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Research to Prevent Blindness

Research Database

Cleveland Clinic Lerner College of Medicine Research, funded by RPB in 2014 matching Departmental Grant

60 Citations, Sorted by Month and Year

December, 2014
Assessment of retinal alterations after intravitreal ocriplasmin with spectral-domain optical coherence tomography.

Itoh Y, Kaiser PK, Singh RP, Srivastava SK, Ehlers JP

Ophthalmology. 2014 Dec;121(12):2506,2507.e2

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: Retina/Retinal Diseases

Cellular and extracellular matrix modulation of corneal stromal opacity.

Torricelli AA, Wilson SE

Exp Eye Res. 2014 Dec;129:151-60

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: Cornea, Other: Wound Healing

Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

Wang H, Guo J, West XZ, Bid HK, Lu L, Hong L, Jang GF, Zhang L, Crabb JW, Clinical Genomic and Proteomic AMD Study Group, Linetsky M, Salomon RG

Chem Res Toxicol. 2014 Dec 15;27(12):2015-22

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: AMD

Does genetic variation influence response to treatment with vascular endothelial growth factor inhibitors in neovascular age-related macular degeneration?

Chakravarthy U, Hagstrom SA

Ophthalmic Epidemiol. 2014 Dec;21(6):345-6

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: AMD, Gene Research/Therapy

Retinal vasculature of adult zebrafish: In vivo imaging using confocal scanning laser ophthalmoscopy.

Bell BA, Xie J, Yuan A, Kaul C, Hollyfield JG, Anand-Apte B

Exp Eye Res. 2014 Dec;129:107-18

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Imaging

Simultaneous assessment of glomerular filtration and barrier function in live zebrafish.

Kotb AM, Muller T, Xie J, Anand-Apte B, Endlich K, Endlich N

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1427-34

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Other: Retinal Cell Biology

November, 2014
Collateral vessel presence in branch and central retinal vein occlusions and their impact on visual acuity and anatomical gains: A retrospective analysis.

Singh RP, Lee TJ, Yau L, Rubio RG

Retina. 2014 Nov;34(11):2242-9

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retinal Vein and Artery Occlusion

Gaze holding after anterior-inferior temporal lobectomy.

Shaikh AG, Ghasia FF

Neurol Sci. 2014 Nov;35(11):1749-56

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Neuro-Ophthalmology

Rare and common variants in extracellular matrix gene fibrillin 2 (FBN2) are associated with macular degeneration.

Ratnapriya R, Zhan X, Fariss RN, Branham KE, Zipprer D, Chakarova CF, Sergeev YV, Campos MM, Othman M, Friedman JS, Maminishkis A, Waseem NH, Brooks M, Rajasimha HK, Edwards AO, Lotery A, Klein BE, Truitt BJ, Li B, Schaumberg DA, Morgan DJ, Morrison MA, Souied E, Tsironi EE, Grassmann F, Fishman GA, Silvestri G, Scholl HP, Kim IK, Ramke J, Tuo J, Merriam JE, Merriam JC, Park KH, Olson LM, Farrer LA, Johnson MP, Peachey NS, Lathrop M, Baron RV, Igo RP,Jr, Klein R, Hagstrom SA, Kamatani Y, Martin TM, Jiang Y, Conley Y, Sahel JA, Zack DJ, Chan CC, Pericak-Vance MA, Jacobson SG, Gorin MB, Klein ML, Allikmets R, Iyengar SK, Weber BH, Haines JL, Leveillard T, Deangelis MM, Stambolian D, Weeks DE, Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A

Hum Mol Genet. 2014 Nov 1;23(21):5827-37

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: AMD

The prospective intraoperative and perioperative ophthalmic ImagiNg with optical CoherEncE TomogRaphy (PIONEER) study: 2-year results.

Ehlers JP, Dupps WJ, Kaiser PK, Goshe J, Singh RP, Petkovsek D, Srivastava SK

Am J Ophthalmol. 2014 Nov;158(5):999-1007

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Imaging, Retina/Retinal Diseases

October, 2014
A protective eye shield for prevention of media opacities during small animal ocular imaging.

Bell BA, Kaul C, Hollyfield JG

Exp Eye Res. 2014 Oct;127:280-7

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: Cataract, Imaging

Intraoperative optical coherence tomography using the RESCAN 700: Preliminary results from the DISCOVER study.

Ehlers JP, Kaiser PK, Srivastava SK

Br J Ophthalmol. 2014 Oct;98(10):1329-32

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optical Coherence Tomography

Retinal infiltrates secondary to metastatic squamous cell carcinoma masquerading as infectious retinitis.

