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Research to Prevent Blindness

Research Database

University of California, San Diego Research, funded by RPB from 2012-2014 matching Departmental Grant

86 Citations, Sorted by Month and Year

December, 2014
Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula.

Zhang C, Tatham AJ, Weinreb RN, Zangwill LM, Yang Z, Zhang JZ, Medeiros FA

Ophthalmology. 2014 Dec;121(12):2371-9

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging

Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold.

Kador KE, Alsehli HS, Zindell AN, Lau LW, Andreopoulos FM, Watson BD, Goldberg JL

Acta Biomater. 2014 Dec;10(12):4939-46

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

The role of soluble adenylyl cyclase in neurite outgrowth.

Stiles TL, Kapiloff MS, Goldberg JL

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2561-8

University of California, San Diego - Departmental Grant

Keywords: Cornea, Imaging

November, 2014
Glaucomatous retinal nerve fiber layer thickness loss is associated with slower reaction times under a divided attention task.

Tatham AJ, Boer ER, Rosen PN, Della Penna M, Meira-Freitas D, Weinreb RN, Zangwill LM, Medeiros FA

Am J Ophthalmol. 2014 Nov;158(5):1008-17

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Neuro-Ophthalmology

October, 2014
Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.

Bailey JN, Yaspan BL, Pasquale LR, Hauser MA, Kang JH, Loomis SJ, Brilliant M, Budenz DL, Christen WG, Fingert J, Gaasterland D, Gaasterland T, Kraft P, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Richards JE, Realini T, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Allingham RR, Weinreb RN, Haines JL, Wiggs JL

Hum Genet. 2014 Oct;133(10):1319-30

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

September, 2014
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.

Springelkamp H, Hohn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, Bailey JN, Gibson J, Thorleifsson G, Janssen SF, Luo X, Ramdas WD, Vithana E, Nongpiur ME, Montgomery GW, Xu L, Mountain JE, Gharahkhani P, Lu Y, Amin N, Karssen LC, Sim KS, van Leeuwen EM, Iglesias AI, Verhoeven VJ, Hauser MA, Loon SC, Despriet DD, Nag A, Venturini C, Sanfilippo PG, Schillert A, Kang JH, Landers J, Jonasson F, Cree AJ, van Koolwijk LM, Rivadeneira F, Souzeau E, Jonsson V, Menon G, Blue Mountains Eye Study-GWAS group, Weinreb RN, de Jong PT, Oostra BA, Uitterlinden AG, Hofman A, Ennis S, Thorsteinsdottir U, Burdon KP, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Spector TD, Mirshahi A, Saw SM, Vingerling JR, Teo YY, Haines JL, Wolfs RC, Lemij HG, Tai ES, Jansonius NM, Jonas JB, Cheng CY, Aung T, Viswanathan AC, Klaver CC, Craig JE, Macgregor S, Mackey DA, Lotery AJ, Stefansson K, Bergen AA, Young TL, Wiggs JL, Pfeiffer N, Wong TY, Pasquale LR, Hewitt AW, van Duijn CM, Hammond CJ

Nat Commun. 2014 Sep 22;5:4883

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Optic Neuropathy

Primary cilia signaling mediates intraocular pressure sensation.

Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG, Sun Y

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12871-6

University of California, San Diego - Departmental Grant

Keywords: Cataract, Glaucoma, Retinitis Pigmentosa

August, 2014
Estimated rates of retinal ganglion cell loss in glaucomatous eyes with and without optic disc hemorrhages.

Gracitelli CP, Tatham AJ, Zangwill LM, Weinreb RN, Liu T, Medeiros FA

PLoS One. 2014 Aug 26;9(8):e105611

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Optic Neuropathy

July, 2014
Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue.

Chen SY, Mahabole M, Horesh E, Wester S, Goldberg JL, Tseng SC

Invest Ophthalmol Vis Sci. 2014 Jul 3;55(8):4842-52

University of California, San Diego - Departmental Grant

Keyword: Cornea

Learning from data: Recognizing glaucomatous defect patterns and detecting progression from visual field measurements.

