hunter JJ, Morgan JI, Merigan WH, Sliney DH, Sparrow JR, Williams DR

Prog Retin Eye Res. 2012 Jan;31(1):28-42

Columbia University - Departmental Grant

Keyword: Retina/Retinal Diseases

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