Singh RP, Steinle NC, Bedi R, Kaiser P, Lowder CY

Retin Cases Brief Rep. 2014 Fall;8(4):333-5

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Ocular Oncology/Pterygium, Retina/Retinal Diseases

Screening of refractive surgery candidates for LASIK and PRK.

Torricelli AA, Bechara SJ, Wilson SE

Cornea. 2014 Oct;33(10):1051-5

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Selective impairment of a subset of ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

Patil H, Saha A, Senda E, Cho KI, Haque M, Yu M, Qiu S, Yoon D, Hao Y, Peachey NS, Ferreira PA

J Biol Chem. 2014 Oct 24;289(43):29767-89

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

The effects of surgical factors on postoperative astigmatism in patients enrolled in the infant aphakia treatment study (IATS).

Wall PB, Lee JA, Lynn MJ, Lambert SR, Traboulsi EI, Infant Aphakia Treatment Study Group

J AAPOS. 2014 Oct;18(5):441-5

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Pediatric

September, 2014
Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

Saadane A, Mast N, Charvet CD, Omarova S, Zheng W, Huang SS, Kern TS, Peachey NS, Pikuleva IA

Am J Pathol. 2014 Sep;184(9):2403-19

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Retinal histopathology in eyes from a patient with stargardt disease caused by compound heterozygous ABCA4 mutations.

Bonilha VL, Rayborn ME, Bell BA, Marino MJ, Fishman GA, Hollyfield JG

Ophthalmic Genet. 2014 Sep 29:1-11

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: Gene Research/Therapy, Retina/Retinal Diseases

Retinal regeneration following OCT-guided laser injury in zebrafish.

DiCicco RM, Bell BA, Kaul C, Hollyfield JG, Anand-Apte B, Perkins BD, Tao YK, Yuan A

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6281-8

Cleveland Clinic Lerner College of Medicine - Stein Professorship - Perkins, Brian / PhD Departmental Grant

Keywords: Imaging, Stem Cell Research/Therapy

August, 2014
BAC-EDTA transepithelial riboflavin-UVA crosslinking has greater biomechanical stiffening effect than standard epithelium-off in rabbit corneas.

Torricelli AA, Ford MR, Singh V, Santhiago MR, Dupps WJ,Jr, Wilson SE

Exp Eye Res. 2014 Aug;125:114-7

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Endothelial PAS domain-containing protein 1 (EPAS1) gene polymorphisms and response to anti-VEGF therapy in the comparison of AMD treatments trials (CATT).

Hagstrom SA, Ying GS, Pauer GJ, Huang J, Maguire MG, Martin DF, CATT Research Group

Ophthalmology. 2014 Aug;121(8):1663,4.e1

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: AMD, Gene Research/Therapy

Nystagmus and related fixation instabilities following extraction of unilateral infantile cataract in the infant aphakia treatment study (IATS).

Felius J, Busettini C, Lynn MJ, Hartmann EE, Lambert SR, Infant Aphakia Treatment Study Group

Invest Ophthalmol Vis Sci. 2014 Aug 5;55(8):5332-7

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cataract

Simultaneous bilateral endophthalmitis after immediate sequential bilateral cataract surgery: What's the risk of functional blindness?

Schachat AP

Am J Ophthalmol. 2014 Aug;158(2):410-1

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cataract

The par-PrkC polarity complex is required for cilia growth in zebrafish photoreceptors.

Krock BL, Perkins BD

PLoS One. 2014 Aug 21;9(8):e104661

Cleveland Clinic Lerner College of Medicine - Stein Professorship - Perkins, Brian / PhD Departmental Grant

Keyword: Other: Retinal Cell Biology

Topical cyclosporine a treatment in corneal refractive surgery and patients with dry eye.

Torricelli AA, Santhiago MR, Wilson SE

J Refract Surg. 2014 Aug;30(8):558-64

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

July, 2014
Optical coherence tomography imaging of macular oedema.

Trichonas G, Kaiser PK

Br J Ophthalmol. 2014 Jul;98 Suppl 2:ii24-9

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optical Coherence Tomography

Utility of intraoperative optical coherence tomography during vitrectomy surgery for vitreomacular traction syndrome.

Ehlers JP, Tam T, Kaiser PK, Martin DF, Smith GM, Srivastava SK

Retina. 2014 Jul;34(7):1341-6

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optical Coherence Tomography

June, 2014
Biomechanics of corneal ectasia and biomechanical treatments.