Yousefi S, Goldbaum MH, Balasubramanian M, Medeiros FA, Zangwill LM, Liebmann JM, Girkin CA, Weinreb RN, Bowd C

IEEE Trans Biomed Eng. 2014 Jul;61(7):2112-24

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy

Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes.

Miki A, Medeiros FA, Weinreb RN, Jain S, He F, Sharpsten L, Khachatryan N, Hammel N, Liebmann JM, Girkin CA, Sample PA, Zangwill LM

Ophthalmology. 2014 Jul;121(7):1350-8

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Retina/Retinal Diseases

June, 2014
Assessment of optic nerve head drusen using enhanced depth imaging and swept source optical coherence tomography.

Silverman AL, Tatham AJ, Medeiros FA, Weinreb RN

J Neuroophthalmol. 2014 Jun;34(2):198-205

University of California, San Diego - Departmental Grant

Keywords: Imaging, Optic Neurology

Detecting glaucoma using automated pupillography.

Tatham AJ, Meira-Freitas D, Weinreb RN, Zangwill LM, Medeiros FA

Ophthalmology. 2014 Jun;121(6):1185-93

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

Diagnostic ability of spectral-domain versus time-domain optical coherence tomography in preperimetric glaucoma.

Jeoung JW, Kim TW, Weinreb RN, Kim SH, Park KH, Kim DM

J Glaucoma. 2014 Jun-Jul;23(5):299-306

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy

Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.

Steketee MB, Oboudiyat C, Daneman R, Trakhtenberg E, Lamoureux P, Weinstein JE, Heidemann S, Barres BA, Goldberg JL

Invest Ophthalmol Vis Sci. 2014 Jun 6;55(7):4369-77

University of California, San Diego - Departmental Grant

Keyword: Imaging

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.

Kang JH, Loomis SJ, Yaspan BL, Bailey JC, Weinreb RN, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Gaasterland D, Gaasterland T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Forman JP, Buys ES, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL, Pasquale LR

Eye (Lond). 2014 Jun;28(6):662-71

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma

May, 2014
Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: Repeatability and assessment of artifacts.

Mansouri K, Medeiros FA, Tatham AJ, Marchase N, Weinreb RN

Am J Ophthalmol. 2014 May;157(5):1022-32

University of California, San Diego - Departmental Grant

Keywords: Diabetic Retinopathy, Glaucoma, Imaging

Regulating set-beta's subcellular localization toggles its function between inhibiting and promoting axon growth and regeneration.

Trakhtenberg EF, Wang Y, Morkin MI, Fernandez SG, Mlacker GM, Shechter JM, Liu X, Patel KH, Lapins A, Yang S, Dombrowski SM, Goldberg JL

J Neurosci. 2014 May 21;34(21):7361-74

University of California, San Diego - Departmental Grant

Keyword: Neuro-Ophthalmology

The pathophysiology and treatment of glaucoma: A review.

Weinreb RN, Aung T, Medeiros FA

JAMA. 2014 May 14;311(18):1901-11

University of California, San Diego - Departmental Grant

Keywords: Cataract, Dry Eye, Glaucoma, Optic Neuropathy

April, 2014
Acute retinal pigment epithelium detachments after photocoagulation.

Moysidis SN, Vajzovic L, Gregori G, Goldberg JL

Retina. 2014 Apr;34(4):749-60

University of California, San Diego - Departmental Grant

Keyword: Retinitis Pigmentosa

Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury.

Lee D, Kim KY, Shim MS, Kim SY, Ellisman MH, Weinreb RN, Ju WK

Apoptosis. 2014 Apr;19(4):603-14

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging

Glaucoma progression detection using structural retinal nerve fiber layer measurements and functional visual field points.

Yousefi S, Goldbaum MH, Balasubramanian M, Jung TP, Weinreb RN, Medeiros FA, Zangwill LM, Liebmann JM, Girkin CA, Bowd C

IEEE Trans Biomed Eng. 2014 Apr;61(4):1143-54

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Optic Neuropathy

Retinal repair with induced pluripotent stem cells.