Roberts CJ, Dupps WJ,Jr

J Cataract Refract Surg. 2014 Jun;40(6):991-8

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Comparison of biomechanical effects of small-incision lenticule extraction and laser in situ keratomileusis: Finite-element analysis.

Sinha Roy A, Dupps WJ,Jr, Roberts CJ

J Cataract Refract Surg. 2014 Jun;40(6):971-80

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Comparison of contact lens and intraocular lens correction of monocular aphakia during infancy: A randomized clinical trial of HOTV optotype acuity at age 4.5 years and clinical findings at age 5 years.

Infant Aphakia Treatment Study Group, Lambert SR, Lynn MJ, Hartmann EE, DuBois L, Drews-Botsch C, Freedman SF, Plager DA, Buckley EG, Wilson ME

JAMA Ophthalmol. 2014 Jun;132(6):676-82

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Pediatric

Inducing a visceral organ to protect a peripheral capillary bed: Stabilizing hepatic HIF-1alpha prevents oxygen-induced retinopathy.

Hoppe G, Lee TJ, Yoon S, Yu M, Peachey NS, Rayborn M, Zutel MJ, Trichonas G, Au J, Sears JE

Am J Pathol. 2014 Jun;184(6):1890-9

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Introduction.

Singh RP

treatment paradigms within the use of anti-VEGF agents. Br J Ophthalmol. 2014 Jun;98 Suppl 1:i1-2

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Pathology detection rate of spectral domain optical coherence tomography devices.

Sharma S, Sayanagi K, Kaiser PK

Br J Ophthalmol. 2014 Jun;98 Suppl 1:i3-6

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: Retina/Retinal Diseases

Patterned corneal collagen crosslinking for astigmatism: Computational modeling study.

Seven I, Sinha Roy A, Dupps WJ,Jr

J Cataract Refract Surg. 2014 Jun;40(6):943-53

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Retinoschisis and hyperopia associated with partial monosomy of 6q and partial trisomy of 11q.

Bagheri N, Bahl RS, Singh AD, Rychwalski PJ

Ophthalmic Genet. 2014 Jun;35(2):107-11

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Pediatric

Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography.

Ford MR, Sinha Roy A, Rollins AM, Dupps WJ,Jr

J Cataract Refract Surg. 2014 Jun;40(6):1041-7

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

The role of preoperative biometry in selecting initial contact lens power in the infant aphakia treatment study.

Trivedi RH, Lambert SR, Lynn MJ, Wilson ME, Infant Aphakia Treatment Study Group

J AAPOS. 2014 Jun;18(3):251-4

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Toric topographically customized transepithelial, pulsed, very high-fluence, higher energy and higher riboflavin concentration collagen cross-linking in keratoconus.

Kanellopoulos AJ, Dupps WJ, Seven I, Asimellis G

Case Rep Ophthalmol. 2014 Jun 18;5(2):172-80

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

May, 2014
The proteomics of drusen.

Crabb JW

Cold Spring Harb Perspect Med. 2014 May 5;4(7):a017194

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: AMD

VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: Comparison of age-related macular degeneration treatments trials (CATT).

Hagstrom SA, Ying GS, Pauer GJ, Sturgill-Short GM, Huang J, Maguire MG, Martin DF, Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group

JAMA Ophthalmol. 2014 May;132(5):521-7

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: AMD, Gene Research/Therapy

April, 2014
Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.

Achberger S, Aldrich W, Tubbs R, Crabb JW, Singh AD, Triozzi PL

Mol Immunol. 2014 Apr;58(2):182-6

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: Ocular Oncology/Pterygium, Other: Biomarkers

GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.

Ray TA, Heath KM, Hasan N, Noel JM, Samuels IS, Martemyanov KA, Peachey NS, McCall MA, Gregg RG

J Neurosci. 2014 Apr 30;34(18):6334-43

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Mouse b-wave mutants.

Pardue MT, Peachey NS

Doc Ophthalmol. 2014 Apr;128(2):77-89

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Predictors of visual acuity and genotype-phenotype correlates in a cohort of patients with stargardt disease.

Miraldi Utz V, Coussa RG, Marino MJ, Chappelow AV, Pauer GJ, Hagstrom SA, Traboulsi EI

Br J Ophthalmol. 2014 Apr;98(4):513-8

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keywords: Gene Research/Therapy, Pediatric

Source of high-frequency oscillations in oblique saccade trajectory.