Al-Shamekh S, Goldberg JL

Transl Res. 2014 Apr;163(4):377-86

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Retinitis Pigmentosa

March, 2014
Detecting glaucoma progression from localized rates of retinal changes in parametric and nonparametric statistical framework with type I error control.

Balasubramanian M, Arias-Castro E, Medeiros FA, Kriegman DJ, Bowd C, Weinreb RN, Holst M, Sample PA, Zangwill LM

Invest Ophthalmol Vis Sci. 2014 Mar 19;55(3):1684-95

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury.

Kim SY, Shim MS, Kim KY, Weinreb RN, Wheeler LA, Ju WK

Cell Death Dis. 2014 Mar 6;5:e1105

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

February, 2014
Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.

Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL

Ophthalmology. 2014 Feb;121(2):508-16

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma.

Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK

Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):993-1005

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

Outflow tract ablation using a conditionally cytotoxic feline immunodeficiency viral vector.

Zhang Z, Dhaliwal AS, Tseng H, Kim JD, Schuman JS, Weinreb RN, Loewen NA

Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):935-40

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Imaging

Predicting progression of glaucoma from rates of frequency doubling technology perimetry change.

Meira-Freitas D, Tatham AJ, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN, Girkin CA, Liebmann JM, Medeiros FA

Ophthalmology. 2014 Feb;121(2):498-507

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma

January, 2014
Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss.

Tatham AJ, Miki A, Weinreb RN, Zangwill LM, Medeiros FA

Ophthalmology. 2014 Jan;121(1):110-8

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Imaging

Evaluation of progressive neuroretinal rim loss as a surrogate end point for development of visual field loss in glaucoma.

Medeiros FA, Lisboa R, Zangwill LM, Liebmann JM, Girkin CA, Bowd C, Weinreb RN

Ophthalmology. 2014 Jan;121(1):100-9

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Imaging

Glaucomatous patterns in frequency doubling technology (FDT) perimetry data identified by unsupervised machine learning classifiers.

Bowd C, Weinreb RN, Balasubramanian M, Lee I, Jang G, Yousefi S, Zangwill LM, Medeiros FA, Girkin CA, Liebmann JM, Goldbaum MH

PLoS One. 2014 Jan 30;9(1):e85941

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Optic Neuropathy

Solutions in pediatric cataracts.

Robbins SL, Breidenstein B, Granet DB

Curr Opin Ophthalmol. 2014 Jan;25(1):12-8

University of California, San Diego - Departmental Grant

Keywords: Cataract, Cornea, Glaucoma, Pediatric, Retinal Detachment

Survival and integration of developing and progenitor-derived retinal ganglion cells following transplantation.

Hertz J, Qu B, Hu Y, Patel RD, Valenzuela DA, Goldberg JL

Cell Transplant. 2014;23(7):855-72

University of California, San Diego - Departmental Grant

Keyword: Cornea

September, 2013
Accuracy of the heidelberg spectralis in the alignment between near-infrared image and tomographic scan in a model eye: A multicenter study.

Barteselli G, Bartsch DU, Viola F, Mojana F, Pellegrini M, Hartmann KI, Benatti E, Leicht S, Ratiglia R, Staurenghi G, Weinreb RN, Freeman WR

Am J Ophthalmol. 2013 Sep;156(3):588-92

University of California, San Diego - Departmental Grant

Keyword: Imaging

Orbitomalar suspension with combined single drill hole canthoplasty.

Oh SR, Korn BS, Kikkawa DO

Ophthal Plast Reconstr Surg. 2013 Sep;29(5):357-60

University of California, San Diego - Departmental Grant

Keywords: Cornea, Imaging, Thyroid Ophthalmology

Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography.

Barteselli G, Chhablani J, Lee SN, Wang H, El Emam S, Kozak I, Cheng L, Bartsch DU, Azen S, Freeman WR

Retina. 2013 Sep;33(8):1574-83

University of California, San Diego - Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Imaging, Retina/Retinal Diseases

August, 2013
A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells.

Hertz J, Robinson R, Valenzuela DA, Lavik EB, Goldberg JL

Acta Biomater. 2013 Aug;9(8):7622-9

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Neuro-Ophthalmology, Stem Cell Research/Therapy

eyeGENE(R): A vision community resource facilitating patient care and paving the path for research through molecular diagnostic testing.

Blain D, Goetz KE, Ayyagari R, Tumminia SJ

Clin Genet. 2013 Aug;84(2):190-7

University of California, San Diego - Departmental Grant

Keywords: AMD, Cornea, Gene Research/Therapy, Retinitis Pigmentosa

Semiautomated quantification of beta-zone parapapillary atrophy using blue light fundus autofluorescence.

Mansouri K, Tung JD, Medeiros FA, Tafreshi A, Dorairaj S, Zangwill L, He F, Jain S, Weinreb RN

Acta Ophthalmol. 2013 Aug;91(5):e379-385

University of California, San Diego - Departmental Grant

Keywords: Cataract, Cornea, Glaucoma, Imaging

Variation of lamina cribrosa depth following trabeculectomy.

Lee EJ, Kim TW, Weinreb RN

Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5392-9

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Neuro-Ophthalmology, Optic Neuropathy

July, 2013
Common variant in VEGFA and response to anti-VEGF therapy for neovascular age-related macular degeneration.

Zhao L, Grob S, Avery R, Kimura A, Pieramici D, Lee J, Rabena M, Ortiz S, Quach J, Cao G, Luo H, Zhang M, Pei M, Song Y, Tornambe P, Goldbaum M, Ferreyra H, Kozak I, Zhang K

Curr Mol Med. 2013 Jul;13(6):929-34

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: AMD, Gene Research/Therapy, Imaging, Retina/Retinal Diseases

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the united states.

Pasquale LR, Loomis SJ, Weinreb RN, Kang JH, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Scott WK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL

Mol Vis. 2013 Jul 12;19:1471-81

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Gene Research/Therapy

TCF7L2 variation and proliferative diabetic retinopathy.

Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw PX, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K

Diabetes. 2013 Jul;62(7):2613-7

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: Diabetic Retinopathy, Retinal Detachment, Other: Retinal Neovascularization

June, 2013
Brimonidine protects against loss of thy-1 promoter activation following optic nerve crush.

Dai Y, Lindsey JD, Duong-Polk KX, Chindasub P, Leung CK, Weinreb RN

BMC Ophthalmol. 2013 Jun 27;13(1):26,2415-13-26

University of California, San Diego - Departmental Grant

Keywords: Imaging, Neuro-Ophthalmology, Optic Neuropathy, Retina/Retinal Diseases

Correlation of spectral domain optical coherence tomography characteristics with visual acuity in eyes with subfoveal scarring after treatment for wet age-related macular degeneration.

El-Emam S, Chhablani J, Barteselli G, Wang H, Lee SN, Kozak I, Cheng L, Freeman WR

Retina. 2013 Jun;33(6):1249-57

University of California, San Diego - Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Retinal Detachment, Retinal Vein and Artery Occlusion

Predicting progression in glaucoma suspects with longitudinal estimates of retinal ganglion cell counts.

Meira-Freitas D, Lisboa R, Tatham A, Zangwill LM, Weinreb RN, Girkin CA, Liebmann JM, Medeiros FA

Invest Ophthalmol Vis Sci. 2013 Jun 19;54(6):4174-83

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Neuro-Ophthalmology, Optic Neuropathy, Retina/Retinal Diseases

The rate of structural change: The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study.

Zangwill LM, Jain S, Dirkes K, He F, Medeiros FA, Trick GL, Brandt JD, Cioffi GA, Coleman AL, Liebmann JM, Piltz-Seymour JR, Gordon MO, Kass MA, Weinreb RN, Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

Am J Ophthalmol. 2013 Jun;155(6):971-82

University of California, San Diego - Departmental Grant

Keywords: Cornea, Glaucoma, Imaging, Optic Neuropathy

Tissue engineering the retinal ganglion cell nerve fiber layer.

Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL

Biomaterials. 2013 Jun;34(17):4242-50

University of California, San Diego - Departmental Grant

Keywords: Cataract, Glaucoma, Retina/Retinal Diseases, Retinitis Pigmentosa

May, 2013
Characterization of microaneurysm closure after focal laser photocoagulation in diabetic macular edema.