Ghasia FF, Shaikh AG

Exp Eye Res. 2014 Apr;121:5-10

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Neuro-Ophthalmology

TGFbeta and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo.

Singh V, Jaini R, Torricelli AA, Santhiago MR, Singh N, Ambati BK, Wilson SE

Exp Eye Res. 2014 Apr;121:35-40

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Viewing condition dependence of the gaze-evoked nystagmus in arnold chiari type 1 malformation.

Ghasia FF, Gulati D, Westbrook EL, Shaikh AG

J Neurol Sci. 2014 Apr 15;339(1-2):134-9

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Neuro-Ophthalmology

March, 2014
Anatomical and visual outcomes following ocriplasmin treatment for symptomatic vitreomacular traction syndrome.

Singh RP, Li A, Bedi R, Srivastava S, Sears JE, Ehlers JP, Schachat AP, Kaiser PK

Br J Ophthalmol. 2014 Mar;98(3):356-60

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: Retina/Retinal Diseases

Emerging treatments for wet age-related macular degeneration.

Smith AG, Kaiser PK

Expert Opin Emerg Drugs. 2014 Mar;19(1):157-64

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: AMD

Glucocorticoids: Structure, signaling and molecular mechanisms in the treatment of diabetic retinopathy and diabetic macular edema.

Zhang X, Wang N, Schachat AP, Bao S, Gillies MC

Curr Mol Med. 2014 Mar;14(3):376-84

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Diabetic Retinopathy

Risk of scar in the comparison of age-related macular degeneration treatments trials.

Daniel E, Toth CA, Grunwald JE, Jaffe GJ, Martin DF, Fine SL, Huang J, Ying GS, Hagstrom SA, Winter K, Maguire MG, Comparison of Age-related Macular Degeneration Treatments Trials Research Group

Ophthalmology. 2014 Mar;121(3):656-66

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: AMD

The impact of metabolic parameters on clinical response to VEGF inhibitors for diabetic macular edema.

Matsuda S, Tam T, Singh RP, Kaiser PK, Petkovsek D, Carneiro G, Zanella MT, Ehlers JP

J Diabetes Complications. 2014 Mar-Apr;28(2):166-70

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: Diabetic Retinopathy

Transforming growth factor beta and platelet-derived growth factor modulation of myofibroblast development from corneal fibroblasts in vitro.

Singh V, Barbosa FL, Torricelli AA, Santhiago MR, Wilson SE

Exp Eye Res. 2014 Mar;120:152-60

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

February, 2014
Comparison of intravitreal ranibizumab and bevacizumab for the treatment of macular edema secondary to retinal vein occlusion.

Yuan A, Ahmad BU, Xu D, Singh RP, Kaiser PK, Martin DF, Sears JE, Schachat AP, Ehlers JP

Int J Ophthalmol. 2014 Feb 18;7(1):86-91

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Imaging, Retinal Vein and Artery Occlusion

Differential loss of prolyl isomerase or chaperone activity of ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

Cho KI, Patil H, Senda E, Wang J, Yi H, Qiu S, Yoon D, Yu M, Orry A, Peachey NS, Ferreira PA

J Biol Chem. 2014 Feb 21;289(8):4600-25

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Retina/Retinal Diseases

Discriminant value of custom ocular response analyzer waveform derivatives in keratoconus.

Hallahan KM, Sinha Roy A, Ambrosio R,Jr, Salomao M, Dupps WJ,Jr

Ophthalmology. 2014 Feb;121(2):459-68

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: Cornea

Intrasurgical dynamics of macular hole surgery: An assessment of surgery-induced ultrastructural alterations with intraoperative optical coherence tomography.

Ehlers JP, Xu D, Kaiser PK, Singh RP, Srivastava SK

Retina. 2014 Feb;34(2):213-21

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keywords: Retina/Retinal Diseases, Other: Optical Coherence Tomography

January, 2014
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials.

Grunwald JE, Daniel E, Huang J, Ying GS, Maguire MG, Toth CA, Jaffe GJ, Fine SL, Blodi B, Klein ML, Martin AA, Hagstrom SA, Martin DF, CATT Research Group

Ophthalmology. 2014 Jan;121(1):150-61

Cleveland Clinic Lerner College of Medicine - Departmental Grant

Keyword: AMD

Wound construction.

Trichonas G, Kaiser PK

Dev Ophthalmol. 2014;54:71-6

Cleveland Clinic Lerner College of Medicine - Lew R. Wasserman Merit Award - Kaiser, Peter Kazuo / MD Departmental Grant

Keyword: Retina/Retinal Diseases

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