Lee SN, Chhablani J, Chan CK, Wang H, Barteselli G, El-Emam S, Gomez ML, Kozak I, Cheng L, Freeman WR

Am J Ophthalmol. 2013 May;155(5):905-12

University of California, San Diego - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

Lisboa R, Paranhos A,Jr, Weinreb RN, Zangwill LM, Leite MT, Medeiros FA

Invest Ophthalmol Vis Sci. 2013 May 13;54(5):3417-25

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Neuro-Ophthalmology

The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells.

Tatham AJ, Weinreb RN, Zangwill LM, Liebmann JM, Girkin CA, Medeiros FA

Invest Ophthalmol Vis Sci. 2013 May 7;54(5):3205-14

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Neuro-Ophthalmology, Retina/Retinal Diseases

April, 2013
Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma.

Lisboa R, Chun YS, Zangwill LM, Weinreb RN, Rosen PN, Liebmann JM, Girkin CA, Medeiros FA

JAMA Ophthalmol. 2013 Apr;131(4):486-94

University of California, San Diego - Departmental Grant

Keywords: Diabetic Retinopathy, Glaucoma, Optic Neuropathy

Combined depth imaging technique on spectral-domain optical coherence tomography.

Barteselli G, Bartsch DU, El-Emam S, Gomez ML, Chhablani J, Lee SN, Conner L, Freeman WR

Am J Ophthalmol. 2013 Apr;155(4):727-32.e1

University of California, San Diego - Departmental Grant

Keywords: Cornea, Imaging

March, 2013
Nanotechnology and glaucoma: Little particles for a big disease.

Pita-Thomas DW, Goldberg JL

Curr Opin Ophthalmol. 2013 Mar;24(2):130-5

University of California, San Diego - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma, Nanotechnology/Drug Delivery, Optic Neuropathy, Retina/Retinal Diseases

February, 2013
A novel rodent model of posterior ischemic optic neuropathy.

Wang Y, Brown DP,Jr, Duan Y, Kong W, Watson BD, Goldberg JL

JAMA Ophthalmol. 2013 Feb;131(2):194-204

University of California, San Diego - Departmental Grant

Keywords: Imaging, Neuro-Ophthalmology, Optic Neuropathy, Retina/Retinal Diseases

Combining structure and function to evaluate glaucomatous progression: Implications for the design of clinical trials.

Lisboa R, Weinreb RN, Medeiros FA

Curr Opin Pharmacol. 2013 Feb;13(1):115-22

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging

Series length used during trend analysis affects sensitivity to changes in progression rate in the ocular hypertension treatment study.

Gardiner SK, Demirel S, De Moraes CG, Liebmann JM, Cioffi GA, Ritch R, Gordon MO, Kass MA, Ocular Hypertension Treatment Study Group

Invest Ophthalmol Vis Sci. 2013 Feb 15;54(2):1252-9

University of California, San Diego - Departmental Grant

Keyword: Glaucoma

January, 2013
Combined depth imaging using optical coherence tomography as a novel imaging technique to visualize vitreoretinal choroidal structures.

Barteselli G, Bartsch DU, Freeman WR

Retina. 2013 Jan;33(1):247-8

University of California, San Diego - Departmental Grant

Keyword: Imaging

Inhibition of histone deacetylases 1 and 3 protects injured retinal ganglion cells.

Chindasub P, Lindsey JD, Duong-Polk K, Leung CK, Weinreb RN

Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):96-102

University of California, San Diego - Departmental Grant

Keyword: Imaging

Vitamin A supplementation ameliorates obesity-associated retinal degeneration in WNIN/Ob rats.

Tiruvalluru M, Ananthathmakula P, Ayyalasomayajula V, Nappanveettil G, Ayyagari R, Reddy GB

Nutrition. 2013 Jan;29(1):298-304

University of California, San Diego - Departmental Grant

Keywords: Cataract, Diabetic Retinopathy, Gene Research/Therapy, Retina/Retinal Diseases

November, 2012
Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography.

Lisboa R, Leite MT, Zangwill LM, Tafreshi A, Weinreb RN, Medeiros FA

Ophthalmology. 2012 Nov;119(11):2261-9

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Optic Neuropathy, Other: Spectral Domain Optical Coherence Tomography (SD-OCT

Estimating the rate of retinal ganglion cell loss in glaucoma.

Medeiros FA, Zangwill LM, Anderson DR, Liebmann JM, Girkin CA, Harwerth RS, Fredette MJ, Weinreb RN

Am J Ophthalmol. 2012 Nov;154(5):814-24.e1

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Optic Neuropathy

Use of antimetabolites in the reconstruction of severe anophthalmic socket contraction.

Priel A, Oh SR, Whipple KM, Korn BS, Kikkawa DO

Ophthal Plast Reconstr Surg. 2012 Nov;28(6):409-12

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Plastic Surgery, Other: Antimetabolites, Other: Reconstructive Surgery

October, 2012
Positional independence of optic nerve head and retinal nerve fiber layer thickness measurements with spectral-domain optical coherence tomography.

Mansouri K, Liu JH, Tafreshi A, Medeiros FA, Weinreb RN

Am J Ophthalmol. 2012 Oct;154(4):712-21.e1

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Other: Specral-Domain Optical Coherence Tomography (SD-OCT

The structure and function relationship in glaucoma: Implications for detection of progression and measurement of rates of change.

Medeiros FA, Zangwill LM, Bowd C, Mansouri K, Weinreb RN

Invest Ophthalmol Vis Sci. 2012 Oct 5;53(11):6939-46

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Imaging, Other: Retinal Ganglion Cell

September, 2012
A combined index of structure and function for staging glaucomatous damage.

Medeiros FA, Lisboa R, Weinreb RN, Girkin CA, Liebmann JM, Zangwill LM

Arch Ophthalmol. 2012 Sep 1;130(9):1107-16

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy, Other: Combined Index of Structure and Function (CSFI

Effect of change in drusen evolution on photoreceptor inner segment/outer segment junction.

Hartmann KI, Gomez ML, Bartsch DU, Schuster AK, Freeman WR

Retina. 2012 Sep;32(8):1492-9

University of California, San Diego - Departmental Grant

Keywords: AMD, Diabetic Retinopathy, Imaging, Retina/Retinal Diseases

August, 2012
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

Shaw PX, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13757-62

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: AMD, Other: Genotype

Genetic analysis of simultaneous geographic atrophy and choroidal neovascularization.

Grob S, Luo J, Hughes G, Lee C, Zhou X, Lee J, Du H, Ferreyra H, Freeman WR, Kozak I, Zhang K

Eye (Lond). 2012 Aug;26(8):1106-13

University of California, San Diego - Departmental Grant

Keywords: AMD, Imaging, Retina/Retinal Diseases

Twenty-four-hour effects of bimatoprost 0.01% monotherapy on intraocular pressure and ocular perfusion pressure.

Tung JD, Tafreshi A, Weinreb RN, Slight JR, Medeiros FA, Liu JH

BMJ Open. 2012 Aug 23;2(4):e001106

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Other: Bimatoprost, Other: Intraocular Pressure, Other: Ocular Perfusion Pressure

July, 2012
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.

Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE, Hawthorne F, Budenz DL, Friedman DS, Gaasterland D, Haines J, Kang JH, Lee R, Lichter P, Liu Y, Pasquale LR, Pericak-Vance M, Realini A, Schuman JS, Singh K, Vollrath D, Weinreb R, Wollstein G, Zack DJ, Zhang K, Young T, Allingham RR, Wiggs JL, Ashley-Koch A, Hauser MA

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4468-74

University of California, San Diego - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma

June, 2012
A novel compound heterozygous mutation in the BEST1 gene causes autosomal recessive best vitelliform macular dystrophy.

Zhao L, Grob S, Corey R, Krupa M, Luo J, Du H, Lee C, Hughes G, Lee J, Quach J, Zhu J, Shaw PX, Kozak I, Zhang K

Eye (Lond). 2012 Jun;26(6):866-71

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: Gene Research/Therapy, Macular Dystrophy, Other: Mutations

Combining structural and functional measurements to improve estimates of rates of glaucomatous progression.

Medeiros FA, Zangwill LM, Girkin CA, Liebmann JM, Weinreb RN

Am J Ophthalmol. 2012 Jun;153(6):1197-205.e1

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Other: Confocal Scanning Laser Ophthalmoscopy (CSLO

Localized glaucomatous change detection within the proper orthogonal decomposition framework.

Balasubramanian M, Kriegman DJ, Bowd C, Holst M, Weinreb RN, Sample PA, Zangwill LM

Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3615-28

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Other: Proper Orthogonal Decomposition (POD

Ophthalmic drug discovery: Novel targets and mechanisms for retinal diseases and glaucoma.

Zhang K, Zhang L, Weinreb RN

Nat Rev Drug Discov. 2012 Jun 15;11(7):541-59

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: AMD, Glaucoma, Other: Ophthalmic Drug

April, 2012
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL

PLoS Genet. 2012 Apr;8(4):e1002654

University of California, San Diego - Departmental Grant

Keywords: Gene Research/Therapy, Glaucoma, Other: Optic Nerve Degeneration

Incorporating risk factors to improve the assessment of rates of glaucomatous progression.

Medeiros FA, Zangwill LM, Mansouri K, Lisboa R, Tafreshi A, Weinreb RN

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2199-207

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Optic Neuropathy

Predicting glaucomatous progression in glaucoma suspect eyes using relevance vector machine classifiers for combined structural and functional measurements.

Bowd C, Lee I, Goldbaum MH, Balasubramanian M, Medeiros FA, Zangwill LM, Girkin CA, Liebmann JM, Weinreb RN

Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2382-9

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Other: Relevance Vector Machine (RVM

Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography.

Chhablani J, Barteselli G, Wang H, El-Emam S, Kozak I, Doede AL, Bartsch DU, Cheng L, Freeman WR

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2274-80

University of California, San Diego - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging, Myopia/Presbyopia

Retinal adherence and fibrillary surface changes correlate with surgical difficulty of epiretinal membrane removal.

Kim JS, Chhablani J, Chan CK, Cheng L, Kozak I, Hartmann K, Freeman WR

Am J Ophthalmol. 2012 Apr;153(4):692-7.e1-2

University of California, San Diego - Departmental Grant

Keywords: Diabetic Retinopathy, Imaging, Retina/Retinal Diseases

Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

Deng WT, Dinculescu A, Li Q, Boye SL, Li J, Gorbatyuk MS, Pang J, Chiodo VA, Matthes MT, Yasumura D, Liu L, Alkuraya FS, Zhang K, Vollrath D, LaVail MM, Hauswirth WW

Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1895-904

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: Gene Research/Therapy, Retinitis Pigmentosa

March, 2012
Continuous 24-hour intraocular pressure monitoring for glaucoma--time for a paradigm change.

Mansouri K, Weinreb R

Swiss Med Wkly. 2012 Mar 28;142:w13545

University of California, San Diego - Departmental Grant

Keywords: Glaucoma, Other: Intraocular Pressure, Other: 24 hour, Other: Sensimed Triggerfish

Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function.

Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K

J Biol Chem. 2012 Mar 30;287(14):11469-80

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: Macular Dystrophy, Retina/Retinal Diseases, Other: ELOVL4 Protein

January, 2012
Effects of aging on 24-hour intraocular pressure measurements in sitting and supine body positions.

Mansouri K, Weinreb RN, Liu JH

Invest Ophthalmol Vis Sci. 2012 Jan 10;53(1):112-6

University of California, San Diego - Departmental Grant

Keywords: Other: Aging, Other: Intraocular Pressure, Other: Sitting and Supine Body Positions

High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6.

Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw PX, Zhang K

J Biol Chem. 2012 Jan 6;287(2):1520-6

University of California, San Diego - Senior Scientific Investigator Award - Zhang, Kang / MD, PhD Departmental Grant

Keywords: AMD, Gene Research/Therapy, Other: Genome-wide Association Study (GWAS

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